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Association of total marine fatty acids, eicosapentaenoic and docosahexaenoic acids, with aortic stiffness in Koreans, whites, and Japanese Americans.

Abstract：

BACKGROUND:Few previous studies have reported the association of aortic stiffness with marine n-3 fatty acids (Fas) in the general population. The aim of this study was to determine the combined and independent associations of 2 major marine n-3 FAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with aortic stiffness evaluated using carotid-femoral pulse wave velocity (cfPWV) in Korean, white, and Japanese American men. METHODS:A population-based sample of 851 middle-aged men (299 Koreans, 266 whites, and 286 Japanese Americans) was examined for cfPWV during 2002-2006. Serum FAs, including EPA and DHA, were measured as a percentage of total FAs using gas chromatography. Multiple regression analysis was used to examine the association of EPA and DHA with cfPWV after adjusting for blood pressure and other confounders. RESULTS:Mean EPA and DHA levels were 1.9 (SD = 1.0) and 4.8 (SD = 1.4) for Koreans, 0.8 (SD = 0.6) and 2.4 (SD = 1.2) for whites, and 1.0 (SD = 1.0) and 3.2 (SD = 1.4) for Japanese Americans. Both EPA and DHA were significantly higher in Koreans than in the other 2 groups (P < 0.01). Multiple regression analyses in Koreans showed that cfPWV had a significant inverse association with total marine n-3 FAs and with EPA alone after adjusting for blood pressure and other potential confounders. In contrast, there was no significant association of cfPWV with DHA. Whites and Japanese Americans did not show any significant associations of cfPWV with total marine n-3 FAs, EPA, or DHA. CONCLUSIONS:High levels of EPA observed in Koreans have an inverse association with aortic stiffness.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Sekikawa A,Shin C,Masaki KH,Barinas-Mitchell EJ,Hirooka N,Willcox BJ,Choo J,White J,Evans RW,Fujiyoshi A,Okamura T,Miura K,Muldoon MF,Ueshima H,Kuller LH,Sutton-Tyrrell K,ERA JUMP Study Group.

doi

10.1093/ajh/hpt107

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1321-7

issue

eissn

0895-7061

issn

1941-7225

pii

hpt107

journal_volume

pub_type

杂志文章

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Association of total marine fatty acids, eicosapentaenoic and docosahexaenoic acids, with aortic stiffness in Koreans, whites, and Japanese Americans.