Abstract:
BACKGROUND:For persons of childbearing potential prescribed isotretinoin, the iPLEDGE program requires use of 2 simultaneous methods of contraception or commitment to abstinence. OBJECTIVE:To model the relative effectiveness of a variety of contraception strategies for patients taking isotretinoin, including those that are acceptable according to iPLEDGE. METHODS:We performed a decision analysis modeling the estimated rate of pregnancy with various contraception strategies during a typical 6-month course of isotretinoin. RESULTS:Tier 1 contraception options (eg, subdermal hormonal implant, intrauterine devices) each had effectiveness of >99.5% alone. When combined with a secondary form of contraception, tier 2 contraception options (eg, depot medroxyprogesterone injections, combined oral contraceptives) each had effectiveness >99%. LIMITATIONS:Sensitivity analyses were conducted to evaluate the impact of uncertain parameters on the results. CONCLUSION:There may be opportunities to simplify iPLEDGE by recognizing the high effectiveness of tier 1 contraception options and increasing use of secondary forms of contraception among those using tier 2 contraception options as their primary form of contraception. Future studies are needed to understand the most effective strategies in clinical practice to prevent unintended pregnancy for patients taking isotretinoin to improve outcomes and provide patient-centered care.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Barbieri JS,Roe AH,Mostaghimi Adoi
10.1016/j.jaad.2020.02.022subject
Has Abstractpub_date
2020-07-01 00:00:00pages
104-108issue
1eissn
0190-9622issn
1097-6787pii
S0190-9622(20)30230-9journal_volume
83pub_type
杂志文章abstract::In addition to being recognized as a chronic inflammatory disease that manifests in the skin, psoriasis is increasingly understood to be a systemic disease that causes immune dysregulation throughout the body. The systemic nature of psoriasis is evidenced by the higher burden of comorbidities and shorter life expectan...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.jaad.2018.02.040
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:It is unclear whether the type 2 T helper cell-specific immunosuppressive action of dupilumab interferes with patch testing. OBJECTIVES:We sought to evaluate the reliability of patch testing on dupilumab and the contribution of allergic contact dermatitis (ACD) to complex dermatitis in patients with residua...
journal_title:Journal of the American Academy of Dermatology
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更新日期:2020-01-01 00:00:00
abstract::This review begins with a classification of adverse drug reactions and a summary of those features that distinguish allergic from toxic and idiosyncratic reactions. Factors that influence the risk of developing drug allergy are then reviewed, followed by a discussion of the known and suspected immunologic mechanisms r...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/s0190-9622(82)70073-8
更新日期:1982-05-01 00:00:00
abstract::A new, quantitative modification of the vasoconstrictor assay was used to measure bioavailability of generic topical corticosteroid products in two categories: betamethasone valerate 0.1% cream and triamcinolone 0.1% cream. Betamethasone valerate products could be separated into two distinct categories, and triamcinol...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(89)70091-8
更新日期:1989-05-01 00:00:00
abstract::Clinical and laboratory records of 100 biopsy-proved cases of generalized granuloma annulare seen at the Mayo Clinic between 1966 and 1986 were reviewed. The skin eruption involved predominantly annular lesions in 67 patients and predominantly nonannular papules in 33. The ratio of female-to-male patients was 2.9:1 in...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:1989-01-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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doi:10.1016/j.jaad.2019.06.024
更新日期:2020-04-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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doi:10.1016/j.jaad.2018.01.014
更新日期:2018-07-01 00:00:00
abstract::We report a case of a neonate with a congenital tumor on the left palm. The patient had a grapefruit-sized tumor and coagulopathy at birth and was presumed to have a hemangioendothelioma with associated Kasabach-Merritt phenomenon. When the tumor failed to respond to systemic steroids, a biopsy specimen was taken, rev...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:2004-02-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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更新日期:2003-10-01 00:00:00
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abstract::Preventing death from malignant melanoma is the most pressing issue in preventive dermatology in the United States because the mortality rate has increased markedly. Dermatologists, as the physicians best suited by training to identify early malignant melanoma, need to take the lead in developing a national project of...
journal_title:Journal of the American Academy of Dermatology
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doi:
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journal_title:Journal of the American Academy of Dermatology
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更新日期:1996-06-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(97)80009-6
更新日期:1997-11-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/0190-9622(91)70147-t
更新日期:1991-06-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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更新日期:1988-12-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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doi:10.1016/j.jaad.2006.11.033
更新日期:2007-07-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2004.01.054
更新日期:2004-08-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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更新日期:2017-08-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
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更新日期:1982-11-01 00:00:00
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journal_title:Journal of the American Academy of Dermatology
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更新日期:2000-12-01 00:00:00
abstract::Comparison of the TRUE Test patch test system with the chamber system recommended by the North American Contact Dermatitis Group showed concordance of results in 98% of tests with nickel, epoxy resin, and ethylenediamine dihydrochloride. Also, a panel of 12 TRUE Test screening allergens tested on 128 patients showed n...
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更新日期:1989-10-01 00:00:00