Abstract:
BACKGROUND:Glial cell line-derived neurotrophic factor (GDNF) and a related family member, neurturin (NTN), and their cognate receptors (GFRalpha-1 and GFRalpha-2, for GDNF and NTN, respectively) are distal members of the transforming growth factor-beta superfamily. They are involved in the control of murine hair follicle (HF) cycling. This study tests the hypothesis that GDNF and NTN, and their cognate receptors, are expressed in the human HF and their expression varies in the different stages of the HF cycle. METHODS:The expression pattern of these proteins was examined in human HF by immunofluorescence, immunoalkalinephosphatase staining methods, and reverse transcription-polymerase chain reaction (GDNF). The functional effects (GDNF and NTN) were examined in organ culture of the microdissected HFs. RESULTS:GDNF, NTN, GFRalpha-1, GFRalpha-2, and c-Ret proteins were weakly expressed in catagen and telogen HFs. In contrast, they were strongly expressed in the epithelial and mesenchymal compartments of the anagen HF. GDNF gene was transcribed, both in the human scalp skin and in the isolated anagen HFs (reverse transcription-polymerase chain reaction). In HF organ culture, GDNF (but not NTN) increased the number of the proliferating HF keratinocytes (Ki 67 + cells). GDNF partially protected HFs from transforming growth factor-beta2-induced premature catagen transition. LIMITATIONS:None. CONCLUSIONS:GDNF, NTN, GFRalpha-1, GFRalpha-2, and c-Ret proteins are differentially expressed in the different stages of HF cycle. GFRalpha-mediated signaling involves c-Ret and may play a role in human HF biology.
journal_name
J Am Acad Dermatoljournal_title
Journal of the American Academy of Dermatologyauthors
Adly MA,Assaf HA,Pertile P,Hussein MR,Paus Rdoi
10.1016/j.jaad.2007.10.014subject
Has Abstractpub_date
2008-02-01 00:00:00pages
238-50issue
2eissn
0190-9622issn
1097-6787pii
S0190-9622(07)01594-0journal_volume
58pub_type
杂志文章abstract:BACKGROUND:Actinic keratosis (AK) is the earliest clinical manifestation of squamous cell carcinoma. Metastatic SCC causes the majority of the 1300 to 2300 deaths attributed to nonmelanoma skin cancer in the United States each year. Recent studies have shown that intralesional administration of interferon can be used s...
journal_title:Journal of the American Academy of Dermatology
pub_type: 临床试验,杂志文章
doi:10.1067/mjd.2002.123492
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Access to dermatologists is low among Medicaid-insured patients. Higher clinic nonattendance among Medicaid-insured patients might affect provider decisions to accept these patients. OBJECTIVE:To determine the effect of different scheduling policies on the attendance among children seen at a pediatric derma...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2019.02.018
更新日期:2019-08-01 00:00:00
abstract::A syndrome of congenital atrichia, palmoplantar hyperkeratosis, mental retardation, and early loss of teeth was observed in four siblings (three women and one man). The pedigree is suggestive of either an autosomal recessive mode of inheritance or the inheritance of a (small) chromosomal translocation. This combinatio...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/s0190-9622(94)70108-3
更新日期:1994-05-01 00:00:00
abstract::Our studies of mononuclear leukocyte peripheral blood homogenates demonstrate significantly increased cyclic adenosine monophosphate-specific phosphodiesterase activity in patients with atopic dermatitis who were untreated for 1 week, compared with normal adult nonatopic control subjects. Phosphodiesterase activity is...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(89)70150-x
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:Bath-PUVA is used to treat a variety of dermatoses. However, the kinetics of 8-methoxypsoralen during treatment are not completely clarified. OBJECTIVE:The purpose of this study was to investigate the intensity of the phototoxic response and the persistence of phototoxicity after bath-PUVA. METHODS:Twelve ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(98)70322-6
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:In 1982 we reported our preliminary observations on the use of home UV phototherapy for patch and early plaque phase mycosis fungoides (MF). OBJECTIVE:Our purpose was to present follow-up data of the original 31 patients, covering an interval of up to 15 years. METHODS:All patients used a commercially avai...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/0190-9622(93)70155-m
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:Single-institution studies show that frozen section Mohs micrographic surgery (MMS) is an effective treatment modality for cutaneous melanoma, but no multi-institutional studies have been published. OBJECTIVE:To characterize the use of MMS in the treatment of melanoma at 3 academic and 8 private practices t...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.jaad.2019.05.057
更新日期:2019-09-01 00:00:00
abstract::Eosinophilic spongiosis has a distinctive but not diagnostic histologic pattern of the epidermis. This pattern may be seen in a wide variety of clinical disorders. We have observed it most commonly in bullous pemphigoid, particularly the urticarial stage. In most biopsy specimens that show eosinophilic spongiosis, add...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(83)70036-8
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:No large studies have defined the best treatment of actinic cheilitis. METHODS:We conducted a systematic review to define the best therapies for actinic cheilitis in clinical response and recurrences. RESULTS:We first identified 444 papers, and 49 were finally considered, including 789 patients and 843 tre...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.jaad.2019.07.106
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Some hereditary palmoplantar keratodermas (PPK) have been defined at the molecular level. OBJECTIVE:Our purpose was to establish the cause of a hereditary PPK with unique histopathologic findings in the epidermis. METHODS:Investigative studies included light and electron microscopy and determination of gen...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(97)70208-1
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Psoriasis's effect on diabetes onset is well documented, but its effect on course of diabetes is poorly understood. OBJECTIVE:We sought to compare risks of developing microvascular and macrovascular complications between diabetic patients with and without psoriasis. METHODS:Adults with 2 or more diabetes d...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2015.02.1095
更新日期:2015-06-01 00:00:00
abstract::Dermatologists frequently are consulted by a pregnant patient or a woman of childbearing age who desires acne therapy. Because there are no published studies in which women took acne medications throughout pregnancy, information about safety must be obtained indirectly from studies in which the agents were taken for a...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/s0190-9622(88)70195-4
更新日期:1988-09-01 00:00:00
abstract::A diabetic renal transplant recipient developed fever, generalized rash, and genital ulcers which showed typical histologic changes of cytomegalovirus (CMV) infection in the dermal vascular endothelium. This infection was confirmed by rising serologic titer of specific antibody, positive viral cultures, and typical nu...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(83)70212-4
更新日期:1983-12-01 00:00:00
abstract::A 1 U/ml solution of bleomycin sulfate in physiologic saline solution was injected intralesionally in 38 patients, and was compared with physiologic saline solution injection into paired warts in the same patient. No patient received more than 2 ml of bleomycin. Ninety-seven of 143 warts (67.8%) showed complete resolu...
journal_title:Journal of the American Academy of Dermatology
pub_type: 临床试验,杂志文章
doi:10.1016/s0190-9622(88)70140-1
更新日期:1988-06-01 00:00:00
abstract::Dialogues in Dermatology, a monthly audio program from the American Academy of Dermatology, contains discussions between dermatologists on timely topics. Commentaries from Dialogues Editor-in-Chief Warren R. Heymann, MD, are provided after each discussion as a topic summary and are provided here as a special service t...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2008.01.018
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Mohs micrographic surgery (MMS) has a low rate of surgical site infection (SSI) without the use of prophylactic antibiotics. In the studies to date, there has been variation in the steps taken by each surgeon to prevent SSIs but in all cases sterile technique was used during wound reconstruction. OBJECTIVE:...
journal_title:Journal of the American Academy of Dermatology
pub_type: 临床试验,杂志文章
doi:10.1016/j.jaad.2010.07.029
更新日期:2010-11-01 00:00:00
abstract::Skin biopsy specimens from 24 patients with different lichenoid skin diseases that had been proved histologically were studied immunohistologically. Marked differences were noted in the number of OKT6+/S100+ Langerhans cells within the epidermis and dermis in the lesional skin between lichen planus (and its related di...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(88)70011-0
更新日期:1988-01-01 00:00:00
abstract::Squamous cell carcinoma of the penis is almost exclusively a lesion of uncircumcised older men. It represents about 1% of cancers in men in the United States and 11% to 12% of all cancers in men in countries where circumcision is not routinely practiced. Verrucous carcinoma is an uncommon variant that accounts for onl...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:
更新日期:1997-08-01 00:00:00
abstract::Diagnosis and classification of cutaneous lymphoid infiltrates are often hampered by lack of frozen tissue to allow detailed immunophenotyping. Therefore antibodies that recognize antigens resistant to routine tissue processing would be of value. In this study we present a detailed analysis of two such antibodies agai...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(89)70155-9
更新日期:1989-07-01 00:00:00
abstract::Human papillomavirus (HPV) is responsible for common condyloma acuminata and a number of premalignant and malignant anogenital lesions. These conditions are of particular concern in immunocompromised individuals who have higher risk of malignant transformation and are more difficult to treat. This is part I of a two-p...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.jaad.2010.12.050
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Dermatomyositis is associated with significant morbidity and occasional mortality. Currently there is no consensus on treatment for patients with dermatomyositis. OBJECTIVE:Our purpose was to review the clinical features and response to therapy of patients with dermatomyositis and compare these data with pr...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/s0190-9622(98)70496-7
更新日期:1998-03-01 00:00:00
abstract::The efficacy of a sunscreen containing an investigational drug, butyl methoxydibenzoylmethane in combination with padimate O against the erythemogenic effect of ultraviolet A (UVA) radiation was evaluated in two double-blind studies involving subjects sensitized with topical 8-methoxypsoralen. UVA radiation was suppli...
journal_title:Journal of the American Academy of Dermatology
pub_type: 临床试验,杂志文章
doi:10.1016/s0190-9622(87)70195-9
更新日期:1987-08-01 00:00:00
abstract::Acitretin, a metabolite of etretinate, was given to 38 patients for the treatment of psoriasis. During the first 8 weeks patients received either placebo, 10 mg, 25 mg, 50 mg, or 75 mg of acitretin daily in a double-blind manner. The dosages of 10 mg and 25 mg daily did not achieve any statistically significant improv...
journal_title:Journal of the American Academy of Dermatology
pub_type: 临床试验,杂志文章
doi:10.1016/s0190-9622(88)70086-9
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:Tinea corporis gladiatorum has been an infrequently reported condition in the dermatological literature. Two previous reports have investigated wrestlers during recognized epidemics of tinea corporis gladiatorum, but no study has examined wrestlers to determine the point prevalence of tinea corporis gladiato...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1067/mjd.2000.109284
更新日期:2000-12-01 00:00:00
abstract::The use of fingerprints for personal identification became widespread early in this century. How the fingerprints slowly became standardized involves many persons, including Nathaniel Grew, Johannes Purkinje, William Herschel, Henry Faulds, Charles Darwin, Francis Galton, Mark Twain, Juan Vucetich, Edward Henry, and J...
journal_title:Journal of the American Academy of Dermatology
pub_type: 传,历史文章,杂志文章
doi:10.1016/0190-9622(90)70194-m
更新日期:1990-07-01 00:00:00
abstract::Thyroid autoimmunity has been increasingly reported to be associated with chronic urticaria and angioedema. The administration of thyroid hormone may alleviate chronic urticaria and/or angioedema in selected patients. This review focuses on the association of thyroid autoimmunity with chronic urticaria and/or angioede...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/s0190-9622(99)70193-3
更新日期:1999-02-01 00:00:00
abstract::Apoptosis, a genetically encoded program that results in cell death, represents a fundamental biologic concept that has relevance to a wide range of dermatologic processes. This review discusses the basic biology of apoptosis and its relevance to cutaneous disease. ...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/s0190-9622(97)80266-6
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND:The administration of a local anesthetic is often painful. OBJECTIVE:The purpose of this study was to determine whether rapidly shaking and pinching the skin during local anesthetic administration decreases pain perception. METHODS:The skin at the intended site of lidocaine injection was rapidly pinched be...
journal_title:Journal of the American Academy of Dermatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0190-9622(98)70404-9
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Genetic and environmental risk factors have been associated with the development of multiple primary melanomas (MPM). We hypothesized that individuals with MPM may have increased predisposition to developing internal malignancies. OBJECTIVE:To identify the risk of subsequent malignancies in MPM patients. M...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章
doi:10.1016/j.jaad.2018.09.027
更新日期:2018-10-01 00:00:00
abstract::Sound surgical technique is necessary to achieve excellent surgical outcomes. Despite the fact that dermatologists perform more office-based cutaneous surgery than any other specialty, few dermatologists have opportunities for practical instruction to improve surgical technique after residency and fellowship. This 2-p...
journal_title:Journal of the American Academy of Dermatology
pub_type: 杂志文章,评审
doi:10.1016/j.jaad.2014.08.006
更新日期:2015-03-01 00:00:00