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Cutaneous squamous cell carcinomas of the lower extremity: a distinct subset of squamous cell carcinomas.

Abstract：

BACKGROUND:Some patients develop a disproportionate number of cutaneous squamous cell carcinomas (SCCs) on their lower extremity (LE). OBJECTIVE:We sought to characterize the clinical features, treatment, and outcome in patients who develop multiple LE SCCs. METHODS:We identified 22 patients with 4 or more biopsy-diagnosed LE SCCs during a 4.5-year study period. The location, size, treatment, and clinical outcome of each LE SCC were recorded. RESULTS:Of the 22 patients studied, 18 were female. Of the 360 SCCs our patients developed, 260 (72.2%) were on the LE. The incidence of SCCs in these patients was nearly 7 times greater than the incidence of basal cell carcinoma in the same patients. LIMITATIONS:The number of patients is small and limits definitive conclusions about prevalence of SCCs on the LE in the general population. CONCLUSIONS:LE SCCs are a distinct subset of cutaneous SCCs and may have distinctive clinical features and biologic behavior requiring additional study.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Kim C,Ko CJ,Leffell DJ

doi

10.1016/j.jaad.2013.09.026

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

70-4

issue

1

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(13)01005-0

journal_volume

70

pub_type

杂志文章

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