Insulin resistance in secondary hypertension.

Abstract:

:The insulin sensitivity of five essential hypertensive patients was compared to five patients with renovascular hypertension, five patients with primary hyperaldosteronism, and five normotensive subjects, using the euglycemic hyperinsulinemic clamp technique. Essential hypertensive patients had significantly lower insulin sensitivity than patients with hyperaldosteronism and renovascular hypertensive patients (P = .0066, P = .004, respectively). Hyperaldosteronism patients also had less insulin sensitivity than renovascular hypertensive patients (P = .016). A significant negative correlation was found between body mass index and insulin sensitivity index for essential hypertension patients only (r = -0.87, P less than .003). No such correlation was found in the secondary hypertension patients. The findings suggest a causal relationship between insulin resistance and the development of essential hypertension. Secondary hypertension, on the other hand, is not such an insulin resistant state.

journal_name

Am J Hypertens

authors

Shamiss A,Carroll J,Rosenthal T

doi

10.1093/ajh/5.1.26

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

26-8

issue

1

eissn

0895-7061

issn

1941-7225

journal_volume

5

pub_type

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