Inflammatory vitiligo in Vogt-Koyanagi-Harada disease.

Abstract:

:Vogt-Koyanagi-Harada disease is a rare disease characterized by uveitis, meningitis, dysacusis, alopecia, poliosis, and vitiligo. We describe a 48-year-old patient with Vogt-Koyanagi-Harada disease associated with thin inflammatory raised erythema and plaque-type inflammatory erythema superimposed on vitiligo. Interestingly, inflammatory raised erythema was separated from the perfect vitiligo, and the incomplete vitiligo lay between them initially. Thereafter, incomplete vitiligo became completely depigmented with diminution of inflammatory raised erythema. This is the second case of vitiligo with inflammatory raised borders associated with Vogt-Koyanagi-Harada disease. Our results of immunohistochemical and electron microscopic studies suggested the involvement of T-cell-mediated cytotoxicity and apoptosis in the development of skin lesions.

journal_name

J Am Acad Dermatol

authors

Tsuruta D,Hamada T,Teramae H,Mito H,Ishii M

doi

10.1067/mjd.2001.110879

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

129-31

issue

1

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(01)72081-6

journal_volume

44

pub_type

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