Therapeutic evaluation for intralesional injection of bleomycin sulfate in 143 resistant warts.

Abstract:

:A 1 U/ml solution of bleomycin sulfate in physiologic saline solution was injected intralesionally in 38 patients, and was compared with physiologic saline solution injection into paired warts in the same patient. No patient received more than 2 ml of bleomycin. Ninety-seven of 143 warts (67.8%) showed complete resolution after one or two bleomycin injections, while 25 warts (17.5%) showed incomplete resolution. Bleomycin local injection failed to elicit any therapeutic response in 21 warts (14.7%). The cure rate was 77% for warts on the extremities, 71.4% for periungual warts, and 47.6% for the plantar warts. The responsive warts showed hemorrhagic eschars that healed without scarring. It is concluded that this form of treatment for resistant warts, up to the dose used, is safe, reliable, and accepted by the patient.

journal_name

J Am Acad Dermatol

authors

Amer M,Diab N,Ramadan A,Galal A,Salem A

doi

10.1016/s0190-9622(88)70140-1

subject

Has Abstract

pub_date

1988-06-01 00:00:00

pages

1313-6

issue

6

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(88)70140-1

journal_volume

18

pub_type

临床试验,杂志文章
  • George Cheyne Shattuck's dissertation on the skin.

    abstract::George Cheyne Shattuck's 1808 dissertation on structure and function of the skin is one of the earliest American writings on the topic of skin diseases. Although this essay contributed no important new observations, it does provide insight into the attitudes of American physicians in the post-Revolutionary War period ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 传,历史文章,杂志文章

    doi:10.1067/mjd.2002.119644

    authors: Valentine MC

    更新日期:2002-04-01 00:00:00

  • Dermatoscopy use by US dermatologists: a cross-sectional survey.

    abstract:BACKGROUND:Although dermatoscopy is widely used in Europe and Australia, little is known about dermatoscopy use by US dermatologists. OBJECTIVE:We sought to estimate the prevalence of dermatoscopy use by US dermatologists and examine associations with practice characteristics. METHODS:We conducted a cross-sectional s...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2009.09.050

    authors: Engasser HC,Warshaw EM

    更新日期:2010-09-01 00:00:00

  • Misclassification of study designs in the dermatology literature.

    abstract:BACKGROUND:The appropriate classification of study designs is important for review and assessment of the relevant scientific literature as a basis for decision making; however, little is known about whether study designs have been appropriately reported in the dermatology literature. OBJECTIVE:We aimed to validate the...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2017.10.049

    authors: Ohn J,Eun SJ,Kim DY,Park HS,Cho S,Yoon HS

    更新日期:2018-08-01 00:00:00

  • Benign lymphangiomatous papules of the skin associated with ovarian fibroma.

    abstract::Benign lymphangiomatous papules of the skin are considered reactive lymphatic proliferations either caused by disruption of the lymphatic flow or tissue damage produced by operation or radiation therapy. We report a 72-year-old woman with umbilical papules and vesicle-like lesions that led to the diagnosis of a large ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2006.05.056

    authors: Bodet D,Rodríguez-Cano L,Bartralot R,Mollet J,Medina A,Heras C,Bassas P,Huguet P,García-Patos V

    更新日期:2007-02-01 00:00:00

  • Therapeutic interventions for vitiligo.

    abstract:BACKGROUND:Current treatments for vitiligo, a common pigmentary disorder affecting around 1% of the world's population, are largely unsatisfactory. OBJECTIVE:We sought to report a Cochrane review of all interventions for the treatment of vitiligo. METHODS:We systematically searched a range of databases for randomized...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 社论,评审

    doi:10.1016/j.jaad.2008.06.023

    authors: Whitton ME,Ashcroft DM,González U

    更新日期:2008-10-01 00:00:00

  • Pili torti in association with citrullinemia.

    abstract::A 2 1/2-year-old white girl with citrullinemia accompanied by neurologic symptoms presented with 2- to 3-week loss of scalp hair. Examination of the scalp revealed 90% of the hairs to be broken off, leaving a stubble of hairs less than 1 mm in length. Microscopically, plucked hairs demonstrated flattening, twisting th...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(85)80018-9

    authors: Patel HP,Unis ME

    更新日期:1985-01-01 00:00:00

  • Linear seborrheic keratoses associated with underlying malignancy.

    abstract::A clinical syndrome, consisting of eruptive linear seborrheic keratoses associated with adenomatous colonic polyps (malignant but without invasion of the stalk) and/or frankly invasive colonic adenocarcinomas, is described in five patients. Partial to almost complete regression of the cutaneous lesions over the succee...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(88)70141-3

    authors: Heng MC,Soo-Hoo K,Levine S,Petresek D

    更新日期:1988-06-01 00:00:00

  • Sulfur revisited.

    abstract::Sulfur is a time-honored therapeutic agent useful in a variety of dermatologic disorders. Its keratolytic action is due to formation of hydrogen sulfide through a reaction that depends upon direct interaction between sulfur particles and keratinocytes. The smaller the particle size, the greater the degree of such inte...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(88)70079-1

    authors: Lin AN,Reimer RJ,Carter DM

    更新日期:1988-03-01 00:00:00

  • The value of patch testing patients with a scattered generalized distribution of dermatitis: retrospective cross-sectional analyses of North American Contact Dermatitis Group data, 2001 to 2004.

    abstract:BACKGROUND:A scattered generalized distribution (SGD) of dermatitis is a challenging problem; patch testing is a strategy for evaluating allergic contact dermatitis as a relevant factor. OBJECTIVE:We sought to analyze patient characteristics and most frequently relevant positive allergens in patients presenting for pa...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2008.05.008

    authors: Zug KA,Rietschel RL,Warshaw EM,Belsito DV,Taylor JS,Maibach HI,Mathias CG,Fowler JF Jr,Marks JG Jr,DeLeo VA,Pratt MD,Sasseville D,Storrs FJ

    更新日期:2008-09-01 00:00:00

  • Autologous cell-based therapy for male and female pattern hair loss using dermal sheath cup cells: A randomized placebo-controlled double-blinded dose-finding clinical study.

    abstract:BACKGROUND:Few effective treatments are available for male pattern hair loss (MPHL) or, especially, for female pattern hair loss (FPHL). Recently, cell-based therapies using autologous or allogeneic cells have been used clinically. OBJECTIVE:We examined the safety and efficacy of autologous cell-based therapy using de...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jaad.2020.02.033

    authors: Tsuboi R,Niiyama S,Irisawa R,Harada K,Nakazawa Y,Kishimoto J

    更新日期:2020-07-01 00:00:00

  • Circulating adhesion molecules as prognostic factors for cutaneous melanoma.

    abstract:BACKGROUND:Overexpression of adhesion molecules in tissues of human neoplasms, including malignant melanoma, has been reported to be clinically relevant, but the predictive value of circulating adhesion molecules for clinical outcome and life expectancy in patients with primary malignant melanoma (PMM) and metastases o...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(97)70282-2

    authors: Schaider H,Rech-Weichselbraun I,Richtig E,Seidl H,Soyer HP,Smolle J,Kerl H

    更新日期:1997-02-01 00:00:00

  • Multiple vascular fibromas and myxoid fibromas of the fingers. A histologic and ultrastructural study.

    abstract::A father and his son were seen because of multiple wartlike lesions on their fingers and palms. On histologic examination, these lesions showed changes compatible with vascular fibromas, myxoid fibromas, and, in a few instances, verruca vulgaris. We are not aware of reports of similar cases in the dermatologic literat...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(80)80367-7

    authors: Coskey RJ,Mehregan AH,Lupulescu AP

    更新日期:1980-05-01 00:00:00

  • Mohs micrographic surgery for the treatment of primary cutaneous melanoma.

    abstract:BACKGROUND:Mohs micrographic surgery is thought to be a useful therapy for cutaneous melanoma. Controversy persists, however, because there are few published reports that document its safety and efficacy. OBJECTIVE:Our purpose was to determine the safety and efficacy of Mohs micrographic surgery for the treatment of c...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(97)80131-4

    authors: Zitelli JA,Brown C,Hanusa BH

    更新日期:1997-08-01 00:00:00

  • Transient myeloproliferative disorder with vesiculopustular eruption: Early smear is useful for quick diagnosis.

    abstract::We report a male infant with Down syndrome who had a transient myeloproliferative disorder associated with skin lesions. He was transferred to a neonatal intensive care unit because of low body weight, fetal edema, disseminated intravascular coagulation, and 10% blast cells in the peripheral blood. On postnatal day (P...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2008.09.029

    authors: Uhara H,Shiohara M,Baba A,Shiohara J,Saida T

    更新日期:2009-05-01 00:00:00

  • Effects of tofacitinib on cardiovascular risk factors and cardiovascular outcomes based on phase III and long-term extension data in patients with plaque psoriasis.

    abstract:BACKGROUND:Psoriasis is a systemic inflammatory condition that is associated with a higher risk of cardiovascular (CV) disease. Tofacitinib is being investigated as a treatment for psoriasis. OBJECTIVE:We sought to evaluate the effects of tofacitinib on CV risk factors and major adverse CV events (MACEs) in patients w...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2016.06.012

    authors: Wu JJ,Strober BE,Hansen PR,Ahlehoff O,Egeberg A,Qureshi AA,Robertson D,Valdez H,Tan H,Wolk R

    更新日期:2016-11-01 00:00:00

  • Usefulness of flow cytometry in the diagnosis of mycosis fungoides.

    abstract:BACKGROUND:The pathologic evaluation of mycosis fungoides (MF) is a challenging area in dermatopathology. OBJECTIVE:We sought to determine the usefulness of flow cytometry for the diagnosis of MF from skin biopsy specimens. METHODS:Skin biopsy specimens from 22 patients with a clinical suggestion for MF were evaluate...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2007.01.017

    authors: Oshtory S,Apisarnthanarax N,Gilliam AC,Cooper KD,Meyerson HJ

    更新日期:2007-09-01 00:00:00

  • Lipedematous scalp and lipedematous alopecia: a clinical and histologic analysis of 3 cases.

    abstract:BACKGROUND:Lipedematous alopecia and lipedematous scalp are two similar unusual conditions mostly affecting healthy black women. OBJECTIVE:The purpose of our study was to report three cases of this condition with emphasis on clinical and histologic findings, and to review the literature on the subject. METHODS:The st...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jaad.2004.05.016

    authors: Martín JM,Monteagudo C,Montesinos E,Guijarro J,Llombart B,Jordá E

    更新日期:2005-01-01 00:00:00

  • Premature epiphyseal closure in a child receiving oral 13-cis-retinoic acid.

    abstract::A boy with epidermolytic hyperkeratosis was treated systemically for 4 1/2 years with 13-cis-retinoic acid. At the age of 10 1/2 years, he developed pain in his right knee and radiographic evidence of partial closure of the proximal epiphysis of the right tibia. Similar radiographic changes have been described in indi...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(82)70148-3

    authors: Milstone LM,McGuire J,Ablow RC

    更新日期:1982-11-01 00:00:00

  • An outbreak of tinea corporis gladiatorum on a high school wrestling team.

    abstract:BACKGROUND:An outbreak of tinea corporis occurred in members of a high school wrestling team during the 1992-1993 season. OBJECTIVE:To control the outbreak, we conducted an epidemiologic investigation. METHODS:We examined 28 team members and obtained skin scrapings from 16. To control the outbreak we recommended (1) ...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/s0190-9622(94)70145-8

    authors: Beller M,Gessner BD

    更新日期:1994-08-01 00:00:00

  • Repetitive pinching of the skin during lidocaine infiltration reduces patient discomfort.

    abstract:BACKGROUND:The administration of a local anesthetic is often painful. OBJECTIVE:The purpose of this study was to determine whether rapidly shaking and pinching the skin during local anesthetic administration decreases pain perception. METHODS:The skin at the intended site of lidocaine injection was rapidly pinched be...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0190-9622(98)70404-9

    authors: Fosko SW,Gibney MD,Harrison B

    更新日期:1998-07-01 00:00:00

  • Successful use of rituximab in the treatment of childhood and juvenile pemphigus.

    abstract:BACKGROUND:There is a lack of data on outcomes of management of pemphigus in children. OBJECTIVE:We sought to evaluate rituximab treatment in childhood and juvenile pemphigus. METHOD:All cases of pemphigus treated with rituximab in patients younger than 18 years were included. Clinical and epidemiologic data and deta...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2014.05.071

    authors: Vinay K,Kanwar AJ,Sawatkar GU,Dogra S,Ishii N,Hashimoto T

    更新日期:2014-10-01 00:00:00

  • Invasive squamous cell carcinoma initially diagnosed as a giant keratoacanthoma.

    abstract::Keratoacanthoma (KA) is currently considered a benign epithelial neoplasm. We report a patient with a lesion diagnosed as a KA that behaved aggressively like a squamous cell carcinoma (SCC). Similar reports are not uncommon in the literature. Because there are currently no criteria by which KA can be differentiated fr...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章,评审

    doi:10.1016/s0190-9622(84)80010-9

    authors: Goldenhersh MA,Olsen TG

    更新日期:1984-02-01 00:00:00

  • Epidermal growth factor receptor inhibitors and hair.

    abstract::Dialogues in Dermatology, a monthly audio program from the American Academy of Dermatology, contains discussions between dermatologists on timely topics. Commentaries from Dialogues Editor-in-Chief Warren R. Heymann, MD, are provided after each discussion as a topic summary and are provided here as a special service t...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2007.09.007

    authors: Heymann WR

    更新日期:2008-04-01 00:00:00

  • A comparative histopathologic study of photodistributed and nonphotodistributed lichenoid drug eruptions.

    abstract::This study compares the histopathologic characteristics of photodistributed and nonphotodistributed lichenoid drug eruptions in 13 patients. Both types have been said to be, in an unknown proportion, different from idiopathic lichen planus in that they can involve the deep as well as the superficial plexus, can contai...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/0190-9622(90)70275-m

    authors: West AJ,Berger TG,LeBoit PE

    更新日期:1990-10-01 00:00:00

  • Risk of subsequent cutaneous squamous cell carcinoma in patients with melanoma.

    abstract:BACKGROUND:Patients with melanoma are at increased risk for cutaneous squamous cell carcinomas (SCCs). OBJECTIVE:We sought to examine the incidence of subsequent SCC among melanoma survivors and the impact of patient and melanoma characteristics on SCC risk. METHODS:Kaiser Permanente Northern California members given...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2014.04.019

    authors: Asgari MM,Warton EM,Quesenberry CP,Koralek DO,Taylor M

    更新日期:2014-09-01 00:00:00

  • Psoriatic lesions are characterized by higher bacterial load and imbalance between Cutibacterium and Corynebacterium.

    abstract:BACKGROUND:Several studies have found that the microbiota of psoriatic lesions is different from that of healthy skin. OBJECTIVE:To characterize the microbiota of lesional and unaffected skin in patients with psoriasis and controls and investigate the correlation between cutaneous microbiota and clinical features of p...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2019.06.024

    authors: Quan C,Chen XY,Li X,Xue F,Chen LH,Liu N,Wang B,Wang LQ,Wang XP,Yang H,Zheng J

    更新日期:2020-04-01 00:00:00

  • Cannabis arteritis.

    abstract::Cannabis arteritis is a serious peripheral vascular disease affecting young adults consuming cannabis. An increasing number of cases have been recently reported in Europe. The risk of amputation is high. Cannabis arteritis is often confused with atherosclerosis. We present a new case in which complete arterial revascu...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2007.04.024

    authors: Noël B,Ruf I,Panizzon RG

    更新日期:2008-05-01 00:00:00

  • Atopic dermatitis, stinging, and effects of chronic stress: a pathocausal study.

    abstract:BACKGROUND:Patients with atopic dermatitis (AD) often have increased skin sensitivity and this symptom often worsens during stress. OBJECTIVE:We sought to find out whether patients with AD had stinging, and to identify the pathocausal neuroimmune mechanisms, including the role of stress. METHODS:In all, 25 patients w...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2004.05.035

    authors: Lonne-Rahm S,Berg M,Mårin P,Nordlind K

    更新日期:2004-12-01 00:00:00

  • Comparison of a picosecond alexandrite laser versus a Q-switched alexandrite laser for the treatment of nevus of Ota: A randomized, split-lesion, controlled trial.

    abstract:BACKGROUND:Novel picosecond lasers have been available for various pigmentary disorders. However, there are limited data directly comparing picosecond lasers and Q-switched lasers for treatment of nevus of Ota. OBJECTIVE:To compare the efficacy and safety of a picosecond alexandrite laser (PSAL) with a Q-switched alex...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1016/j.jaad.2019.03.016

    authors: Ge Y,Yang Y,Guo L,Zhang M,Wu Q,Zeng R,Rong H,Jia G,Shi H,Fang J,Lin T

    更新日期:2020-08-01 00:00:00

  • Phototesting in lupus erythematosus: a 15-year experience.

    abstract::It has long been observed that sun exposure can induce or exacerbate skin lesions in patients with certain forms of lupus erythematosus. Despite the frequency of photosensitivity in these patients, the mechanism by which ultraviolet radiation alters the pathogenic course of this disease remains poorly understood. Afte...

    journal_title:Journal of the American Academy of Dermatology

    pub_type: 杂志文章

    doi:10.1067/mjd.2001.114589

    authors: Kuhn A,Sonntag M,Richter-Hintz D,Oslislo C,Megahed M,Ruzicka T,Lehmann P

    更新日期:2001-07-01 00:00:00