Subacute radiation dermatitis from fluoroscopy during coronary artery stenting: evidence for cytotoxic lymphocyte mediated apoptosis.

Abstract:

:A patient with fluoroscopy-induced subacute radiation dermatitis is described. Her biopsy specimen showed vacuolar change and necrotic keratinocytes with lymphocytes in direct apposition, or "satellitosis". Lymphocytes in the dermis and infiltrating the epidermis were predominantly CD8+ and a number of the lymphocytes stained for TIA-1, a cytotoxic granule protein in T-cells and natural killer cells, that appears to be involved in the induction of apoptosis. Our findings suggest cytotoxic lymphocyte mediated apoptosis is involved in the pathogenesis of subacute radiation dermatitis.

journal_name

J Am Acad Dermatol

authors

Stone MS,Robson KJ,LeBoit PE

doi

10.1016/s0190-9622(98)70577-8

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

333-6

issue

2 Pt 2

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(98)70577-8

journal_volume

38

pub_type

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