Abstract:
:Kinetics of optical tweezers (OT)-induced spontaneous aggregation and disaggregation of red blood cells (RBCs) were studied at the level of cell doublets to assess RBC interaction mechanics. Measurements were performed under in vitro conditions in plasma and fibrinogen and fibrinogen + albumin solutions. The RBC spontaneous aggregation kinetics was found to exhibit different behavior depending on the cell environment. In contrast, the RBC disaggregation kinetics was similar in all solutions qualitatively and quantitatively, demonstrating a significant contribution of the studied proteins to the process. The impact of the study on assessing RBC interaction mechanics and the protein contribution to the reversible RBC aggregation process is discussed.
journal_name
J Biomed Optjournal_title
Journal of biomedical opticsauthors
Lee K,Kinnunen M,Khokhlova MD,Lyubin EV,Priezzhev AV,Meglinski I,Fedyanin AAdoi
10.1117/1.JBO.21.3.035001subject
Has Abstractpub_date
2016-03-01 00:00:00pages
35001issue
3eissn
1083-3668issn
1560-2281pii
2502359journal_volume
21pub_type
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