Abstract:
BACKGROUND:Psoriasis and migraine are common conditions with potential overlap of pathophysiological mechanisms. Both these diseases have been associated with increased cardiovascular risk but little is known about their interplay. OBJECTIVE:We sought to investigate the link between psoriasis, and the risk of new-onset migraine, in a nationwide cohort of the Danish population. METHODS:Data on all Danish citizens aged 18 years or older from January 1, 1997, to December 31, 2011, were linked at individual-level in nationwide registers. Incidence rates per 1000 person-years were calculated and crude and adjusted incidence rate ratios were estimated by Poisson regression models. RESULTS:The study comprised a total of 5,379,859 individuals, including 53,006 and 6831 patients with mild and severe psoriasis, respectively, and 6243 patients with psoriatic arthritis. Fully adjusted incidence rate ratios for migraine were 1.37 (95% confidence interval 1.30-1.45), 1.55 (95% confidence interval 1.29-1.86), and 1.92 (95% confidence interval 1.65-2.22) for mild psoriasis, severe psoriasis, and psoriatic arthritis, respectively. Stratification for sex revealed increased risk of migraine in both male and female patients. LIMITATIONS:We were unable to distinguish between subtypes of migraine, eg, migraine with and without aura. CONCLUSIONS:Psoriasis was associated with a disease severity-dependent increased risk of migraine independent of measured confounders. Further studies are warranted to determine the effects of antipsoriatic treatment on this association, and whether migraine modifies the psoriasis-associated risk of cardiovascular disease.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Egeberg A,Mallbris L,Hilmar Gislason G,Skov L,Riis Hansen Pdoi
10.1016/j.jaad.2015.08.039subject
Has Abstractpub_date
2015-11-01 00:00:00pages
829-35issue
5eissn
0190-9622issn
1097-6787pii
S0190-9622(15)02109-Xjournal_volume
73pub_type
杂志文章abstract::An unusual American epidemic consisting of twenty cases of granuloma inguinale is chronicled. Evidence from this series supports the venereal transmission of the disorder. Trimethoprim/sulfamethoxazole proved to be a safe and effective therapy. ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 临床试验,杂志文章
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journal_title:Journal of the American Academy of Dermatology
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