End points in dermatologic clinical trials: A review for clinicians.

abstract：BACKGROUND:Botulinum toxin type A (BTX-A) is widely used for facial esthetics but is incompletely studied. OBJECTIVE:This study was conducted to evaluate the efficacy and safety of BTX-A treatment of glabellar lines. METHODS:Patients with moderate to severe glabellar lines at maximum frown received intramuscular inje...

journal_title：Journal of the American Academy of Dermatology

authors： Carruthers JA,Lowe NJ,Menter MA,Gibson J,Nordquist M,Mordaunt J,Walker P,Eadie N,BOTOX Glabellar Lines I Study Group.

更新日期：2002-06-01 00:00:00

abstract：:A new section entitled "Dermatology Grand Rounds at the NIH" appears this month. The idea behind it is to provide a unique look at instructive dermatologic cases being presented at the weekly Dermatology Branch Grand Rounds at the National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland. Pati...

journal_title：Journal of the American Academy of Dermatology

authors： Blauvelt A,Cobb MW,Turner ML

更新日期：2000-10-01 00:00:00

abstract：:Clinical examination is critical for the diagnosis and identification of response to treatment. It is fortunate that technologies are continuing to evolve, enabling augmentation of classical clinical examination with noninvasive imaging modalities. This article discusses emerging technologies with a focus on digital p...

journal_title：Journal of the American Academy of Dermatology

authors： Schneider SL,Kohli I,Hamzavi IH,Council ML,Rossi AM,Ozog DM

更新日期：2019-04-01 00:00:00

abstract：:Five patients with cutaneous leishmaniasis are described. Four of these patients acquired leishmaniasis in Texas. Four cases represent acute cutaneous leishmaniasis, and one case probably represents chronic cutaneous leishmaniasis. The classification and treatment of cutaneous leishmaniasis are reviewed. One patient i...

journal_title：Journal of the American Academy of Dermatology

authors： Nelson DA,Gustafson TL,Spielvogel RL

更新日期：1985-06-01 00:00:00

abstract：:Six months after the occurrence of pyoderma gangrenosum, subcorneal pustular dermatosis developed in a 60-year-old woman. The patient's serum was found to contain an IgA-lambda paraprotein. Although similar cases have been reported, this case is unique in that a distinct episode of pyoderma gangrenosum was followed by...

journal_title：Journal of the American Academy of Dermatology

authors： Kohl PK,Hartschuh W,Tilgen W,Frosch PJ

更新日期：1991-02-01 00:00:00

abstract：:Pruritic folliculitis of pregnancy is a rare pregnancy dermatosis that clears spontaneously in the postpartum period. We describe a patient with characteristic clinical and histopathologic features of this dermatosis. ...

journal_title：Journal of the American Academy of Dermatology

authors： Kroumpouzos G,Cohen LM

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Molluscum contagiosum (MC) is a common and at times severely disfiguring cutaneous viral infection in patients with human immunodeficiency virus (HIV) infection. OBJECTIVE:The purpose of this study was to describe the clinical course of MC in patients with HIV infection and to examine the relation between p...

journal_title：Journal of the American Academy of Dermatology

authors： Schwartz JJ,Myskowski PL

更新日期：1992-10-01 00:00:00

abstract：:Infantile acropustulosis (IA) is a syndrome characterized by recurrent crops of 1- to 2-mm intensely pruritic vesicopustules that are found primarily on the distal extremities of infants. It is reportedly responsive to sulfones and unresponsive to other therapy, but if left untreated spontaneously resolves at about 2 ...

journal_title：Journal of the American Academy of Dermatology

authors： Jennings JL,Burrows WM

更新日期：1983-11-01 00:00:00

abstract：:A patient is described who developed sore throat, palpable purpura, and a distinctive panniculitis. The pathologic alterations in the subcutis were similar to what Wells described in the dermis as eosinophilic cellulitis. In our experience the presence of such a picture primarily in the subcutis is unique. Streptococc...

journal_title：Journal of the American Academy of Dermatology

authors： Burket JM,Burket BJ

更新日期：1985-01-01 00:00:00

abstract：:Subacute myelomonocytic leukemia is typically preceded by a preleukemic phase lasting 1 to 10 years. We describe a case of subacute myelomonocytic leukemia preceded by pruritus for 7 years and by the intermittent appearance of nonspecific necrotic dermal nodules for 4 years. ...

journal_title：Journal of the American Academy of Dermatology

authors： Peterson AO Jr,Jarratt M

更新日期：1980-06-01 00:00:00

abstract：BACKGROUND:Guselkumab, an interleukin-23 blocker, was superior to adalimumab in treating moderate to severe psoriasis in a phase II trial. OBJECTIVES:We sought to compare efficacy and safety of guselkumab with adalimumab and placebo in patients with psoriasis treated for 1 year. METHODS:Patients were randomized to gu...

journal_title：Journal of the American Academy of Dermatology

authors： Blauvelt A,Papp KA,Griffiths CE,Randazzo B,Wasfi Y,Shen YK,Li S,Kimball AB

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Epidemiology and patterns of antibiotic resistance for Staphylococcus aureus are changing in the United States. OBJECTIVE:We sought to determine the epidemiology and antibiotic susceptibility profiles in S aureus cutaneous infections in a pediatric dermatology tertiary health care facility in North Carolina...

journal_title：Journal of the American Academy of Dermatology

authors： Ortega-Loayza AG,Diamantis SA,Gilligan P,Morrell DS

更新日期：2010-05-01 00:00:00

abstract：:Discoid lupus erythematosus lesions show hyperkeratosis and atrophy, which may reflect abnormal epidermal proliferation, differentiation, or both. In this investigation, markers for epidermal proliferation, differentiation and inflammation were studied in cutaneous lesions of discoid lupus erythematosus. Frozen sectio...

journal_title：Journal of the American Academy of Dermatology

authors： de Jong EM,van Erp PE,Ruiter DJ,van de Kerkhof PC

更新日期：1991-12-01 00:00:00

abstract：:The deep penetrating nevus (DPN), also known as the plexiform spindle cell nevus, is a pigmented lesion that commonly arises on the head and neck in the first few decades of life. Histopathologically, the DPN is wedge-shaped and contains melanocytes that exhibit deep infiltration into the dermis. Given these features,...

journal_title：Journal of the American Academy of Dermatology

authors： Strazzula L,Senna MM,Yasuda M,Belazarian L

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Dermatomyositis is associated with significant morbidity and occasional mortality. Currently there is no consensus on treatment for patients with dermatomyositis. OBJECTIVE:Our purpose was to review the clinical features and response to therapy of patients with dermatomyositis and compare these data with pr...

journal_title：Journal of the American Academy of Dermatology

authors： Dawkins MA,Jorizzo JL,Walker FO,Albertson D,Sinal SH,Hinds A

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Treatment guidelines are lacking for classic Kaposi sarcoma. OBJECTIVE:We sought to review the evidence on efficacy of treatments for classic Kaposi sarcoma. METHODS:Articles published in English or French in MEDLINE, Trip, Cochrane Library, and Pascal databases from 1980 to December 2010 were screened. St...

journal_title：Journal of the American Academy of Dermatology

authors： Régnier-Rosencher E,Guillot B,Dupin N

更新日期：2013-02-01 00:00:00

abstract：:The literature concerning the use and possible mode of action of thalidomide in reactional lepromatous leprosy and in various other conditions is reviewed. Although it has no action against the leprosy bacillus, its value in the treatment of the adverse reactions in this type of leprosy is well established, many lepro...

journal_title：Journal of the American Academy of Dermatology

authors： Barnhill RL,McDougall AC

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND:The enzyme indoleamine 2,3-dioxygenase (IDO) degrades the essential amino acid tryptophan, and this degradation is an immunosuppressive mechanism that is mainly used by antigen-presenting cells. IDO-expressing dendritic cells and macrophages have previously been identified as components of lymph node granulo...

journal_title：Journal of the American Academy of Dermatology

authors： von Bubnoff D,Scheler M,Wilms H,Wenzel J,von Bubnoff N,Häcker G,Schultze J,Popov A,Racz P,Bieber T,Wickenhauser C

更新日期：2011-10-01 00:00:00

abstract：:Nail-patella syndrome (NPS) is an autosomal dominant genetic defect, which may be associated with, or closely linked to, the locus controlling palmar and plantar hyperhidrosis (HH). A clinical review of a family with NPS involving six generations was performed. Data were accumulated by personal examination and analysi...

journal_title：Journal of the American Academy of Dermatology

authors： Pechman KJ,Bergfeld WF

更新日期：1980-12-01 00:00:00

abstract：BACKGROUND:Mohs micrographic surgery (MMS) has a low rate of surgical site infection (SSI) without the use of prophylactic antibiotics. In the studies to date, there has been variation in the steps taken by each surgeon to prevent SSIs but in all cases sterile technique was used during wound reconstruction. OBJECTIVE:...

journal_title：Journal of the American Academy of Dermatology

authors： Rogers HD,Desciak EB,Marcus RP,Wang S,MacKay-Wiggan J,Eliezri YD

更新日期：2010-11-01 00:00:00

abstract：:Critical to the proper management of pyoderma gangrenosum are correct diagnosis, identification and treatment of any underlying disorder, and the proper choice of topical and systemic therapy. Many agents are available for the treatment of pyoderma gangrenosum. We review the current therapeutic options, their efficacy...

journal_title：Journal of the American Academy of Dermatology

authors： Chow RK,Ho VC

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Psoriasis and migraine are common conditions with potential overlap of pathophysiological mechanisms. Both these diseases have been associated with increased cardiovascular risk but little is known about their interplay. OBJECTIVE:We sought to investigate the link between psoriasis, and the risk of new-onse...

journal_title：Journal of the American Academy of Dermatology

authors： Egeberg A,Mallbris L,Hilmar Gislason G,Skov L,Riis Hansen P

更新日期：2015-11-01 00:00:00

abstract：:Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against S...

journal_title：Journal of the American Academy of Dermatology

authors： Macias ES,Pereira FA,Rietkerk W,Safai B

更新日期：2011-03-01 00:00:00

abstract：:Rosacea is a skin condition of abnormal inflammation and vascular dysfunction. The active contribution of a microbial agent in the development or progression of rosacea continues to be debated. Research supports the presence of commensal Demodex folliculorum mites at increased density in the skin and associates Helico...

journal_title：Journal of the American Academy of Dermatology

authors： Holmes AD

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that patients with psoriasis may have an increased risk of a variety of noncutaneous diseases, including arterial and venous occlusive diseases. Changes in plasma lipid and lipoprotein composition in patients with psoriasis may be the reason for the increased risk of athero...

journal_title：Journal of the American Academy of Dermatology

authors： Seçkin D,Tokgözoğlu L,Akkaya S

更新日期：1994-09-01 00:00:00

abstract：:Hyperpigmentation, pulmonary infiltration, and erythema nodosum occurred in a patient receiving long-term minocycline therapy. Bronchoalveolar lavage revealed both a neutrophilic and an eosinophilic alveolitis. The pulmonary and systemic symptoms promptly resolved after discontinuation of minocycline. ...

journal_title：Journal of the American Academy of Dermatology

authors： Bridges AJ,Graziano FM,Calhoun W,Reizner GT

更新日期：1990-05-01 00:00:00

abstract：:Molecules of the extracellular matrix may influence the biologic behavior of basal cell keratinocytes. In the unwounded situation, basal cells are in contact with the basement membrane of the dermo-epidermal junction and eventually detach from this structure, move vertically, and differentiate. During wound healing th...

journal_title：Journal of the American Academy of Dermatology

authors： Woodley DT,O'Keefe EJ,Prunieras M

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:In patients with malignancy-associated Sweet syndrome, a thorough evaluation for leukemia cutis should be considered. OBJECTIVE:We sought to describe the clinicopathologic characteristics of histiocytoid Sweet syndrome. METHODS:We retrospectively identified patients with histiocytoid Sweet syndrome at our ...

journal_title：Journal of the American Academy of Dermatology

authors： Chavan RN,Cappel MA,Ketterling RP,Wada DA,Rochet NM,Knudson R,Gibson LE

更新日期：2014-06-01 00:00:00

abstract：:Pruritus is a common and often times difficult to treat symptom in many dermatologic and systemic diseases. For pruritus with an inflammatory or autoimmune origin, therapies such as topical corticosteroids and antihistamines are often initiated. However, in the case that these and additional systemic therapies are ine...

journal_title：Journal of the American Academy of Dermatology

authors： Sharma D,Kwatra SG

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Noninvoluting congenital hemangioma (NICH) is a distinct vascular tumor of infancy. OBJECTIVE:We describe the clinical characteristics, histopathology, imaging, and natural history of NICH and compare our findings with previous reports. METHODS:We conducted a retrospective review of charts and photographic...

journal_title：Journal of the American Academy of Dermatology

authors： Lee PW,Frieden IJ,Streicher JL,McCalmont T,Haggstrom AN

更新日期：2014-05-01 00:00:00