Effects of calcium channel and renin-angiotensin system blockade on intravascular and neurohormonal mechanisms of hypertensive vascular disease.

abstract：:Despite intense investigation and clinical attention, many challenges remain in the management of the hypertensive patient. It is clear that hypertension remains inadequately controlled worldwide, with the control rate in the United States approximating 27%. Furthermore, several recent studies have underscored that it...

journal_title：American journal of hypertension

authors： Epstein M

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:This study investigates the effects of chronic administration of omapatrilat (OMA) on blood pressure (BP), renal injury, and other variables in N(omega)-nitro-L-arginine methyl ester (L-NAME) hypertension and in the low-renin model produced by the simultaneous administration of L-NAME and deoxycorticosterone...

journal_title：American journal of hypertension

authors： Rodriguez-Gomez I,Wangensteen R,Atucha NM,O'Valle F,Del Moral RG,Garcia-Estañ J,Vargas F,Osuna A

更新日期：2003-01-01 00:00:00

abstract：:Kidney stones affect hypertensive patients disproportionately compared to normotensive individuals. On the other hand, some prospective data suggest that a history of nephrolithiasis was associated with a greater tendency to develop hypertension. Newer epidemiologic data also link obesity and diabetes, features of the...

journal_title：American journal of hypertension

authors： Obligado SH,Goldfarb DS

更新日期：2008-03-01 00:00:00

abstract：:Increased dietary sodium intake has been associated with an increase in blood pressure as well as a decrease in insulin-mediated glucose disposal in young healthy adults. The purpose of this study was to determine whether dietary sodium intake is associated with changes in oral glucose tolerance, insulin sensitivity, ...

journal_title：American journal of hypertension

authors： Dengel DR,Mayuga RS,Kairis GM,Goldberg AP,Weir MR

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) predicts cardiovascular outcome. Oxidative stress is considered to be involved in endothelial alteration. We hypothesized that in essential hypertension (EH), oxidative stress, as measured by 8-iso-prostaglandin-F(2alpha) (8-iso-PGF(2alpha)), should be associated with increased CRP a...

journal_title：American journal of hypertension

authors： Cottone S,Mulè G,Nardi E,Vadalà A,Guarneri M,Briolotta C,Arsena R,Palermo A,Riccobene R,Cerasola G

更新日期：2006-03-01 00:00:00

abstract：:Time-related changes in plasma levels of aldosterone, deoxycorticosterone, corticosterone, and cortisol were studied during treatment with spironolactone in 8 patients with primary aldosteronism due to adenomas. Plasma renin activity (PRA), serum sodium and serum potassium were also measured. The patients were treated...

journal_title：American journal of hypertension

authors： Sakamoto H,Ichikawa S,Sakamaki T,Nakamura T,Ono Z,Takayama Y,Murata K

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Endothelial progenitor cells (EPCs) provide paracrine support to the vascular endothelium and may also replace damaged or senescent endothelial cells. Low numbers of endothelial progenitor colony-forming units (CFU-ECs) in culture are a predictive biomarker of vascular disease. We hypothesized that the numbe...

journal_title：American journal of hypertension

authors： Lin C,Rajakumar A,Plymire DA,Verma V,Markovic N,Hubel CA

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:The prevalence of childhood elevated blood pressure (BP) has increased in the United States, particularly among African Americans. The influence of maternal plasma folate levels, alone or in combination with maternal cardiometabolic risk factors (hypertensive disorders, diabetes, and prepregnancy obesity), o...

journal_title：American journal of hypertension

authors： Wang H,Mueller NT,Li J,Sun N,Huo Y,Ren F,Wang X

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The collateral circulation is important in maintenance of blood supply to the ischemic kidney distal to renal artery stenosis (RAS). Obesity metabolic syndrome (MetS) preserves renal blood flow (RBF) in the stenotic kidney, but whether this is related to an increase of collateral vessel growth is unknown. We...

journal_title：American journal of hypertension

authors： Zhang X,Kim SR,Ferguson CM,Ebrahimi B,Hedayat AF,Lerman A,Lerman LO

更新日期：2018-11-13 00:00:00

abstract：:Arterial stiffness has been known as a sign of cardiovascular risk since the 19th century. Despite this, accurate measurement and clinical utility have only emerged in recent times. Arterial stiffness and its hemodynamic consequences are now established as predictors of adverse cardiovascular outcome. They are easily ...

journal_title：American journal of hypertension

authors： Adji A,O'Rourke MF,Namasivayam M

更新日期：2011-01-01 00:00:00

abstract：:In a population of 887 men and 1159 women aged 40 to 89 years in southern California, age adjusted systolic and diastolic blood pressures correlated significantly with sodium/potassium ratios estimated from casual urine samples. The relationship was apparent over the whole range of blood pressures and urinary electrol...

journal_title：American journal of hypertension

authors： Khaw KT,Barrett-Connor E

更新日期：1990-06-01 00:00:00

abstract：:We investigated the effects of 17 beta-estradiol (beta E2), alpha-estradiol (alpha E2), and progesterone (P) on baseline and vasopressin (AVP)-induced [Ca2+]i in human platelets obtained from healthy male and female volunteers. Platelets were treated with beta E2, alpha E2, P, or ethanol vehicle for 30 min at 37 degre...

journal_title：American journal of hypertension

authors： Raman BB,Standley PR,Rajkumar V,Ram JL,Sowers JR

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Nocturnal blood pressure (BP) is associated with risk for cardiovascular events. However, the relationship between nocturnal BP in young adults and cognitive function in midlife remains unclear. METHODS:We used data from the ambulatory BP monitoring substudy of the Coronary Artery Risk Development in Young ...

journal_title：American journal of hypertension

authors： Yano Y,Ning H,Muntner P,Reis JP,Calhoun DA,Viera AJ,Levine DA,Jacobs DR Jr,Shimbo D,Liu K,Greenland P,Lloyd-Jones D

更新日期：2015-10-01 00:00:00

abstract：:Further improvement in blood pressure control at the population level will result from dealing with hard-to-solve problems, such as access to care, long-term management of a chronic disease, and societal influences on lifestyle. Additional knowledge and experimental data are needed, reinforced by clear public health c...

journal_title：American journal of hypertension

authors： Lang T

更新日期：1998-07-01 00:00:00

abstract：:The effect of a surgical cure of hypercortisolism on hypertension in 54 patients with Cushing's syndrome was assessed. The correlation between preoperative duration of hypertension and posttreatment blood pressure was significant (P < .01). Restoration of normal cortisol was associated with blood pressure normalizatio...

journal_title：American journal of hypertension

authors： Fallo F,Sonino N,Barzon L,Pistorello M,Pagotto U,Paoletta A,Boscaro M

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Hypertension is the most prevalent chronic disease worldwide. Lifestyle behaviors for its prevention and control are recommended within worldwide guidelines. Nevertheless, their combined relationship with blood pressure (BP) level, particularly in the general population, would need more investigations. Our a...

journal_title：American journal of hypertension

authors： Lelong H,Galan P,Kesse-Guyot E,Fezeu L,Hercberg S,Blacher J

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:The ratio of urinary concentrations of tetrahydrocortisol plus allotetrahydrocortisol to tetrahydrocortisone [(THF + ATHF)/THE] reflects the activity of the enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11BHSD2), which converts cortisol to cortisone in the kidney and thereby protects the mineralocortico...

journal_title：American journal of hypertension

authors： Melander O,Frandsen E,Groop L,Hulthén UL

更新日期：2003-09-01 00:00:00

abstract：:The Na-K-Cl cotransport activity in red blood cells from essential hypertensive men with low (n = 8, mean age 42 +/- 4 years) or normal renin activity (n = 4, mean age 43 +/- 3 years), and in normotensive men with normal renin activity (n = 7, mean age 38 +/- 4 years) has been evaluated by means of a recently develope...

journal_title：American journal of hypertension

authors： Cacciafesta M,Ferri C,Carlomagno A,De Angelis C,Scuteri A,Guidoni L,Luciani AM,Rosi A,Viti V,Santucci A

更新日期：1994-02-01 00:00:00

abstract：:Migration of monocytes into the subendothelial space of the aorta has been considered to be an important event in the development of atherosclerosis. Because hypertension is commonly associated with atherosclerosis, we studied the effect of applied pressure on the migration of monocytes. Direct applied pressure increa...

journal_title：American journal of hypertension

authors： Singhal PC,Sagar P,Gupta S,Arya M,Gupta M,Prasad A,Loona R,Sharma P,Mattana J

更新日期：1997-11-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood flow that plays an important role in blood pressure (BP) elevation in some models of experimental hypertension such as DOCA-salt rat, DOCA-salt-treated spontaneously hypertensive rats (SHR), stroke-prone SHR, Dahl salt-sensitive rats, ang...

journal_title：American journal of hypertension

authors： Schiffrin EL

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Recently, the central augmentation index (AIx) has been reported to show a nonlinear correlation with age. We investigated whether the AIx of the central artery changes with the progression of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. METHODS:We simultaneously recorded pre...

journal_title：American journal of hypertension

authors： Katsuda S,Miyake M,Kobayashi D,Hazama A,Kusanagi M,Takazawa K

更新日期：2013-03-01 00:00:00

abstract：:The aim of this study was to compare sexual activity and plasma testosterone levels of hypertensive men with those of healthy normotensive controls. We investigated 110 newly diagnosed, never treated hypertensive (blood pressure [BP] > or = 140/95 mm Hg) men and 110 healthy normotensive (diastolic BP <90 mm Hg) men. A...

journal_title：American journal of hypertension

authors： Fogari R,Zoppi A,Preti P,Rinaldi A,Marasi G,Vanasia A,Mugellini A

更新日期：2002-03-01 00:00:00

abstract：:Previous investigations have demonstrated an association between impaired insulin sensitivity and elevated erythrocyte sodium-lithium countertransport (Na(+)-Li+ CT) activity. It has been speculated that insulin resistance and endogenous hyperinsulinemia are causally related to the development of elevated Na(+)-Li+ CT...

journal_title：American journal of hypertension

authors： Wolpert HA,Steen SN,Istfan NW,Simonson DC

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Large artery stiffness is increased in diabetes mellitus and causes an excessive pulsatile load to the heart and to the microvasculature. The identification of pathways related to arterial stiffness may provide novel therapeutic targets to ameliorate arterial stiffness in diabetes. Matrix Gla-Protein (MGP) i...

journal_title：American journal of hypertension

authors： Sardana M,Vasim I,Varakantam S,Kewan U,Tariq A,Koppula MR,Syed AA,Beraun M,Drummen NE,Vermeer C,Akers SR,Chirinos JA

更新日期：2017-02-01 00:00:00

abstract：:Arterial hypertension is the most common chronic medical condition requiring office visits to physicians and is a major contributing factor to the development of myocardial infarction and stroke. Its importance as a cardiovascular risk factor is at least as significant in women as in men; however, the ever-growing lit...

journal_title：American journal of hypertension

authors： Ruilope LM,Suarez C

更新日期：1997-10-01 00:00:00

abstract：:We have previously reported that myocardial microsomal Na+,K(+)-ATPase activity, arterial wall ouabain-sensitive 86Rb uptake, and arterial smooth muscle cell membrane potentials are decreased and plasma Na(+)-K+ pump inhibitory activity is increased in rats during the fifth week of one-kidney, one-clip hypertension. W...

journal_title：American journal of hypertension

authors： Pamnani MB,Bryant HJ,Clough DL,Haddy FJ

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Blood pressure is a complex quantitative trait with a strong genetic component. In this study, we leveraged the Veterans Affairs electronic medical record system to explore the relationship between Paraoxonase 1 (PON1)-108 C/T (rs705379) and mean arterial blood pressure (MAP). METHODS:Outpatient blood press...

journal_title：American journal of hypertension

authors： Bhatnagar V,Liu L,Nievergelt CM,Richard E,Brophy VH,Pandey B,Lipkowitz MS,O'Connor DT

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Differences between the antihypertensive responses to drug therapy measured by office blood pressure (OBP) and ambulatory blood pressure monitoring (ABPM) techniques have been noted but rarely analyzed. We studied whether the OBP and 24-h ABPM responses to hydrochlorothiazide differ and, if so, the relevance...

journal_title：American journal of hypertension

authors： Finkielman JD,Schwartz GL,Chapman AB,Boerwinkle E,Turner ST

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:The reduction of coronary flow reserve (CFR) found in arterial hypertension may be due to changes in afterload, left ventricular (LV) structure, and metabolic factors. Also, insulin-like growth factor-1 (IGF-1) may be associated with the magnitude of CFR in relation to its modulating action on cardiac and en...

journal_title：American journal of hypertension

authors： Galderisi M,Caso P,Cicala S,De Simone L,Barbieri M,Vitale G,de Divitiis O,Paolisso G

更新日期：2002-09-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH) is more prevalent in black than white hypertensives, but this difference is greater when identified by electrocardiography (ECG) than by echocardiography. We evaluated the proposal that current ECG criteria for LVH are less specific, and therefore, less useful, in blacks than whites....

journal_title：American journal of hypertension

authors： Chapman JN,Mayet J,Chang CL,Foale RA,Thom SA,Poulter NR

更新日期：1999-05-01 00:00:00