Congenital melanocytic nevi in young children: Histopathologic features and clinical outcomes.

abstract：:Cytokines are glycoproteins produced by many different cells. Via binding to specific receptors on target cells they regulate the activation, differentiation, and proliferation of immune and nonimmune cells. After injury keratinocytes synthesize and release cytokines such as interleukins, colony stimulating factors, a...

journal_title：Journal of the American Academy of Dermatology

authors： Luger TA,Schwarz T

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:There is no effective treatment for progressive macular hypomelanosis. Recent findings indicate that Propionibacterium acnes may play a role in the pathogenesis. OBJECTIVES:We sought to compare the effectiveness of antimicrobial therapy with anti-inflammatory therapy in patients with progressive macular hyp...

journal_title：Journal of the American Academy of Dermatology

authors： Relyveld GN,Kingswijk MM,Reitsma JB,Menke HE,Bos JD,Westerhof W

更新日期：2006-11-01 00:00:00

abstract：:Poison ivy, poison oak, and poison sumac are now classified in the genus Toxicodendron which is readily distinguished from Rhus. In the United States, there are two species of poison oak, Toxicodendron diversilobum (western poison oak) and Toxicodendron toxicarium (eastern poison oak). There are also two species of po...

journal_title：Journal of the American Academy of Dermatology

authors： Guin JD,Gillis WT,Beaman JH

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Dermoscopy improves the recognition of melanoma and Spitz nevus but occasionally melanoma may exhibit a symmetric pattern mimicking Spitz nevus. OBJECTIVE:We sought to investigate the likelihood of finding melanoma when excising a symmetric Spitzoid-looking lesion in patients aged 12 years or older. METHOD...

journal_title：Journal of the American Academy of Dermatology

authors： Lallas A,Moscarella E,Longo C,Kyrgidis A,de Mestier Y,Vale G,Guida S,Pellacani G,Argenziano G

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Vitiligo is an autoimmune disease of the skin with limited treatment options; there is an urgent need to identify and validate biomarkers of disease activity to support vitiligo clinical studies. OBJECTIVE:To investigate potential biomarkers of disease activity directly in the skin of vitiligo subjects and ...

journal_title：Journal of the American Academy of Dermatology

authors： Strassner JP,Rashighi M,Ahmed Refat M,Richmond JM,Harris JE

更新日期：2017-05-01 00:00:00

abstract：:We describe three unusual features of juvenile xanthogranuloma that were observed in three different children. We also describe the mixed and clustered forms of juvenile xanthogranuloma and a giant juvenile xanthogranuloma of the nose. ...

journal_title：Journal of the American Academy of Dermatology

authors： Caputo R,Grimalt R,Gelmetti C,Cottoni F

更新日期：1993-11-01 00:00:00

abstract：:Punctate hyperkeratosis of the palms and soles is an uncommon autosomal dominant condition. We report a 65-year-old man with this condition and review the literature. With electron microscopy, we have examined both clinically affected and adjacent clinically unaffected palmar skin. The only ultrastructural differences...

journal_title：Journal of the American Academy of Dermatology

authors： Rubenstein DJ,Schwartz RA,Hansen RC,Payne CM

更新日期：1980-07-01 00:00:00

abstract：:Keratosis lichenoides chronica is a rare dermatosis of unknown etiology with a wide variety of cutaneous manifestations. We present a 47-year-old male with a history of progressive and recalcitrant hyperkeratotic and warty plaques, mimicking verrucous secondary syphilis both clinically and microscopically. We review t...

journal_title：Journal of the American Academy of Dermatology

authors： Jayaraman AG,Pomerantz D,Robinson-Bostom L

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:HLA-DR1 is associated with the development of multiple basal cell carcinomas (BCC). However, the association is weak. OBJECTIVE:The purpose of our study was to determine whether HLA-DR1 is a marker for susceptibility to the development of many BCCs during a lifetime. METHODS:Persons with multiple BCCs were...

journal_title：Journal of the American Academy of Dermatology

authors： Czarnecki D,Lewis A,Nicholson I,Tait B,Nash C

更新日期：1992-05-01 00:00:00

abstract：:Cutaneous extramedullary hemopoiesis (EMH) is a rare complication of chronic myeloproliferative and myelodysplastic disorders. Chronic idiopathic myelofibrosis (CIMF) is the most common underlying condition. To date, fewer than 30 cases have been reported in the literature and there has been significant confusion with...

journal_title：Journal of the American Academy of Dermatology

authors： Haniffa MA,Wilkins BS,Blasdale C,Simpson NB

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Maternal smoking during pregnancy has been shown to lead to immunologic changes in the offspring. However, little is known about the influence of this exposure on atopic manifestations. OBJECTIVE:Our purpose was to investigate the influence of air pollutants on manifestations of atopy in preschool children....

journal_title：Journal of the American Academy of Dermatology

authors： Schäfer T,Dirschedl P,Kunz B,Ring J,Uberla K

更新日期：1997-04-01 00:00:00

abstract：:Clinical trials are critical for the development of new therapies in dermatology, and their results help determine US Food and Drug Administration (FDA) approval and guide care. Of special relevance is the clinical trial efficacy end point, the metric from which statistically significant outcome is derived. Clinicians...

journal_title：Journal of the American Academy of Dermatology

authors： Wei EX,Kirsner RS,Eaglstein WH

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:In 1982 we reported our preliminary observations on the use of home UV phototherapy for patch and early plaque phase mycosis fungoides (MF). OBJECTIVE:Our purpose was to present follow-up data of the original 31 patients, covering an interval of up to 15 years. METHODS:All patients used a commercially avai...

journal_title：Journal of the American Academy of Dermatology

authors： Resnik KS,Vonderheid EC

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Kaposi's varicelliform eruption (KVE), first described in 1887 by Moritz Kaposi, refers to a disseminated cutaneous infection with herpesvirus type 1 or 2, vaccinia virus, or coxsackievirus A16 in a patient with another underlying dermatosis. When herpesvirus type 1 or 2 is the pathogenic virus, the term "ec...

journal_title：Journal of the American Academy of Dermatology

authors： Santmyire-Rosenberger BR,Nigra TP

更新日期：2005-07-01 00:00:00

abstract：:Histoplasma capsulatum and Trichosporon inkin may cause disseminated disease in immunocompromised patients. Disseminated T inkin, the causative agent of white piedra, is rare and difficult to diagnose. We report the case of a 28 year-old man with newly diagnosed HIV infection who developed asymptomatic lesions on his ...

journal_title：Journal of the American Academy of Dermatology

authors： David C,Martin DB,Deng A,Cooper JZ

更新日期：2008-08-01 00:00:00

abstract：:We report an unusual case of congenital melanocytic nevus presenting in a 19-year-old African woman as widespread papules and variably sized nodules and tumors affecting the entire body, including the palms, soles, and oral mucous membrane. Histopathologic examination of 3 representative skin lesions showed mainly der...

journal_title：Journal of the American Academy of Dermatology

authors： Rose C,Kaddu S,El-Sherif TF,Kerl H

更新日期：2003-10-01 00:00:00

abstract：:With the growth of dermatologic surgery the appropriate use of local anesthesia is becoming an important issue. Thoughtful use of local anesthesia can improve the patient's experience and facilitate the surgical procedure. In this review we discuss historical and pharmacologic aspects of local anesthetic agents. Empha...

journal_title：Journal of the American Academy of Dermatology

authors： Grekin RC,Auletta MJ

更新日期：1988-10-01 00:00:00

abstract：:Hyperpigmentation, pulmonary infiltration, and erythema nodosum occurred in a patient receiving long-term minocycline therapy. Bronchoalveolar lavage revealed both a neutrophilic and an eosinophilic alveolitis. The pulmonary and systemic symptoms promptly resolved after discontinuation of minocycline. ...

journal_title：Journal of the American Academy of Dermatology

authors： Bridges AJ,Graziano FM,Calhoun W,Reizner GT

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Darier disease (DD) is an autosomal dominant genodermatosis caused by mutations in the ATP2A2 gene. It has been reported that depletion of Ca(2+) stores within the endoplasmic reticulum of keratinocytes is associated with impaired cell cycle regulation and terminal differentiation. Mechanical stress, heat, o...

journal_title：Journal of the American Academy of Dermatology

authors： Godic A,Korosec B,Miljković J,Kansky A,Glavac D

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Pseudoxanthoma elasticum (PXE) is a systemic connective tissue disorder involving elastic fiber calcification and fragmentation with major clinical manifestations occurring in the cutaneous, ocular, and cardiovascular systems. Normalization of the serum calcium-phosphate product through hemodialysis in a pre...

journal_title：Journal of the American Academy of Dermatology

authors： Sherer DW,Singer G,Uribarri J,Phelps RG,Sapadin AN,Freund KB,Yanuzzi L,Fuchs W,Lebwohl M

更新日期：2005-10-01 00:00:00

abstract：:The Patient Protection and Affordable Care Act will have substantial effects on the US health care system. Physicians hold varied opinions regarding the overall merits or drawbacks of the health system reform law, but it is critical that we understand its components and the implications for our practices and our patie...

journal_title：Journal of the American Academy of Dermatology

authors： Resneck JS Jr

更新日期：2010-10-01 00:00:00

abstract：:Four patients are described with stony-hard induration of the skin and deeper tissues, most pronounced on the buttocks, thighs, and legs, and with limitation of joint mobility and contractures of the lower limbs. Two patients were siblings and one was the product of a consanguineous marriage. The disorder appears to b...

journal_title：Journal of the American Academy of Dermatology

authors： Jablonska S,Schubert H,Kikuchi I

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Some studies have purported to link isotretinoin prescribed for acne with the development of inflammatory bowel disease (IBD). OBJECTIVE:We sought to identify existence of disproportionate attorney-initiated reporting of isotretinoin-associated IBD in the Food and Drug Administration Adverse Event Reporting...

journal_title：Journal of the American Academy of Dermatology

authors： Stobaugh DJ,Deepak P,Ehrenpreis ED

更新日期：2013-09-01 00:00:00

abstract：:A diabetic renal transplant recipient developed fever, generalized rash, and genital ulcers which showed typical histologic changes of cytomegalovirus (CMV) infection in the dermal vascular endothelium. This infection was confirmed by rising serologic titer of specific antibody, positive viral cultures, and typical nu...

journal_title：Journal of the American Academy of Dermatology

authors： Pariser RJ

更新日期：1983-12-01 00:00:00

abstract：:Mycobacterium avium complex, a common opportunistic pathogen among patients with AIDS, usually manifests as disseminated disease involving the lung, lymph nodes, and gastrointestinal tract. Primary cutaneous infections with M avium complex are extremely rare, and most cutaneous lesions are caused by dissemination. Cut...

journal_title：Journal of the American Academy of Dermatology

authors： Kayal JD,McCall CO

更新日期：2002-11-01 00:00:00

abstract：:Onycholysis (ONY) of the fingernails is a common disorder that is diagnosed with ease but often managed with great difficulty. The full spectrum of causes is broad and not always readily apparent. In this review, an approach to the evaluation and management of ONY is offered. ...

journal_title：Journal of the American Academy of Dermatology

authors： Kechijian P

更新日期：1985-03-01 00:00:00

abstract：:Good to excellent clinical results have been obtained in the treatment of severe inflammatory acne (acne conglobata, acne fulminans, and acne conglobata with hidradenitis and dissecting cellulitis of the scalp) with orally administered isotretinoin (13-cis-retinoic acid). Similar promising results have been obtained i...

journal_title：Journal of the American Academy of Dermatology

authors： Plewig G,Nikolowski J,Wolff HH

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:Although several studies have documented an undersupply of dermatologic services in the United States, little is known about the dermatopathology workforce. OBJECTIVE:Objectives included the following: (1) describe the dermatopathology workforce in the United States; (2) identify characteristics associated ...

journal_title：Journal of the American Academy of Dermatology

authors： Suwattee P,Cham PM,Abdollahi M,Warshaw EM

更新日期：2011-12-01 00:00:00

abstract：:A distinctive new hair condition, the loose anagen syndrome, features anagen hairs that are loosely anchored and easily pulled from the scalp. The children studied had sparse hair that did not grow long and that pulled easily from the scalp. The majority of patients were blond girls, aged 2 to 5 years, but both sexes ...

journal_title：Journal of the American Academy of Dermatology

authors： Price VH,Gummer CL

更新日期：1989-02-01 00:00:00

abstract：:Blue-brown macules of the face occurring on both sides of the forehead, temple, eyelids, malar area, alae of the nose, and root of the nose are often observed in middle-aged Japanese women. These lesions histologically are a form of dermal melanocytosis as shown by electron microscopic examination. They differ clinica...

journal_title：Journal of the American Academy of Dermatology

authors： Hori Y,Kawashima M,Oohara K,Kukita A

更新日期：1984-06-01 00:00:00