Blood Neutrophil to Lymphocyte Ratio as a Predictor of Hypertension.

Abstract:

BACKGROUND:Hypertension is a significant global public health challenge. Low-grade inflammation is known to facilitate the development of essential hypertension and target-organ hypertensive damage. Neutrophil to lymphocyte ratio (NLR) is a simple and reliable indicator of inflammation that may also be useful in the prediction of hypertension. METHODS:Participants were recruited from Tianjin Medical University's General Hospital-Health Management Centre. A total of 28,850 initially hypertension-free subjects were followed from 2007 to 2013. Adjusted Cox proportional hazards regression models were used to assess relationships between NLR categories and incidence of hypertension. RESULTS:During the ~6-year follow-up period (median duration of follow-up (interquartile range): 2.63 (2.58-2.68)), 1,824 subjects developed hypertension. The hazard ratios of hypertension incidence were evaluated in increasing NLR quintiles. Compared with participants with the lowest NLR levels, the multivariable-adjusted hazard ratios (95% confidence interval) of hypertension were related to increasing NLR quintiles and were as follows: 1.08 (0.92, 1.26), 0.97 (0.83, 1.14), 1.10 (0.94, 1.28), and 1.23 (1.06, 1.43), respectively (P for trend < 0.01). Similar results also were observed in the white blood cell and neutrophil counts, but not lymphocyte counts. CONCLUSIONS:The study is the first to show the elevated NLR levels significantly correlate with an increased risk of developing hypertension. This result may be useful in elucidating the mechanism underlying the development of hypertension. New therapeutic approaches aimed at inflammation might be proposed to control hypertension and hypertensive damage.

journal_name

Am J Hypertens

authors

Liu X,Zhang Q,Wu H,Du H,Liu L,Shi H,Wang C,Xia Y,Guo X,Li C,Bao X,Su Q,Sun S,Wang X,Zhou M,Jia Q,Zhao H,Song K,Niu K

doi

10.1093/ajh/hpv034

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

1339-46

issue

11

eissn

0895-7061

issn

1941-7225

pii

hpv034

journal_volume

28

pub_type

杂志文章
  • Time-related changes in plasma adrenal steroids during treatment with spironolactone in primary aldosteronism.

    abstract::Time-related changes in plasma levels of aldosterone, deoxycorticosterone, corticosterone, and cortisol were studied during treatment with spironolactone in 8 patients with primary aldosteronism due to adenomas. Plasma renin activity (PRA), serum sodium and serum potassium were also measured. The patients were treated...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/3.7.533

    authors: Sakamoto H,Ichikawa S,Sakamaki T,Nakamura T,Ono Z,Takayama Y,Murata K

    更新日期:1990-07-01 00:00:00

  • Blood pressure, low-density lipoprotein cholesterol, and incidences of coronary artery disease and ischemic stroke in Japanese: the Suita study.

    abstract:BACKGROUND:Blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) are risk factors for coronary artery disease (CAD) and ischemic stroke. However, the hazards of their coexistence are not fully understood in Asian populations. We investigated whether the relationship between BP and cardiovascular disease (...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpu059

    authors: Tsukinoki R,Okamura T,Watanabe M,Kokubo Y,Higashiyama A,Nishimura K,Takegami M,Murakami Y,Okayama A,Miyamoto Y

    更新日期:2014-11-01 00:00:00

  • Gene polymorphism of the renin-angiotensin system associates with risk for lacunar infarction. The Ohasama study.

    abstract::The polymorphism of the angiotensin-converting enzyme gene is considered to be associated with increased risk for stroke, but there is a diversity in the results obtained. The genetic involvement of the renin-angiotensin system in stroke also remains unclear. To predict the genetic risk of lacunar infarction, we condu...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(99)00184-3

    authors: Takami S,Imai Y,Katsuya T,Ohkubo T,Tsuji I,Nagai K,Satoh H,Hisamichi S,Higaki J,Ogihara T

    更新日期:2000-02-01 00:00:00

  • Short-term antihypertensive medication does not exacerbate sleep-disordered breathing in newly diagnosed hypertensive patients.

    abstract::It has been speculated for some time that various antihypertensive medications may have a deleterious effect on respiration during sleep and thereby enhance the apparent association between hypertension and sleep apnea/hypopnea (SAH). However, there are few data to support this contention. The present study used a dou...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0895-7061(96)00507-9

    authors: Bartel PR,Loock M,Becker P,Robinson E,van der Meyden C,Rossouw S

    更新日期:1997-06-01 00:00:00

  • Adipose tissue-specific regulation of angiotensinogen in obese humans and mice: impact of nutritional status and adipocyte hypertrophy.

    abstract:BACKGROUND:The adipose tissue renin-angiotensin system (RAS) has been implicated in the pathophysiology of obesity and dysfunction of adipose tissue. However, neither regulation of angiotensinogen (AGT) expression in adipose tissue nor secretion of adipose tissue-derived AGT has been fully elucidated in humans. METHOD...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2009.263

    authors: Yasue S,Masuzaki H,Okada S,Ishii T,Kozuka C,Tanaka T,Fujikura J,Ebihara K,Hosoda K,Katsurada A,Ohashi N,Urushihara M,Kobori H,Morimoto N,Kawazoe T,Naitoh M,Okada M,Sakaue H,Suzuki S,Nakao K

    更新日期:2010-04-01 00:00:00

  • Angiotensin II subtype-1 receptor antagonists improve hemodynamic and renal changes without affecting glucose metabolisms in genetic rat model of non-insulin-dependent diabetes mellitus.

    abstract::The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is a new genetic model of non-insulin-dependent diabetes mellitus (NIDDM). We investigated whether treatment with an angiotensin II (ANGII) subtype-1 receptor antagonist delays the onset of NIDDM and attenuates diabetic nephropathy in the OLETF rat. OLETF rats fed a re...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(98)00276-3

    authors: Uehara Y,Hirawa N,Kawabata Y,Numabe A,Gomi T,Ikeda T,Omata M

    更新日期:1999-01-01 00:00:00

  • Myocardial collagen and mechanics after preventing hypertrophy in hypertensive rats.

    abstract::To determine if a remodeling of the collagen matrix would occur in the absence of hypertrophy and cell necrosis and if such a remodeling could alter active and passive stiffness of the intact myocardium, five rats with genetic hypertension (SHR) were treated (SHRT) with hydralazine for 32 weeks, beginning at four week...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/2.9.675

    authors: Narayan S,Janicki JS,Shroff SG,Pick R,Weber KT

    更新日期:1989-09-01 00:00:00

  • Effects of omapatrilat on blood pressure and renal injury in L-NAME and L-NAME plus DOCA-treated rats.

    abstract:BACKGROUND:This study investigates the effects of chronic administration of omapatrilat (OMA) on blood pressure (BP), renal injury, and other variables in N(omega)-nitro-L-arginine methyl ester (L-NAME) hypertension and in the low-renin model produced by the simultaneous administration of L-NAME and deoxycorticosterone...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(02)03144-8

    authors: Rodriguez-Gomez I,Wangensteen R,Atucha NM,O'Valle F,Del Moral RG,Garcia-Estañ J,Vargas F,Osuna A

    更新日期:2003-01-01 00:00:00

  • Plasma marinobufagenin-like and ouabain-like immunoreactivity in adrenocorticotropin-treated rats.

    abstract::Recently, an endogenous digitalis-like factor (EDLF) was shown to be stimulated in corticotropin (ACTH) hypertension in the rat. We have shown that mammalian plasma contains a vasoconstrictor Na,K-ATPase inhibitor, which cross-reacts with an antibody to amphibian EDLF, marinobufagenin. In the present experiment, the e...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(98)00042-9

    authors: Fedorova OV,Anderson DE,Bagrov AY

    更新日期:1998-07-01 00:00:00

  • Glucose metabolism and insulin receptor binding and mRNA levels in tissues of Dahl hypertensive rats.

    abstract::Increased insulinemic response to an oral glucose load has been demonstrated in Dahl salt-sensitive hypertensive rats. To determine whether this abnormality is mediated at the level of the insulin receptor, we compared insulin receptor binding and mRNA levels in tissues of Dahl salt-sensitive rats (DS) and in their no...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(97)00220-3

    authors: Sechi LA,Griffin CA,Zingaro L,Catena C,De Carli S,Schambelan M,Bartoli E

    更新日期:1997-11-01 00:00:00

  • Postpartum abnormalities of carbohydrate and cellular calcium metabolism in pregnancy induced hypertension.

    abstract::We have previously reported that young, primigravid, African-American women who developed preeclampsia exhibited insulin resistance (elevated fasting insulin:glucose ratios) and abnormal intracellular free calcium ([Ca2+]i) metabolism as early as the second trimester of pregnancy. To determine if these abnormalities p...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/6.4.302

    authors: Sowers JR,Standley PR,Jacober S,Niyogi T,Simpson L

    更新日期:1993-04-01 00:00:00

  • Effects of aging and hypertension on plasma angiotensin II and platelet angiotensin II receptor density.

    abstract::Plasma renin activity (PRA) declines with age in normal individuals, but the effect of age on plasma angiotensin II (ANG II) is less clear. A decline in plasma ANG II with age could result in altered platelet ANG II receptor density since plasma hormone levels influence their target organ receptors. To investigate thi...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/5.10.687

    authors: Duggan J,Kilfeather S,O'Brien E,O'Malley K,Nussberger J

    更新日期:1992-10-01 00:00:00

  • Hemodynamic and renal effects of indomethacin in losartan-treated hypertensive individuals.

    abstract::This study was undertaken to examine whether prostaglandin (PG) inhibition with indomethacin interferes with angiotensin II receptor blockade (losartan) during treatment for arterial hypertension. In a double-blind crossover design 10 patients with essential arterial hypertension and treated with losartan were randomi...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0895-7061(98)00228-3

    authors: Olsen ME,Thomsen T,Hassager C,Ibsen H,Dige-Petersen H

    更新日期:1999-02-01 00:00:00

  • Hypertension, pulse, and other cardiovascular risk factors and vitamin D status in Finnish men.

    abstract:BACKGROUND:Debate exists about the relationship between hypovitaminosis D and cardiovascular (CVD) risk. METHODS:This study investigated baseline (n=2,271) 25-hydroxyvitamin D (25(OH)D) and baseline and 4 year (n=1,957) CVD risk in a cohort of Finnish middle-aged male smokers. RESULTS:The prevalences of measured hype...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpt051

    authors: Ke L,Graubard BI,Albanes D,Fraser DR,Weinstein SJ,Virtamo J,Brock KE

    更新日期:2013-08-01 00:00:00

  • Ethnic differences in the identification of left ventricular hypertrophy in the hypertensive patient.

    abstract::Left ventricular hypertrophy (LVH) is more prevalent in black than white hypertensives, but this difference is greater when identified by electrocardiography (ECG) than by echocardiography. We evaluated the proposal that current ECG criteria for LVH are less specific, and therefore, less useful, in blacks than whites....

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(99)00027-8

    authors: Chapman JN,Mayet J,Chang CL,Foale RA,Thom SA,Poulter NR

    更新日期:1999-05-01 00:00:00

  • The plasma renin test reveals the contribution of body sodium-volume content (V) and renin-angiotensin (R) vasoconstriction to long-term blood pressure.

    abstract::Body sodium works together with the plasma renin-angiotensin system to ensure adequate blood flow to the tissues. Body sodium content determines the extracellular fluid (ECF) volume ensuring that, with each heart beat, a sufficient volume of fluid is delivered into the arterial space. At the same time the kidneys moni...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1038/ajh.2011.171

    authors: Laragh JH,Sealey JE

    更新日期:2011-11-01 00:00:00

  • Common genetic variations in the vitamin D pathway in relation to blood pressure.

    abstract:BACKGROUND:Vitamin D is involved in blood pressure (BP) regulation. Genetic variations may influence the effect of vitamin D on BP, but data from epidemiologic studies remain inconsistent. METHODS:We conducted a comprehensive genetic association study in the Women's Genome Health Study (WGHS) with genome-wide genotype...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,meta分析

    doi:10.1093/ajh/hpu049

    authors: Wang L,Chu A,Buring JE,Ridker PM,Chasman DI,Sesso HD

    更新日期:2014-11-01 00:00:00

  • Opposite effects of cell growth factors and cicletanine sulfate on the sodium-independent [Cl-/HCO3-] exchange in cultured vascular smooth muscle.

    abstract::Cicletanine sulfate was tested on bicarbonate-dependent pHi changes in cultured vascular smooth muscle (A10 line). Cicletanine sulfate exhibited double reactivity with regard to the cell alkalinization induced by bicarbonate uptake. The analysis of 11 concentration-response curves revealed a high reactivity component ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/6.8.674

    authors: Fanous K,Nazaret C,Senn N,Decoopman-Morin E,Allard M,Garay RP

    更新日期:1993-08-01 00:00:00

  • Brachial Pressure Control Fails to Account for Most Distending Pressure-Independent, Age-Related Aortic Hemodynamic Changes in Adults.

    abstract:BACKGROUND:Although several characteristics of aortic function, which are largely determined by age, predict outcomes beyond brachial blood pressure (BP), the extent to which brachial BP control accounts for age-related variations in aortic function is uncertain. We aimed to determine the extent to which brachial BP co...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpv140

    authors: Hodson B,Norton GR,Booysen HL,Sibiya MJ,Raymond A,Maseko MJ,Majane OH,Libhaber E,Sareli P,Woodiwiss AJ

    更新日期:2016-05-01 00:00:00

  • The influence of captopril on the epinephrine response to insulin-induced hypoglycemia in humans. The interaction between the renin-angiotensin system and the sympathetic nervous system.

    abstract::The aim of this study was to assess whether an interaction exists between the renin-angiotensin system and the sympathetic nervous system at the level of the adrenal medulla during insulin-induced hypoglycemia in normal humans. Seventeen healthy volunteers were studied in a randomized, single-dose, double-blind, cross...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ajh/5.6.361

    authors: Madsen BK,Hølmer P,Ibsen H,Christensen NJ

    更新日期:1992-06-01 00:00:00

  • Heritability of the retinal microcirculation in Flemish families.

    abstract:BACKGROUND:Few population studies have described the heritability and intrafamilial concordance of the retinal microvessels, or the genetic or environmental correlations of the phenotypes of these vessels. METHODS:We randomly selected 413 participants from 70 families (mean age, 51.5 years; 50.1% women) from a Flemish...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hps064

    authors: Liu YP,Kuznetsova T,Jin Y,Thijs L,Asayama K,Gu YM,Bochud M,Verhamme P,Struijker-Boudier HA,Staessen JA

    更新日期:2013-03-01 00:00:00

  • Impact of Uric Acid on Hypertension Occurrence and Target Organ Damage: Insights From the STANISLAS Cohort With a 20-Year Follow-up.

    abstract:BACKGROUND:Recent studies have shown that hyperuricemia may be associated with incident hypertension (HTN). We examined whether serum uric acid (SUA) is a predictor of HTN and target organ damage (TOD) 20 years later in initially healthy middle-aged individuals. METHODS:Participants from the Suivi Temporaire Annuel No...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpaa030

    authors: Kanbay M,Girerd N,Machu JL,Bozec E,Duarte K,Boivin JM,Wagner S,Ferreira JP,Zannad F,Rossignol P

    更新日期:2020-09-10 00:00:00

  • The sympathetic nervous system and long-term blood pressure regulation.

    abstract::There is considerable evidence that activation of the sympathetic nervous system plays an important role in the pathogenesis of several cardiovascular diseases, including hypertension. However, the mechanisms that account for sympathetic activation and the precise mechanisms that mediate neurally induced hypertension ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/s0895-7061(01)02082-9

    authors: Lohmeier TE

    更新日期:2001-06-01 00:00:00

  • Pretreatment blood pressure as a predictor of 21-year mortality.

    abstract::Our objective was to evaluate pretreatment predictors of longevity, particularly blood pressure, in a large cohort of hypertensive men. During 1974 to 1976, 10,367 male hypertensive veterans (47% black) were identified at screening and subsequently characterized in 32 special Veterans Administration (VA) hypertension ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(99)00214-9

    authors: Perry HM Jr,Miller JP,Baty JD,Carmody SE,Sambhi MP

    更新日期:2000-06-01 00:00:00

  • The C825T GNB3 polymorphism, independent of blood pressure, predicts cerebrovascular risk at a population level.

    abstract:BACKGROUND:The role of C825T polymorphism of the candidate GNB3 gene in predicting cerebrovascular outcome has been poorly explored in longitudinal setting at a population level. METHODS:In an epidemiological setting, 1,678 men and women from general population were genotyped for C825T polymorphism of GNB3 gene and fo...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2011.257

    authors: Casiglia E,Tikhonoff V,Boschetti G,Bascelli A,Saugo M,Guglielmi G,Caffi S,Rigoni G,Giordano N,Grasselli C,Martini B,Mazza A,De Lazzari F,Palatini P

    更新日期:2012-04-01 00:00:00

  • L-dopa and streptozotocin-induced diabetic nephropathy in rats.

    abstract::The purpose of the present study was to determine whether the physiological dopamine prodrug, L-dopa, could suppress streptozotocin-induced diabetic glomerular hyperfiltration, and thus prevent further evolution of the diabetic nephropathy. Male Wistar rats treated with streptozotocin (60 mg/kg, intravenously) rapidly...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/3.6.72s

    authors: Barthelmebs M,Vailly B,Velly J,Grima M,Imbs JL

    更新日期:1990-06-01 00:00:00

  • Sympathetic nervous control of blood pressure. Role in primary hypertension.

    abstract::After a brief historic survey, sympathetic-neurogenic contributions to the multifactorial, polygenetically linked etiology of primary (essential) hypertension are outlined towards the background of experimental findings both in various rat models and in human subjects. It is emphasized how at least some variants of bo...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/2.3.103s

    authors: Folkow B

    更新日期:1989-03-01 00:00:00

  • Social and economic factors as obstacles to blood pressure control.

    abstract::Further improvement in blood pressure control at the population level will result from dealing with hard-to-solve problems, such as access to care, long-term management of a chronic disease, and societal influences on lifestyle. Additional knowledge and experimental data are needed, reinforced by clear public health c...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(98)00082-x

    authors: Lang T

    更新日期:1998-07-01 00:00:00

  • Dietary calcium. A method of lowering blood pressure.

    abstract::Previous work in this laboratory has shown that supplemental dietary calcium using milk as the source can lower blood pressure and serum cholesterol levels. Attempting to circumvent lactose intolerance, a 6-month crossover study of blood pressure and serum lipids in 50 free-living volunteers was done comparing 1,150 m...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/1.3.149s

    authors: Bierenbaum ML,Wolf E,Bisgeier G,Maginnis WP

    更新日期:1988-07-01 00:00:00

  • Vitamin D and subsequent systolic hypertension among women.

    abstract:BACKGROUND:We examined data from a cohort of Caucasian women for evidence of an association between serum vitamin D (25-hydroxyvitamin D (25(OH)D)) insufficiency and greater risk of systolic hypertension in the population-based longitudinal Michigan Bone Health and Metabolism Study (MBHMS). METHODS:The cohort includes...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2010.226

    authors: Griffin FC,Gadegbeku CA,Sowers MR

    更新日期:2011-03-01 00:00:00