Abstract：
:Nail-patella syndrome (NPS) is an autosomal dominant genetic defect, which may be associated with, or closely linked to, the locus controlling palmar and plantar hyperhidrosis (HH). A clinical review of a family with NPS involving six generations was performed. Data were accumulated by personal examination and analysis of medical and family records for the trials characterizing NPS as well as the coincidence of HH. A family pedigree of each entity was constructed and the pedigree for HH was compared to the NPS pedigree. Thirty-three of sixty-eight members of the extended family were affected with NPS and nine members had HH. The NPS pedigree supported the previously known autosomal dominant mode of inheritance. The incidence of HH indicated a direct inheritance and occurred only in members affected with NPS. The pedigree provides evidence for concluding that HH occurred as a spontaneous mutation transmitted as an autosomal dominant trait closely linked to NPS or that HH represents a previous unrecognized associated disorder.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Pechman KJ,Bergfeld WFdoi
10.1016/s0190-9622(80)80079-xsubject
Has Abstractpub_date
1980-12-01 00:00:00pages
627-32issue
6eissn
0190-9622issn
1097-6787pii
S0190-9622(80)80079-Xjournal_volume
3pub_type
杂志文章abstract：:Recently, low-dose 5-fluorouracil/cisplatin induction concurrent with radiation (chemoradiation) has been reported to be effective for locally advanced squamous cell carcinoma of the otorhinolaryngologic and gynecologic regions. However, to date, this therapeutic option has not been evaluated for squamous cell carcino...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2005.12.035
更新日期：2006-11-01 00:00:00
abstract：BACKGROUND:Melanoma is the most lethal form of skin cancer. Diagnosis of amelanotic melanoma and detection of micrometastases in sentinel lymph nodes pose diagnostic and therapeutic dilemmas for the dermatopathologist and clinician. OBJECTIVE:The purpose of this article is to determine the utility of immunohistochemis...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2001.117526
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND:Onychomycosis is an increasing problem with limited therapeutic options. OBJECTIVE:We evaluated the safety and efficacy, of oral terbinafine, a new fungicidal antimycotic, in patients with toenail onychomycosis. METHODS:A North American multicenter, double-blind, placebo-controlled study evaluated the myco...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s0190-9622(97)70111-7
更新日期：1997-11-01 00:00:00
abstract：:Several technics for immunofluorescent staining have been described in the literature and are presently used by laboratories performing direct and indirect tissue immunofluorescence. The purpose of this communication is to describe a simple immunofluorescent technic that uses a five-slide polypropylene slide mailer co...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(85)70220-4
更新日期：1985-11-01 00:00:00
abstract：:A PABA ester-oxybenzone preparation is superior to PABA or sulisobenzone alone in protecting the skin from methoxsalen-induced ultraviolet A (UVA) phototoxicity after water substantivity challenge. Such a mixture would be useful as a UVA screen for uninvolved or actinically damaged skin in patients receiving psoralens...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0190-9622(83)70141-6
更新日期：1983-09-01 00:00:00
abstract：:Mycophenolate mofetil (MMF) has been widely used as an immunosuppressant in organ transplantation. MMF has recently been added to therapeutic regimens for skin disorders. Expanding the use of MMF in dermatology, we describe additional patients with autoimmune and inflammatory skin diseases, including 4 cases of pemphi...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(99)70203-3
更新日期：1999-02-01 00:00:00
abstract：:A new disorder of the hair follicle is described that leads to increased fragility of the shaft. Light microscopic studies of hair follicles revealed disturbances of keratinization in the shafts that are very likely responsible for the breakage. The most consistent change seen by transmission electron microscopy was i...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(86)70142-4
更新日期：1986-07-01 00:00:00
abstract：:We describe a case of generalized, asymptomatic, chronic annular lichen planus. The centers of the large annular lesions were atrophic and had lost their elasticity. Histologic examination revealed an absence of elastic fiber in the center. Electron microscopy revealed fragmented elastic fibers. Examination of early l...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(91)70212-k
更新日期：1991-08-01 00:00:00
abstract：:Forty cases of lentigo maligna (LM) and lentigo maligna melanoma (LMM) treated by conventional fractionated radiotherapy are reviewed. Fourteen of seventeen LM patients are alive and well 4 months to 5 years following irradiation, one patient died of intercurrent disease without recurrence, and two had residual or rec...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(82)70021-0
更新日期：1982-03-01 00:00:00
abstract：CAPSULE SUMMARY:In this article, we try to use the syringes without the piston part to control the amount of saline fluid in dermabrasion surgery. It is very convenient to obtain materials and simple to operate in skin surgery. ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2020.10.010
更新日期：2020-10-10 00:00:00
abstract：BACKGROUND:Few studies have evaluated the relationship between hidradenitis suppurativa (HS) and type 2 diabetes mellitus (T2DM), and the existing data show conflicting results. OBJECTIVE:To determine the prevalence of T2DM among patients with HS and identify at-risk demographic subgroups. METHODS:Cross-sectional ana...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2018.01.014
更新日期：2018-07-01 00:00:00
abstract：:Verruciform xanthomas occur on mucocutaneous surfaces and are characterized by hyperkeratosis, acanthosis, and the occurrence of "foam cells" stuffed with lipid surrounding capillaries in the dermis between rete pegs. Ultrastructural examination of a lesion on the penis revealed the presence of melanocytes with many l...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(91)70117-k
更新日期：1991-05-01 00:00:00
abstract：BACKGROUND:The eruptive appearance of numerous seborrheic keratoses, the sign of Leser-Trélat, has been regarded as a reliable cutaneous marker of internal malignancy. OBJECTIVE:We have evaluated the possible association of malignant disease and the sign in 1752 consecutive cases of seborrheic keratoses. METHODS:Firs...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(92)70139-7
更新日期：1992-06-01 00:00:00
abstract：:Alendronate is a bisphosphonate compound used to treat diseases of pathologic bone resorption. Cutaneous reactions to this medication are rare. We report the case of a superficial gyrate erythema that occurred as a reaction to weekly alendronate therapy used in the treatment of postmenopausal osteoporosis. ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2003.245
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:Patients with pemphigus vulgaris (PV) are genetically linked to two alleles of the HLA subgroup, and circulating antibodies were found in first-degree relatives of these patients, thus showing genetic predisposition. OBJECTIVE:Our purpose was to determine the occurrence of circulating true PV-IgG in patient...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(97)70324-4
更新日期：1997-01-01 00:00:00
abstract：:Chemotherapy-induced alopecia is a distressing side effect common to certain treatment regimens in oncology. Unfortunately, chemotherapy-induced alopecia is an often overlooked or minor factor among our current research priorities and thus advances in amelioration have been minimal. This review offers a comprehensive ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2011.02.026
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:Previous studies have suggested that the atopy patch test (APT) may make oral challenge superfluous in diagnosing children with food hypersensitivity. OBJECTIVE:To investigate the clinical relevance of APT in predicting hypersensitivity to cow's milk and hen's egg in 486 unselected children 3 years of age. ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章
doi：10.1016/j.jaad.2004.03.025
更新日期：2004-10-01 00:00:00
abstract：BACKGROUND:Little is known about how individuals with a predisposition for rosacea appear in childhood. This retrospective, matched control, longitudinal study examined the relationship between childhood stye and adult rosacea. METHODS:The records of the Rochester Epidemiology Project were examined to identify patient...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2006.03.023
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:Deep nasal defects of the dorsum, sidewall, and ala can be challenging to repair. OBJECTIVE:The article describes our experience with a muscle hinge transposition flap with overlying local full-thickness skin grafting for repair of deep nasal defects in a single-stage procedure. METHODS:A muscle hinge tran...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2000.108374
更新日期：2000-11-01 00:00:00
abstract：:The role of estrogens in the development of skin cancer is controversial. Sex steroids have a profound effect on the epidermis and epidermal appendages. Estradiol in pharmacologic doses has been reported to stimulate basal cell carcinoma in an animal model. Sex hormones act by means of a specific protein receptor. In ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(88)70101-2
更新日期：1988-05-01 00:00:00
abstract：BACKGROUND:Junctional nevi are traditionally associated with children and younger patients. We noticed that these lesions are also often found in elderly patients. OBJECTIVE:We sought to determine if junctional nevi are found in all age groups. METHODS:All biopsy reports for junctional nevi for the year 2001 at the P...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2006.11.035
更新日期：2007-05-01 00:00:00
abstract：:The most common active ingredient in hair coloring is para-phenylenediamine (PPDA), which can produce contact dermatitis, particularly in persons who dye their scalp hair and in hairdressers. We have identified another group of patients also at risk, namely men from Arab countries, who commonly grow beards and dye the...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2001.113444
更新日期：2001-05-01 00:00:00
abstract：:George Cheyne Shattuck's 1808 dissertation on structure and function of the skin is one of the earliest American writings on the topic of skin diseases. Although this essay contributed no important new observations, it does provide insight into the attitudes of American physicians in the post-Revolutionary War period ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 传,历史文章,杂志文章
doi：10.1067/mjd.2002.119644
更新日期：2002-04-01 00:00:00
abstract：:Psoriasis is a common, chronic, inflammatory, multisystem disease with predominantly skin and joint manifestations affecting approximately 2% of the population. In this fifth of 6 sections of the guidelines of care for psoriasis, we discuss the use of ultraviolet (UV) light therapy for the treatment of patients with p...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2009.08.026
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Studies of noncutaneous and cutaneous malignancies support the hypothesis that poor risk-perception status contributes to health disparity. OBJECTIVE:We evaluated skin cancer (SC) risk perceptions across race and other demographic markers using the Health Information National Trends Survey (HINTS) and compa...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2011.05.021
更新日期：2012-05-01 00:00:00
abstract：:Five patients with the yellow nail syndrome triad are described; all five had yellow nails, primary lymphedema, and respiratory tract involvement. Four of the patients noted the onset of the syndrome after an episode of pneumonia. Four patients had a chronic productive cough, two had bronchiectasis, two had chronic si...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(84)70021-1
更新日期：1984-02-01 00:00:00
abstract：:Blood eosinophilia is a common feature of eosinophilic fasciitis and is variably reported in systemic sclerosis and localized scleroderma. Since these diseases share cutaneous fibrosis as the final outcome and have other clinical and pathologic features that are difficult to differentiate, the presence of blood eosino...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(87)70251-5
更新日期：1987-10-01 00:00:00
abstract：BACKGROUND:Recently, an automated robotic hair restoration device was developed and is increasingly being used for hair restoration. OBJECTIVE:We sought to analyze the hair follicles of Korean patients that were harvested by a hair restoration robotic device. METHODS:Data were reviewed from a total of 22 patients who...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2014.07.058
更新日期：2015-01-01 00:00:00
abstract：:Subungual Bowen's disease and squamous cell carcinoma are not as rare as has been implied by earlier literature. The course of the lesions is protracted. Clinically the diseases may mimic onychomycosis, chronic paronychia, eczema, verruca vulgaris, pyogenic granuloma, subungual exostosis, or malignant melanoma. Histol...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(84)70165-4
更新日期：1984-08-01 00:00:00
abstract：BACKGROUND:The development of autoimmune sequelae is one of the characteristic features of drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome; however, the incidence of sequelae and prognosis of patients with DRESS are unknown. OBJECTIVE:We sought to investigate the...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2012.08.009
更新日期：2013-03-01 00:00:00
