当前位置： SCI文献检索 > AMERICAN JOURNAL OF HYPERTENSION期刊下所有文献 > High plasma immunoreactive leptin level in essential hypertension.

High plasma immunoreactive leptin level in essential hypertension.

Abstract：

:Insulin resistance, the most important factor in metabolic syndrome X, has been considered to raise blood pressure. Recently it was reported that insulin resistance was related to an elevated plasma level of leptin, which is an adipocyte-specific ob gene product and which plays a role in food intake suppression, thermogenesis, and energy expenditure through the activation of the hypothalamus. However there are no reports that deal with the relationship of insulin resistance to plasma leptin and blood pressure. To evaluate the role of leptin in essential hypertensives, two groups of subjects who were carefully matched for body mass index (BMI) were studied; 22 normotensives (NT, age: 46.5 +/- 2.6 years, BMI: 23.9 +/- 0.4 kg/m2, male/female: 14/8) and 45 mild-to-moderate essential hypertensives (EHT, age: 51.9 +/- 2.0 years, BMI: 24.5 +/- 0.4 kg/m2, male/female: 21/24). We applied the euglycemic hyperinsulinemic glucose clamp technique to all subjects and insulin sensitivity was evaluated as the M value. EHT showed a significantly lower M value (160.2 +/- 7.4 v 184.3 +/- 7.3 mg/m2/min, P < .05) and higher basal plasma immunoreactive leptin level (7.6 +/- 0.8 v 5.0 +/- 0.8 ng/mL, P < .05) than NT, despite the fact that there was no significant difference between NT and EHT in age, gender, or BMI. The relationship between mean blood pressure and leptin showed a significant positive correlation in all of the subjects (r = 0.31, P < .05), suggesting that leptin may be related to a pathophysiology of essential hypertension.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Agata J,Masuda A,Takada M,Higashiura K,Murakami H,Miyazaki Y,Shimamoto K

doi

10.1016/s0895-7061(97)00310-5

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

1171-4

issue

10 Pt 1

eissn

0895-7061

issn

1941-7225

pii

S0895-7061(97)00310-5

journal_volume

10

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF HYPERTENSION文献大全
  • Trends in Hospitalization for Hypertensive Emergency, and Relationship of End-Organ Damage With In-Hospital Mortality.

    abstract：BACKGROUND:There are no comprehensive guidelines on management of hypertensive emergency (HTNE) and complications. Despite advances in antihypertensive medications HTNE is accompanied with significant morbidity and mortality. METHODS:We queried the 2002-2012 nationwide inpatient sample database to identify patients wi...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpx048

    authors： Shah M,Patil S,Patel B,Arora S,Patel N,Garg L,Agrawal S,Jacobs L,Steigerwalt SP,Martinez MW

    更新日期：2017-07-01 00:00:00

  • Gender differences in insulin-stimulated glucose utilization among African-Americans.

    abstract：:The purpose of this study was to determine whether there are gender differences in plasma insulin levels or insulin resistance in young adult African-Americans. Male (n = 53) and female (n = 45) subjects (age 23 to 28 years) included normotensives (N, blood pressure [BP] < 135/85 mm Hg) and borderline hypertensives (B...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/7.11.948

    authors： Falkner B,Hulman S,Kushner H

    更新日期：1994-11-01 00:00:00

  • Aortic pulse pressure is associated with carotid IMT in chronic kidney disease: report from Chronic Renal Insufficiency Cohort.

    abstract：BACKGROUND:Patients with chronic kidney disease (CKD) have a disproportionate risk of cardiovascular disease. This study was designed to assess the association between two noninvasive measures of cardiovascular risk, pulse wave analysis (PWA), and carotid intima-media thickness (IMT), in a cohort of CKD patients enroll...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2009.156

    authors： DeLoach SS,Appel LJ,Chen J,Joffe MM,Gadegbeku CA,Mohler ER 3rd,Parsa A,Perumal K,Rafey MA,Steigerwalt SP,Teal V,Townsend RR,Rosas SE

    更新日期：2009-12-01 00:00:00

  • Association of Post-Saline Load Plasma Aldosterone Levels With Left Ventricular Hypertrophy in Primary Hypertension.

    abstract：BACKGROUND:Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular morbidity in hypertension. Current evidence suggests a contribution to LVH of plasma aldosterone levels that are inappropriately elevated for the salt status. The aim of this study was to investigate whether inappropriate mod...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpv104

    authors： Catena C,Verheyen ND,Url-Michitsch M,Kraigher-Krainer E,Colussi G,Pilz S,Tomaschitz A,Pieske B,Sechi LA

    更新日期：2016-03-01 00:00:00

  • Antihypertensive Drug Therapy. The effect of JNC criteria on prescribing patterns and patient status through the first year.

    abstract：:This study was designed to evaluate the impact of the protocol-driven antihypertensive therapy on outcomes guided by the Joint National Committee (JNC) on Detection, Evaluation, and Treatment of high blood pressure. In a systematic hypertension control program for union employees conducted in New York City, untreated ...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章

    doi：10.1016/0895-7061(95)00438-6

    authors： Alderman MH,Madhavan S,Cohen H

    更新日期：1996-05-01 00:00:00

  • Arterial stiffness is associated with carotid atherosclerosis in hypertensive patients (the Campania Salute Network).

    abstract：BACKGROUND:Pulse pressure/stroke volume indexed to height(2.04) (PP/SVi) is a validated measure of arterial stiffness, but its relation to carotid atherosclerosis is unknown. METHODS:Clinical, echocardiographic, and carotid ultrasound data from 6,209 hypertensive patients without prevalent cardiovascular (CV) disease ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2012.38

    authors： Casalnuovo G,Gerdts E,de Simone G,Izzo R,De Marco M,Giudice R,Trimarco B,De Luca N

    更新日期：2012-07-01 00:00:00

  • Compliance in the treatment of hypertension. A need for action.

    abstract：:Compliance is commonly defined as the extent to which a person's behavior coincides with medical or health advice. There is evidence that noncompliance is a common problem with many medications, including antihypertensive treatment. Since noncompliance can have serious adverse effects on patient health it is important...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/0895-7061(95)00195-6

    authors： Sanson-Fisher RW,Clover K

    更新日期：1995-10-01 00:00:00

  • Effects of dietary fish oil on Rb+ efflux from aorta of stroke prone spontaneously hypertensive rats.

    abstract：:The effect of fish oil on potassium efflux and basal tension in aortas from stroke prone spontaneously hypertensive rats (SHRSP) was evaluated. Four-week-old male Wistar-Kyoto rats (WKY) and SHRSP were divided into two groups: one received a 5% corn oil diet; the other a 5% menhaden oil diet. After 15 weeks, mean syst...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/5.7.473

    authors： Smith JM,Paulson DJ,Labak S

    更新日期：1992-07-01 00:00:00

  • Chronic Dantrolene Treatment Does Not Affect Hypertension, but Attenuates Sympathetic Stimulation Enhanced Atrial Fibrillation Inducibility in SHR.

    abstract：BACKGROUND:Ryanodine receptor (RyR) dysfunction in skeletal muscle (RyR1) leads to malignant hyperthermia, and in cardiac muscle (RyR2) triggers cardiac arrhythmias. We hypothesized that RyR dysfunction in vascular smooth muscle could increase vascular resistance and hypertension, and may contribute to increased atrial...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpaa021

    authors： Lee JS,Greco L,Migirov A,Li Y,Gerdes AM,Zhang Y

    更新日期：2020-04-29 00:00:00

  • Relation of left ventricular hypertrophy, afterload, and contractility to left ventricular performance in Goldblatt hypertension.

    abstract：:To analyze the determinants of left ventricular (LV) performance (myocardial afterload, chamber size, mass, and contractility) in Goldblatt hypertension, 19 anesthetized one-kidney, one-clip (1K1C) and 28 two-kidney, one-clip (2K1C) male Wistar rats were studied 58 to 62 days after clipping, together with 19 sham-oper...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/5.5.292

    authors： de Simone G,Devereux RB,Volpe M,Camargo MJ,Wallerson DC,Laragh JH

    更新日期：1992-05-01 00:00:00

  • Hypertension, pulse, and other cardiovascular risk factors and vitamin D status in Finnish men.

    abstract：BACKGROUND:Debate exists about the relationship between hypovitaminosis D and cardiovascular (CVD) risk. METHODS:This study investigated baseline (n=2,271) 25-hydroxyvitamin D (25(OH)D) and baseline and 4 year (n=1,957) CVD risk in a cohort of Finnish middle-aged male smokers. RESULTS:The prevalences of measured hype...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpt051

    authors： Ke L,Graubard BI,Albanes D,Fraser DR,Weinstein SJ,Virtamo J,Brock KE

    更新日期：2013-08-01 00:00:00

  • Aortic Hemodynamics and Arterial Stiffness Responses to Muscle Metaboreflex Activation With Concurrent Cold Pressor Test.

    abstract：BACKGROUND:Overweight/obese young men have increased sympatho-excitation to cold and pain stress-induced by the cold pressor test (CPT) that may lead to abnormal hemodynamic responses. Concurrent CPT and exercise may augment the sympathetic-induced increases in aortic blood pressure (BP), pressure wave reflection (augm...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,随机对照试验

    doi：10.1093/ajh/hpv043

    authors： Kalfon R,Campbell J,Alvarez-Alvarado S,Figueroa A

    更新日期：2015-11-01 00:00:00

  • Association of total marine fatty acids, eicosapentaenoic and docosahexaenoic acids, with aortic stiffness in Koreans, whites, and Japanese Americans.

    abstract：BACKGROUND:Few previous studies have reported the association of aortic stiffness with marine n-3 fatty acids (Fas) in the general population. The aim of this study was to determine the combined and independent associations of 2 major marine n-3 FAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with aort...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpt107

    authors： Sekikawa A,Shin C,Masaki KH,Barinas-Mitchell EJ,Hirooka N,Willcox BJ,Choo J,White J,Evans RW,Fujiyoshi A,Okamura T,Miura K,Muldoon MF,Ueshima H,Kuller LH,Sutton-Tyrrell K,ERA JUMP Study Group.

    更新日期：2013-11-01 00:00:00

  • Angiotensin II type 1 receptor polymorphisms in the cardiovascular health study: relation to blood pressure, ethnicity, and cardiovascular events.

    abstract：BACKGROUND:The angiotensin II type 1 receptor A1166C polymorphism has been associated with increased risks of hypertension and myocardial infarction in several small studies. We examined the association between this polymorphism and new-onset hypertension, blood pressure (BP) control, and incident cardiovascular events...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0895-7061(02)03063-7

    authors： Hindorff LA,Heckbert SR,Tracy R,Tang Z,Psaty BM,Edwards KL,Siscovick DS,Kronmal RA,Nazar-Stewart V

    更新日期：2002-12-01 00:00:00

  • Genetic polymorphism of the alpha 2-adrenergic receptor is associated with increased platelet aggregation, baroreceptor sensitivity, and salt excretion in normotensive humans.

    abstract：:It is likely that a number of independent heritable traits, each encoded by a singular gene, contribute to pathologic elevations in blood pressure in humans. Genetic polymorphisms of individual genes may result in intermediate phenotypes which, by themselves, do not raise blood pressure, but, coupled with environmenta...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(95)00155-I

    authors： Freeman K,Farrow S,Schmaier A,Freedman R,Schork T,Lockette W

    更新日期：1995-09-01 00:00:00

  • Pseudo renal artery stenosis (PRAS) syndrome.

    abstract：:During the course of a long-term, prospective, randomized study in 77 hypertensive nephrosclerosis patients, five patients developed evidence suggestive of renal artery stenosis. However, arteriography demonstrated patent renal arteries. The evidence suggestive of renal artery stenosis was: (1) converting-enzyme inhib...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/ajh/2.5.349

    authors： Pettinger WA,Mitchell HC,Lee HC,Redman HC

    更新日期：1989-05-01 00:00:00

  • Enhanced endogenous epinephrine release from the vascular adrenergic neurons in spontaneously hypertensive rats.

    abstract：:This study was performed to investigate the role of endogenous epinephrine in the regulation of vascular tone in hypertension. The release of endogenous epinephrine and norepinephrine from the vascular adrenergic neurons by periarterial nerve stimulation was examined in spontaneously hypertensive rats (SHR) and age-ma...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/3.1.52

    authors： Tsuda K,Tsuda S,Masuyama Y

    更新日期：1990-01-01 00:00:00

  • Impact of Uric Acid on Hypertension Occurrence and Target Organ Damage: Insights From the STANISLAS Cohort With a 20-Year Follow-up.

    abstract：BACKGROUND:Recent studies have shown that hyperuricemia may be associated with incident hypertension (HTN). We examined whether serum uric acid (SUA) is a predictor of HTN and target organ damage (TOD) 20 years later in initially healthy middle-aged individuals. METHODS:Participants from the Suivi Temporaire Annuel No...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpaa030

    authors： Kanbay M,Girerd N,Machu JL,Bozec E,Duarte K,Boivin JM,Wagner S,Ferreira JP,Zannad F,Rossignol P

    更新日期：2020-09-10 00:00:00

  • Hyperinsulinemia, insulin resistance, and hyperglycemia: contributing factors in the pathogenesis of hypertension and atherosclerosis.

    abstract：:Subtle abnormalities of carbohydrate metabolism and overt diabetes mellitus are both associated with a substantial increase in the prevalence of hypertension and the accelerated development of atherosclerosis. Hypertension is also a presumed independent risk factor for atherosclerosis, although some of the atherogenic...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/6.7.260s

    authors： Sowers JR,Standley PR,Ram JL,Jacober S,Simpson L,Rose K

    更新日期：1993-07-01 00:00:00

  • Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension.

    abstract：BACKGROUND:C-reactive protein (CRP) predicts cardiovascular outcome. Oxidative stress is considered to be involved in endothelial alteration. We hypothesized that in essential hypertension (EH), oxidative stress, as measured by 8-iso-prostaglandin-F(2alpha) (8-iso-PGF(2alpha)), should be associated with increased CRP a...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2005.09.005

    authors： Cottone S,Mulè G,Nardi E,Vadalà A,Guarneri M,Briolotta C,Arsena R,Palermo A,Riccobene R,Cerasola G

    更新日期：2006-03-01 00:00:00

  • Physical Activity Is Associated With Reduced Left Ventricular Mass in Obese and Hypertensive African Americans.

    abstract：BACKGROUND:Physical activity (PA) has been associated with decreased left ventricular (LV) hypertrophy in previous studies. However, little is known about the relationship between PA and LV structure and factors which influence this relationship among African Americans. METHODS:We evaluated 1,300 African Americans wit...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpx044

    authors： Kamimura D,Loprinzi PD,Wang W,Suzuki T,Butler KR,Mosley TH,Hall ME

    更新日期：2017-06-01 00:00:00

  • Effect of the Nonsteroidal Mineralocorticoid Receptor Blocker, Esaxerenone, on Nocturnal Hypertension: A Post Hoc Analysis of the ESAX-HTN Study.

    abstract：BACKGROUND:Nocturnal hypertension is an important phenotype of abnormal diurnal blood pressure (BP) variability and a known risk marker for target organ damage and cardiovascular events. This study aimed to assess the differential BP-lowering effects of esaxerenone vs. eplerenone on nocturnal BP in hypertensive patient...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpaa155

    authors： Kario K,Ito S,Itoh H,Rakugi H,Okuda Y,Yoshimura M,Yamakawa S

    更新日期：2020-11-09 00:00:00

  • Brachial Pressure Control Fails to Account for Most Distending Pressure-Independent, Age-Related Aortic Hemodynamic Changes in Adults.

    abstract：BACKGROUND:Although several characteristics of aortic function, which are largely determined by age, predict outcomes beyond brachial blood pressure (BP), the extent to which brachial BP control accounts for age-related variations in aortic function is uncertain. We aimed to determine the extent to which brachial BP co...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpv140

    authors： Hodson B,Norton GR,Booysen HL,Sibiya MJ,Raymond A,Maseko MJ,Majane OH,Libhaber E,Sareli P,Woodiwiss AJ

    更新日期：2016-05-01 00:00:00

  • Arterial stiffening, wave reflection, and inflammation in habitually exercising systemic lupus erythematosus patients.

    abstract：BACKGROUND:Chronic systemic inflammation has been implicated in the pathogenesis of hypertension and cardiovascular disease. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation and an increased risk for cardiovascular disease. Currently few studies have evaluated the potent...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2011.143

    authors： Barnes JN,Nualnim N,Sugawara J,Sommerlad SM,Renzi CP,Tanaka H

    更新日期：2011-11-01 00:00:00

  • Report of the Working Party Group on Determining the Radionuclide of Choice.

    abstract：:There are a variety of radiopharmaceuticals that can be used to perform captopril renography effectively. We examined a number of technetium and iodine compounds and the circumstances under which each radiopharmaceutical compound is the compound of choice. Considerations of cost, ease of use, reliability, dosage, and ...

    journal_title：American journal of hypertension

    pub_type： 共识发展会议,杂志文章,评审

    doi：10.1093/ajh/4.12.747s

    authors： Blaufox MD,Dubovsky EV,Hilson AJ,Taylor A Jr,de Zeeuw R

    更新日期：1991-12-01 00:00:00

  • Effects of calcium channel and renin-angiotensin system blockade on intravascular and neurohormonal mechanisms of hypertensive vascular disease.

    abstract：:Several classes of antihypertensive drugs have been shown to improve vascular function through mechanisms other than reducing blood pressure (BP) alone. Certain dihydropyridine calcium channel blockers (CCBs) and inhibitors of the renin-angiotensin system (RAS) increase nitric oxide (NO) bioavailability and decrease o...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1038/ajh.2008.258

    authors： Mizuno Y,Jacob RF,Mason RP

    更新日期：2008-10-01 00:00:00

  • Blood pressure and the risk of stroke, cardiovascular disease, and all-cause mortality among Japanese: the JPHC Study.

    abstract：BACKGROUND:Little is known about the influence of blood pressure (BP) on cardiovascular disease (CVD) outcomes among Asian populations. METHODS:We examined population attributable fractions (PAFs) and hazard ratios (HRs) associated with BP in relation to stroke and coronary heart disease (CHD) incident and mortality w...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2008.356

    authors： Ikeda A,Iso H,Yamagishi K,Inoue M,Tsugane S

    更新日期：2009-03-01 00:00:00

  • Dietary fiber intake in early pregnancy and risk of subsequent preeclampsia.

    abstract：BACKGROUND:Substantial epidemiological evidence documents diverse health benefits, including reduced risks of hypertension, associated with diets high in fiber. Few studies, however, have investigated the extent to which dietary fiber intake in early pregnancy is associated with reductions in preeclampsia risk. We asse...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2008.209

    authors： Qiu C,Coughlin KB,Frederick IO,Sorensen TK,Williams MA

    更新日期：2008-08-01 00:00:00

  • Factors Associated With Treatment and Control of Hypertension in a Healthy Elderly Population Free of Cardiovascular Disease: A Cross-sectional Study.

    abstract：BACKGROUND:Despite readily available treatments, control of blood pressure (BP) with population aging remains suboptimal. Further, there are gaps in the understanding of the management of high BP in the aged. We explored antihypertensive treatment and control among elderly hypertensive participants free from overt card...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,多中心研究

    doi：10.1093/ajh/hpz192

    authors： Chowdhury EK,Nelson MR,Ernst ME,Margolis KL,Beilin LJ,Johnston CI,Woods RL,Murray AM,Wolfe R,Storey E,Shah RC,Lockery JE,Tonkin AM,Newman AB,Williamson JD,Abhayaratna WP,Stocks NP,Fitzgerald SM,Orchard SG,Trevaks RE

    更新日期：2020-04-01 00:00:00

  • Plasma insulin levels do not change during atrial natriuretic factor infusion in human essential hypertensives.

    abstract：:In order to evaluate the effects of atrial natriuretic factor (ANF) infusion on plasma insulin (IRI) in hypertension, 32 essential hypertensives (aged 40 to 62 years) were studied. After 1 week of pharmacologic washout under normal sodium intake (120 mEq of Na+/day), patients were randomly assigned to receive either A...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/ajh/4.11.880

    authors： Ferri C,De Mattia G,Piccoli A,Carlomagno A,Luparini RL,Germanò G,Giarrizzo C,Torregrossa G,Santucci A,Balsano F

    更新日期：1991-11-01 00:00:00