当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY期刊下所有文献 > Photochemotherapy for severe psoriasis without or in combination with acitretin: a randomized, double-blind comparison study.

Photochemotherapy for severe psoriasis without or in combination with acitretin: a randomized, double-blind comparison study.

Abstract：

:In a randomized, double-blind comparative study 60 patients with severe, widespread psoriasis were treated either with photochemotherapy (PUVA) alone or in combination with acitretin. Forty-eight patients completed the study; of these, 25 received placebo combined with PUVA and 23 received acitretin with PUVA. Marked or complete clearing of psoriasis occurred in 80% of the patients (20 of 25) without acitretin and in 96% of the patients (22 of 23) with adjunctive acitretin administration. The mean cumulative UVA dose given to patients in the acitretin-PUVA group was 42% less than that required for patients in the placebo-PUVA group. We conclude that acitretin substantially augments the efficacy of photochemotherapy in the treatment of severe psoriasis.

journal_name

J Am Acad Dermatol

journal_title

Journal of the American Academy of Dermatology

authors

Tanew A,Guggenbichler A,Hönigsmann H,Geiger JM,Fritsch P

doi

10.1016/0190-9622(91)70253-x

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

682-4

issue

4

eissn

0190-9622

issn

1097-6787

pii

0190-9622(91)70253-X

journal_volume

25

pub_type

临床试验,杂志文章,随机对照试验

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