Combined sentinel lymphadenectomy and mohs micrographic surgery for high-risk cutaneous squamous cell carcinoma.

Abstract:

BACKGROUND:There are subgroups of cutaneous squamous cell carcinoma (SCC) that have a higher risk for both regional and distant metastasis. When cutaneous SCC does metastasize, it typically spreads first to local nodal groups. Sentinel lymph node (SLN) localization has been successfully used to evaluate nodal metastasis in breast carcinoma, melanoma, and other select tumors. It may also be useful in certain high-risk cutaneous SCCs. Currently, Mohs micrographic surgery is the treatment of choice for these tumors. METHODS:A patient presented with a high-risk recurrent SCC on the forehead. The regional nodal groups were clinically negative and radiographically negative by computed tomographic scan. Sentinel lymphadenectomy was performed by means of technetium 99m-radiolabeled sulfur colloid. The main tumor was resected with Mohs micrographic surgery. RESULTS:A left preauricular SLN was localized by lymphoscintigraphy. The SLN was located intraoperatively by means of a gamma probe and excised. Subsequent pathologic evaluation of the SLN was negative for evidence of metastatic SCC by light microscopy with hematoxylin and eosin, and with immunohistochemical stains for cytokeratins AE1 and AE3. The day after SLN excision, the tumor was removed via Mohs micrographic surgery with clear surgical margins after a total of 8 stages. Aggressive subclinical spread by both subcutaneous "skating" and perineural invasion was noted. CONCLUSION:The combination of Mohs micrographic surgery and sentinel lymphadenectomy is feasible and has theoretical utility in the management of a subset of cutaneous SCCs at high risk for metastasis. The ability of sentinel lymphadenectomy to identify regionally metastatic cutaneous SCC as well as the additive benefit of SLN and Mohs micrographic extirpation in the treatment of high-risk cutaneous SCC remain to be further clarified.

journal_name

J Am Acad Dermatol

authors

Weisberg NK,Bertagnolli MM,Becker DS

doi

10.1067/mjd.2000.106367

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

483-8

issue

3

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(00)23768-7

journal_volume

43

pub_type

杂志文章
  • Onychomatricoma: genome-wide analyses of a rare nail matrix tumor.

    abstract:BACKGROUND:Onychomatricoma (OM) is a rare benign tumor of the nail matrix in which genome-wide analyses have never been performed. It is clinically characterized by an increased transversal curvature of the nail plate, a longitudinal yellowish discoloration, and splinter hemorrhages. Once the nail plate has been remove...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2009.07.051

    authors: Cañueto J,Santos-Briz Á,García JL,Robledo C,Unamuno P

    更新日期:2011-03-01 00:00:00

  • Pompholyx and eczematous reactions associated with intravenous immunoglobulin therapy.

    abstract:INTRODUCTION:Intravenous immunoglobulin (IVIG) is used to treat many inflammatory and autoimmune disorders and although generally well tolerated, cutaneous side effects occur. OBJECTIVE:We reviewed reports of pompholyx and eczematous reactions associated with IVIG. METHODS:A literature search was performed using the ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2010.12.034

    authors: Gerstenblith MR,Antony AK,Junkins-Hopkins JM,Abuav R

    更新日期:2012-02-01 00:00:00

  • Actinic reticuloid. A clinical photobiologic, histopathologic, and follow-u study of 16 patients.

    abstract::We report a detailed clinical, histopathologic, and photobiologic study of 16 Dutch patients with actinic reticuloid. All were middle-aged or elderly men who had persistent plaques on light-exposed skin only (two patients), extension of lesions to nonexposed areas (four patients), or prolonged or persistent episodes o...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:

    authors: Toonstra J,Henquet CJ,van Weelden H,van der Putte SC,van Vloten WA

    更新日期:1989-08-01 00:00:00

  • Outcomes research in your office.

    abstract::This article reviews the definition of outcomes research. It explores the reasons that outcomes research should be conducted by practicing physicians in both university and private practice settings. Methods for outcomes research with examples relevant to dermatologists are detailed. ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(98)70164-1

    authors: Faust HB

    更新日期:1998-06-01 00:00:00

  • A randomized, open-label trial of continuous versus interrupted etanercept therapy in the treatment of psoriasis.

    abstract:BACKGROUND:Although etanercept is used as a continuous therapy for moderate to severe plaque psoriasis, intermittent use may be necessary in some instances. OBJECTIVE:In this randomized, open-label study, we evaluated the effectiveness and safety of continuous versus interrupted etanercept therapy. METHODS:All patien...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jaad.2006.09.002

    authors: Moore A,Gordon KB,Kang S,Gottlieb A,Freundlich B,Xia HA,Stevens SR

    更新日期:2007-04-01 00:00:00

  • Promotion of frequent tanning sessions by indoor tanning facilities: two studies.

    abstract:BACKGROUND:Indoor tanning may increase the risk of melanoma and other health problems. Frequent users of indoor tanning facilities may be at particularly high risk. OBJECTIVE:In study 1 our purpose was to assess the prevalence and nature of indoor tanning advertisements; in study 2 we aimed to assess tanning facility ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2002.119560

    authors: Kwon HT,Mayer JA,Walker KK,Yu H,Lewis EC,Belch GE

    更新日期:2002-05-01 00:00:00

  • Bullosis diabeticorum. Report of a case with a review of the literature.

    abstract::The case of a male diabetic patient with recurrent bullous lesions restricted to the hands is reported. Areas of spongiosis in the epidermis, as well as subepidermal blister formation, were observed in repeated biopsies. On electron microscopy, separation was seen at the level of the lamina lucida. No immunopathology ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:

    authors: Toonstra J

    更新日期:1985-11-01 00:00:00

  • How fingerprints came into use for personal identification.

    abstract::The use of fingerprints for personal identification became widespread early in this century. How the fingerprints slowly became standardized involves many persons, including Nathaniel Grew, Johannes Purkinje, William Herschel, Henry Faulds, Charles Darwin, Francis Galton, Mark Twain, Juan Vucetich, Edward Henry, and J...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 传,历史文章,杂志文章

    doi:10.1016/0190-9622(90)70194-m

    authors: Caplan RM

    更新日期:1990-07-01 00:00:00

  • Cutaneous squamous cell carcinomas consistently show histologic evidence of in situ changes: a clinicopathologic correlation.

    abstract::Squamous cell carcinoma on sun-damaged skin is a malignant neoplasm that evolves from its inception as squamous cell carcinoma in situ, which is commonly referred to as an actinic keratosis. In this study, we reviewed 1011 squamous cell carcinomas on sun-damaged skin and found that nearly 100% of these lesions contain...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(99)70119-2

    authors: Guenthner ST,Hurwitz RM,Buckel LJ,Gray HR

    更新日期:1999-09-01 00:00:00

  • A single-institution assessment of superficial spreading melanoma (SSM) in the pediatric population: Molecular and histopathologic features compared with adult SSM.

    abstract:BACKGROUND:The epidemiology of pediatric melanoma is distinct from that seen in adults. This is more distinguishable when pediatric patients are separated into prepubertal and adolescent groups. OBJECTIVE:In this study, we compared epidemiologic, clinical, histologic, and molecular characteristics of pediatric superfi...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2017.05.051

    authors: Verzì AE,Bubley JA,Haugh AM,Zhang B,Wagner A,Kruse L,West DP,Wayne J,Guitart J,Gerami P

    更新日期:2017-11-01 00:00:00

  • Relationship between age and likelihood of lymph node metastases in patients with intermediate thickness melanoma (1.01-4.00 mm): A National Cancer Database study.

    abstract:BACKGROUND:There is large variability in the risk of sentinel lymph node (SLN) positivity among patients with intermediate thickness melanoma (ITM), with a subgroup of patients exhibiting a low risk of nodal disease. OBJECTIVE:To identify a group of patients with ITM for whom the risk of nodal disease is low. METHODS...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2018.08.022

    authors: Hanna AN,Sinnamon AJ,Roses RE,Kelz RR,Elder DE,Xu X,Pockaj BA,Zager JS,Fraker DL,Karakousis GC

    更新日期:2019-02-01 00:00:00

  • Topical protection against long-wave ultraviolet A.

    abstract::A PABA ester-oxybenzone preparation is superior to PABA or sulisobenzone alone in protecting the skin from methoxsalen-induced ultraviolet A (UVA) phototoxicity after water substantivity challenge. Such a mixture would be useful as a UVA screen for uninvolved or actinically damaged skin in patients receiving psoralens...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0190-9622(83)70141-6

    authors: Jarratt M,Hill M,Smiles K

    更新日期:1983-09-01 00:00:00

  • Tinea corporis gladiatorum: a cross-sectional study.

    abstract:BACKGROUND:Tinea corporis gladiatorum has been an infrequently reported condition in the dermatological literature. Two previous reports have investigated wrestlers during recognized epidemics of tinea corporis gladiatorum, but no study has examined wrestlers to determine the point prevalence of tinea corporis gladiato...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2000.109284

    authors: Adams BB

    更新日期:2000-12-01 00:00:00

  • Thalidomide for the treatment of chronic refractory pruritus.

    abstract::Pruritus is a common and often times difficult to treat symptom in many dermatologic and systemic diseases. For pruritus with an inflammatory or autoimmune origin, therapies such as topical corticosteroids and antihistamines are often initiated. However, in the case that these and additional systemic therapies are ine...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2015.09.039

    authors: Sharma D,Kwatra SG

    更新日期:2016-02-01 00:00:00

  • Inflammatory vitiligo in Vogt-Koyanagi-Harada disease.

    abstract::Vogt-Koyanagi-Harada disease is a rare disease characterized by uveitis, meningitis, dysacusis, alopecia, poliosis, and vitiligo. We describe a 48-year-old patient with Vogt-Koyanagi-Harada disease associated with thin inflammatory raised erythema and plaque-type inflammatory erythema superimposed on vitiligo. Interes...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2001.110879

    authors: Tsuruta D,Hamada T,Teramae H,Mito H,Ishii M

    更新日期:2001-01-01 00:00:00

  • Unknown primary Merkel cell carcinoma: 23 new cases and a review.

    abstract:BACKGROUND:Knowledge is limited regarding unknown primary Merkel cell carcinoma (UPMCC). OBJECTIVE:We sought to document the characteristics and behavior of UPMCC, and determine the most appropriate treatment. METHODS:A multicenter, retrospective, consecutive study reviewing patients given a diagnosis of UPMCC betwee...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1016/j.jaad.2012.07.035

    authors: Tarantola TI,Vallow LA,Halyard MY,Weenig RH,Warschaw KE,Weaver AL,Roenigk RK,Brewer JD,Otley CC

    更新日期:2013-03-01 00:00:00

  • The diminishing role of the dermatologist in the office-based care of cutaneous diseases.

    abstract::The number of physicians who provide ambulatory care for patients with skin diseases is rapidly increasing. Current and proposed changes in health care financing may limit direct access to dermatologists. We provide recent data on volume of visits for cutaneous diagnoses, including the types of medical practitioners w...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(93)70243-m

    authors: Stern RS,Nelson C

    更新日期:1993-11-01 00:00:00

  • Kawasaki disease: part II. Complications and treatment.

    abstract::Kawasaki disease, or mucocutaneous lymph node syndrome, is the leading cause of acquired heart disease in children in the United States and other developed countries. Coronary artery lesions are the most significant cause of morbidity and mortality. Treatment should ideally be provided within 10 days of symptom onset ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2013.06.040

    authors: Bayers S,Shulman ST,Paller AS

    更新日期:2013-10-01 00:00:00

  • CD30 (Ki-1)-positive large-cell cutaneous T-cell lymphoma with secondary xanthomatous changes after radiation therapy.

    abstract::A 72-year-old woman with a large mass on her forehead was found to have primary cutaneous CD30-positive large T-cell lymphoma and was treated with radiation therapy. Five weeks after the completion of radiation therapy, a large, yellow plaque developed on the forehead. Histopathologic examination showed numerous xanth...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2003.123

    authors: Chung HG,Chung YL,Kang JM,Yang WI,Suh CO,Hahn JS,Leea MG

    更新日期:2003-02-01 00:00:00

  • Galli-Galli disease: an unrecognized entity or an acantholytic variant of Dowling-Degos disease?

    abstract::Galli-Galli disease is an inherited disease characterized by slowly progressive and disfiguring reticulate hyperpigmentation of the flexures, clinically and histopathologically diagnostic for Dowling-Degos disease, but also associated with suprabasal, nondyskeratotic acantholysis. A few patients exhibiting these featu...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2001.116340

    authors: Braun-Falco M,Volgger W,Borelli S,Ring J,Disch R

    更新日期:2001-11-01 00:00:00

  • Phototherapy treatment of psoriasis today.

    abstract::The use of the various forms of phototherapy remains an essential treatment option for psoriasis vulgaris. Expertise concerning the mechanisms involved with the actions of therapeutic ultraviolet light and the proper delivery of office-based treatments resides within the specialty of dermatology. New therapies for the...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0190-9622(03)01139-3

    authors: Zanolli M

    更新日期:2003-08-01 00:00:00

  • Association between acrochordons and colonic polyps.

    abstract::Fifty-four male and female patients with suspected colonic disease were examined for the presence of acrochordons prior to colonoscopy. Thirty-five of these patients (65%) had skin tags and twenty-six (48%) were found to have colonic polyps. In this study patients with acrochordons were significantly (p less than 0.00...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(86)70130-8

    authors: Beitler M,Eng A,Kilgour M,Lebwohl M

    更新日期:1986-06-01 00:00:00

  • Hair pull test: Evidence-based update and revision of guidelines.

    abstract:BACKGROUND:The hair pull test lacks validation and has unclear pretest guidelines. OBJECTIVE:We sought to quantify normal hair pull test values and elucidate the effect of pretest hair washing and brushing. The impact of hair texture and lifestyle was also examined. METHODS:Participants (n = 181) completed a question...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2016.10.002

    authors: McDonald KA,Shelley AJ,Colantonio S,Beecker J

    更新日期:2017-03-01 00:00:00

  • The specific dermatoses of pregnancy.

    abstract::The terminology of the specific dermatoses of pregnancy has become increasingly confusing, with several names in use for identical clinical disorders. On the basis of our own study of sixty-four patients and a review of the literature, we propose a simplified classification: (1) herpes gestationis (pemphigoid gestatio...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(83)70046-0

    authors: Holmes RC,Black MM

    更新日期:1983-03-01 00:00:00

  • Chronic urticaria and angioedema associated with thyroid autoimmunity: review and therapeutic implications.

    abstract::Thyroid autoimmunity has been increasingly reported to be associated with chronic urticaria and angioedema. The administration of thyroid hormone may alleviate chronic urticaria and/or angioedema in selected patients. This review focuses on the association of thyroid autoimmunity with chronic urticaria and/or angioede...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0190-9622(99)70193-3

    authors: Heymann WR

    更新日期:1999-02-01 00:00:00

  • Improved clinical outcome and biomarkers in adults with papulopustular rosacea treated with doxycycline modified-release capsules in a randomized trial.

    abstract:BACKGROUND:Patients with rosacea have increased amounts of cathelicidin and protease activity but their usefulness as disease biomarkers is unclear. OBJECTIVE:We sought to evaluate the effect of doxycycline treatment on cathelicidin expression, protease activity, and clinical response in rosacea. METHODS:In all, 170 ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.jaad.2016.01.023

    authors: Di Nardo A,Holmes AD,Muto Y,Huang EY,Preston N,Winkelman WJ,Gallo RL

    更新日期:2016-06-01 00:00:00

  • Self-healing papular mucinosis in an adult.

    abstract::Papular mucinosis is a rare, idiopathic cutaneous mucinosis that is typically chronic and progressively severe. We present a case of a 59-year-old woman with a 6-month history of a dramatic papular eruption on her face and neck, with no associated internal organ involvement. A biopsy specimen demonstrated increased de...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(03)00790-4

    authors: Sperber BR,Allee J,James WD

    更新日期:2004-01-01 00:00:00

  • Lichen planopilaris: a clinicopathologic study.

    abstract::Three clinicopathologic variants of lichen planopilaris are described. The first is characterized clinically by individual keratotic follicular papules and histologically by a lichenoid inflammatory cell infiltrate confined to the follicular epithelium. The second variant consists of erythematous to violaceous plaques...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(90)70078-v

    authors: Matta M,Kibbi AG,Khattar J,Salman SM,Zaynoun ST

    更新日期:1990-04-01 00:00:00

  • Hepatobiliary pruritus: what are effective treatments?

    abstract::Pruritus is a common symptom in patients with hepatobiliary disease. Numerous treatments have been attempted. We review published therapeutic trials for hepatobiliary pruritus and utilize statistical analysis to evaluate treatment results. Randomized placebo-controlled studies show cholestyramine, rifampin, naloxone, ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/0190-9622(95)91818-3

    authors: Connolly CS,Kantor GR,Menduke H

    更新日期:1995-11-01 00:00:00

  • Connective tissue nevi: an entity revisited.

    abstract:BACKGROUND:Connective tissue nevi (CTN) may be isolated, either sporadic or hereditary, or syndromic as in the Buschke-Ollendorff syndrome. Few publications have addressed the variable clinical and histopathologic expression of these benign hamartomas. OBJECTIVE:We sought to characterize the clinical and histopatholog...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2011.08.008

    authors: Saussine A,Marrou K,Delanoé P,Bodak N,Hamel D,Picard A,Sassolas B,de Prost Y,Lemerrer M,Fraitag S,Bodemer C

    更新日期:2012-08-01 00:00:00