当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY期刊下所有文献 > A large-scale North American study of fungal isolates from nails: the frequency of onychomycosis, fungal distribution, and antifungal susceptibility patterns.

A large-scale North American study of fungal isolates from nails: the frequency of onychomycosis, fungal distribution, and antifungal susceptibility patterns.

Abstract：

BACKGROUND:Onychomycosis, a fungal infection of the nail bed, is responsible for up to 50% of nail disorders. Although several surveys have been conducted in different parts of the world, there have been no multicenter epidemiologic surveys of onychomycosis in North America. OBJECTIVE:A 12-center study was undertaken to (1) determine the frequency of onychomycosis, (2) identify organisms recovered from the nails, and (3) determine the antifungal susceptibility of isolates. METHODS:A total of 1832 subjects participated in this study and completed a comprehensive questionnaire, and nail clippings were collected for potassium hydroxide examination and culturing. RESULTS:The frequency of onychomycosis, as defined by the presence of septate hyphae on direct microscopy and/or the recovery of a dermatophyte, was found to be 13.8%. In general, the dermatophyte isolates were susceptible to the antifungals tested. CONCLUSION:Because of the limited number of large-scale studies, the baseline incidence is not firmly established. However, the higher frequency of onychomycosis in this study may confirm the suspected increase in incidence of disease in North America.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Ghannoum MA,Hajjeh RA,Scher R,Konnikov N,Gupta AK,Summerbell R,Sullivan S,Daniel R,Krusinski P,Fleckman P,Rich P,Odom R,Aly R,Pariser D,Zaiac M,Rebell G,Lesher J,Gerlach B,Ponce-De-Leon GF,Ghannoum A,Warner J,Is

doi

10.1067/mjd.2000.107754

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

641-8

issue

4

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(00)90461-4

journal_volume

43

pub_type

杂志文章,多中心研究

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