当前位置： SCI文献检索 > AMERICAN JOURNAL OF HYPERTENSION期刊下所有文献 > PAI-1 in human hypertension: relation to hypertensive groups.

PAI-1 in human hypertension: relation to hypertensive groups.

Abstract：

BACKGROUND:Although the renin-angiotensin system and insulin resistance (IR) have been identified as major regulators of plasminogen activator inhibitor type-1 (PAI-1), their roles in hypertensive subjects is not clearly defined. METHODS:We examined the effect of dietary salt restriction on PAI-1 levels in 239 hypertensive subjects from three centers. Subjects were placed on a 200 and 10 mmol/day sodium diets for 1-week periods. Plasma renin activity (PRA) and PAI-1 levels were measured on the last day of both diets and fasting insulin, glucose, and aldosterone (ALDO) levels, only on the low salt diet. RESULTS:Sodium restriction increased PAI-1 levels from 32.1 +/- 2.5 ng/mL to 39.8 +/- 3.2 ng/mL (P = .009). There was a strong positive correlation between PAI-1 levels and PRA (r = 0.228, P = .0004), IR (r = 0.222, P = .001), triglycerides (r = 0.275, P < .001), and ALDO (P = .018 for linear trend). The patients were divided into low renin (low IR and ALDO levels), nonmodulators (normal PRA, high IR, and low ALDO levels), and modulators (normal PRA, intermediate IR, and normal ALDO levels) groups to assess the relative contribution of each factor to PAI-1 levels. Modulators had significantly (P = .019) higher PAI-1 levels compared to the low renin and nonmodulators who had similar PAI-1 levels. CONCLUSIONS:Plasma renin activity, IR, and ALDO all correlate with PAI-1 levels in the hypertensive subjects. However, the data suggest that ALDO may be an important factor contributing to the variability of PAI-1 levels in individual hypertensive subjects.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Srikumar N,Brown NJ,Hopkins PN,Jeunemaitre X,Hunt SC,Vaughan DE,Williams GH

doi

10.1016/s0895-7061(02)02952-7

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

683-90

issue

8

eissn

0895-7061

issn

1941-7225

pii

S0895706102029527

journal_volume

15

pub_type

杂志文章,多中心研究

相关文献

AMERICAN JOURNAL OF HYPERTENSION文献大全
  • Recent landmark clinical trials: how do they modify the therapeutic paradigm?

    abstract：:Despite intense investigation and clinical attention, many challenges remain in the management of the hypertensive patient. It is clear that hypertension remains inadequately controlled worldwide, with the control rate in the United States approximating 27%. Furthermore, several recent studies have underscored that it...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/s0895-7061(02)02948-5

    authors： Epstein M

    更新日期：2002-07-01 00:00:00

  • The C825T GNB3 polymorphism, independent of blood pressure, predicts cerebrovascular risk at a population level.

    abstract：BACKGROUND:The role of C825T polymorphism of the candidate GNB3 gene in predicting cerebrovascular outcome has been poorly explored in longitudinal setting at a population level. METHODS:In an epidemiological setting, 1,678 men and women from general population were genotyped for C825T polymorphism of GNB3 gene and fo...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2011.257

    authors： Casiglia E,Tikhonoff V,Boschetti G,Bascelli A,Saugo M,Guglielmi G,Caffi S,Rigoni G,Giordano N,Grasselli C,Martini B,Mazza A,De Lazzari F,Palatini P

    更新日期：2012-04-01 00:00:00

  • Factors Associated With Physician Recommendation of Home Blood Pressure Monitoring and Blood Pressure in the US Population.

    abstract：BACKGROUND:Hypertension guidelines recommend home blood pressure monitoring (HBPM) to help achieve blood pressure (BP) control. We hypothesized that HBPM use with a physician recommendation would be associated with lower BP and greater medication adherence. METHODS:We used data from 6,320 adults with hypertension in t...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpaa093

    authors： Tang O,Foti K,Miller ER,Appel LJ,Juraschek SP

    更新日期：2020-09-10 00:00:00

  • Linkage of left ventricular early diastolic peak filling velocity to chromosome 5 in hypertensive African Americans: the HyperGEN echocardiography study.

    abstract：BACKGROUND:Altered diastolic filling is an important contributor to several cardiovascular disorders. Multiple lines of evidence suggest a genetic contribution to left ventricular (LV) diastolic filling; however, chromosomal locations harboring genes involved in impaired LV diastolic filling have not been reported. The...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(02)02943-6

    authors： Tang W,Arnett DK,Devereux RB,Atwood LD,Kitzman DW,Rao DC

    更新日期：2002-07-01 00:00:00

  • Identification of a functional Na+/Mg2+ exchanger in human trophoblast cells.

    abstract：BACKGROUND:Ionized magnesium levels are elevated in fetal blood compared with maternal blood, suggesting that the placenta may possess an active transport mechanism for magnesium. In the present study, we sought to determine the existence of an active transport mechanism for magnesium in the placenta using cultured tro...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(02)02272-0

    authors： Standley PR,Standley CA

    更新日期：2002-06-01 00:00:00

  • Insulin resistance, glucose intolerance and hyperinsulinemia in patients with hypertension.

    abstract：:Plasma glucose and insulin responses to an oral glucose challenge and insulin-stimulated glucose uptake were measured in 47 age-, weight-, and sex-matched lean white men (16 with normal blood pressure, 14 with untreated hypertension, nine treated with a thiazide diuretic only, and eight treated with combined diuretic ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/2.6.419

    authors： Swislocki AL,Hoffman BB,Reaven GM

    更新日期：1989-06-01 00:00:00

  • High level of plasma remnant-like particle cholesterol may predispose to development of hypertension in normotensive subjects.

    abstract：BACKGROUND:Remnant-like lipoprotein particle cholesterol (RLP-C) is a highly atherogenic factor. RLP-C induces endothelial dysfunction and is associated with hyperinsulinemia. This study was designed to determine whether high plasma RLP-C levels predispose to the development of hypertension in subjects with normal bloo...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,多中心研究

    doi：10.1093/ajh/hpt011

    authors： Kasahara A,Adachi H,Hirai Y,Enomoto M,Fukami A,Yoshikawa K,Esaki E,Yokoi K,Ogata K,Tsukagawa E,Obuchi A,Yoshimura A,Nakamura S,Imaizumi T

    更新日期：2013-06-01 00:00:00

  • Effect of amlodipine on mesangial cell proliferation and protein synthesis.

    abstract：:Mesangial cells in the glomerulus have several important physiological functions, as has been demonstrated by past research. Platelet derived growth factor, thrombin, endothelin, and angiotensin II have all been shown to affect mesangial cell growth and protein synthesis. First generation Ca channel blockers also have...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：

    authors： Shultz PJ,Raij L

    更新日期：1992-12-01 00:00:00

  • Insulin increases NADH/NAD+ redox state, which stimulates guanylate cyclase in vascular smooth muscle.

    abstract：BACKGROUND:Insulin inhibits contraction and migration of primary confluent, cultured canine vascular smooth muscle cells (VSMCs) with inducible nitric oxide synthase (iNOS) by stimulating cyclic GMP (cGMP) production. The present study was performed to determine how insulin stimulates guanylate cyclase activity in thes...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(01)02289-0

    authors： Kahn AM,Allen JC,Zhang S

    更新日期：2002-03-01 00:00:00

  • Effects of omapatrilat on blood pressure and renal injury in L-NAME and L-NAME plus DOCA-treated rats.

    abstract：BACKGROUND:This study investigates the effects of chronic administration of omapatrilat (OMA) on blood pressure (BP), renal injury, and other variables in N(omega)-nitro-L-arginine methyl ester (L-NAME) hypertension and in the low-renin model produced by the simultaneous administration of L-NAME and deoxycorticosterone...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(02)03144-8

    authors： Rodriguez-Gomez I,Wangensteen R,Atucha NM,O'Valle F,Del Moral RG,Garcia-Estañ J,Vargas F,Osuna A

    更新日期：2003-01-01 00:00:00

  • Effects of estradiol and progesterone on platelet calcium responses.

    abstract：:We investigated the effects of 17 beta-estradiol (beta E2), alpha-estradiol (alpha E2), and progesterone (P) on baseline and vasopressin (AVP)-induced [Ca2+]i in human platelets obtained from healthy male and female volunteers. Platelets were treated with beta E2, alpha E2, P, or ethanol vehicle for 30 min at 37 degre...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(94)00168-B

    authors： Raman BB,Standley PR,Rajkumar V,Ram JL,Sowers JR

    更新日期：1995-02-01 00:00:00

  • Altered stores of atrial natriuretic peptide in specific brain nuclei of NaCl-sensitive spontaneously hypertensive rats.

    abstract：:Previous studies from our laboratories have demonstrated a selective increase in stores of atrial natriuretic peptide (ANP) in the anterior hypothalamus of NaCl-sensitive spontaneously hypertensive rats (SHR-S) compared to NaCl-resistant Wistar-Kyoto (WKY) controls and have suggested that anterior hypothalamic ANP con...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/4.5.449

    authors： Jin HK,Yang RH,Chen YF,Wyss JM,Oparil S

    更新日期：1991-05-01 00:00:00

  • Myocardial collagen and mechanics after preventing hypertrophy in hypertensive rats.

    abstract：:To determine if a remodeling of the collagen matrix would occur in the absence of hypertrophy and cell necrosis and if such a remodeling could alter active and passive stiffness of the intact myocardium, five rats with genetic hypertension (SHR) were treated (SHRT) with hydralazine for 32 weeks, beginning at four week...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/2.9.675

    authors： Narayan S,Janicki JS,Shroff SG,Pick R,Weber KT

    更新日期：1989-09-01 00:00:00

  • Renal protective effects of aliskiren beyond its antihypertensive property in a mouse model of progressive fibrosis.

    abstract：BACKGROUND:The direct renin inhibitor aliskiren is known to exhibit a strong antihypertensive effect. However, the organoprotective potential of aliskiren beyond its antihypertensive properties is less clear. This study investigates the antifibrotic nephroprotective effects of aliskiren in a nonhypertensive mouse model...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2010.231

    authors： Gross O,Girgert R,Rubel D,Temme J,Theissen S,Müller GA

    更新日期：2011-03-01 00:00:00

  • Training students in education of the hypertensive patient: enhanced performance after a simulated patient instructor (SPI)-based exercise.

    abstract：:The process whereby a physician explains to the ill patient what has gone wrong and what can be done about it can be taught and evaluated by simulated patients (SPIs). This study was designed to determine whether a training experience in educating a diabetic SPI improves subsequent performance with a hypertensive SPI....

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(98)00034-x

    authors： Zweifler AJ,Sisson JC,Wolf FM,Trabin NL,Dicken LL,Gruppen LD,Grum CM,Baum KD

    更新日期：1998-05-01 00:00:00

  • Effect of doxazosin monotherapy on blood pressure and plasma lipids in patients with essential hypertension.

    abstract：:The efficacy and safety of doxazosin (DOX) for the treatment of hypertension was investigated. A multicenter, double-blind, placebo-controlled, parallel design was employed. A 4-week placebo runin period was followed by a 9-week double-blind period during which patients were randomly assigned to placebo or 2, 4, or 8 ...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/ajh/1.2.158

    authors： Cubeddu LX,Pool JL,Bloomfield R,Klotman PE,Pickering BI,Wombolt DG,Nelson EB,Halperin A

    更新日期：1988-04-01 00:00:00

  • Prevalence, awareness, treatment, and risk factors associated with hypertension in the Iranian population: the national survey of risk factors for noncommunicable diseases of Iran.

    abstract：BACKGROUND:The prevalence of hypertension in the Middle East is not well defined. We examined the prevalence, awareness, treatment, and control of hypertension in Iran. METHODS:The Survey of Risk Factors of Noncommunicable Diseases was conducted in 2005 and contains a representative sample of the Iranian adult populat...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2008.154

    authors： Esteghamati A,Abbasi M,Alikhani S,Gouya MM,Delavari A,Shishehbor MH,Forouzanfar M,Hodjatzadeh A,Ramezani RD

    更新日期：2008-06-01 00:00:00

  • Temporary treatment with AT1 receptor blocker, valsartan, from early stage of hypertension prevented vascular remodeling.

    abstract：BACKGROUND:The present study examined the inhibitory action of temporary treatment with an angiotensin type 1 (AT(1)) receptor blocker (ARB) on vascular remodeling using hypertensive mice with overexpression of the human renin (hRN) and angiotensinogen (hANG) genes. METHODS:hRN/hANG transgenic mice (hRN/hANG-Tg) were ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2011.6

    authors： Inaba S,Iwai M,Furuno M,Kanno H,Senba I,Okayama H,Mogi M,Higaki J,Horiuchi M

    更新日期：2011-05-01 00:00:00

  • Association between adducin-1 G460W variant and blood pressure in Swedes is dependent on interaction with body mass index and gender.

    abstract：BACKGROUND:The W allele of the G460W polymorphism in the adducin-1 gene has been occasionally associated with increased blood pressure (BP). The aim of this study was to test whether the G460W variant is associated with BP levels and BP progression rate and whether G460W associations with BP are affected by sex, body m...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2007.04.007

    authors： Fava C,Montagnana M,Almgren P,Rosberg L,Guidi GC,Berglund G,Melander O

    更新日期：2007-09-01 00:00:00

  • Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension.

    abstract：BACKGROUND:C-reactive protein (CRP) predicts cardiovascular outcome. Oxidative stress is considered to be involved in endothelial alteration. We hypothesized that in essential hypertension (EH), oxidative stress, as measured by 8-iso-prostaglandin-F(2alpha) (8-iso-PGF(2alpha)), should be associated with increased CRP a...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2005.09.005

    authors： Cottone S,Mulè G,Nardi E,Vadalà A,Guarneri M,Briolotta C,Arsena R,Palermo A,Riccobene R,Cerasola G

    更新日期：2006-03-01 00:00:00

  • A single mechanism to explain the effect of calcium on renal function.

    abstract：:It is known that calcium induces the formation of potent vasodilators in endothelial cells and vasoconstriction in smooth muscle cells, whereas in the renal parenchyma, it modulates sodium excretion through vascular and tubular mechanisms. Consequently, an increased concentration of calcium in renal circulation may in...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/4.7.473s

    authors： Lahera V,Ruilope LM,Romero JC

    更新日期：1991-07-01 00:00:00

  • Effect of hypoxic exercise on atrial natriuretic factor and aldosterone regulation.

    abstract：:To evaluate the possible physiologic role of atrial natriuretic factor (ANF) in the observed dissociation of aldosterone secretion from the renin-angiotensin system during hypoxic exercise, 12 untrained men, ages 18 to 24, were studied on two separate days for 30 min during hypoxic (16% O2) and normoxic (room air) exe...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/4.4.341

    authors： Lawrence DL,Shenker Y

    更新日期：1991-04-01 00:00:00

  • Increase of calmodulin activator in hypertension. Modulation by dietary sodium and calcium.

    abstract：:The aim of this study was to investigate the effects of dietary calcium and sodium on blood pressure (BP) in normotensive rats (Wistar, WKY), spontaneously hypertensive rats (SHR) and Dahl rats and on calmodulin (CaM) activator, a newly-discovered hydrophobic compound that increases CaM activity in SHR and spontaneous...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/3.8.210

    authors： Chang E,Kunes J,Hamet P,Tremblay J

    更新日期：1990-08-01 00:00:00

  • Caffeine attenuates early post-exercise hypotension in middle-aged subjects.

    abstract：BACKGROUND:Sustained hypotension after an acute dynamic exercise bout is due primarily to peripheral vasodilation. We tested the hypothesis that adenosine-mediated vasodilation contributes to hypotension after exercise, by determining the effect of blocking its actions with caffeine. METHODS:Fourteen healthy middle-ag...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.amjhyper.2005.07.022

    authors： Notarius CF,Morris BL,Floras JS

    更新日期：2006-02-01 00:00:00

  • Control of hypertension in treated children and its association with target organ damage.

    abstract：BACKGROUND:The aim of our study was to investigate the control of hypertension (HT) in treated children using ambulatory blood pressure (BP) monitoring (ABPM). METHODS:We retrospectively reviewed all ABPM studies in our center. Controlled HT was defined as systolic and diastolic BP index (patients' BP divided by the 9...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2011.218

    authors： Seeman T,Dostálek L,Gilík J

    更新日期：2012-03-01 00:00:00

  • Oxidative stress in hypertensive,diabetic, and diabetic hypertensive rats.

    abstract：BACKGROUND:Reactive oxygen species play a key role in the formation of endothelial dysfunction accompanying diabetes mellitus, hypertension, and other cardiovascular diseases. METHOD:This study compares oxidative stress (OS) in Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR), non-insulin-dependent Cohen...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2003.07.013

    authors： Friedman J,Peleg E,Kagan T,Shnizer S,Rosenthal T

    更新日期：2003-12-01 00:00:00

  • Effects of diabetes mellitus, pressure-overload and their association on myocardial structure and function.

    abstract：BACKGROUND:Structural and functional changes involved in cardiac injury induced by diabetes mellitus, pressure-overload, or both conditions were evaluated. METHODS:Pressure-overload was established by suprarenal aortic banding in rats. Six weeks later, diabetes was induced by streptozotocin (STZ, 65 mg/kg, intraperito...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2009.159

    authors： Falcão-Pires I,Gonçalves N,Moura C,Lamego I,Eloy C,Lopes JM,Begieneman MP,Niessen HW,Areias JC,Leite-Moreira AF

    更新日期：2009-11-01 00:00:00

  • Effects of calcium channel and renin-angiotensin system blockade on intravascular and neurohormonal mechanisms of hypertensive vascular disease.

    abstract：:Several classes of antihypertensive drugs have been shown to improve vascular function through mechanisms other than reducing blood pressure (BP) alone. Certain dihydropyridine calcium channel blockers (CCBs) and inhibitors of the renin-angiotensin system (RAS) increase nitric oxide (NO) bioavailability and decrease o...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1038/ajh.2008.258

    authors： Mizuno Y,Jacob RF,Mason RP

    更新日期：2008-10-01 00:00:00

  • Relationship of insulin resistance to macro- and microvasculature reactivity in hypertension.

    abstract：BACKGROUND:Although insulin resistance (IR) is thought to be related to vascular dysfunction, the difference in the relationship of IR to microvasculature and macrovasculature reactivity has not yet been clarified. The present study was conducted to clarify whether the IR is more closely related to the macrovasculature...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2010.3

    authors： Yoshida M,Tomiyama H,Yamada J,Matsumoto C,Odaira M,Shiina K,Yamashina A

    更新日期：2010-05-01 00:00:00

  • Effects of galanin on dopamine release in the central nervous system of normotensive and spontaneously hypertensive rats.

    abstract：:Galanin is a 29-amino acid peptide and widely distributed in the brain, although its significance in the control of neural activities is undefined. In the present study, we describe the effects of galanin on the electrically evoked release of dopamine in the rat central nervous system. In addition, to elucidate a poss...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(98)00168-x

    authors： Tsuda K,Tsuda S,Nishio I,Masuyama Y,Goldstein M

    更新日期：1998-12-01 00:00:00