Remission of refractory pyoderma gangrenosum, severe acne, and hidradenitis suppurativa (PASH) syndrome using targeted antibiotic therapy in 4 patients.

Abstract:

:Pyoderma gangrenosum, severe acne, and suppurative hidradenitis (PASH) syndrome can prove refractory to treatment and is characterized by relapses and recurrences. The combination of antibiotic therapy and surgery can produce success in the management of the syndrome. Acute treatment is required, but maintenance therapy is also necessary to prevent disease relapse. The response to antibiotic therapy is hypothesis generating, raising the issue of a modified host response. To date, anecdotal reports support the use of surgery and medical therapy, but controlled investigations with extended follow-up are necessary to substantiate preliminary data observed with individual cases.

journal_name

J Am Acad Dermatol

authors

Join-Lambert O,Duchatelet S,Delage M,Miskinyte S,Coignard H,Lemarchand N,Alemy-Carreau M,Lortholary O,Nassif X,Hovnanian A,Nassif A

doi

10.1016/j.jaad.2015.07.040

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

S66-9

issue

5 Suppl 1

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(15)01988-X

journal_volume

73

pub_type

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