100% Complete response rate in patients with cutaneous metastatic melanoma treated with intralesional interleukin (IL)-2, imiquimod, and topical retinoid combination therapy: results of a case series.

abstract：BACKGROUND:Evaluation of silicone-induced morbidity in skin has been hampered by the difficulty of detecting silicone in tissue because conventional methods are nonquantitative and insensitive. OBJECTIVE:We attempted to determine whether silicone could be identified and quantitated in skin by means of electron spectro...

journal_title：Journal of the American Academy of Dermatology

authors： Haycox CL,Leach-Scampavia D,Olerud JE,Ratner BD

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:ESPRIT is an ongoing, 10-year, observational registry, evaluating long-term safety and effectiveness of adalimumab treatment in routine clinical practice for patients with moderate to severe, chronic plaque psoriasis. OBJECTIVES:Initial 5-year results are reported. METHODS:Two populations were analyzed: th...

journal_title：Journal of the American Academy of Dermatology

authors： Menter A,Thaçi D,Papp KA,Wu JJ,Bereswill M,Teixeira HD,Rubant S,Williams DA

更新日期：2015-09-01 00:00:00

abstract：:A 7.3-year prospective study of 1,380 patients with psoriasis who were treated with oral methoxsalen (8-methoxypsoralen) and ultraviolet A photochemotherapy (PUVA) revealed that patients who continued on PUVA therapy used inpatient hospital treatment less than one fourth as often as those who had discontinued treatmen...

journal_title：Journal of the American Academy of Dermatology

authors： Stern RS

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:There is large variability in the risk of sentinel lymph node (SLN) positivity among patients with intermediate thickness melanoma (ITM), with a subgroup of patients exhibiting a low risk of nodal disease. OBJECTIVE:To identify a group of patients with ITM for whom the risk of nodal disease is low. METHODS...

journal_title：Journal of the American Academy of Dermatology

authors： Hanna AN,Sinnamon AJ,Roses RE,Kelz RR,Elder DE,Xu X,Pockaj BA,Zager JS,Fraker DL,Karakousis GC

更新日期：2019-02-01 00:00:00

abstract：:We present the case of an American adult patient with eosinophilic pustular folliculitis. The majority of previously reported patients have been Japanese. Eosinophilic pustular folliculitis is a rare condition characterized by recurrent, peripherally expanding, sterile papulopustules and plaques. Hair-bearing areas su...

journal_title：Journal of the American Academy of Dermatology

authors： Jaliman HD,Phelps RG,Fleischmajer R

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Deep nasal defects of the dorsum, sidewall, and ala can be challenging to repair. OBJECTIVE:The article describes our experience with a muscle hinge transposition flap with overlying local full-thickness skin grafting for repair of deep nasal defects in a single-stage procedure. METHODS:A muscle hinge tran...

journal_title：Journal of the American Academy of Dermatology

authors： Fader DJ,Wang TS,Johnson TM

更新日期：2000-11-01 00:00:00

abstract：:Lipoid proteinosis is a rare autosomal recessive condition characterized by a diffuse mucocutaneous infiltration with histopathologic deposits that are positive for periodic acid-Schiff reagent and a sudanophil substance. We present a 9-year-old boy with lipoid proteinosis. His parents are siblings. He had classical m...

journal_title：Journal of the American Academy of Dermatology

authors： Barthelemy H,Mauduit G,Kanitakis J,Cambazard F,Thivolet J

更新日期：1986-02-01 00:00:00

abstract：:Six men suffering from acute dermatitis had positive patch tests to Larrea (creosote bush). The lesions preferentially involved sun-exposed sites, simulating a photodermatitis, but also were on the legs and scrotum. Our findings were more consistent with contact allergy than with a primary irritant or a phototoxic res...

journal_title：Journal of the American Academy of Dermatology

authors： Leonforte JF

更新日期：1986-02-01 00:00:00

abstract：:Multiple basal cell epitheliomas developed in two psoriatic patients during treatment with orally administered 8-methoxypsoralen and long-wave ultraviolet radiation (PUVA). Twenty-two basal cell epitheliomas (BCEs) were seen in the two patients, 80% occurring in non-sun-exposed areas. Since neither patient had any his...

journal_title：Journal of the American Academy of Dermatology

authors： Brown FS,Burnett JW,Robinson HM Jr

更新日期：1980-05-01 00:00:00

abstract：:Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against S...

journal_title：Journal of the American Academy of Dermatology

authors： Macias ES,Pereira FA,Rietkerk W,Safai B

更新日期：2011-03-01 00:00:00

abstract：:Transepithelial elimination of granulomas was observed in histologic specimens taken from involved skin of a patient with disseminated tuberculosis and two patients with sarcoidosis. This phenomenon, previously also observed in other granulomatous disorders, represents one of the skin's several mechanisms to rid itsel...

journal_title：Journal of the American Academy of Dermatology

authors： Goette DK,Odom RB

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Hereditary polymorphic light eruption (HPLE) occurs unique ly in the American Indian and Inuit and exhibits autosomal dominant transmission. Because the cutaneous expression of HPLE resembles that of polymorphic light eruption (PLE) and because many non-Indians in the United States have American Indian herit...

journal_title：Journal of the American Academy of Dermatology

authors： Fusaro RM,Johnson JA

更新日期：1996-04-01 00:00:00

abstract：:Five patients received leukapheresis therapy for Sézary syndrome. All patients had erythroderma, lymphocytic band infiltration of the skin, and a normal white blood cell count with an absolute Sézary cell count of more than 1,000/mm3. Improvement in 3 to 6 months occurred, usually with the addition of a combined regim...

journal_title：Journal of the American Academy of Dermatology

authors： Pineda AA,Winkelmann RK

更新日期：1981-11-01 00:00:00

abstract：:Twenty-five years ago the use of pyridoxine was described for the treatment of photosensitivity eruptions. We report two cases of erythropoietic protoporphyria, which were only moderately responsive to beta-carotene and sunscreens, whereas the use of pyridoxine has been associated with a marked reduction in photosensi...

journal_title：Journal of the American Academy of Dermatology

authors： Ross JB,Moss MA

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Dermatomyositis affects visible skin and causes disease symptoms that can affect patients' quality of life (QOL). METHODS:In all, 71 patients with dermatomyositis or dermatomyositis sine myositis completed two QOL measures (the Skindex-16 and the Dermatology Life Quality Index) and a visual analog scale for...

journal_title：Journal of the American Academy of Dermatology

authors： Hundley JL,Carroll CL,Lang W,Snively B,Yosipovitch G,Feldman SR,Jorizzo JL

更新日期：2006-02-01 00:00:00

abstract：:Sixty patients were treated for tinea pedis with 2% topical ketoconazole cream either once or twice daily. All diagnoses were confirmed mycologically. They were randomly assigned in a double-blind study into three groups on the basis of their clinical lesions, that is, vesicular pedis, interdigital pedis, and hyperker...

journal_title：Journal of the American Academy of Dermatology

authors： Greer DL

更新日期：1987-03-01 00:00:00

abstract：:Although sclerotherapy is an established procedure to treat ectatic veins, a wide disparity remains in the reported rates of success, especially for larger varicose veins. This article reviews the venous anatomy of the lower extremity and outlines the indications for sclerotherapy. The historical basis for treatment t...

journal_title：Journal of the American Academy of Dermatology

authors： Green D

更新日期：1998-03-01 00:00:00

abstract：:Our case series report is the first documented depiction of the appearance of aphthous ulcers secondary to imiquimod application. This case series presentation discusses the underlying pathophysiology of aphthous ulcer development and imiquimod therapy in terms of the stimulation of proinflammatory cytokines, such as ...

journal_title：Journal of the American Academy of Dermatology

authors： Chakrabarty AK,Mraz S,Geisse JK,Anderson NJ

更新日期：2005-02-01 00:00:00

abstract：:An unusual American epidemic consisting of twenty cases of granuloma inguinale is chronicled. Evidence from this series supports the venereal transmission of the disorder. Trimethoprim/sulfamethoxazole proved to be a safe and effective therapy. ...

journal_title：Journal of the American Academy of Dermatology

authors： Rosen T,Tschen JA,Ramsdell W,Moore J,Markham B

更新日期：1984-09-01 00:00:00

abstract：:In this article we focus on updates in select etiologies of retiform purpura. These causes of retiform purpura, in addition to bacterial or fungal sepsis, disseminated intravascular coagulation, purpura fulminans, and catastrophic antiphospholipid syndrome, are important diagnoses with potential for morbidity and mort...

journal_title：Journal of the American Academy of Dermatology

authors： Georgesen C,Fox LP,Harp J

更新日期：2020-04-01 00:00:00

abstract：:A case is presented in which a patient experienced the development of both Dupuytren's disease and Peyronie's disease after single episodes of sports-related trauma. These disorders and other fibromatoses are linked not only by similar pathologic features but by increased frequency of simultaneous occurrence. Some gen...

journal_title：Journal of the American Academy of Dermatology

authors： Connelly TJ

更新日期：1999-07-01 00:00:00

abstract：:A syndrome of congenital atrichia, palmoplantar hyperkeratosis, mental retardation, and early loss of teeth was observed in four siblings (three women and one man). The pedigree is suggestive of either an autosomal recessive mode of inheritance or the inheritance of a (small) chromosomal translocation. This combinatio...

journal_title：Journal of the American Academy of Dermatology

authors： Steijlen PM,Neumann HA,der Kinderen DJ,Smeets DF,van der Kerkhof PC,Happle R

更新日期：1994-05-01 00:00:00

abstract：:Five of seven patients with acquired immunodeficiency syndrome (AIDS) who had pruritus and a chronic, nonspecific-appearing skin eruption had increased antibody titers to antigens in the salivary glands of Aedes taeniorhynchus, a salt marsh mosquito common to South Florida. We hypothesize that the pruritus and skin le...

journal_title：Journal of the American Academy of Dermatology

authors： Penneys NS,Nayar JK,Bernstein H,Knight JW

更新日期：1989-08-01 00:00:00

abstract：:In this third and last part of our review of cutaneous vascular proliferations we include malignant vascular neoplasms and a group of heterogeneous cutaneous neoplasms characterized by a significant vascular component. We also review some disorders that, in our opinion, have been erroneously considered as vascular neo...

journal_title：Journal of the American Academy of Dermatology

authors： Requena L,Sangueza OP

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Sox10 is a transcription factor associated with neural crest development. Its expression has been reported in melanocytes and peripheral nerve sheath cells and their associated tumors. OBJECTIVE:To assess Sox10 sensitivity in benign and malignant melanocytic neoplasms of various histologic subtypes and to d...

journal_title：Journal of the American Academy of Dermatology

authors： Shin J,Vincent JG,Cuda JD,Xu H,Kang S,Kim J,Taube JM

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Acral vascular syndromes associated with malignancy have rarely been reported. OBJECTIVE:Our purpose was to assess the clinical and evolving features of paraneoplastic acral vascular syndromes. PATIENTS AND METHODS:Two cases of paraneoplastic gangrene are described and analyzed together with previously rep...

journal_title：Journal of the American Academy of Dermatology

authors： Poszepczynska-Guigné E,Viguier M,Chosidow O,Orcel B,Emmerich J,Dubertret L

更新日期：2002-07-01 00:00:00

abstract：:A case of porphyria cutanea tarda in a human immunodeficiency virus-infected patient with hemophilia is reported. Onset of skin manifestations of porphyria cutanea tarda coincided with deterioration of immune function. However, acquired immunodeficiency syndrome has not yet developed with a follow-up interval of 39 mo...

journal_title：Journal of the American Academy of Dermatology

authors： Conlan MG,Hoots WK

更新日期：1992-05-01 00:00:00

abstract：:Acute generalized exanthematous pustulosis is a severe cutaneous adverse reaction characterized by the rapid development of nonfollicular, sterile pustules on an erythematous base. It is attributed to drugs in the majority of cases. Antibiotics are the most common cause of acute generalized exanthematous pustulosis; h...

journal_title：Journal of the American Academy of Dermatology

authors： Szatkowski J,Schwartz RA

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Necrobiotic xanthogranuloma (NXG) is a rare histiocytic disorder of unknown origin. OBJECTIVE:We conducted an investigation of skin biopsy specimens from 7 patients with NXG for the presence of Borrelia by focus-floating microscopy. METHODS:Focus-floating microscopy is a recently described, modified immuno...

journal_title：Journal of the American Academy of Dermatology

authors： Zelger B,Eisendle K,Mensing C,Zelger B

更新日期：2007-12-01 00:00:00

abstract：:Carcinoma of the cervix is a common neoplasm, which annually affects 50,000 women in the United States. When cervical carcinoma metastasizes, it most often involves the lung, bone, and liver; only rarely does it metastasize to the skin. We describe a patient with previously diagnosed carcinoma of the cervix who presen...

journal_title：Journal of the American Academy of Dermatology

authors： Kagen MH,Ruhl KK,Aghajanian C,Myskowski PL

更新日期：2001-07-01 00:00:00