Abstract：
:Time-related changes in plasma levels of aldosterone, deoxycorticosterone, corticosterone, and cortisol were studied during treatment with spironolactone in 8 patients with primary aldosteronism due to adenomas. Plasma renin activity (PRA), serum sodium and serum potassium were also measured. The patients were treated with spironolactone, 75 to 225 mg daily, and blood samples were withdrawn on days 7, 14, and 21 to 28 of drug administration. Plasma aldosterone concentrations (PAC) were not altered by spironolactone; however, significant increases were observed in plasma deoxycorticosterone on days 21 to 28 and in plasma corticosterone and cortisol on days 14 and 21 to 28. The suppressed PRA values were markedly increased on days 21 to 28 and low levels of serum potassium returned to the normal range on day 7. The lack of increase in PAC, despite a remarkable rise in PRA and serum potassium, suggests biosynthetic inhibition of spironolactone at the sites of 18-hydroxylation and/or 18-oxidation, because of the elevation of deoxycorticosterone and corticosterone.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Sakamoto H,Ichikawa S,Sakamaki T,Nakamura T,Ono Z,Takayama Y,Murata Kdoi
10.1093/ajh/3.7.533subject
Has Abstractpub_date
1990-07-01 00:00:00pages
533-7issue
7eissn
0895-7061issn
1941-7225journal_volume
3pub_type
杂志文章abstract：BACKGROUND:The optimal schedule for self-monitoring home BP (SMHBP) readings is enormously important in the diagnosis of different phenotypes related to hypertension. The aim of this study was to determine the prognostic capacity of a 3-day SMHBP schedule when using or suppressing the first-day measurements in compilin...
journal_title：American journal of hypertension
pub_type： 杂志文章,多中心研究
doi：10.1093/ajh/hpz178
更新日期：2020-02-22 00:00:00
abstract：:The insulin sensitivity of five essential hypertensive patients was compared to five patients with renovascular hypertension, five patients with primary hyperaldosteronism, and five normotensive subjects, using the euglycemic hyperinsulinemic clamp technique. Essential hypertensive patients had significantly lower ins...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/5.1.26
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:The aim of this study was to comprehensively test the associations of genetic variants of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-related genes with blood pressure (BP) responses to dietary sodium intervention in a Chinese population. METHODS:We conducted a 7-day low-sodium intervention ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpw200
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:The direct renin inhibitor aliskiren is known to exhibit a strong antihypertensive effect. However, the organoprotective potential of aliskiren beyond its antihypertensive properties is less clear. This study investigates the antifibrotic nephroprotective effects of aliskiren in a nonhypertensive mouse model...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2010.231
更新日期：2011-03-01 00:00:00
abstract：:The polymorphism of the angiotensin-converting enzyme gene is considered to be associated with increased risk for stroke, but there is a diversity in the results obtained. The genetic involvement of the renin-angiotensin system in stroke also remains unclear. To predict the genetic risk of lacunar infarction, we condu...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(99)00184-3
更新日期：2000-02-01 00:00:00
abstract：BACKGROUND:Essential hypertension ranks among the strongest cardiovascular risk factors. Cytokine production by monocytes plays a key role in atherosclerosis development and acute coronary syndromes. We investigated whether stimulated monocyte cytokine release and its inhibition by glucocorticoids would differ between ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2004.01.010
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Whether left ventricular (LV) geometric remodeling, as indexed by relative wall thickness (RWT), aggregates in families and is inherited independent of LV mass (LVM) and additional confounders is uncertain. METHODS:We determined whether RWT as assessed from 2D targeted M-mode echocardiography shows intrafam...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpu202
更新日期：2015-05-01 00:00:00
abstract：:To determine whether the benefits of antihypertensive treatment vary according to dipper status, 811 asymptomatic elderly Japanese hypertensives underwent 24-h ambulatory blood pressure monitoring. During a mean follow-up period of 41 months, 32 stroke events were observed in patients who remained nonmedicated (n = 38...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1016/s0895-7061(02)03020-0
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:Azilsartan medoxomil (AZL-M), an angiotensin II receptor blocker, demonstrates antihypertensive and organ protective effects in hypertension. We investigated the efficacy of AZL-M to ameliorate metabolic syndrome and kidney damage associated with type 2 diabetes using Zucker diabetic fatty (ZDF) rats. METHO...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpu016
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Blood pressure is known to be higher in heavy drinkers than in nondrinkers. The aim of this study was to determine whether the alcohol-blood pressure relationship is modified by therapy for hypertension in the elderly. METHODS:Men aged > or = 65 years (n = 1,396) with or without current history of antihyper...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2010.52
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:In patients free from overt cardiac disease, R wave in aVL lead (RaVL) is strongly correlated with left ventricular mass index (LVMI) assessed by transthoracic echocardiography. The aim of the present study was to extend this finding to other settings (cardiomyopathy or conduction disorders), by comparing EC...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpu268
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:We examined data from a cohort of Caucasian women for evidence of an association between serum vitamin D (25-hydroxyvitamin D (25(OH)D)) insufficiency and greater risk of systolic hypertension in the population-based longitudinal Michigan Bone Health and Metabolism Study (MBHMS). METHODS:The cohort includes...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2010.226
更新日期：2011-03-01 00:00:00
abstract：:Use of thiazide diuretics and beta-blockers in the treatment of hypertension may result in metabolic derangements and/or disturbances in the parameters of renal function, which offset the benefits of blood pressure reduction by adversely affecting other cardiovascular risk factors, particularly in special patient grou...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1990-12-01 00:00:00
abstract：:The association between obesity and hypertension is well recognized. However, the exact mechanisms whereby obesity causes hypertension are complex and multifactorial. The current article summarizes some of the known mechanisms responsible for obesity hypertension. ...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1016/s0895-7061(01)02299-3
更新日期：2002-02-01 00:00:00
abstract：:Alterations in Na, K ATPase pump activity as well as erythrocyte (RBC) intracellular sodium concentration (Nai) have been demonstrated in humans and rats with established hypertension. The contribution of hypertension itself to these changes is unclear. Accordingly, we investigated RBC ion transport and plasma ouabain...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/2.8.604
更新日期：1989-08-01 00:00:00
abstract：BACKGROUND:Many patients prefer herbal medications to conventional drugs. Limited trial evidence suggests that garlic preparations reduce high blood pressure (BP). METHODS:We searched electronic databases through March 2014 to identify all randomized controlled trials that compared a garlic preparation to placebo in h...
journal_title：American journal of hypertension
pub_type： 杂志文章,meta分析,评审
doi：10.1093/ajh/hpu165
更新日期：2015-03-01 00:00:00
abstract：:When injected into the medullary site of the hypotensive action of clonidine, imidazolines and related compounds decrease blood pressure (BP), whereas no phenylethylamine compounds were capable of producing such an effect at the same site. There is much biochemical and pharmacologic evidence to support the involvement...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1016/s0895-7061(01)02238-5
更新日期：2001-11-01 00:00:00
abstract：BACKGROUND:Recent reports suggesting that primary aldosteronism (PA) is more common than historically thought have often relied on use of the plasma aldosterone concentration (PAC) to plasma renin activity (PRA) ratio (ARR) to identify patients with PA. Prior determinations of the validity of the ARR had been generally...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2005.01.002
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:Carotid-femoral pulse-wave velocity (PWV) provides a comprehensive noninvasive indication of arterial stiffness, and is now established as a strong marker of cardiovascular disease (CVD). The correlation between peripheral blood pressure (BP) and PWV and their respective influences on mortality have been poo...
journal_title：American journal of hypertension
pub_type： 杂志文章,多中心研究
doi：10.1093/ajh/hps042
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:It is known that essential hypertension may be implicated in the development of cognitive impairment that is associated to microvascular disease of the brain. It has been hypothesized that increased arterial stiffness of the large arteries may lead to microvascular changes due to increased pulsatile flow. Ou...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2009.35
更新日期：2009-05-01 00:00:00
abstract：:Fenoldopam (Corlopam), a new dopaminergic agent in clinical development by SmithKline Beecham Pharmaceuticals, is a dopamine-1 (DA1) agonist at post-synaptic dopamine receptors. Preclinical and clinical studies have demonstrated that it is a potent renal vasodilator as well as a peripheral vasodilator. In both normal ...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1093/ajh/3.6.120s
更新日期：1990-06-01 00:00:00
abstract：BACKGROUND:Genetic factors may influence blood pressure (BP) responses to dietary potassium intake. We examined the association of genetic variants in the apelin-APJ system and angiotensin-converting enzyme 2 (ACE2) with BP responses to potassium supplementation. METHODS:We conducted a 7-day potassium supplementation ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2010.36
更新日期：2010-06-01 00:00:00
abstract：:Antihypertensive monotherapy, although commonly used, does not address the multifactorial nature of hypertension as a disease with many pathways. Using more than one drug makes more therapeutic sense because combination agents cover more than one pathway, yet the use of drugs in tandem is typically relegated to more p...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(99)00112-0
更新日期：1999-08-01 00:00:00
abstract：BACKGROUND:We reported that insulin modestly stimulates NAD(P)H oxidase activity in cultured rat vascular smooth muscle cells (VSMC) and synergistically stimulates enzyme activity with angiotensin II (Ang II), leading to synergistic stimulation of VSMC migration. The aim of this study was to determine the mechanism of ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2005.11.017
更新日期：2006-06-01 00:00:00
abstract：BACKGROUND:Dyslipidemia in hypertensive sibships may be characterized by atherogenic small low-density lipoprotein (LDL) particles. Whether LDL particle size is associated with the extent of coronary atherosclerosis in hypertensive sibships is unknown. METHODS:Subjects (n = 792, mean age 62 years, 60% women) were asce...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2004.06.012
更新日期：2004-09-01 00:00:00
abstract：:Arterial stiffness has been known as a sign of cardiovascular risk since the 19th century. Despite this, accurate measurement and clinical utility have only emerged in recent times. Arterial stiffness and its hemodynamic consequences are now established as predictors of adverse cardiovascular outcome. They are easily ...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1038/ajh.2010.192
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:This structured metaanalysis focused on determining the relationship between hypertension (HTN) and thoracic aortic dissection (TAD). METHODS:Electronic searches were conducted using the MedLine database, for the period 1946 through May 2013, and manual searches from reference lists. Demographic data, patie...
journal_title：American journal of hypertension
pub_type： 杂志文章,meta分析
doi：10.1093/ajh/hpt293
更新日期：2014-07-01 00:00:00
abstract：:The renin-angiotensin-aldosterone system plays a major role in the pathogenesis of hypertension by enhancing the production or the activity of angiotensin II (ANG II). We evaluated the effects of hormone replacement therapy (HRT) on the renin-angiotensin-aldosterone system and on bradykinin in postmenopausal women (PM...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(00)01253-x
更新日期：2001-03-01 00:00:00
abstract：BACKGROUND:Overweight/obese young men have increased sympatho-excitation to cold and pain stress-induced by the cold pressor test (CPT) that may lead to abnormal hemodynamic responses. Concurrent CPT and exercise may augment the sympathetic-induced increases in aortic blood pressure (BP), pressure wave reflection (augm...
journal_title：American journal of hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1093/ajh/hpv043
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Hypertension is a risk factor for coronary heart disease (CHD), but the causes of hypertension remain largely unknown. Genetic variation is thought to contribute to the etiology of hypertension. We tested a single-nucleotide polymorphism (SNP) (Lys67Arg, rs197922) in the Golgi SNAP Receptor Complex Member 2 ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2008.336
更新日期：2009-02-01 00:00:00
