Abstract：
:It has long been observed that sun exposure can induce or exacerbate skin lesions in patients with certain forms of lupus erythematosus. Despite the frequency of photosensitivity in these patients, the mechanism by which ultraviolet radiation alters the pathogenic course of this disease remains poorly understood. After development of standardized test methods, our group demonstrated in 1986 that skin lesions in patients with lupus erythematosus can be experimentally reproduced by UVA and UVB irradiation. In the following years, phototesting has received much attention as a valid model to study photosensitivity of different forms of lupus erythematosus and the pathogenetic mechanism of this disease. Further investigations have also made it possible to find genetic and immunologic factors associated with photosensitivity and have helped to identify the pathophysiologic steps involved in the induction of such skin lesions. We present phototesting results and clinical correlations of more than 400 patients with different forms of lupus erythematosus and discuss the recent advances in provocative phototesting.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Kuhn A,Sonntag M,Richter-Hintz D,Oslislo C,Megahed M,Ruzicka T,Lehmann Pdoi
10.1067/mjd.2001.114589subject
Has Abstractpub_date
2001-07-01 00:00:00pages
86-95issue
1eissn
0190-9622issn
1097-6787pii
S0190-9622(01)91037-0journal_volume
45pub_type
杂志文章abstract：BACKGROUND:Onychomycosis, a fungal infection of the nail bed, is responsible for up to 50% of nail disorders. Although several surveys have been conducted in different parts of the world, there have been no multicenter epidemiologic surveys of onychomycosis in North America. OBJECTIVE:A 12-center study was undertaken ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,多中心研究
doi：10.1067/mjd.2000.107754
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND:For treatment of localized scleroderma numerous treatments, including ones with potentially hazardous side effects, are currently used with only limited success. OBJECTIVE:We attempted to determine the efficacy of low-dose UVA1 irradiation in patients with severe localized scleroderma. METHODS:Patients wer...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(98)70533-x
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:The Food and Drug Administration (FDA) has received reports of depression and suicide in patients treated with isotretinoin. OBJECTIVE:Our purpose was to provide the number and describe the cases of depression and suicide reported to the FDA in US patients treated with isotretinoin and to consider the natur...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2001.117730
更新日期：2001-10-01 00:00:00
abstract：:Primary cutaneous T-cell lymphomas are non-Hodgkin's lymphomas with varied clinical presentation and prognosis. The most common subtypes of cutaneous T-cell lymphomas are the epidermotropic variants mycosis fungoides and Sézary syndrome. Treatment of mycosis fungoides has encompassed a variety of modalities including ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章
doi：10.1016/j.jaad.2003.11.058
更新日期：2004-07-01 00:00:00
abstract：:Topical photodynamic therapy (PDT) is used to treat nonmelanoma skin cancers, such as actinic keratoses, Bowen's disease, and basal cell carcinoma (superficial and nodular). This article presents up-to-date, practical, evidence-based recommendations on the use of topical PDT using 5-aminolevulinic acid or methyl amino...
journal_title：Journal of the American Academy of Dermatology
pub_type： 共识发展会议,杂志文章,实务指引
doi：10.1016/j.jaad.2006.06.006
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:There are large discrepancies in reported mortality for bullous pemphigoid (BP). OBJECTIVE:We sought to determine the mortality of a large cohort of patients with BP and compare this with age-matched control subjects. METHODS:Data were collected on 223 patients with a new diagnosis of BP between 1998 and 2...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2008.07.022
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:Although dermatoscopy is widely used in Europe and Australia, little is known about dermatoscopy use by US dermatologists. OBJECTIVE:We sought to estimate the prevalence of dermatoscopy use by US dermatologists and examine associations with practice characteristics. METHODS:We conducted a cross-sectional s...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2009.09.050
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:Surgeons use absorbable and nonabsorbable sutures for epidermal wound closure. No large, randomized studies have compared the effect of these suture types on facial scar appearance. OBJECTIVE:To assess postsurgical facial scar appearance using either rapidly absorbable polyglactin 910 or nylon for epidermal...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2020.06.016
更新日期：2020-11-01 00:00:00
abstract：:Pyoderma gangrenosum may occur in unusual sites and not be readily recognized. Delays in diagnosis and appropriate treatment may result in extensive ulcerations and scarring. We present two patients with pyoderma gangrenosum involving the breasts after breast operation. Delays in diagnosis resulted in extensive ulcera...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2006.02.066
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:There has been considerable controversy about the relation between Kimura's disease and angiolymphoid hyperplasia with eosinophilia (ALHE). OBJECTIVE:We describe the clinical and histopathologic differences between the two diseases. METHODS:We reviewed clinical findings and histopathologic changes in two c...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(92)70293-o
更新日期：1992-12-01 00:00:00
abstract：:POEMS syndrome is an unusual plasma cell dyscrasia with multisystemic manifestations featuring polyneuropathy, organomegaly, endocrinopathy, M protein and constant skin involvement. We have seen a 58-year-old white man presenting with generalized eruptive angiomas as a rare skin manifestation of this syndrome. We revi...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(85)70123-5
更新日期：1985-05-01 00:00:00
abstract：:Twenty-five years ago the use of pyridoxine was described for the treatment of photosensitivity eruptions. We report two cases of erythropoietic protoporphyria, which were only moderately responsive to beta-carotene and sunscreens, whereas the use of pyridoxine has been associated with a marked reduction in photosensi...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(90)70043-h
更新日期：1990-02-01 00:00:00
abstract：:The fixed cutaneous type of sporotrichosis is difficult to diagnose because clinical lesions are variable in appearance and the cells of Sporothrix schenckii are usually scarce in skin biopsy specimens. We have described two patients with lesions of fixed cutaneous sporotrichosis that resembled other inflammatory skin...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(85)70129-6
更新日期：1985-06-01 00:00:00
abstract：BACKGROUND:The use of cutaneous resurfacing lasers to treat rhytides is widely accepted. Several carbon dioxide lasers, many using fundamentally different technologies, are available. OBJECTIVE:The purpose of this study was to compare the results obtained and side effects after treating rhytides with 3 different carbo...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0190-9622(98)70002-7
更新日期：1998-10-01 00:00:00
abstract：:From the origin of civilization the pursuit of beauty has exemplified the highest order of the human being's quest for achievement, and from the beginning, this pursuit has focused, in part, on perfecting the human form. Freed from much of the time-consuming burden of attending to elemental needs, the present generati...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/s0190-9622(89)70340-6
更新日期：1989-12-01 00:00:00
abstract：:Patients with HIV and AIDS are living longer because of advancements in antiretroviral therapy. These patients are often susceptible to debilitating inflammatory disorders that are refractory to standard treatment. We discuss the relationship of tumor necrosis factor-alpha and HIV and then review 27 published cases of...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2015.11.043
更新日期：2016-05-01 00:00:00
abstract：:Chronic skin ulcers, which are frequently located on the lower legs, are a common cause of patient morbidity and incur significant direct and indirect costs in their treatment. The most important process for their development is probably impairment of blood flow to the capillaries and small vessels. Examples of such u...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(85)80002-5
更新日期：1985-02-01 00:00:00
abstract：BACKGROUND:Because of the relatively rare occurrence of malignant melanoma (MM) of the eyelid, prognostic factors in relation to survival in these patients have not been established. OBJECTIVE:Our purpose was to examine prognostic indicators in relation to survival in patients with MM of the eyelid. METHODS:All patie...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/0190-9622(92)70148-9
更新日期：1992-07-01 00:00:00
abstract：BACKGROUND:Melanoma in African Americans is rare, and the diagnosis is often delayed, leading to advanced presentation and poor prognosis. OBJECTIVE:The purpose of this retrospective study is to determine whether African American patients diagnosed with melanoma at the Washington Hospital Center were initially seen wi...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(03)02091-7
更新日期：2004-01-01 00:00:00
abstract：:Cutaneous findings are not uncommonly a concomitant finding in patients afflicted with gastrointestinal (GI) diseases. The dermatologic manifestations may precede clinically evident GI disease. Part I of this 2-part CME review focuses on dermatologic findings as they relate to hereditary and nonhereditary polyposis di...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章,评审
doi：10.1016/j.jaad.2012.10.037
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:Even with the addition of dermoscopy, a significant morphologic overlap exists between irritated seborrheic keratosis (ISK) and squamous cell carcinoma (SCC). OBJECTIVE:The aim of this study was to investigate the dermoscopic criteria that could serve as potent predictors for the differential diagnosis betw...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2020.02.019
更新日期：2020-02-14 00:00:00
abstract：BACKGROUND:There is limited data on zoster recurrence. OBJECTIVE:To examine in detail zoster recurrence in a population-based cohort. METHODS:Using data from a large cohort (The 45 and Up Study) with linked medical data (2004-2015), the incidence of first and recurrent zoster was examined using survival analyses meth...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2020.06.1013
更新日期：2020-07-02 00:00:00
abstract：:Levels of IgE antibodies to Staphylococcus aureus and Staphylococcus epidermidis were determined in eleven patients with typical atopic dermatitis, with no history of furuncles or severe staphylococcal infection. Increased IgE binding to S. aureus but not to S. epidermidis was observed. Fifteen patients with hyperimmu...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(82)80017-0
更新日期：1982-07-01 00:00:00
abstract：BACKGROUND:A radiofrequency-controlled electrosurgical device (ESD) has been adapted for skin peeling. A high-voltage, low-amperage current converts an irrigant into an ionized vapor, causing molecular dissociation and superficial damage in adjacent tissue. OBJECTIVE:We compared the clinical and histologic effects of ...
journal_title：Journal of the American Academy of Dermatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1067/mjd.2001.109856
更新日期：2001-03-01 00:00:00
abstract：:Treatment of cicatricial pemphigoid is a problem because patients afflicted are elderly, the disease is chronic, systemic agents required for control are potentially toxic (particularly to older patients), and the disease is often in an advanced stage when the diagnosis is established and requires aggressive therapy f...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(82)70014-3
更新日期：1982-02-01 00:00:00
abstract：BACKGROUND:Condyloma acuminatum are common lesions caused by human papillomavirus (HPV). HPV is associated with many human cancers, and a vaccine now prevents infection with high-risk HPV. However, eradication of established disease is difficult, indicating that these lesions are capable of local immunosuppression. OB...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2008.08.011
更新日期：2008-12-01 00:00:00
abstract：:The case of a 2-year-old Puerto Rican boy is presented. Clinical and histologic features are detailed because he showed peculiar jet black patches of pigmentation on the fingers of the right hand. This case, except for the lack of progression of the disease after a 2-year period of follow-up, shows many similarities t...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/s0190-9622(80)80391-4
更新日期：1980-02-01 00:00:00
abstract：BACKGROUND:Melanoma is the most lethal form of skin cancer. Diagnosis of amelanotic melanoma and detection of micrometastases in sentinel lymph nodes pose diagnostic and therapeutic dilemmas for the dermatopathologist and clinician. OBJECTIVE:The purpose of this article is to determine the utility of immunohistochemis...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1067/mjd.2001.117526
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND:Few data exist on the relationship between psoriasis and melanocytic lesions. OBJECTIVES:We sought to investigate number of melanocytic nevi in psoriatic patients compared with control subjects and its relationship with disease severity and treatment. METHODS:We performed a prospective study in 189 psoriat...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/j.jaad.2013.08.017
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Hereditary palmoplantar keratoderma (HPPK), type papulosa, is rare, and epidemiologic data are sporadic and inconsistent. An epidemiologic population study of this disease has not been performed previously. OBJECTIVE:We performed a large population study on prevalence of HPPK, type papulosa, in Croatia. ME...
journal_title：Journal of the American Academy of Dermatology
pub_type： 杂志文章
doi：10.1016/0190-9622(93)70207-a
更新日期：1993-09-01 00:00:00
