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Role of immunohistochemistry in the diagnosis of undifferentiated tumors involving the skin.

Abstract：

:Twenty undifferentiated skin tumors were examined by immunostaining in an attempt to achieve more precise identification. Light microscopy yielded only a differential diagnosis, whereas immunostaining of formalin-fixed, paraffin-embedded tissue sections with a panel of antibodies to intermediate filaments and other cell components led to a definitive diagnosis. Four cytokeratin-positive epithelial tumors were subtyped into squamous cell carcinomas and adenocarcinomas with the use of antibodies to different cytokeratin polypeptides. Fifteen vimentin-positive tumors were subdivided into malignant melanomas with the use of antibody to S-100 protein, lymphomas with the use of antibody to immunoglobulin, and mesenchymal tumors (angiosarcomas, atypical fibroxanthomas, dermatofibrosarcoma protuberans, and meningiomas) with the use of antibody to S-100 protein, factor VIII, and lysozyme. One desmin-positive tumor was diagnosed as a leiomyosarcoma of the skin. A scheme is presented for using immunohistochemistry to facilitate the diagnosis of undifferentiated tumors involving the skin.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Kahn H,Baumal R,From L

doi

10.1016/s0190-9622(86)70133-3

subject

Has Abstract

pub_date

1986-06-01 00:00:00

pages

1063-72

issue

6

eissn

0190-9622

issn

1097-6787

pii

S0190-9622(86)70133-3

journal_volume

14

pub_type

杂志文章

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