Eosinophilic myositis/perimyositis: frequency and spectrum of cutaneous manifestations.

Abstract:

BACKGROUND:Eosinophilic myositis/perimyositis (EM/P) are a group of rare idiopathic muscle disorders associated with eosinophilia. OBJECTIVE:We describe the frequency and spectrum of cutaneous manifestations in EM/P and compare them with the idiopathic hypereosinophilic syndrome (HES). METHODS:We review the literature on EM/P and describe an additional case associated with angioedema. RESULTS:Of a total of 26 reported patients with EM/P, cutaneous manifestations were observed in 10. These were, in order of frequency, deep subcutaneous induration, erythema, angioedema, urticaria, and papular lesions. CONCLUSION:Skin lesions occur less frequently in EM/P than in HES. Although erythematous papulonodular lesions and urticaria/angioedema are most commonly observed in HES, the most frequent skin manifestations of EM/P are subcutaneous induration and erythema. In HES, angioedema has been correlated with a favorable prognosis. At least some of these patients apparently have an idiopathic eosinophilic disorder distinct from HES, including EM/P. In contrast to HES, the overall prognosis of EM/P is good, particularly when muscle lesions are focal, and the principal histopathologic finding is perimysial infiltrates.

journal_name

J Am Acad Dermatol

authors

Trüeb RM,Pericin M,Winzeler B,Wüthrich B,Burg G

doi

10.1016/s0190-9622(97)70136-1

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

385-91

issue

3 Pt 1

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(97)70136-1

journal_volume

37

pub_type

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