Impaired vasodilator capacity and exaggerated pressor response to isometric exercise in subjects with family history of hypertension.


:The nature of the cardiovascular response to isometric exercise is still debated. An adequate blood supply to exercising muscles at the onset of contraction seems to be an important factor controlling the extent of pressor response to isometric contraction. In comparison to normotensive subjects without familiar hypertensive history (F-), normotensive subjects with family history of hypertension (F+) have a reduced peripheral vasodilator capacity which impairs the possibility to adjust the muscular blood flow during exercise. An enhanced pressor response to handgrip test was observed in F+ and this hyperresponsivity was inversely related to the extent of forearm vasodilation capacity and largely prevented by the pretest increase of blood flow in exercising muscles. Our results suggest the importance of local vasodilating capacity as a determinant of reflex pressor response to isometric exercise.


Am J Hypertens


Borghi C,Costa FV,Boschi S,Ambrosioni E




Has Abstract


1988-07-01 00:00:00




3 Pt 3








  • Protein kinase C mediates insulin-inhibited Ca2+ transport and contraction of vascular smooth muscle.

    abstract::Insulin acutely inhibits contraction of primary cultured vascular smooth muscle (VSM) cells from canine femoral artery by inhibiting contractile agonist-induced Ca2+ influx. Insulin also inhibits contraction at step(s) distal to intracellular Ca2+ concentration (Ca2+i) by stimulating cyclic guanosine monophosphate (GM...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kahn AM,Allen JC,Seidel CL,Song T

    更新日期:2000-04-01 00:00:00

  • Effects of diabetes mellitus, pressure-overload and their association on myocardial structure and function.

    abstract:BACKGROUND:Structural and functional changes involved in cardiac injury induced by diabetes mellitus, pressure-overload, or both conditions were evaluated. METHODS:Pressure-overload was established by suprarenal aortic banding in rats. Six weeks later, diabetes was induced by streptozotocin (STZ, 65 mg/kg, intraperito...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Falcão-Pires I,Gonçalves N,Moura C,Lamego I,Eloy C,Lopes JM,Begieneman MP,Niessen HW,Areias JC,Leite-Moreira AF

    更新日期:2009-11-01 00:00:00

  • Young Scholars Award Lecture: Intratubular angiotensinogen in hypertension and kidney diseases.

    abstract::Recent findings related to the renin-angiotensin system have provided a more elaborated understanding of the pathophysiology of hypertension and kidney diseases. These findings have led to unique concepts and issues regarding the intrarenal renin-angiotensin system. Angiotensinogen is the only known substrate for reni...

    journal_title:American journal of hypertension



    authors: Kobori H,Ozawa Y,Suzaki Y,Prieto-Carrasquero MC,Nishiyama A,Shoji T,Cohen EP,Navar LG

    更新日期:2006-05-01 00:00:00

  • Albumin excretion rate and metabolic modifications in patients with essential hypertension. Effects of two angiotensin converting enzyme inhibitors.

    abstract::A prospective randomized, double-blind, double-dummy study investigated the effects of two angiotensin converting enzyme (ACE) inhibitors on urinary albumin excretion in nondiabetic patients with mild to moderate essential hypertension. At the end of a 4-week placebo run-in period, 36 patients were randomly allocated ...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Puig JG,Mateos FA,Ramos TH,Lavilla MP,Capitán MC,Gil A

    更新日期:1994-01-01 00:00:00

  • Hypertension, pulse, and other cardiovascular risk factors and vitamin D status in Finnish men.

    abstract:BACKGROUND:Debate exists about the relationship between hypovitaminosis D and cardiovascular (CVD) risk. METHODS:This study investigated baseline (n=2,271) 25-hydroxyvitamin D (25(OH)D) and baseline and 4 year (n=1,957) CVD risk in a cohort of Finnish middle-aged male smokers. RESULTS:The prevalences of measured hype...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Ke L,Graubard BI,Albanes D,Fraser DR,Weinstein SJ,Virtamo J,Brock KE

    更新日期:2013-08-01 00:00:00

  • Therapeutic benefit of captopril in salt-loaded stroke-prone spontaneously hypertensive rats is independent of hypotensive effect.

    abstract::In the present study we examined whether the angiotensin I converting enzyme inhibitor, captopril, would protect stroke-prone spontaneously hypertensive rats (SHRSP) from stroke and renal pathology over a 26-week period. In the control group of six untreated SHRSP fed Stroke-Prone Rodent Diet and 1% NaCl drinking solu...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Stier CT Jr,Chander P,Gutstein WH,Levine S,Itskovitz HD

    更新日期:1991-08-01 00:00:00

  • Likelihood ratios in the diagnosis of renal artery stenosis by magnetic resonance angiography compared with renal angiography.

    abstract:BACKGROUND:Renal angiography (RA) is considered to be the gold standard for the diagnosis of renal artery stenosis (RAS). However, it is invasive and potentially harmful; hence there is a need for an optimal noninvasive test. Magnetic resonance angiography (MRA) is currently accepted as the optimal noninvasive test by ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Attallah N,Yee J,Gutierrez A,Musial J,Parasuraman R

    更新日期:2003-12-01 00:00:00

  • Association of genetic variants in the apelin-APJ system and ACE2 with blood pressure responses to potassium supplementation: the GenSalt study.

    abstract:BACKGROUND:Genetic factors may influence blood pressure (BP) responses to dietary potassium intake. We examined the association of genetic variants in the apelin-APJ system and angiotensin-converting enzyme 2 (ACE2) with BP responses to potassium supplementation. METHODS:We conducted a 7-day potassium supplementation ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Zhao Q,Gu D,Kelly TN,Hixson JE,Rao DC,Jaquish CE,Chen J,Huang J,Chen CS,Gu CC,Whelton PK,He J

    更新日期:2010-06-01 00:00:00

  • Obese children and adolescents have elevated nighttime blood pressure independent of insulin resistance and arterial stiffness.

    abstract:BACKGROUND:Insulin resistance has been related to elevated blood pressure (BP) in obese children and may adversely affect the vasculature by arterial stiffening. The objective was to investigate whether daytime and nighttime BP were elevated and related to insulin resistance and arterial stiffness in obese children and...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Hvidt KN,Olsen MH,Holm JC,Ibsen H

    更新日期:2014-11-01 00:00:00

  • Asymmetric dimethylarginine (ADMA) has a role in regulating systemic vascular tone in young healthy subjects: the cardiovascular risk in young Finns study.

    abstract:BACKGROUND:This study was designed to evaluate whether plasma asymmetric dimethylarginine (ADMA) has any role in predicting hemodynamic responses in clinically healthy young subjects. ADMA, as an endogenous nitric oxide (NO) synthase inhibitor, has been demonstrated to associate with hypertension and vascular reactivit...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Päivä H,Kähönen M,Lehtimäki T,Raitakari OT,Jula A,Viikari J,Alfthan G,Juonala M,Laaksonen R,Hutri-Kähönen N

    更新日期:2008-08-01 00:00:00

  • Aortic pulse pressure is associated with carotid IMT in chronic kidney disease: report from Chronic Renal Insufficiency Cohort.

    abstract:BACKGROUND:Patients with chronic kidney disease (CKD) have a disproportionate risk of cardiovascular disease. This study was designed to assess the association between two noninvasive measures of cardiovascular risk, pulse wave analysis (PWA), and carotid intima-media thickness (IMT), in a cohort of CKD patients enroll...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: DeLoach SS,Appel LJ,Chen J,Joffe MM,Gadegbeku CA,Mohler ER 3rd,Parsa A,Perumal K,Rafey MA,Steigerwalt SP,Teal V,Townsend RR,Rosas SE

    更新日期:2009-12-01 00:00:00

  • Chronic hypertension leads to hyperinsulinemia in Sprague-Dawley rats treated with nitric oxide synthase inhibitor.

    abstract::Insulin resistance and hypertension, as well as dyslipidemia, frequently cooccur. Evidence that nitric oxide (NO) plays a crucial role in the long-term regulation of systolic blood pressure led us to examine whether enhanced vasoconstriction and hypertension induced by NO synthase inhibitor could lead to insulin and l...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Erlich Y,Rosenthal T

    更新日期:1998-09-01 00:00:00

  • Intracerebroventricular metformin attenuates salt-induced hypertension in spontaneously hypertensive rats.

    abstract::The aim of this study was to examine the effects of long-term continuous intracerebroventricular (icv) infusion of metformin on blood pressure (BP) in spontaneously hypertensive rats (SHR). To accelerate the development of hypertension, SHR were fed a 8% NaCl diet during the 3-week study period. Metformin was given in...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Petersen JS,Andersen D,Muntzel MS,Diemer NH,Holstein-Rathlou NH

    更新日期:2001-11-01 00:00:00

  • Relationship Between Carotid Atherosclerosis and Pulse Pressure with Renal Hemodynamics in Hypertensive Patients.

    abstract:BACKGROUND:Structural atherosclerotic damage, arterial stiffness, pulse pressure (PP), and renal hemodynamics may interact and influence each other. Renal resistance index (RRI) appears as a good indicator of systemic vascular changes. The aim of our study was to assess the independent relationships of carotid intima-m...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Geraci G,Mulè G,Costanza G,Mogavero M,Geraci C,Cottone S

    更新日期:2016-04-01 00:00:00

  • Report of the Working Party Group on Determining the Radionuclide of Choice.

    abstract::There are a variety of radiopharmaceuticals that can be used to perform captopril renography effectively. We examined a number of technetium and iodine compounds and the circumstances under which each radiopharmaceutical compound is the compound of choice. Considerations of cost, ease of use, reliability, dosage, and ...

    journal_title:American journal of hypertension

    pub_type: 共识发展会议,杂志文章,评审


    authors: Blaufox MD,Dubovsky EV,Hilson AJ,Taylor A Jr,de Zeeuw R

    更新日期:1991-12-01 00:00:00

  • Detection of arteriolar narrowing in fundoscopic examination: evidence of a low performance of direct ophthalmoscopy in comparison with a microdensitometric method.

    abstract:BACKGROUND:Retinal abnormalities, particularly arteriolar narrowing, are powerful predictors of cardiovascular events. The precision of internists and ophthalmologists in the assessment of retinal vessels widths has been disputed but not evaluated against a technology of edge detection. METHODS:Fifty-two patients with...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Maestri MM,Fuchs SC,Ferlin E,Pakter HM,Nunes G,Moraes RS,Gus M,Moreira LB,Fuchs FD

    更新日期:2007-05-01 00:00:00

  • The diagnosis of renovascular hypertension. A clinician's viewpoint.

    abstract::The sensitivity and specificity of screening and diagnostic studies for renovascular hypertension has been the focus of debate and disappointment for many years. The use of these studies has been further restricted by the insistence of clinicians that studies provide visual identification of the anatomy of the renal v...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Vidt DG

    更新日期:1991-12-01 00:00:00

  • Characterization of imidazoline-guanidinium receptive sites in renal medulla from human kidney.

    abstract::Previous studies showed that alpha 2-adrenergic receptors and imidazoline-guanidinium receptive sites (IGRS) are colocalized in rabbit and human renal proximal tubule. In the present study we investigated the localization of these two binding sites in the renal medulla from human kidney. Binding studies performed with...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Lachaud V,Limon I,Tesson F,Coupry I,Parini A

    更新日期:1992-04-01 00:00:00

  • Blood pressure percentiles in 22,051 German children and adolescents: The PEP Family Heart Study.

    abstract:BACKGROUND:Strong associations between blood pressure (BP) and overweight raise the question whether overweight children (body mass index (BMI) ≥85th percentile) should be included in the normative database. METHODS:Using the LMS (Lamda-Mu-Sigma) method, we developed age-, gender-, and height-adjusted percentile curve...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: Schwandt P,Scholze JE,Bertsch T,Liepold E,Haas GM

    更新日期:2015-05-01 00:00:00

  • Childhood predictors of high blood pressure.

    abstract::Longitudinal studies in children have tracked blood pressure through childhood and from childhood into adult life. However, many children do not maintain their rank during these periods of observation. Several of the factors contributing to maintenance of rank order are reviewed, such as initial level of blood pressur...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Mahoney LT,Clarke WR,Burns TL,Lauer RM

    更新日期:1991-11-01 00:00:00

  • Predictive value for mortality of the double product at rest obtained by home blood pressure measurement: the Ohasama study.

    abstract:BACKGROUND:To clarify whether the double product (DP) (product of systolic blood pressure (SBP) and pulse rate (PR)) at rest based on home blood pressure (HBP) measurement has prognostic value for mortality. METHODS:HBP data of 2,583 participants from a Japanese general population (40% men) ≥35 years of age (mean, 59 ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Inoue R,Ohkubo T,Kikuya M,Metoki H,Asayama K,Kanno A,Obara T,Hirose T,Hara A,Hoshi H,Totsune K,Satoh H,Kondo Y,Imai Y

    更新日期:2012-05-01 00:00:00

  • Impaired diurnal blood pressure variation and all-cause mortality.

    abstract:BACKGROUND:Most healthy people exhibit a decrease in systolic blood pressure (SBP) at night. A drop of <10% from mean daytime values, "non-dipping," is associated with kidney disease and cardiovascular events. We hypothesized that non-dipping would predict all-cause mortality. METHODS:Consecutive patients referred for...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Brotman DJ,Davidson MB,Boumitri M,Vidt DG

    更新日期:2008-01-01 00:00:00

  • Renal tissue kallikrein in newborn and young SHR.

    abstract::Since young SHR excrete less urinary kallikrein than WKY, active and total kallikrein (A and T Kall, respectively) was measured (amidolytic assay) in the renal cortex of both strains. Neither at birth nor at age 4 weeks did renal T Kall differ between SHR and WKY. Renal A Kall was significantly lower in newborn SHR an...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Ader JL,Tran-Van T,Praddaude F

    更新日期:1988-07-01 00:00:00

  • High muscle sympathetic nerve activity is associated with left ventricular dysfunction in treated hypertensive patients.

    abstract:BACKGROUND:The presence of asymptomatic left ventricular diastolic dysfunction (LVDD) in hypertensive patients can be associated with the development of cardiac events. The increase in sympathetic activity may be 1 of the mechanisms that predisposes to this outcome. In this study, we analyzed 2 hypotheses: (i) whether ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,随机对照试验


    authors: de Souza SB,Rocha JA,Cuoco MA,Guerra GM,Ferreira-Filho JC,Borile S,Krieger EM,Bortolotto LA,Consolim-Colombo FM

    更新日期:2013-07-01 00:00:00

  • Effects of gender on sympathovagal imbalance, prehypertension status, and cardiovascular risks in first-degree relatives of type 2 diabetics.

    abstract:BACKGROUND:Although cardiovascular (CV) risks are reported in first-degree relatives (FDRs) of type 2 diabetics, effects of gender on sympathovagal imbalance (SVI) and CV risks in these subjects have not been investigated. METHODS:Body mass index (BMI), blood pressure variability parameters including baroreflex sensit...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Pal GK,Adithan C,Ananthanarayanan PH,Pal P,Nanda N,Durgadevi T,Lalitha V,Syamsunder AN,Dutta TK

    更新日期:2014-03-01 00:00:00

  • Efficacy of low-dose spironolactone in subjects with resistant hypertension.

    abstract:BACKGROUND:Previous reports have demonstrated the antihypertensive efficacy of high doses of spironolactone in subjects with primary aldosteronism and, to a lesser degree, subjects with resistant hypertension. METHODS:In current analysis, we examined the antihypertensive benefit of adding low-dose spironolactone to mu...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Nishizaka MK,Zaman MA,Calhoun DA

    更新日期:2003-11-01 00:00:00

  • Effect of surgical treatment on hypertension in Cushing's syndrome.

    abstract::The effect of a surgical cure of hypercortisolism on hypertension in 54 patients with Cushing's syndrome was assessed. The correlation between preoperative duration of hypertension and posttreatment blood pressure was significant (P < .01). Restoration of normal cortisol was associated with blood pressure normalizatio...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Fallo F,Sonino N,Barzon L,Pistorello M,Pagotto U,Paoletta A,Boscaro M

    更新日期:1996-01-01 00:00:00

  • Hypertension induced by aortic coarctation above the renal arteries is associated with immune cell infiltration of the kidneys.

    abstract:BACKGROUND:Renal tubulointerstitial infiltration of activated T cells and macrophages is invariably present and plays a role in elevation of arterial pressure in nearly all animal models of hypertension (HTN). The role, if any, of elevated renal arterial pressure in the pathogenesis of this inflammatory process is unce...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Rodriguez-Iturbe B,Quiroz Y,Kim CH,Vaziri ND

    更新日期:2005-11-01 00:00:00

  • Long-term renal preservation in essential hypertension. Angiotensin converting enzyme inhibition is superior to beta-blockade.

    abstract::Antihypertensive treatment is known to slow down the decline in glomerular filtration rate (GFR) with time. Angiotensin converting enzyme (ACE) inhibition has been shown to be more effective in this regard than conventional antihypertensive therapy. In a recent prospective, randomized, double blind trial in 257 patien...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Himmelmann A,Hansson L,Hansson BG,Hedstrand H,Skogström K,Ohrvik J,Furängen A

    更新日期:1996-09-01 00:00:00

  • Inflammatory activation and left ventricular mass in essential hypertension.

    abstract:BACKGROUND:Inflammation is an independent risk factor for high blood pressure, and as a consequence inflammatory cytokines could be related with left ventricular hypertrophy (LVH). We sought to assess the association and predictive role of different cytokine levels with LVH in a group of patients with essential hyperte...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Roselló-Lletí E,Rivera M,Martínez-Dolz L,González Juanatey JR,Cortés R,Jordán A,Morillas P,Lauwers C,Calabuig JR,Antorrena I,de Rivas B,Portolés M,Bertomeu V

    更新日期:2009-04-01 00:00:00