Antihypertensive and humoral effects of nifedipine in essential hypertension uncontrolled by hydrochlorothiazide alone.

abstract：BACKGROUND:The angiotensin II type 1 receptor A1166C polymorphism has been associated with increased risks of hypertension and myocardial infarction in several small studies. We examined the association between this polymorphism and new-onset hypertension, blood pressure (BP) control, and incident cardiovascular events...

journal_title：American journal of hypertension

authors： Hindorff LA,Heckbert SR,Tracy R,Tang Z,Psaty BM,Edwards KL,Siscovick DS,Kronmal RA,Nazar-Stewart V

更新日期：2002-12-01 00:00:00

abstract：:The hypertensive transgenic rat model TGR(mRen2)27 has been used to investigate the development of cardiac and vascular hypertrophy in response to two different drug regimes. Cardiac hypertrophy was shown to be related to age and gender with the copy number of mouse renin transgenes having an additive effect. A simila...

journal_title：American journal of hypertension

authors： Brosnan MJ,Devlin AM,Clark JS,Mullins JJ,Dominiczak AF

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Insulin inhibits contraction and migration of primary confluent, cultured canine vascular smooth muscle cells (VSMCs) with inducible nitric oxide synthase (iNOS) by stimulating cyclic GMP (cGMP) production. The present study was performed to determine how insulin stimulates guanylate cyclase activity in thes...

journal_title：American journal of hypertension

authors： Kahn AM,Allen JC,Zhang S

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:The expression of Na(+)-K(+)-2Cl(-) cotransporter 1 (NKCC1) is upregulated in spontaneously hypertensive rat (SHR). We investigated whether expression of NKCC1 is epigenetically regulated during postnatal development of hypertension. METHODS:The mesenteric arteries from 5-, 10-, and 18-week-old Wistar-Kyoto...

journal_title：American journal of hypertension

authors： Cho HM,Lee HA,Kim HY,Han HS,Kim IK

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:This study analyzed whether hypertension induced by N(omega)-nitro-l-arginine methyl ester (L-NAME) is associated with dysregulation of the main antioxidant enzymes (superoxide dismutase [SOD], catalase, glutathione peroxidase [GPX], and glutathione reductase [GR]) and whether chronic administration of tempo...

journal_title：American journal of hypertension

authors： Sainz J,Wangensteen R,Rodríguez Gómez I,Moreno JM,Chamorro V,Osuna A,Bueno P,Vargas F

更新日期：2005-06-01 00:00:00

abstract：:The relations between left ventricular mass (LVM), peripheral resistance artery structure, and ambulatory BP were studied in 83 patients with previously untreated or poorly regulated essential hypertension and 20 healthy controls of similar age and sex. LVM was assessed by echocardiography. Signs of left ventricular h...

journal_title：American journal of hypertension

authors： Sihm I,Schroeder AP,Aalkjaer C,Holm M,Mørn B,Mulvany M,Thygesen K,Lederballe O

更新日期：1995-10-01 00:00:00

abstract：:Endothelin-1 is a potent vasoconstrictor peptide produced in blood vessels and other tissues that may play an important role in the control of local blood flow and could be involved in the pathogenesis of hypertension. Our previous studies have documented increases in endothelin-1 peptide content and gene expression i...

journal_title：American journal of hypertension

authors： Day R,Larivière R,Schiffrin EL

更新日期：1995-03-01 00:00:00

abstract：:Because left ventricular hypertrophy (LVH) is a strong risk factor for cardiac morbidity and mortality considerable interest has been generated concerning the possible effects of modifying LVH in hypertensive patients. In animal models disproportionate regression of left ventricular (LV) mass in relation to blood pres...

journal_title：American journal of hypertension

authors： Liebson PR

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Myocardial infarction (MI) is commonly associated with cardiac hypertrophy, reduced Ca²(+) uptake into the sarcoplasmic reticulum (SR) and impaired myocardial relaxation. Treatment to prevent MI-associated complications is currently lacking. The purpose of the present study was to investigate the remodeling ...

journal_title：American journal of hypertension

authors： Costa DG,da Silva JS,Kümmerle AE,Sudo RT,Landgraf SS,Caruso-Neves C,Fraga CA,de Lacerda Barreiro EJ,Zapata-Sudo G

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:The brain is perfused at high-volume flow throughout systole and diastole. We explored the association of blood flow in the middle cerebral artery (MCA) with the pulsatile components of blood pressure in the systemic circulation and indices of arterial stiffness. METHODS:We enrolled 334 untreated subjects (...

journal_title：American journal of hypertension

authors： Xu TY,Staessen JA,Wei FF,Xu J,Li FH,Fan WX,Gao PJ,Wang JG,Li Y

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:Structural atherosclerotic damage, arterial stiffness, pulse pressure (PP), and renal hemodynamics may interact and influence each other. Renal resistance index (RRI) appears as a good indicator of systemic vascular changes. The aim of our study was to assess the independent relationships of carotid intima-m...

journal_title：American journal of hypertension

authors： Geraci G,Mulè G,Costanza G,Mogavero M,Geraci C,Cottone S

更新日期：2016-04-01 00:00:00

abstract：:To evaluate the possible physiologic role of atrial natriuretic factor (ANF) in the observed dissociation of aldosterone secretion from the renin-angiotensin system during hypoxic exercise, 12 untrained men, ages 18 to 24, were studied on two separate days for 30 min during hypoxic (16% O2) and normoxic (room air) exe...

journal_title：American journal of hypertension

authors： Lawrence DL,Shenker Y

更新日期：1991-04-01 00:00:00

abstract：:Hypertension is a common finding among obstructive sleep apnea (OSA) patients, and is thought to be caused by sympathetic hyperactivity. The present study compares the contributions of the respiratory disturbance index (RDI) as a reflection of sleep fragmentation, and the magnitude of oxygen desaturation, to sympathet...

journal_title：American journal of hypertension

authors： Peled N,Greenberg A,Pillar G,Zinder O,Levi N,Lavie P

更新日期：1998-11-01 00:00:00

abstract：:Increased adrenergic activity has been suggested to mediate the hypertension associated with hyperinsulinemia. This study tested whether combined alpha1- and beta-adrenergic receptor blockade would prevent insulin-induced hypertension when euglycemia was maintained by continuous intravenous glucose infusion. Sprague-D...

journal_title：American journal of hypertension

authors： Keen HL,Brands MW,Alonso-Galicia M,Hall JE

更新日期：1996-12-01 00:00:00

abstract：:Despite intense investigation and clinical attention, many challenges remain in the management of the hypertensive patient. It is clear that hypertension remains inadequately controlled worldwide, with the control rate in the United States approximating 27%. Furthermore, several recent studies have underscored that it...

journal_title：American journal of hypertension

authors： Epstein M

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Research on associations between blood pressure, brain structure, and cognitive function has produced somewhat inconsistent results. In part, this may be due to differences in age ranges studied and because of sex differences in physiology and/or exposure to risk factors, which may lead to different time cou...

journal_title：American journal of hypertension

authors： Cherbuin N,Mortby ME,Janke AL,Sachdev PS,Abhayaratna WP,Anstey KJ

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Ascending aortic fractional pulse pressure and fractional systolic pressure (FSP) were demonstrated to differentiate patients with and without coronary artery disease. However, no study so far has analyzed the relationship between FSP and fractional diastolic pressure (FDP) and the extent of coronary artery ...

journal_title：American journal of hypertension

authors： Jankowski P,Kawecka-Jaszcz K,Bryniarski L,Czarnecka D,Brzozowska-Kiszka M,Pośnik-Urbańska A,Kopeć G,Dragan J,Klecha A,Dudek D

更新日期：2004-08-01 00:00:00

abstract：:Reversible posterior leukoencephalopathy syndrome (RPLS) is an uncommon entity related to multiple and different pathologies, the most common being hypertensive crisis. It is believed to be secondary to the breakdown on the blood-brain barrier. At the beginning, it is undistinguishable from other leukoencephalopathies...

journal_title：American journal of hypertension

authors： Giner V,Fernández C,Esteban MJ,Galindo MJ,Forner MJ,Guix J,Redón J

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Erectile dysfunction (ED) is common among men taking antihypertensive drugs to control blood pressure. We evaluated the safety and efficacy of sildenafil citrate for treating ED in men taking multiple antihypertensive medications in a randomized, double-blind, placebo-controlled trial. METHODS:A total of 56...

journal_title：American journal of hypertension

authors： Pickering TG,Shepherd AM,Puddey I,Glasser DB,Orazem J,Sherman N,Mancia G

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Endothelial dysfunction and arterial stiffening are commonly observed in type 2 diabetes. These abnormalities might be secondary to increased plasma concentrations of homocysteine. We sought to determine whether oral folic acid supplementation, by lowering homocysteine levels, enhanced endothelial function a...

journal_title：American journal of hypertension

authors： Mangoni AA,Sherwood RA,Asonganyi B,Swift CG,Thomas S,Jackson SH

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:There is evidence from genome wide association study that single-nucleotide polymorphisms (SNPs) in the 5' end of the uromodulin gene (UMOD) affect uromodulin excretion and blood pressure (BP). Uromodulin is almost exclusively expressed in the thick ascending limb of the loop of Henle (TAL) and its effect on...

journal_title：American journal of hypertension

authors： McCallum L,Brooksbank K,McConnachie A,Aman A,Lip S,Dawson J,MacIntyre IM,MacDonald TM,Webb DJ,Padmanabhan S

更新日期：2020-10-21 00:00:00

abstract：:The purpose of this study was to determine whether there are gender differences in plasma insulin levels or insulin resistance in young adult African-Americans. Male (n = 53) and female (n = 45) subjects (age 23 to 28 years) included normotensives (N, blood pressure [BP] < 135/85 mm Hg) and borderline hypertensives (B...

journal_title：American journal of hypertension

authors： Falkner B,Hulman S,Kushner H

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) predicts cardiovascular outcome. Oxidative stress is considered to be involved in endothelial alteration. We hypothesized that in essential hypertension (EH), oxidative stress, as measured by 8-iso-prostaglandin-F(2alpha) (8-iso-PGF(2alpha)), should be associated with increased CRP a...

journal_title：American journal of hypertension

authors： Cottone S,Mulè G,Nardi E,Vadalà A,Guarneri M,Briolotta C,Arsena R,Palermo A,Riccobene R,Cerasola G

更新日期：2006-03-01 00:00:00

abstract：:To examine the effects of hypertension on renal graft function, we studied the clinical course of 144 kidney transplant recipients who had functioning grafts for three to 13 years. The patients were divided into three groups: normotensive (n = 32), controlled hypertensive (n = 49) and uncontrolled hypertensive group (...

journal_title：American journal of hypertension

authors： Cheigh JS,Haschemeyer RH,Wang JC,Riggio RR,Tapia L,Stenzel KH,Rubin AL

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) are risk factors for coronary artery disease (CAD) and ischemic stroke. However, the hazards of their coexistence are not fully understood in Asian populations. We investigated whether the relationship between BP and cardiovascular disease (...

journal_title：American journal of hypertension

authors： Tsukinoki R,Okamura T,Watanabe M,Kokubo Y,Higashiyama A,Nishimura K,Takegami M,Murakami Y,Okayama A,Miyamoto Y

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Complement factor H (CFH) is a plasma protein that is essential in the regulation of the alternative complement pathway and has been implicated as taking part in complement inhibition in atherogenesis. We evaluated the association of the Y402H polymorphism with incident coronary heart disease (CHD), incident...

journal_title：American journal of hypertension

authors： Volcik KA,Ballantyne CM,Braun MC,Coresh J,Mosley TH,Boerwinkle E

更新日期：2008-05-01 00:00:00

abstract：:The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is a new genetic model of non-insulin-dependent diabetes mellitus (NIDDM). We investigated whether treatment with an angiotensin II (ANGII) subtype-1 receptor antagonist delays the onset of NIDDM and attenuates diabetic nephropathy in the OLETF rat. OLETF rats fed a re...

journal_title：American journal of hypertension

authors： Uehara Y,Hirawa N,Kawabata Y,Numabe A,Gomi T,Ikeda T,Omata M

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Most patients with hypertension require more than one agent to control blood pressure (BP). The purpose of this study was to assess the efficacy and safety of the angiotensin II receptor blocker olmesartan medoxomil in combination with hydrochlorothiazide (HCTZ). METHODS:This was a randomized, double-blind,...

journal_title：American journal of hypertension

authors： Chrysant SG,Weber MA,Wang AC,Hinman DJ

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:We compare patterns of blood pressure (BP) and prevalence of hypertension between white-Dutch and their South-Asian and African minority groups with their corresponding white-English and their South-Asian and African ethnic minority groups; and the contribution of physical activity, body sizes, and socioecon...

journal_title：American journal of hypertension

authors： Agyemang C,Kunst A,Bhopal R,Zaninotto P,Unwin N,Nazroo J,Nicolaou M,Redekop WK,Stronks K

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Carvedilol is known to be an adrenoreceptor blocker and free radical scavenger, used in hypertension and cardiac failure. However, its therapeutic actions cannot be fully explained by these mechanisms. In these studies, we tested the hypothesis that carvedilol action is associated with the synthesis/release ...

journal_title：American journal of hypertension

authors： Afonso RA,Patarrao RS,Macedo MP,Carmo MM

更新日期：2006-04-01 00:00:00