Abstract：
BACKGROUND:Long-term adverse effects of propranolol treatment for infantile hemangioma (IH) in young children have been suggested. OBJECTIVE:To compare growth and development in children treated with propranolol for IH with nontreated healthy controls. METHODS:Eighty two (73%) children with IH aged 43 to 51 months treated with propranolol for 6 months or longer, and without other developmental risk factors, were recruited (cases) and matched with 4 twin counterparts and 78 children from a community-based cohort (control subjects). Parents completed the 48-months Ages and Stages Questionnaire (ASQ). Percentages of children with abnormal ASQ results were compared using χ(2) analyses. Mean ASQ scores and growth were compared using Mann-Whitney U tests. RESULTS:Six (7.3%) cases had abnormal ASQ results, compared with 10 (12.2%) controls (P = .292). Mean ASQ total score (25th-75th percentile) was 52.9 (50.8-57.0) for cases and 51.9 (49.0-56.0) for controls (P = .383). Height and weight of cases and controls were comparable. LIMITATIONS:A parent-completed screening instrument was used. The exclusion of children born at gestational age less than 36 weeks and/or children born small for gestational age partly limits generalizability. CONCLUSION:We found no increased developmental risk or growth impairment at age 4 years in patients with IH treated with propranolol.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Moyakine AV,Kerstjens JM,Spillekom-van Koulil S,van der Vleuten CJdoi
10.1016/j.jaad.2016.02.1218subject
Has Abstractpub_date
2016-07-01 00:00:00pages
59-63.e1issue
1eissn
0190-9622issn
1097-6787pii
S0190-9622(16)01483-3journal_volume
75pub_type
杂志文章abstract：BACKGROUND:Genital or vulval lichen planus (VLP) may have a disabling effect on a patient's quality of life. Evidence-based management guidelines are lacking for VLP. OBJECTIVE:We sought to review clinical presentation and treatment of patients who received a diagnosis of VLP. METHODS:The 100 consecutive patients who...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2017.07.030
更新日期：2017-12-01 00:00:00
abstract：:Melanocytic nevi are a strong phenotypic marker of cutaneous melanoma risk. Changes in nevi during childhood and adolescence make these prime periods for studying nevogenesis. Insights gained by the study of nevi in childhood have implications for melanoma detection in both adults and children. A more comprehensive un...
journal_title：Journal of the American Academy of Dermatology
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abstract：:We describe four patients who developed basal cell carcinoma (BCC) among multiple facial trichoepitheliomas. The only clinical feature that distinguished the carcinomas from the trichoepitheliomas was their larger size in three of the four patients. None of the lesions ulcerated. Whether the BCCs developed independent...
journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/0190-9622(93)70046-v
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journal_title：Journal of the American Academy of Dermatology
pub_type： 信件,评审
doi：10.1016/j.jaad.2005.10.059
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abstract：:Sulfur is a time-honored therapeutic agent useful in a variety of dermatologic disorders. Its keratolytic action is due to formation of hydrogen sulfide through a reaction that depends upon direct interaction between sulfur particles and keratinocytes. The smaller the particle size, the greater the degree of such inte...
journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/s0190-9622(85)80050-5
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
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doi：10.1016/s0190-9622(88)70250-9
更新日期：1988-11-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(86)70110-2
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journal_title：Journal of the American Academy of Dermatology
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2013.04.067
更新日期：2013-12-01 00:00:00
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journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(86)70132-1
更新日期：1986-06-01 00:00:00
abstract：BACKGROUND:Many drugs have been used to treat scabies, but it is unclear which of them is the most efficacious. OBJECTIVE:To evaluate the comparative efficacy and safety of antiscabietic agents. METHODS:A systematic review of randomized controlled trials was conducted. Direct and network meta-analyses were applied to...
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pub_type： 杂志文章,meta分析
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更新日期：2019-05-01 00:00:00
