Abstract:
BACKGROUND:Depression is a highly prevalent disease with a high morbidity and mortality risk. Its pathophysiology is not entirely clear. However, type 2 diabetes is an important risk factor for depression. One mechanism that may explain this association may include the formation of advanced glycation end products (AGEs). We therefore investigated the association of AGEs with depressive symptoms and depressive disorder. In addition, we examined whether the potential association was present for somatic and/or cognitive symptoms of depression. METHODS:Cross-sectional data were used from the Maastricht Study (N = 862, mean age 59.8 ± 8.5 years, 55% men). AGE accumulation was measured with skin autofluorescence (SAF) by use of the AGE Reader. Plasma levels of protein-bound pentosidine were measured with high-performance liquid chromatography and fluorescence detection. Nε-(carboxymethyl)lysine (CML) and Nε-(carboxyethyl)lysine (CEL) were measured with ultraperformance liquid chromatography and tandem mass spectrometry. Depressive symptoms and depressive disorder were assessed by the nine-item Patient Health Questionnaire and the Mini-International Neuropsychiatric Interview. RESULTS:Higher SAF was associated with depressive symptoms (β = 0.42, 95% CI 0.12-0.73, P = .007) and depressive disorder (OR = 1.42, 95% CI 1.04-1.95, P = .028) after adjustment for age, sex, type 2 diabetes, smoking, BMI, and kidney function. Plasma pentosidine, CML, and CEL were not independently associated with depressive symptoms and depressive disorder. CONCLUSIONS:This study shows that AGE accumulation in the skin is independently associated with higher levels of depressive symptoms and depressive disorder. This association is present for both somatic and cognitive symptoms of depression. This might suggest that AGEs are involved in the development of depression.
journal_name
Depress Anxietyjournal_title
Depression and anxietyauthors
van Dooren FE,Pouwer F,Schalkwijk CG,Sep SJ,Stehouwer CD,Henry RM,Dagnelie PC,Schaper NC,van der Kallen CJ,Koster A,Denollet J,Verhey FR,Schram MTdoi
10.1002/da.22527subject
Has Abstractpub_date
2017-01-01 00:00:00pages
59-67issue
1eissn
1091-4269issn
1520-6394journal_volume
34pub_type
杂志文章abstract::This study seeks to determine how panic disorder patients with anxiety and depression comorbidity differ from panic disorder patients without comorbidity at the time of presentation for treatment. One-hundred seventy-one panic disorder patients presenting for their initial assessment and treatment at the Payne Whitney...
journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/(sici)1520-6394(1997)5:2<97::aid-da6>3.0.c
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journal_title:Depression and anxiety
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abstract:BACKGROUND:Panic disorder (PD) is highly comorbid with major depressive disorder (MDD) with potential impact on patient-reported outcomes of quality of life (QOL), functioning, and depressive symptom severity. METHODS:Using data from the sequenced treatment alternatives to relieve depression (STAR*D) trial, we compare...
journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20169
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journal_title:Depression and anxiety
pub_type: 杂志文章
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22672
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journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
doi:10.1002/da.20090
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journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章,多中心研究
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abstract::We assessed psychophysiological responses to imagery of traumatic events, panic attacks, and loss of vigilance (i.e., being hypnotized) in participants diagnosed with panic disorder. Participants were either currently experiencing nocturnal panic or daytime panics only. It was hypothesized that nocturnal panickers wou...
journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.10091
更新日期:2003-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章,随机对照试验
doi:10.1002/da.22331
更新日期:2015-03-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 临床试验,杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22342
更新日期:2015-05-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22990
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20649
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journal_title:Depression and anxiety
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.22145
更新日期:2014-07-01 00:00:00
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20618
更新日期:2009-01-01 00:00:00
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journal_title:Depression and anxiety
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journal_title:Depression and anxiety
pub_type: 杂志文章
doi:10.1002/da.20168
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journal_title:Depression and anxiety
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doi:10.1002/(sici)1520-6394(1998)8:2<65::aid-da4>3.0.c
更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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