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The specificity and sensitivity of Nikolskiy sign in the diagnosis of pemphigus.

Abstract：

BACKGROUND:The Nikolskiy sign is a well-known mechanical symptom that can be helpful in the diagnosis of pemphigus. The reports about associations with other than pemphigus cause confusion concerning the diagnostic importance of the Nikolskiy sign in pemphigus. OBJECTIVE:Our purpose was to examine the significance and usefulness of the Nikolskiy sign on the clinical diagnosis of pemphigus by determination of its sensitivity and specificity. METHODS:Presence of the Nikolskiy sign with the modifications of "direct" and "marginal" on 123 consecutive patients with various cutaneous diseases presenting as intact blisters and/or erosions was sought. RESULTS:A positive Nikolskiy sign was demonstrated in 24 (19.5%) of the 123 patients. Of the positive 24 patients, 18 had pemphigus, 4 had bullous pemphigoid, 1 had linear IgA dermatosis, and 1 had staphylococcal scalded skin syndrome. The sensitivity of "direct" Nikolskiy sign (38%) was less than that of the "marginal" form (69%), but the specificity of "direct" Nikolskiy sign (100%) was higher than that of the "marginal" form (94%) in the diagnosis of pemphigus. LIMITATIONS:This study was primarily concerned with the diagnostic importance of the Nikolskiy sign in pemphigus. We did not focus on its prognostic value in pemphigus. The small size of the group of patients with pemphigus, which is related to low annual incidence of pemphigus in our region, is another limitation of this study. CONCLUSIONS:The Nikolskiy sign offers a moderately sensitive but highly specific tool for the diagnosis of pemphigus.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Uzun S,Durdu M

doi

10.1016/j.jaad.2005.10.019

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

411-5

issue

3

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(05)03252-4

journal_volume

54

pub_type

杂志文章

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