Abstract：
BACKGROUND:Appropriate primary end points in randomized controlled trials (RCTs) improve the quality of the measurement and enable comparison of the findings with those of other trials. OBJECTIVE:To assess the quality of reporting primary end points in RCTs recently published in dermatology journals. METHODS:We identified 134 primary reports of RCTs among original articles in 4 dermatology journals published from January 2016 to December 2018. Details were extracted from articles, supplements, and trial registries. A multivariable logistic regression analysis was conducted to identify factors associated with adequate primary end point reporting. RESULTS:Adequate primary end point reporting was conducted in 76 of 134 RCTs (56.7%). Nine missed the definition of primary end points, and 13 did not define the timing of primary end points in the publications. Among 113 RCTs reporting primary end points explicitly in the articles, 16 showed discrepancies between registration and publication, and 21 were not able to valuate prespecification of primary end points. Multicenter studies and sponsor-initiated trials were significantly associated with adequate reporting quality after adjusting for covariates. LIMITATIONS:Prespecification was evaluated based on a comparison of the article and registry. CONCLUSIONS:The quality of primary end point reporting, particularly in prespecification, has remained unsatisfactory in the recent dermatology literature.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Kim DY,Oh S,Yoon HSdoi
10.1016/j.jaad.2020.04.067subject
Has Abstractpub_date
2020-04-22 00:00:00eissn
0190-9622issn
1097-6787pii
S0190-9622(20)30682-4pub_type
杂志文章abstract：:We describe a 48-year-old woman with a 12-year history of porphyria cutanea tarda who showed a remarkable exacerbation of her eruptions accompanied by high serum levels of iron and ferritin at menopause. As iron storage is known to be a triggering factor of porphyria cutanea tarda, the possible role of menstruation as...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/s0190-9622(03)00483-3
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND:Early specialist evaluation during rapid proliferative growth of complicated infantile hemangiomas (IH) is crucial. Health disparities and barriers of access-to-care for children with IH have not been examined. OBJECTIVE:Investigate whether socioeconomic status (SES) is associated with age at subspecialist ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2018.09.041
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Epidermal spongiosis with exocytosis of eosinophils (ES) has been reported in biopsy specimens from patients with various dermatoses. Its diagnostic value and the patient's outcome remain poorly understood in those cases in which ES is not associated directly with diagnostic features of a bullous dermatosis....
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(94)70120-2
更新日期：1994-06-01 00:00:00
abstract：:We describe a 39-year-old man with a 3-year history of a recalcitrant psoriasiform eruption that was accentuated in the intertriginous areas. Hsitopathology was consistent with psoriasis. A glucagon level was 744 pg/mL with the upper limit of normal being 130 pg/mL. Computed tomographic scan of the abdomen revealed a ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/s0190-9622(02)61774-8
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND:Mohs micrographic surgery (MMS) has a low rate of surgical site infection (SSI) without the use of prophylactic antibiotics. In the studies to date, there has been variation in the steps taken by each surgeon to prevent SSIs but in all cases sterile technique was used during wound reconstruction. OBJECTIVE:...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章
doi：10.1016/j.jaad.2010.07.029
更新日期：2010-11-01 00:00:00
abstract：:"Poikiloderma" is a morphologic and descriptive term referring to a combination of cutaneous atrophy, telangiectasia, and varied macular pigmentary changes that result in a mottled skin appearance. Its etiology includes both congenital and acquired causes. Many studies have reported different causes of acquired poikil...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2012.06.015
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:Dermatoscopy is the most commonly used noninvasive tool for the diagnosis of pigmented skin lesions, but few studies have investigated the value of cytology in the identification of those lesions. OBJECTIVE:We compared the accuracy of dermatoscopy with that of the Tzanck smear test in the diagnosis of pigme...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章
doi：10.1016/j.jaad.2010.08.019
更新日期：2011-11-01 00:00:00
abstract：:Dermatofibrosarcoma protuberans (DFSP) is a rare, clinically challenging, soft tissue tumor. The main histologic differential of DFSP is usually a dermatofibroma. In 1990, the first report appeared demonstrating that cells of DFSP express the human progenitor antigen CD34 on their surface. Since then, there have been ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(97)70146-4
更新日期：1997-09-01 00:00:00
abstract：BACKGROUND:The Patient-Reported Outcomes Measurement Information System (PROMIS) Itch Questionnaire (PIQ) was recently developed. OBJECTIVE:To validate PIQ short forms in adults with AD. METHODS:Self-administered questionnaires and skin examinations were performed in 239 adults with atopic dermatitis (AD) in a dermat...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2019.11.057
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:Many drugs have been used to treat scabies, but it is unclear which of them is the most efficacious. OBJECTIVE:To evaluate the comparative efficacy and safety of antiscabietic agents. METHODS:A systematic review of randomized controlled trials was conducted. Direct and network meta-analyses were applied to...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,meta分析
doi：10.1016/j.jaad.2019.01.004
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Conventional therapy of severe bullous pemphigoid (BP) relies on the use of high-dose systemic corticosteroids with or without adjuvants, notably immunosuppressive agents. This approach can result in debilitating and potentially fatal side effects, hence the need to explore alternative therapies. Intravenous...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,meta分析
doi：10.1067/mjd.2000.112288
更新日期：2001-01-01 00:00:00
abstract：:Sera from 34 patients with lepromatous leprosy were screened for the presence of autoantibodies by indirect immunofluorescence using two epithelial cell lines, PTK2 and HEp2, as substrates. Indirect immunofluorescence staining of both substrates with the serum of a patient with lepromatous leprosy revealed a cytoplasm...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(88)70120-6
更新日期：1988-05-01 00:00:00
abstract：BACKGROUND:Little is known about the utilization of medical services for psoriasis. OBJECTIVE:Our purpose was to quantify the medical resources utilized in the United States for the treatment of psoriasis. METHODS:By utilizing data tapes from the National Center of Health Statistics we estimated the number of outpati...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(96)90676-3
更新日期：1996-10-01 00:00:00
abstract：:Malignant melanoma is considered the most lethal skin cancer if it is not detected and treated during its early stages. About 10% of melanoma patients report a family history of melanoma; however, individuals with features of true hereditary melanoma (ie, unilateral lineage, multigenerational, multiple primary lesions...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2015.08.038
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Although cyclosporine has been found to be effective therapy for severe psoriasis, only limited data exist about efficacy and safety during long-term treatment with a low-dose regimen. Furthermore, little is known about the course of psoriasis after drug withdrawal. OBJECTIVE:Our purpose was to assess the r...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/0190-9622(95)91393-9
更新日期：1995-09-01 00:00:00
abstract：:A 49-year-old man presented with an acute onset of folliculitis on his right cheek. The folliculitis was unresponsive to antibiotics. A potassium hydroxide preparation of a scraping from the affected area revealed the presence of numerous Demodex mites. The patient was treated with topical crotamiton (Eurax) cream res...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(86)70287-9
更新日期：1986-11-01 00:00:00
abstract：:As a wider variety of organisms are being identified in superficial fungal infections, more accurate methods of identification may be required to determine fungal susceptibility. The sensitivity of available methods, such as the minimal inhibitory concentration test, is reviewed. The sensitivities of causative pathoge...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(08)81835-x
更新日期：1993-07-01 00:00:00
abstract：:As discussed in the first article in this continuing medical education series, angioinvasive fungal infections pose a significant risk to immunocompromised and immunocompetent patients alike, with a potential for severe morbidity and high mortality. The first article in this series focused on the epidemiology and clin...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2018.04.058
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Although several studies have documented an undersupply of dermatologic services in the United States, little is known about the dermatopathology workforce. OBJECTIVE:Objectives included the following: (1) describe the dermatopathology workforce in the United States; (2) identify characteristics associated ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2010.09.733
更新日期：2011-12-01 00:00:00
abstract：:A new technic is described for more accurately checking the surgical margins of skin tumors removed by standard surgical excision. Vertical sections of surgical specimens represent check points of the margin only 7 microns thick. This means most of the surgical margin is not checked microscopically, allowing small tum...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(82)70131-8
更新日期：1982-10-01 00:00:00
abstract：:The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is a rare disorder caused by mutations of the FOXP3 gene. The FOXP3 gene encodes a DNA-binding protein of the forkhead/winged-helix family and is the central controller of the development of CD4+CD25+ regulatory T cells. CD4+CD25+ regu...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2005.08.047
更新日期：2006-07-01 00:00:00
abstract：:Pyoderma gangrenosum is a neutrophilic dermatosis that may be associated with myeloid malignancies. Less information is available about the association of pyoderma gangrenosum with lymphoid malignancies. We present, to our knowledge, the first case of pyoderma gangrenosum associated with biphenotypic acute leukemia wh...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2001.112377
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:Giant angiofibromas in patients with tuberous sclerosis complex (TSC) are rare. OBJECTIVE:We sought to report two patients who had TSC with unusually large and disfiguring facial angiofibromas and to identify underlying histopathologic changes that may possibly explain the clinical features. METHODS:We per...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2012.03.021
更新日期：2012-12-01 00:00:00
abstract：:Capecitabine, an oral fluoropyrimidine and 5-fluorouracil (FU) prodrug recently approved for the treatment of metastatic colon and breast cancer, is currently under investigation in patients with gastric cancer. It has the advantage of oral administration, and good tolerability with its activity being comparable with ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2007.06.040
更新日期：2008-08-01 00:00:00
abstract：:Three patients with advanced atherosclerotic vascular disease developed multiple cholesterol emboli. The clinical presentation typically includes livedo reticularis of the lower part of the body and purple toes. Small areas of necrosis and ulceration may be present distally, despite palpable pulses. Muscular and abdom...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(85)70165-x
更新日期：1985-08-01 00:00:00
abstract：:We report two cases of mycosis fungoides with marked, pleomorphic follicular manifestations. Follicular hyperkeratosis, comedo-like lesions, acquired epidermal cysts, and patchy alopecia developed in various locations in both patients. Findings of histopathologic and immunohistochemical studies showed atypical CD4+ T ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：:The main limitation for the use of direct immunofluorescence in skin biopsies was the necessity for frozen tissue. In 1973 Michel et al reported use of a liquid fixative, consisting of ammonium sulfate, N-ethyl-maleimide, magnesium sulfate, and potassium citrate, for handling skin biopsy specimens. The present study i...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(85)70103-x
更新日期：1985-05-01 00:00:00
abstract：BACKGROUND:Psoriasis is a systemic inflammatory condition that is associated with a higher risk of cardiovascular (CV) disease. Tofacitinib is being investigated as a treatment for psoriasis. OBJECTIVE:We sought to evaluate the effects of tofacitinib on CV risk factors and major adverse CV events (MACEs) in patients w...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2016.06.012
更新日期：2016-11-01 00:00:00
abstract：:Comparison of the TRUE Test patch test system with the chamber system recommended by the North American Contact Dermatitis Group showed concordance of results in 98% of tests with nickel, epoxy resin, and ethylenediamine dihydrochloride. Also, a panel of 12 TRUE Test screening allergens tested on 128 patients showed n...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章
doi：10.1016/s0190-9622(89)70262-0
更新日期：1989-10-01 00:00:00
abstract：:Alendronate is a bisphosphonate compound used to treat diseases of pathologic bone resorption. Cutaneous reactions to this medication are rare. We report the case of a superficial gyrate erythema that occurred as a reaction to weekly alendronate therapy used in the treatment of postmenopausal osteoporosis. ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2003.245
更新日期：2003-06-01 00:00:00
