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B-type natriuretic Peptide is associated with both augmentation index and left ventricular mass in diabetic patients without heart failure.

Abstract：

BACKGROUND:B-type natriuretic peptide (BNP) increases the risk of death and cardiovascular events in patients without heart failure, even at BNP values within the "normal" range. The reasons for this are unclear. METHODS:We performed two separate studies (n = 33 and n = 129) on subjects with type 2 diabetes mellitus in whom frank left ventricular systolic dysfunction had been excluded to ascertain whether a high-normal BNP could be identifying either greater augmentation of the ascending aortic pressure wave, increased left ventricular mass, or a subtly lower left ventricular ejection fraction (but within the normal range). RESULTS:Our results demonstrate that an increased augmentation index is an independent predictor of BNP levels even when BNP levels are within the normal range (P = .006 in study one and P = .007 in study two). A high-normal BNP also correlated with increased left ventricular mass and (P = .021) with a subtly lower left ventricular ejection fraction (P < .001). CONCLUSIONS:We found that high-normal BNP levels identified increased augmentation of the ascending aortic pressure wave as well as subtle left ventricular abnormalities.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Dawson A,Davies JI,Morris AD,Struthers AD

doi

10.1016/j.amjhyper.2005.06.016

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

1586-91

issue

12 Pt 1

eissn

0895-7061

issn

1941-7225

pii

S0895-7061(05)01053-8

journal_volume

18

pub_type

杂志文章

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