当前位置： SCI文献检索 > AMERICAN JOURNAL OF HYPERTENSION期刊下所有文献 > Arterial stiffening, wave reflection, and inflammation in habitually exercising systemic lupus erythematosus patients.

Arterial stiffening, wave reflection, and inflammation in habitually exercising systemic lupus erythematosus patients.

Abstract：

BACKGROUND:Chronic systemic inflammation has been implicated in the pathogenesis of hypertension and cardiovascular disease. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation and an increased risk for cardiovascular disease. Currently few studies have evaluated the potential cardiovascular benefits of exercise in SLE. It is unknown whether the favorable effect of habitual exercise on arterial stiffness observed in healthy adults can be extended to SLE. Therefore, as an initial step, we determined the association between habitual exercise, inflammatory markers, central arterial compliance, and aortic wave reflection in healthy adults and SLE patients. METHODS:We studied 41 adults, aged 33 ± 11 years (15 healthy controls, 12 sedentary SLE, and 14 physically active SLE patients). RESULTS:Age, body mass index, and metabolic risk factors were not different between the three groups. Carotid arterial compliance was lower whereas augmentation index (AI) and inflammatory markers (C-reactive protein (CRP), interleukin (IL)-12, tumor necrosis factor-α (TNF-α)) were higher in sedentary SLE patients compared with healthy controls, but were not different between physically active SLE patients and healthy controls. Cardiac ejection fraction was lower in sedentary SLE than physically active SLE or healthy controls. In the pooled population, carotid arterial compliance was inversely associated with TNF-α (r = -0.38; P < 0.01), and AI was positively associated with both CRP (r = 0.33; P < 0.05) and intercellular adhesion molecule-1 (r = 0.28; P < 0.05). CONCLUSIONS:SLE-associated stiffening of the central artery and wave reflection were not observed in habitually exercising adults with SLE. Furthermore, greater arterial stiffness was associated with higher inflammatory markers, suggesting that need for studies on inflammation and SLE-associated arterial stiffening.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Barnes JN,Nualnim N,Sugawara J,Sommerlad SM,Renzi CP,Tanaka H

doi

10.1038/ajh.2011.143

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

1194-200

issue

eissn

0895-7061

issn

1941-7225

pii

ajh2011143

journal_volume

pub_type

杂志文章

在线工具

Arterial stiffening, wave reflection, and inflammation in habitually exercising systemic lupus erythematosus patients.