Aortic Fibrosis, Induced by High Salt Intake in the Absence of Hypertensive Response, is Reduced by a Monoclonal Antibody to Marinobufagenin.

Abstract:

BACKGROUND:Marinobufagenin (MBG) is an endogenous Na/K-ATPase inhibitor, a natriuretic and a vasoconstrictor. MBG is implicated in salt-sensitive hypertension, cardiac hypertrophy, and initiate the pro-fibrotic signaling. Previously it was demonstrated that immunoneutralization of an endogenous MBG by 3E9 anti-MBG-antibody (mAb) in vivo lowered blood pressure (BP) and reversed cardiac fibrosis in salt-sensitive, and in partially nephrectomized rats. In the present study, we investigated whether mAb alleviates vascular remodeling induced in normotensive rats on high salt intake. METHODS:Wistar rats (5 months old) received normal (CTRL; n = 8) or high salt intake (2% NaCl in drinking water) for 4 weeks ( n = 16). Rats from the group on a high salt intake were administered vehicle (SALT; n = 8) or mAb (50 µg/kg) (SALT-AB; n = 8) during the last week of high salt diet. BP, erythrocyte Na/K-ATPase activity, levels of MBG in plasma and 24-hour urine, and sensitivity of aortic explants to the vasorelaxant effect of sodium nitroprusside (SNP) were measured. Aortic collagen abundance was determined immunohistochemically. RESULTS:In SALT vs. CTRL, heightened levels of MBG were associated with inhibition of erythrocyte Na/K-ATPase in the absence of BP changes. High salt intake was accompanied by a 2.5-fold increase in aortic collagen abundance and by a reduction of sensitivity of aortic explants to the vasorelaxant effect of SNP following endothelin-1-induced constriction. In the SALT-AB group, all NaCl-mediated effects were reversed by immunoneutralization of MBG. CONCLUSIONS:High salt intake in young normotensive rats can induce vascular fibrosis via pressure-independent/MBG-dependent mechanisms, and this remodeling is reduced by immunoneutralization of MBG.

journal_name

Am J Hypertens

authors

Grigorova YN,Juhasz O,Zernetkina V,Fishbein KW,Lakatta EG,Fedorova OV,Bagrov AY

doi

10.1093/ajh/hpv155

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

641-6

issue

5

eissn

0895-7061

issn

1941-7225

pii

hpv155

journal_volume

29

pub_type

杂志文章
  • Adrenocortical activity in the newborn spontaneously hypertensive rat.

    abstract::Blood pressure is reportedly elevated in the spontaneously hypertensive rat (SHR) neonate, the etiology of which remains unclear. Aberrations in the hypothalamic-pituitary-adrenal axis have been implicated, as it is well accepted that excess corticosteroids are associated with hypertension. We examined aspects of adre...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(99)00010-2

    authors: Malee MP,Wu KY

    更新日期:1999-05-01 00:00:00

  • Sympathetic and renin-angiotensin systems contribute to increased blood pressure in sucrose-fed rats.

    abstract:BACKGROUND:This study evaluated the effect of chronic sucrose feeding on hemodynamic parameters and renal sympathetic nervous activity. In addition, angiotensin I, II, and 1-7 levels were determined in plasma, heart, kidney, and the epididymal adipose tissue. METHODS:Male Wistar rats were treated for 30 days with 20% ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2007.01.014

    authors: Freitas RR,Lopes KL,Carillo BA,Bergamaschi CT,Carmona AK,Casarini DE,Furukawa L,Heimann JC,Campos RR,Dolnikoff MS

    更新日期:2007-06-01 00:00:00

  • Chronic local cold stress to the soles induces hypertension in rats.

    abstract::The purpose of this study was to determine whether cold-stress stimulation to the soles of paws produces continuous hypertension in rats. Wistar-Kyoto rats were kept in cages with a 0 degrees C floor and 23 degrees C room temperature (cold-stressed group, n = 10) or in cages with 23 degrees C floor and 23 degrees C ro...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(99)00144-2

    authors: Kanayama N,Khatun S,Belayet H,She L,Terao T

    更新日期:1999-11-01 00:00:00

  • Comparative Study of the Efficacy of Olmesartan/Amlodipine vs. Perindopril/Amlodipine in Peripheral and Central Blood Pressure Parameters After Missed Dose in Type 2 Diabetes.

    abstract:BACKGROUND:Central aortic blood pressure (CBP) and CBP-derived parameters are independent predictors of cardiovascular risk. Angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme inhibitors plus calcium channel blockers are the recommended first-line treatments in hypertensive diabetic patients; howe...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/ajh/hpw033

    authors: Redon J,Pichler G,Missed Dose Study Group.

    更新日期:2016-09-01 00:00:00

  • Renal macrostructure and cortical circulation in hypertension assessed by dynamic computed tomography.

    abstract::The aim of this study was to assess the macrostructure of the kidney and the grade of heterogeneity in renal cortical circulation in the early stages of essential hypertension. The subjects consisted of 84 patients (<50 years old) who underwent dynamic computed tomography (CT) because of various abdominal diseases and...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(00)01281-4

    authors: Kojima S,Shida M,Tanaka K,Takano H,Yokoyama H,Kuramochi M

    更新日期:2001-06-01 00:00:00

  • Associations of epithelial sodium channel genes with blood pressure changes and hypertension incidence: the GenSalt study.

    abstract:BACKGROUND:We examined the associations of epithelial sodium channel (ENaC) genes with blood pressure (BP) changes and hypertension incidence in a longitudinal family study. METHODS:A total of 2,755 Han Chinese participants of the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) baseline examination were eli...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpu060

    authors: Yang X,He J,Gu D,Hixson JE,Huang J,Rao DC,Shimmin LC,Chen J,Rice TK,Li J,Schwander K,Kelly TN

    更新日期:2014-11-01 00:00:00

  • Serum creatinine level in predicting the development of hypertension. Ten-year follow-up of Japanese adults in a rural community.

    abstract::In a 10-year prospective study, we investigated the utility of the serum creatinine level in predicting the development of hypertension in Japanese adults, all of whom lived in a rural community. The study included 229 subjects, 91 men and 138 women aged 30 to 69 years, who were normotensive (systolic blood pressure 1...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/7.5.390

    authors: Miura K,Nakagawa H,Nakamura H,Tabata M,Nagase H,Yoshida M,Okada A

    更新日期:1994-05-01 00:00:00

  • Retinal arteriolar narrowing and left ventricular hypertrophy in African Americans. the Atherosclerosis Risk in Communities (ARIC) study.

    abstract:BACKGROUND:Whether microvascular disease contributes to the development of left ventricular hypertrophy (LVH) is unclear. We examined the relationship of retinal microvascular signs with LVH in an African-American population. METHODS:A population-based, cross-sectional study of 1,439 middle-aged African-American parti...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2007.57

    authors: Tikellis G,Arnett DK,Skelton TN,Taylor HW,Klein R,Couper DJ,Richey Sharrett A,Yin Wong T

    更新日期:2008-03-01 00:00:00

  • Treatment of mild hypertension with urapidil or captopril.

    abstract::The aim of this study was to compare the efficacy (lowering diastolic blood pressure to 90 mm Hg or less) of urapidil, a postsynaptic alpha-blocker with central action with that of captopril in a randomized, double-blind, multicenter study. Two hundred ninety-five essential hypertensives (WHO I/II) (140 male, 155 fema...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ajh/1.3.233s

    authors: Rosenthal J,Schäfer N,Haerlin R,Wurst W,Solleder P

    更新日期:1988-07-01 00:00:00

  • Recommendations for special populations: diabetes mellitus and the metabolic syndrome.

    abstract::Cardiovascular diseases (CVD) are the major causes of mortality in persons with diabetes, and many factors, including hypertension, contribute to this high prevalence of CVD. The incidence of hypertension in patients with diabetes is approximately twofold higher than in age-matched subjects without the disease, and co...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/j.amjhyper.2003.07.009

    authors: Sowers JR

    更新日期:2003-11-01 00:00:00

  • Role of Nitric Oxide Synthase on Blood Pressure Regulation and Vascular Function in Pregnant Rats on a High-Fat Diet.

    abstract:BACKGROUND:While obesity is a leading risk factor for preeclampsia, the mechanisms whereby obese women are more susceptible to pregnancy-induced hypertension are unclear. As high-fat diet (HFD) is an important contributor to the development of obesity, we tested the hypothesis that pregnant rats on HFD have hypertensio...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpw153

    authors: Palei AC,Spradley FT,Granger JP

    更新日期:2017-03-01 00:00:00

  • PTH Is a Promising Auxiliary Index for the Clinical Diagnosis of Aldosterone-Producing Adenoma.

    abstract:BACKGROUND:Parathyroid hormone (PTH) stimulates aldosterone secretion in human adrenocortex and is regulated by the renin-angiotensin-aldosterone system. We speculated that measurement of PTH may be a valuable aid in the diagnosis of aldosterone-producing adenoma (APA). METHODS:To test this hypothesis, we recruited 14...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpv146

    authors: Zhang LX,Gu WJ,Li YJ,Wang Y,Wang WB,Wang AP,Shen L,Zang L,Yang GQ,Lu ZH,Dou JT,Mu YM

    更新日期:2016-05-01 00:00:00

  • Interdependence of blood pressure and heart period regulation in mild hypertension.

    abstract::Blood pressure and heart period variability have been measured directly in 142 subjects with mild hypertension over 24 h. The variabilities have been expressed as the standard deviation of 2 min averages of all beats over 24 h. Baroreflex sensitivity was assessed in 102 subjects by the phenylephrine method. Blood pres...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/4.3.234

    authors: Coats AJ,Conway J,Sleight P,Meyer TE,Somers VK,Floras JS,Vann Jones J

    更新日期:1991-03-01 00:00:00

  • Different normalizations for body size and population attributable risk of left ventricular hypertrophy: the MAVI study.

    abstract:BACKGROUND:Different methods of normalizing left ventricular (LV) mass for body size identify generally similar relative risks of adverse cardiovascular outcome but with variable prevalences of LV hypertrophy (H). Preliminary results from a population with high prevalence of obesity suggest that the population attribut...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.amjhyper.2005.05.027

    authors: de Simone G,Devereux RB,Maggioni AP,Gorini M,de Divitiis O,Verdecchia P,MAVI (MAssa Ventricolare sinistra nell'Ipertensione) Study Group.

    更新日期:2005-10-01 00:00:00

  • Age is a major determinant of the divergent blood pressure responses to varying salt intake in essential hypertension.

    abstract::Blood pressure responses to 1 week of low (20 mmol sodium/day) and high (300 mmol sodium/day) salt intake were investigated in a double-blind, randomized study in 46 white, nonobese subjects with essential hypertension (13 women, 33 men; mean age 45.3 +/- 2.2 years, age range 25 to 80 years). The individuals were clas...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0895-7061(95)00213-9

    authors: Overlack A,Ruppert M,Kolloch R,Kraft K,Stumpe KO

    更新日期:1995-08-01 00:00:00

  • Endocrine and renal effects of nifedipine gastrointestinal therapeutic system in patients with essential hypertension. Results of a multicenter trial. The Modern Approach to the Treatment of Hypertension Study Group.

    abstract::Use of thiazide diuretics and beta-blockers in the treatment of hypertension may result in metabolic derangements and/or disturbances in the parameters of renal function, which offset the benefits of blood pressure reduction by adversely affecting other cardiovascular risk factors, particularly in special patient grou...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Tuck ML,Bravo EL,Krakoff LR,Friedman CP

    更新日期:1990-12-01 00:00:00

  • Association of central aortic pressures indexes with development of diabetes mellitus in essential hypertension.

    abstract:BACKGROUND:Diabetes mellitus (DM) and hypertension (HT) frequently coexist. Increased central aortic pressures indexes are associated with HT; however, possible associations of these indexes with future development of DM have never been studied in HT. METHODS:We recruited 178 patients with uncomplicated nondiabetic HT...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2010.145

    authors: Chen JY,Chou CH,Lee YL,Tsai WC,Lin CC,Huang YY,Chen JH

    更新日期:2010-10-01 00:00:00

  • Hemodynamic and endocrine responsiveness to mental arithmetic task and mirror drawing test in patients with essential hypertension.

    abstract::To evaluate the reactivity to psychological stress in patients with essential hypertension we investigated hemodynamic and endocrinologic changes during a mental arithmetic task (MAT) and a mirror drawing test (MDT) in 10 hypertensive subjects. Hemodynamic changes were assessed continuously using an ambulatory radionu...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0895-7061(96)00382-2

    authors: Yoshiuchi K,Nomura S,Ando K,Ohtake T,Shimosawa T,Kumano H,Kuboki T,Suematsu H,Fujita T

    更新日期:1997-03-01 00:00:00

  • Measurement of central systolic blood pressure by pulse volume plethysmography with a noninvasive blood pressure monitor.

    abstract:BACKGROUND:Central systolic blood pressure (SBP) can be estimated by an oscillometric method developed from a pulse volume plethysmography (PVP) device. The present study applied this novel method to a noninvasive blood pressure monitor (NBPM). METHODS:We enrolled 50 patients (37 men, age range 30-84 years) referred f...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2011.259

    authors: Sung SH,Cheng HM,Chuang SY,Shih YT,Wang KL,Chen YH,Lin SJ,Yu WC,Chen CH

    更新日期:2012-05-01 00:00:00

  • L-dopa and streptozotocin-induced diabetic nephropathy in rats.

    abstract::The purpose of the present study was to determine whether the physiological dopamine prodrug, L-dopa, could suppress streptozotocin-induced diabetic glomerular hyperfiltration, and thus prevent further evolution of the diabetic nephropathy. Male Wistar rats treated with streptozotocin (60 mg/kg, intravenously) rapidly...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/3.6.72s

    authors: Barthelmebs M,Vailly B,Velly J,Grima M,Imbs JL

    更新日期:1990-06-01 00:00:00

  • The Case for Low Blood Pressure Targets.

    abstract::The "totality" of hypertension clinical trial endpoint data has shown that the absolute benefit of pharmacological blood pressure (BP) lowering is directly related to the BP level and baseline cardiovascular risk, albeit with attenuation of the relative risk reduction per unit of BP lowering in patients with diabetes ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/hpw087

    authors: Flack JM,Nolasco C,Levy P

    更新日期:2017-01-01 00:00:00

  • Association of Orthostatic Hypotension Timing With Clinical Events in Adults With Diabetes and Hypertension: Results From the ACCORD Trial.

    abstract:OBJECTIVE:To determine the effects of orthostatic hypotension (OH) measurement timing on its associations with dizziness, falls, fractures, cardiovascular disease (CVD), and mortality. METHODS:We analyzed OH measurements from the Action to Control Cardiovascular Risk in Diabetes BP trial, which evaluated two blood pre...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpz015

    authors: Juraschek SP,Lipsitz LA,Beach JL,Mukamal KJ

    更新日期:2019-06-11 00:00:00

  • Effects of aging and hypertension on plasma angiotensin II and platelet angiotensin II receptor density.

    abstract::Plasma renin activity (PRA) declines with age in normal individuals, but the effect of age on plasma angiotensin II (ANG II) is less clear. A decline in plasma ANG II with age could result in altered platelet ANG II receptor density since plasma hormone levels influence their target organ receptors. To investigate thi...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/5.10.687

    authors: Duggan J,Kilfeather S,O'Brien E,O'Malley K,Nussberger J

    更新日期:1992-10-01 00:00:00

  • The C825T GNB3 polymorphism, independent of blood pressure, predicts cerebrovascular risk at a population level.

    abstract:BACKGROUND:The role of C825T polymorphism of the candidate GNB3 gene in predicting cerebrovascular outcome has been poorly explored in longitudinal setting at a population level. METHODS:In an epidemiological setting, 1,678 men and women from general population were genotyped for C825T polymorphism of GNB3 gene and fo...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2011.257

    authors: Casiglia E,Tikhonoff V,Boschetti G,Bascelli A,Saugo M,Guglielmi G,Caffi S,Rigoni G,Giordano N,Grasselli C,Martini B,Mazza A,De Lazzari F,Palatini P

    更新日期:2012-04-01 00:00:00

  • Association of Post-Saline Load Plasma Aldosterone Levels With Left Ventricular Hypertrophy in Primary Hypertension.

    abstract:BACKGROUND:Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular morbidity in hypertension. Current evidence suggests a contribution to LVH of plasma aldosterone levels that are inappropriately elevated for the salt status. The aim of this study was to investigate whether inappropriate mod...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpv104

    authors: Catena C,Verheyen ND,Url-Michitsch M,Kraigher-Krainer E,Colussi G,Pilz S,Tomaschitz A,Pieske B,Sechi LA

    更新日期:2016-03-01 00:00:00

  • Increasing prevalence of hypertension among patients with thoracic aorta dissection: trends over eight decades--a structured meta-analysis.

    abstract:BACKGROUND:This structured metaanalysis focused on determining the relationship between hypertension (HTN) and thoracic aortic dissection (TAD). METHODS:Electronic searches were conducted using the MedLine database, for the period 1946 through May 2013, and manual searches from reference lists. Demographic data, patie...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,meta分析

    doi:10.1093/ajh/hpt293

    authors: Chan KK,Rabkin SW

    更新日期:2014-07-01 00:00:00

  • Blood pressure response to dietary calcium intervention in humans.

    abstract::Epidemiological and experimental studies have suggested that dietary calcium deficiency may lead to the development of hypertension. This article reviews findings in human trials on calcium intervention with special reference to the responses of blood pressure and biochemical variables. Calcium supplementation consist...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/3.8.147

    authors: Mikami H,Ogihara T,Tabuchi Y

    更新日期:1990-08-01 00:00:00

  • Birth measurements, family history, and environmental factors associated with later-life hypertensive status.

    abstract:BACKGROUND:This birth cohort study was conducted to investigate the contribution of prenatal and antenatal environmental exposures to later-life hypertensive status. METHODS:Two thousand five hundred and three individuals born in 1921-1954 at the Peking Union Medical College Hospital (PUMCH) were targeted; 2,081 (83.1...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2011.262

    authors: Chen X,Zhang ZX,George LK,Wang ZS,Fan ZJ,Xu T,Zhou XL,Han SM,Wen HB,Zeng Y

    更新日期:2012-04-01 00:00:00

  • Blood pressure and cognitive functioning among independent elderly.

    abstract:BACKGROUND:The morbidity and mortality benefits of blood pressure (BP) control for the elderly is well documented. The cognitive consequences of hypertension control in this population, however, are still under debate. We aim to study the association between BP and cognitive performance in the elderly. Specifically, we...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(03)01005-7

    authors: Paran E,Anson O,Reuveni H

    更新日期:2003-10-01 00:00:00

  • Blood flow pattern in the middle cerebral artery in relation to indices of arterial stiffness in the systemic circulation.

    abstract:BACKGROUND:The brain is perfused at high-volume flow throughout systole and diastole. We explored the association of blood flow in the middle cerebral artery (MCA) with the pulsatile components of blood pressure in the systemic circulation and indices of arterial stiffness. METHODS:We enrolled 334 untreated subjects (...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2011.223

    authors: Xu TY,Staessen JA,Wei FF,Xu J,Li FH,Fan WX,Gao PJ,Wang JG,Li Y

    更新日期:2012-03-01 00:00:00