Transient myeloproliferative disorder with vesiculopustular eruption: Early smear is useful for quick diagnosis.

Abstract:

:We report a male infant with Down syndrome who had a transient myeloproliferative disorder associated with skin lesions. He was transferred to a neonatal intensive care unit because of low body weight, fetal edema, disseminated intravascular coagulation, and 10% blast cells in the peripheral blood. On postnatal day (PD) 1, erythema with small papules, vesicles, and pustules appeared on the entire body. A smear preparation from the pustules on PD 2 showed 10% blast cells. A biopsy specimen taken on PD 5 revealed subcorneal pustules containing neutrophils and eosinophils. Genetic analyses detected a somatic mutation (197G>T, Glu295Stop) in exon 2 of GATA-1. On PD 10, the eruptions resolved spontaneously and the population of blast cells in peripheral blood decreased to 1%. The number of blast cells in pustules decreased markedly after three days. Therefore, we recommend that cytologic examination should be performed as early as possible.

journal_name

J Am Acad Dermatol

authors

Uhara H,Shiohara M,Baba A,Shiohara J,Saida T

doi

10.1016/j.jaad.2008.09.029

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

869-71

issue

5

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(08)01209-7

journal_volume

60

pub_type

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