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Interleukin 17, inflammation, and cardiovascular risk in patients with psoriasis.

Abstract：

:In addition to being recognized as a chronic inflammatory disease that manifests in the skin, psoriasis is increasingly understood to be a systemic disease that causes immune dysregulation throughout the body. The systemic nature of psoriasis is evidenced by the higher burden of comorbidities and shorter life expectancies of patients with psoriasis, particularly those with early-onset and severe disease. Notably, psoriasis is associated with an increased risk for cardiovascular disease, which is the most common cause of morbidity and mortality in patients with psoriasis. In this review, we examine the association between psoriasis and cardiovascular disease and specifically focus on the role of interleukin 17-mediated inflammation as a potential mechanistic link between psoriasis and cardiovascular disease. Moreover, we describe potential treatment approaches to reduce the burden of cardiovascular disease in patients with psoriasis and discuss the clinical importance of the association of these 2 diseases with respect to patient management and education.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Lockshin B,Balagula Y,Merola JF

doi

10.1016/j.jaad.2018.02.040

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

345-352

issue

2

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(18)30325-6

journal_volume

79

pub_type

杂志文章,评审

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