Abstract：
BACKGROUND:Most patients with hypertension require more than one agent to control blood pressure (BP). The purpose of this study was to assess the efficacy and safety of the angiotensin II receptor blocker olmesartan medoxomil in combination with hydrochlorothiazide (HCTZ). METHODS:This was a randomized, double-blind, factorial design study. After a placebo run-in period, eligible patients (n = 502) with a baseline mean seated diastolic blood pressure (SeDBP) of 100 to 115 mm Hg were randomized to one of 12 groups: placebo, olmesartan medoxomil monotherapy (10, 20, or 40 mg/day, HCTZ monotherapy (12.5 or 25 mg/day), or one of six groups of olmesartan medoxomil/HCTZ combination therapy. The primary endpoint was the change in mean trough SeDBP from baseline at week 8. Statistical analyses were conducted to determine whether at least one combination produced a larger reduction in SeDBP at week 8 than the individual corresponding component doses, but did not compare BP reductions with different combination doses. RESULTS:Olmesartan medoxomil plus HCTZ produced greater reductions in both SeDBP and seated systolic blood pressure (SeSBP) at week 8 than did monotherapy with either component. All olmesartan medoxomil/HCTZ combinations significantly reduced SeDBP and SeSBP compared with placebo in a dose-dependent manner. Reductions from baseline in mean trough SeSBP/SeDBP were 3.3/8.2 mm Hg, 20.1/16.4 mm Hg, and 26.8/21.9 mm Hg with placebo, olmesartan medoxomil/HCTZ 20/12.5 mg, and olmesartan medoxomil/HCTZ 40/25 mg, respectively. All treatments were well tolerated. CONCLUSIONS:Olmesartan medoxomil/HCTZ combination therapy produced BP reductions of up to 26.8/21.9 mm Hg and was well tolerated.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Chrysant SG,Weber MA,Wang AC,Hinman DJdoi
10.1016/j.amjhyper.2003.11.003subject
Has Abstractpub_date
2004-03-01 00:00:00pages
252-9issue
3eissn
0895-7061issn
1941-7225pii
S089570610301210Xjournal_volume
17pub_type
临床试验,杂志文章,随机对照试验abstract：BACKGROUND:Guidelines recommend that patients with newly elevated office blood pressure undergo ambulatory blood pressure monitoring (ABPM) or home blood pressure monitoring (HBPM) to rule-out white coat hypertension before being diagnosed with hypertension. We explored patients' perspectives of the barriers and facili...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpy062
更新日期：2018-07-16 00:00:00
abstract：BACKGROUND:Strong associations between blood pressure (BP) and overweight raise the question whether overweight children (body mass index (BMI) ≥85th percentile) should be included in the normative database. METHODS:Using the LMS (Lamda-Mu-Sigma) method, we developed age-, gender-, and height-adjusted percentile curve...
journal_title：American journal of hypertension
pub_type： 杂志文章,多中心研究
doi：10.1093/ajh/hpu208
更新日期：2015-05-01 00:00:00
abstract：:Longitudinal studies in children have tracked blood pressure through childhood and from childhood into adult life. However, many children do not maintain their rank during these periods of observation. Several of the factors contributing to maintenance of rank order are reviewed, such as initial level of blood pressur...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1093/ajh/4.11s.608s
更新日期：1991-11-01 00:00:00
abstract：BACKGROUND:The prognostic value of left ventricular (LV) concentric remodeling in essential hypertension, and particularly in uncomplicated mild hypertension, is not yet completely clear. We investigated cardiovascular outcome in uncomplicated mild hypertensive patients with normal LV geometry and LV concentric remodel...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2004.06.016
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:Pulse pressure, a measure of central arterial stiffness and a predictor of cardiovascular mortality, has known genetic components. METHODS:To localize the genetic effects of pulse pressure, we conducted a genome-wide linkage analysis of 1,892 American-Indian participants of the Strong Heart Family Study (SH...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2007.34
更新日期：2008-02-01 00:00:00
abstract：:The effects of activators and inhibitors of protein kinase C (PKC) on the production of C-type natriuretic peptide (CNP) by cultured human aortic endothelial cells were examined. The PKC activators phorbol 12-myristate 13-acetate (PMA) and 1-oleoyl 2-acetyl glycerol (OAG) stimulated CNP release; the maximal effects we...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(96)00107-0
更新日期：1996-09-01 00:00:00
abstract：:Galanin is a 29-amino acid peptide and widely distributed in the brain, although its significance in the control of neural activities is undefined. In the present study, we describe the effects of galanin on the electrically evoked release of dopamine in the rat central nervous system. In addition, to elucidate a poss...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(98)00168-x
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:Left ventricular (LV) hypertrophy and impaired diastolic function may occur early in systemic hypertension, but longitudinal studies are missing. METHODS:We performed an echocardiographic follow-up study in young initially normotensive male offspring of hypertensive (OHyp) (n = 25) and normotensive (ONorm) ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(00)01245-0
更新日期：2001-02-01 00:00:00
abstract：BACKGROUND:Few previous studies have reported the association of aortic stiffness with marine n-3 fatty acids (Fas) in the general population. The aim of this study was to determine the combined and independent associations of 2 major marine n-3 FAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with aort...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpt107
更新日期：2013-11-01 00:00:00
abstract：:The role of renal sympathetic nerve activity (RSNA) in the maintenance phase of essential hypertension has not yet been clearly defined. Renal function and mean arterial pressure (MAP) were studied in four Yucatan miniature swine (YMS) with established DOCA hypertension prior to and for 3 weeks after surgical renal de...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/3.1.62
更新日期：1990-01-01 00:00:00
abstract：:The changes induced by transient hypertension on cardiac structure and function are unclear. Pregnancy-induced hypertension offers a natural and spontaneous model of this condition. To assess the potential of echocardiographic Doppler to unmask left ventricular function impairment, we studied 28 women aged 26.4 +/- 7....
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(00)01264-4
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:While obesity is a leading risk factor for preeclampsia, the mechanisms whereby obese women are more susceptible to pregnancy-induced hypertension are unclear. As high-fat diet (HFD) is an important contributor to the development of obesity, we tested the hypothesis that pregnant rats on HFD have hypertensio...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpw153
更新日期：2017-03-01 00:00:00
abstract：:In this review we have analyzed the present knowledge about the differentiation and growth processes in vascular smooth muscle cells (SMC) in hypertension. The study of smooth muscle (SM) and nonmuscle (NM) myosin isoform expression has permitted us to identify a three-stage specific maturational pathway, namely, feta...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1093/ajh/7.7.661
更新日期：1994-07-01 00:00:00
abstract：:Preeclampsia is a pregnancy-induced hypertensive disorder characterized by proteinuria and widespread maternal endothelial dysfunction. It remains one of the most common disorders in pregnancy and remains one of the leading causes of maternal and fetal morbidity. Recent research has revealed that placental insufficien...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1038/ajh.2011.99
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:The direct renin inhibitor aliskiren is known to exhibit a strong antihypertensive effect. However, the organoprotective potential of aliskiren beyond its antihypertensive properties is less clear. This study investigates the antifibrotic nephroprotective effects of aliskiren in a nonhypertensive mouse model...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2010.231
更新日期：2011-03-01 00:00:00
abstract：:The objective of this study was to evaluate whether the major histocompatibility complex of the rat can be related to blood pressure (BP) level and BP response to stress. Blood pressure was determined under light ether anesthesia or during moderate restraint stress in normotensive Lewis rats, in rat strains congenic w...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/0895-7061(96)00023-4
更新日期：1996-07-01 00:00:00
abstract：BACKGROUND:It is unclear whether serum uric acid (SUA) is associated with development of new-onset diabetes (NOD) in patients with hypertension and left ventricular hypertrophy (LVH). The aim of the present investigation was to test the hypothesis that SUA predicts development of NOD in these patients. METHODS:In the ...
journal_title：American journal of hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1038/ajh.2010.89
更新日期：2010-08-01 00:00:00
abstract：:Alteration of calcium metabolism and changes in the levels of calcium-regulating hormones have been described in essential hypertension. In the majority of the reported clinical trials, calcium supplementation has resulted in a decrease in blood pressure. However, the mechanisms by which such a response would be media...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1093/ajh/6.12.996
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Insulin resistance (IR) and the metabolic syndrome (MetS) may contribute to cardiovascular risk in chronic kidney disease (CKD). We examine the association between IR and vascular function in CKD. Furthermore, we define the prevalence of MetS and examine the association between defining MetS and vascular fun...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpt077
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:The expression of Na(+)-K(+)-2Cl(-) cotransporter 1 (NKCC1) is upregulated in spontaneously hypertensive rat (SHR). We investigated whether expression of NKCC1 is epigenetically regulated during postnatal development of hypertension. METHODS:The mesenteric arteries from 5-, 10-, and 18-week-old Wistar-Kyoto...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2011.136
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:There is growing evidence that residential environment is associated with hypertension. Recently, interest has also turned toward examining the possible influence of remoteness on hypertension. The aim of this study is to explore the effect of remoteness, the shortest path between the subject location and th...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2012.36
更新日期：2012-07-01 00:00:00
abstract：BACKGROUND:Clonidine, a centrally acting antihypertensive agent, has been used successfully in pregnancy. We sought to describe the pharmacodynamic effects of clonidine in pregnancy and the associated impact on fetal growth. METHODS:A retrospective cohort study was performed. Maternal hemodynamics were measured before...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2010.159
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:Salt sensitivity of blood pressure (SSBP) increases the risk of cardiovascular complications, and the heritability of SSBP is about 50% in Chinese population. However, studies identifying genes involved in BP responses to acute sodium loading and diuresis shrinkage are still limited. METHOD:A total of 342 e...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpx179
更新日期：2018-03-10 00:00:00
abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors have been widely used in the treatment of hypertension, but the comparative effectiveness in reducing mortality among different drugs is seldom reported. METHODS:We identified hypertensive patients who started captopril, enalapril, lisinopril, fosinopril, perin...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpu237
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Obstructive sleep apnea (OSA) induces inflammation and vascular damage that might contribute to an increased risk of cardiovascular disease (CVD). However, the mechanisms linking OSA and CVD are not fully understood. Pentraxin3 may play a significant role in vascular inflammation and damage. Currently, there...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2010.248
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:In uremic animals, vitamin D receptor (VDR) agonists like paricalcitol (Pc) attenuate cardiac hypertrophy, but this effect has not been replicated consistently in humans with chronic kidney disease. Elevated fibroblast growth factor 23 (FGF23) levels cause cardiac hypertrophy with activation of the myocardia...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpy154
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:We tested the hypothesis that repetitive severe hypoxemia resulting from obstructive sleep apnea would increase serum erythropoietin, and that this increase would be attenuated by effective treatment of obstructive sleep apnea. METHODS:We studied healthy untreated patients with obstructive sleep apnea (18 se...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2004.04.011
更新日期：2004-09-01 00:00:00
abstract：:The purpose of the present study was to determine whether the physiological dopamine prodrug, L-dopa, could suppress streptozotocin-induced diabetic glomerular hyperfiltration, and thus prevent further evolution of the diabetic nephropathy. Male Wistar rats treated with streptozotocin (60 mg/kg, intravenously) rapidly...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/3.6.72s
更新日期：1990-06-01 00:00:00
abstract：:Cicletanine sulfate was tested on bicarbonate-dependent pHi changes in cultured vascular smooth muscle (A10 line). Cicletanine sulfate exhibited double reactivity with regard to the cell alkalinization induced by bicarbonate uptake. The analysis of 11 concentration-response curves revealed a high reactivity component ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/6.8.674
更新日期：1993-08-01 00:00:00
abstract：:Increased insulinemic response to an oral glucose load has been demonstrated in Dahl salt-sensitive hypertensive rats. To determine whether this abnormality is mediated at the level of the insulin receptor, we compared insulin receptor binding and mRNA levels in tissues of Dahl salt-sensitive rats (DS) and in their no...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(97)00220-3
更新日期：1997-11-01 00:00:00
