Clinical experience with intravenous fenoldopam.

Abstract:

:Fenoldopam (Corlopam), a new dopaminergic agent in clinical development by SmithKline Beecham Pharmaceuticals, is a dopamine-1 (DA1) agonist at post-synaptic dopamine receptors. Preclinical and clinical studies have demonstrated that it is a potent renal vasodilator as well as a peripheral vasodilator. In both normal volunteers and hypertensive patients intravenous fenoldopam causes dose-related decreases in blood pressure and important increases in renal hemodynamics and function including increased renal blood flow, diuresis and natriuresis. Fenoldopam does not alter glomerular filtration. Intravenous fenoldopam has been demonstrated to be efficacious in severe hypertensive patients in several multicenter, multinational trials. In severe hypertension efficacy trials fenoldopam was judged to be as effective as sodium nitroprusside and to produce less serious side effects. In patients with moderate to severe heart failure, fenoldopam has been demonstrated to produce dose-related acute increases in cardiac output, stroke volume and work index, decreased systemic vascular resistance but no important changes in pulmonary wedge pressure or right atrial pressure. In CHF patients fenoldopam has been demonstrated to be as efficacious as sodium nitroprusside. Fenoldopam, as a specific (DA1) agonist resulting in decreased peripheral and renal vascular resistance, diuresis, natriuresis and increases in cardiac hemodynamics on intravenous administration, appears to be an efficacious agent which offers a reasonable alternative in the treatment of severe hypertension and acute congestive heart failure.

journal_name

Am J Hypertens

authors

Holcslaw TL,Beck TR

doi

10.1093/ajh/3.6.120s

subject

Has Abstract

pub_date

1990-06-01 00:00:00

pages

120S-125S

issue

6 Pt 2

eissn

0895-7061

issn

1941-7225

journal_volume

3

pub_type

杂志文章,评审
  • Association of total marine fatty acids, eicosapentaenoic and docosahexaenoic acids, with aortic stiffness in Koreans, whites, and Japanese Americans.

    abstract:BACKGROUND:Few previous studies have reported the association of aortic stiffness with marine n-3 fatty acids (Fas) in the general population. The aim of this study was to determine the combined and independent associations of 2 major marine n-3 FAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with aort...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpt107

    authors: Sekikawa A,Shin C,Masaki KH,Barinas-Mitchell EJ,Hirooka N,Willcox BJ,Choo J,White J,Evans RW,Fujiyoshi A,Okamura T,Miura K,Muldoon MF,Ueshima H,Kuller LH,Sutton-Tyrrell K,ERA JUMP Study Group.

    更新日期:2013-11-01 00:00:00

  • Association of increased erythrocyte Na+/H+ exchanger with renal Na+ retention in patients with essential hypertension.

    abstract::The goal of this study was to investigate the activity of the Na+/H+ exchanger in erythrocytes of patients with essential hypertension and its relation with urinary Na+ excretion. The study was performed in cells from 27 untreated hypertensive patients and 30 normotensive controls with similar age and sex distribution...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/0895-7061(94)00172-8

    authors: Díez J,Alonso A,Garciandía A,López R,Gómez-Alamillo C,Arrázola A,Fortuño A

    更新日期:1995-02-01 00:00:00

  • Increased expression and activity of phospholipase C in renal arterioles of young spontaneously hypertensive rats.

    abstract:BACKGROUND:The aims of this study were to document the presence of phospholipase C (PLC) isozymes beta(1), gamma(1), and delta(1) in freshly isolated renal glomeruli and resistance vessels, to compare their expression and activity to that in aorta, and to contrast values between 6-week-old Wistar-Kyoto (WKY) controls a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2006.06.009

    authors: Peng Z,Dang A,Arendshorst WJ

    更新日期:2007-01-01 00:00:00

  • Acculturation is associated with hypertension in a multiethnic sample.

    abstract:BACKGROUND:Hypertension varies in prevalence among race/ethnic groups in the United States. Within-ethnic group differences associated with acculturation have been less frequently examined. We studied the association of three measures of acculturation (language spoken at home, place of birth, and years living in the US...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2006.09.025

    authors: Moran A,Diez Roux AV,Jackson SA,Kramer H,Manolio TA,Shrager S,Shea S

    更新日期:2007-04-01 00:00:00

  • Impaired diurnal blood pressure variation and all-cause mortality.

    abstract:BACKGROUND:Most healthy people exhibit a decrease in systolic blood pressure (SBP) at night. A drop of <10% from mean daytime values, "non-dipping," is associated with kidney disease and cardiovascular events. We hypothesized that non-dipping would predict all-cause mortality. METHODS:Consecutive patients referred for...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2007.7

    authors: Brotman DJ,Davidson MB,Boumitri M,Vidt DG

    更新日期:2008-01-01 00:00:00

  • Pressor and bradycardic effects of centrally administered relaxin in conscious rats.

    abstract::The current study tested the hypothesis that centrally administered relaxin elevates arterial pressure in conscious rats and that this hypertensive effect is mediated, at least in part, by central or peripheral vasopressin. Injection of human relaxin (0.068 or 0.34 microgram in 200 nL artificial cerebrospinal fluid) i...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/0895-7061(94)00208-s

    authors: Yang RH,Bunting S,Wyss JM,Berecek KH,Zhang L,Jin H

    更新日期:1995-04-01 00:00:00

  • Pediatric Liddle Syndrome Caused by a Novel SCNN1G Variant in a Chinese Family and Characterized by Early-Onset Hypertension.

    abstract:BACKGROUND:Liddle syndrome (LS), an autosomal dominant disorder, is a common monogenic hypertension in pediatrics. In this study, we reported a novel SCNN1G variant in a Chinese family with pediatric LS, and conduct a systematic review of epithelial sodium channel (ENaC)-gene-positive LS cases to conclude the clinical ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpaa037

    authors: Fan P,Pan XC,Zhang D,Yang KQ,Zhang Y,Tian T,Luo F,Ma WJ,Liu YX,Wang LP,Zhang HM,Song L,Cai J,Zhou XL

    更新日期:2020-07-18 00:00:00

  • In situ hybridization shows increased endothelin-1 mRNA levels in endothelial cells of blood vessels of deoxycorticosterone acetate-salt hypertensive rats.

    abstract::Endothelin-1 is a potent vasoconstrictor peptide produced in blood vessels and other tissues that may play an important role in the control of local blood flow and could be involved in the pathogenesis of hypertension. Our previous studies have documented increases in endothelin-1 peptide content and gene expression i...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/0895-7061(95)96213-4

    authors: Day R,Larivière R,Schiffrin EL

    更新日期:1995-03-01 00:00:00

  • Hepatic effects of a fructose diet in the stroke-prone spontaneously hypertensive rat.

    abstract:BACKGROUND:Feeding stroke-prone spontaneously hypertensive rats (SHRSP) a diet rich in fructose results in a profound glucose intolerance not observed in the normotensive Wistar Kyoto (WKY) strain. The aim of this study was to investigate the role of the liver in the underlying mechanisms in the SHRSP. METHODS:SHRSP a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2008.41

    authors: Brosnan MJ,Carkner RD

    更新日期:2008-06-01 00:00:00

  • Interaction of 1,25-dihydroxyvitamin D and plasma renin activity in high renin essential hypertension.

    abstract::Renin secretion by the kidney is inhibited by an increase in free intracellular calcium concentration. This increase in free intracellular calcium content may be augmented by serum 1,25-dihydroxyvitamin D. In 10 subjects with high renin hypertension, an increase in dietary sodium intake resulted in an increase in urin...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ajh/3.12.903

    authors: Burgess ED,Hawkins RG,Watanabe M

    更新日期:1990-12-01 00:00:00

  • Hypertension in kidney transplant recipients. Effect on long-term renal allograft survival.

    abstract::To examine the effects of hypertension on renal graft function, we studied the clinical course of 144 kidney transplant recipients who had functioning grafts for three to 13 years. The patients were divided into three groups: normotensive (n = 32), controlled hypertensive (n = 49) and uncontrolled hypertensive group (...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/2.5.341

    authors: Cheigh JS,Haschemeyer RH,Wang JC,Riggio RR,Tapia L,Stenzel KH,Rubin AL

    更新日期:1989-05-01 00:00:00

  • Impaired vasodilator capacity and exaggerated pressor response to isometric exercise in subjects with family history of hypertension.

    abstract::The nature of the cardiovascular response to isometric exercise is still debated. An adequate blood supply to exercising muscles at the onset of contraction seems to be an important factor controlling the extent of pressor response to isometric contraction. In comparison to normotensive subjects without familiar hyper...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/1.3.106s

    authors: Borghi C,Costa FV,Boschi S,Ambrosioni E

    更新日期:1988-07-01 00:00:00

  • Blood Neutrophil to Lymphocyte Ratio as a Predictor of Hypertension.

    abstract:BACKGROUND:Hypertension is a significant global public health challenge. Low-grade inflammation is known to facilitate the development of essential hypertension and target-organ hypertensive damage. Neutrophil to lymphocyte ratio (NLR) is a simple and reliable indicator of inflammation that may also be useful in the pr...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpv034

    authors: Liu X,Zhang Q,Wu H,Du H,Liu L,Shi H,Wang C,Xia Y,Guo X,Li C,Bao X,Su Q,Sun S,Wang X,Zhou M,Jia Q,Zhao H,Song K,Niu K

    更新日期:2015-11-01 00:00:00

  • Effects of aging on the insulin actions for the glucose metabolism and renal function in normotensives and essential hypertensives.

    abstract::It has been suggested that hyperinsulinemia compensating insulin resistance in glucose metabolism may be a pathogenic factor in essential hypertension. On the other hand, age-associated increases in the prevalence of glucose intolerance and hypertension are also well established. The aim of this study is to clarify th...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(98)00113-7

    authors: Miyazaki Y,Hirata A,Murakami H,Fukuoka M,Agata J,Higashiura K,Masuda A,Ura N,Shimamoto K

    更新日期:1998-09-01 00:00:00

  • Protein phosphorylation and intracellular free calcium in platelets of patients with essential hypertension.

    abstract::Platelet intracellular free calcium concentration [Ca2+]i from patients with essential hypertension has been found to be elevated, but the intracellular effects of this increase are still unclear. As protein phosphorylation is an important regulatory step in cell activation and increased protein phosphorylation has be...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/5.3.117

    authors: Haller H,Lindschau C,Quass P,Distler A

    更新日期:1992-03-01 00:00:00

  • Pseudo renal artery stenosis (PRAS) syndrome.

    abstract::During the course of a long-term, prospective, randomized study in 77 hypertensive nephrosclerosis patients, five patients developed evidence suggestive of renal artery stenosis. However, arteriography demonstrated patent renal arteries. The evidence suggestive of renal artery stenosis was: (1) converting-enzyme inhib...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ajh/2.5.349

    authors: Pettinger WA,Mitchell HC,Lee HC,Redman HC

    更新日期:1989-05-01 00:00:00

  • Association of genetic variants in the apelin-APJ system and ACE2 with blood pressure responses to potassium supplementation: the GenSalt study.

    abstract:BACKGROUND:Genetic factors may influence blood pressure (BP) responses to dietary potassium intake. We examined the association of genetic variants in the apelin-APJ system and angiotensin-converting enzyme 2 (ACE2) with BP responses to potassium supplementation. METHODS:We conducted a 7-day potassium supplementation ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2010.36

    authors: Zhao Q,Gu D,Kelly TN,Hixson JE,Rao DC,Jaquish CE,Chen J,Huang J,Chen CS,Gu CC,Whelton PK,He J

    更新日期:2010-06-01 00:00:00

  • Prevalence, awareness, treatment, and risk factors associated with hypertension in the Iranian population: the national survey of risk factors for noncommunicable diseases of Iran.

    abstract:BACKGROUND:The prevalence of hypertension in the Middle East is not well defined. We examined the prevalence, awareness, treatment, and control of hypertension in Iran. METHODS:The Survey of Risk Factors of Noncommunicable Diseases was conducted in 2005 and contains a representative sample of the Iranian adult populat...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2008.154

    authors: Esteghamati A,Abbasi M,Alikhani S,Gouya MM,Delavari A,Shishehbor MH,Forouzanfar M,Hodjatzadeh A,Ramezani RD

    更新日期:2008-06-01 00:00:00

  • Antihypertensive action of beta-adrenoceptor blocking drugs. The role of intrarenal mechanisms.

    abstract::The different modes of antihypertensive action of beta-adrenoceptor blocking drugs are reviewed with a special emphasis on renal mechanisms of action. Beta-adrenoceptors occur in the kidney at the level of the juxtaglomerular and tubular cells. Direct intrarenal effects of beta-blockers include the decrease in renin r...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/2.11.237s

    authors: Struyker-Boudier HA,Smits JF

    更新日期:1989-11-01 00:00:00

  • Twenty-Five-Year Changes in Office and Ambulatory Blood Pressure: Results from the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

    abstract:BACKGROUND:Blood pressure (BP) measured in the office setting increases from early through later adulthood. However, it is unknown to what extent out-of-office BP derived via ambulatory BP monitoring (ABPM) increases over time, and which participant characteristics and risk factors might contribute to these increases. ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpaa189

    authors: Bundy JD,Jaeger BC,Huffman MD,Knox SS,Thomas SJ,Shimbo D,Booth Iii JN,Lewis CE,Edwards LJ,Schwartz JE,Muntner P

    更新日期:2020-11-17 00:00:00

  • Enhanced 45Ca2+ efflux in cultured vascular smooth muscle cells from spontaneously hypertensive rats.

    abstract::Ca2+ efflux from cultured vascular smooth muscle cells (VSMC) consists of two mechanisms: one is dependent on extracellular sodium, mediated by the Na(+)-Ca2+ exchange (Na+o-dependent Ca2+ efflux), and the other is independent of extracellular sodium but is mediated by the Ca(2+)-pump (Na+o-independent Ca2+ efflux). I...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/7.7.597

    authors: Chen S,Roufogalis BD

    更新日期:1994-07-01 00:00:00

  • Serum hepatocyte growth factor concentration is correlated with the forearm vasodilator response in hypertensive patients.

    abstract::To evaluate the clinical importance of serum hepatocyte growth factor (HGF) concentration, we designed two clinical investigations. The first study analyzed the correlation between serum HGF concentration and clinical arterial stiffness or the vasodilator response to reactive hyperemia in hypertensive patients. The se...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(02)02274-4

    authors: Komai N,Ohishi M,Morishita R,Moriguchi A,Kaibe M,Matsumoto K,Rakugi H,Higaki J,Ogihara T

    更新日期:2002-06-01 00:00:00

  • Renal denervation decreases blood pressure in DOCA-treated miniature swine with established hypertension.

    abstract::The role of renal sympathetic nerve activity (RSNA) in the maintenance phase of essential hypertension has not yet been clearly defined. Renal function and mean arterial pressure (MAP) were studied in four Yucatan miniature swine (YMS) with established DOCA hypertension prior to and for 3 weeks after surgical renal de...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/3.1.62

    authors: O'Hagan KP,Thomas GD,Zambraski EJ

    更新日期:1990-01-01 00:00:00

  • Increased Circulating Visfatin Is Associated With Progression of Kidney Disease in Non-Diabetic Hypertensive Patients.

    abstract:BACKGROUD:Declining renal function is an independent risk factor for all-cause mortality in cardiovascular disease. Visfatin has been described as a marker of inflammation and endothelial dysfunction, but whether circulating visfatin levels are predictive to a subsequent decline in renal function remains unclear. METH...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpv132

    authors: Hsu CY,Huang PH,Chen TH,Chiang CH,Leu HB,Huang CC,Chen JW,Lin SJ

    更新日期:2016-04-01 00:00:00

  • Altered stores of atrial natriuretic peptide in specific brain nuclei of NaCl-sensitive spontaneously hypertensive rats.

    abstract::Previous studies from our laboratories have demonstrated a selective increase in stores of atrial natriuretic peptide (ANP) in the anterior hypothalamus of NaCl-sensitive spontaneously hypertensive rats (SHR-S) compared to NaCl-resistant Wistar-Kyoto (WKY) controls and have suggested that anterior hypothalamic ANP con...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/4.5.449

    authors: Jin HK,Yang RH,Chen YF,Wyss JM,Oparil S

    更新日期:1991-05-01 00:00:00

  • Compliance in the treatment of hypertension. A need for action.

    abstract::Compliance is commonly defined as the extent to which a person's behavior coincides with medical or health advice. There is evidence that noncompliance is a common problem with many medications, including antihypertensive treatment. Since noncompliance can have serious adverse effects on patient health it is important...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/0895-7061(95)00195-6

    authors: Sanson-Fisher RW,Clover K

    更新日期:1995-10-01 00:00:00

  • Asymmetric dimethylarginine (ADMA) has a role in regulating systemic vascular tone in young healthy subjects: the cardiovascular risk in young Finns study.

    abstract:BACKGROUND:This study was designed to evaluate whether plasma asymmetric dimethylarginine (ADMA) has any role in predicting hemodynamic responses in clinically healthy young subjects. ADMA, as an endogenous nitric oxide (NO) synthase inhibitor, has been demonstrated to associate with hypertension and vascular reactivit...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2008.215

    authors: Päivä H,Kähönen M,Lehtimäki T,Raitakari OT,Jula A,Viikari J,Alfthan G,Juonala M,Laaksonen R,Hutri-Kähönen N

    更新日期:2008-08-01 00:00:00

  • Left ventricular function impairment in pregnancy-induced hypertension.

    abstract::The changes induced by transient hypertension on cardiac structure and function are unclear. Pregnancy-induced hypertension offers a natural and spontaneous model of this condition. To assess the potential of echocardiographic Doppler to unmask left ventricular function impairment, we studied 28 women aged 26.4 +/- 7....

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(00)01264-4

    authors: Vázquez Blanco M,Roisinblit J,Grosso O,Rodriguez G,Robert S,Berensztein CS,Vega HR,Lerman J

    更新日期:2001-03-01 00:00:00

  • Associations between nondipping of nocturnal blood pressure decrease and cardiovascular target organ damage in strictly selected community-dwelling normotensives.

    abstract:BACKGROUND:In hypertensives, nondippers are more likely than dippers to suffer silent, as well as overt, hypertensive target organ damage. In this study, we investigated whether a nondipper status was associated with target organ damage in normotensives. METHODS:We performed ambulatory blood pressure (BP) monitoring, ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(03)00567-3

    authors: Hoshide S,Kario K,Hoshide Y,Umeda Y,Hashimoto T,Kunii O,Ojima T,Shimada K

    更新日期:2003-06-01 00:00:00

  • Blood pressure response to dietary calcium intervention in humans.

    abstract::Epidemiological and experimental studies have suggested that dietary calcium deficiency may lead to the development of hypertension. This article reviews findings in human trials on calcium intervention with special reference to the responses of blood pressure and biochemical variables. Calcium supplementation consist...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/3.8.147

    authors: Mikami H,Ogihara T,Tabuchi Y

    更新日期:1990-08-01 00:00:00