Abstract:
:The sensitivity and specificity of screening and diagnostic studies for renovascular hypertension has been the focus of debate and disappointment for many years. The use of these studies has been further restricted by the insistence of clinicians that studies provide visual identification of the anatomy of the renal vasculature. Digital subtraction angiography continues to provide an increasingly attractive alternative offering visualization of the renal arteries. Reevaluation of screening and diagnostic studies is needed to determine their potential value, particularly in patients with atherosclerotic renovascular disease and renal insufficiency and in assessing the potential salvability of the ischemic kidney.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Vidt DGdoi
10.1093/ajh/4.12.663ssubject
Has Abstractpub_date
1991-12-01 00:00:00pages
663S-668Sissue
12 Pt 2eissn
0895-7061issn
1941-7225journal_volume
4pub_type
杂志文章,评审abstract::We have explored the effect of verapamil on renal hemodynamics and the renin-aldosterone system in ten patients with chronic renal disease and hypertension before and after 3 months of therapy. The mean +/- SEM glomerular filtration rates were 55 +/- 7 mL/min pre- and 55 +/- 8 mL/min posttherapy; the renal plasma flow...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/4.12.939
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors and calcium channel blockers (CCBs) increase arterial compliance and decrease left ventricular mass in hypertensive patients. This study examined whether combined therapy has greater arterial and cardiac effects than doubled doses of the individual drugs. METHO...
journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.amjhyper.2003.08.002
更新日期:2004-01-01 00:00:00
abstract::The results of our previous studies suggested that endothelin-1 (ET-1) might be contributory to the impaired uteroplacental blood flow seen in preeclampsia. The aim of this study was to investigate the in vitro influence of isradipine on ET-1-induced contraction of myometrial resistance arteries from pregnant women, a...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/7.7.50s
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:The independent prognostic significance of the metabolic syndrome (MetS) in the elderly is not yet clear. We investigated the association between MetS and cardiovascular risk (composite endpoint of stroke and coronary events) in elderly treated hypertensive patients. METHODS:Cardiovascular outcome was evalu...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpv121
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:A successful weight loss program is essential treatment for obesity-related diseases, but it is well known that the majority of individuals do not succeed in weight loss maintenance. The present study evaluates hormonal mechanisms and the relationship of beta2-adrenoceptor polymorphisms involved in individua...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2005.05.006
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:High waist circumference (WC) (women: >88 cm; men: >102 cm) increases cardiovascular risk. Less is known about moderate WC (women: 80-88 cm; men: 94-102 cm). Therefore, we examined the association between moderate WC and hypertension prevalence, independent of body mass index (BMI). METHODS:Among 24,247 eli...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2010.258
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Obesity has been described as a predictor of cardiovascular mortality, and some studies have reported an association with obesity and increased aortic stiffness. Other studies have not identified obesity to be an independent risk factor. Therefore, the purpose of our study was to determine the association be...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2012.91
更新日期:2012-10-01 00:00:00
abstract::The process whereby a physician explains to the ill patient what has gone wrong and what can be done about it can be taught and evaluated by simulated patients (SPIs). This study was designed to determine whether a training experience in educating a diabetic SPI improves subsequent performance with a hypertensive SPI....
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(98)00034-x
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:Nocturnal hypertension is an important phenotype of abnormal diurnal blood pressure (BP) variability and a known risk marker for target organ damage and cardiovascular events. This study aimed to assess the differential BP-lowering effects of esaxerenone vs. eplerenone on nocturnal BP in hypertensive patient...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpaa155
更新日期:2020-11-09 00:00:00
abstract:BACKGROUND:The aim was to determine the proportions and correlates of essential hypertension among children in a tertiary pediatric hypertension clinic. METHODS:We evaluated 423 consecutive children and collected demographic and clinical history by retrospective chart review. RESULTS:We identified 275 (65%) hypertens...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpu083
更新日期:2015-01-01 00:00:00
abstract::Angiotensin receptors became relatively easy to study when radioactive derivatives of the peptide were synthesized for radioimmunoassays. Binding assays in vitro led to the discovery of receptors in many tissues different from those involved in the classic actions of angiotensin. The physiologic significance of recept...
journal_title:American journal of hypertension
pub_type: 历史文章,杂志文章
doi:10.1016/s0895-7061(99)00212-5
更新日期:2000-04-01 00:00:00
abstract::The purpose of this study has been to test the hypothesis of an alpha 2-adrenoreceptor alteration in human essential hypertension. The design of the study involved the oral administration of 10 mg yohimbine, an alpha 2-adrenergic antagonist, to 25 healthy volunteers and 29 sex- and age-matched untreated hypertensive p...
journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0895-7061(95)00037-P
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:Apelin is an adipokine directly associated with adiposity, insulin resistance, and decreased blood pressure. Urinary 8-isoprostane is a marker of chronic oxidative endothelial stress. Visfatin, an adipokine that acts by binding and activating the insulin receptor, has been associated with hypertension. As se...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpw007
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Hypertension has recently been identified as the leading risk factor for global mortality. This study aims to present the national prevalence of hypertension and prehypertension and, their determinants in Vietnamese adults. METHODS:Nationally representative data were obtained from the National Adult Overwei...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpu092
更新日期:2015-01-01 00:00:00
abstract::The nonpeptide angiotensin II (AII)-receptor antagonist losartan is a selective blocker of the pressor effects of AII. It is now being evaluated as an anti-hypertensive drug in multicenter clinical trials in the United States and other countries. Preliminary inpatient studies have shown that after 5 days of treatment,...
journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1093/ajh/5.12.247s
更新日期:1992-12-01 00:00:00
abstract::Primary investigators of randomized drug trials in hypertension were invited to rate quality of such trials. The intention of the survey was to ask if antihypertensive drug therapy reduces incidence of coronary heart disease (CHD) in hypertensive patients. Response was obtained for 7 of the 11 invited investigators, c...
journal_title:American journal of hypertension
pub_type: 杂志文章,meta分析
doi:10.1093/ajh/7.8.703
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:The reduction of coronary flow reserve (CFR) found in arterial hypertension may be due to changes in afterload, left ventricular (LV) structure, and metabolic factors. Also, insulin-like growth factor-1 (IGF-1) may be associated with the magnitude of CFR in relation to its modulating action on cardiac and en...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(02)02967-9
更新日期:2002-09-01 00:00:00
abstract::Although left ventricular hypertrophy (LVH) is an adaptive response to the increased load imposed on the heart in patients with hypertension, it ultimately is itself a major risk factor for cardiovascular disease. The influence of LVH on left ventricular function and on the coronary circulation, and the occurrence of ...
journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1093/ajh/6.3.14s
更新日期:1993-03-01 00:00:00
abstract::Ambulatory blood pressure (BP) and heart rate (HR) were measured in a physically fit, normotensive postmenopausal African American woman, before and after 15 weeks of aerobic training. Mean BP, HR, and HR variability were normal at the outset and were further improved by training. Training had no effect on circadian B...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(02)02973-4
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Recently, some investigators have shown that telmisartan, an angiotensin II (Ang II)-receptor blocker (ARB), is a partial agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma). We investigate whether telmisartan improves cardiovascular remodeling associated with the production of endot...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.27
更新日期:2008-05-01 00:00:00
abstract::A prospective randomized, double-blind, double-dummy study investigated the effects of two angiotensin converting enzyme (ACE) inhibitors on urinary albumin excretion in nondiabetic patients with mild to moderate essential hypertension. At the end of a 4-week placebo run-in period, 36 patients were randomly allocated ...
journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1093/ajh/7.1.46
更新日期:1994-01-01 00:00:00
abstract::The aim of this study was to assess the contribution of physical activity levels to blood pressure (BP) variability, and to assess the effect age, gender, body mass index, and use of antihypertensive medications on this relationship. We simultaneously monitored 24-h ambulatory BP by automated recorder and activity by ...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(00)01186-9
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:It is known that essential hypertension may be implicated in the development of cognitive impairment that is associated to microvascular disease of the brain. It has been hypothesized that increased arterial stiffness of the large arteries may lead to microvascular changes due to increased pulsatile flow. Ou...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2009.35
更新日期:2009-05-01 00:00:00
abstract::In a 10-year prospective study, we investigated the utility of the serum creatinine level in predicting the development of hypertension in Japanese adults, all of whom lived in a rural community. The study included 229 subjects, 91 men and 138 women aged 30 to 69 years, who were normotensive (systolic blood pressure 1...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/7.5.390
更新日期:1994-05-01 00:00:00
abstract::This study examined the role of the lipoxygenase (LO) pathway in the maintenance of hypertension in rats with two-kidney, one clip (2K,1C) Goldblatt hypertension. A single dose of the lipoxygenase blocker phenidone was injected intraperitoneally to 2K,1C rats during the early phase (14 days) of the development of hype...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/2.11.853
更新日期:1989-11-01 00:00:00
abstract::Medical literature that has coalesced during the past two to three decades has identified adequate intake of nutrients from dairy foods as a common factor in the reduction of the disease burden of several common medical conditions. These include obesity, hypertension, type 2 diabetes, osteoporosis, kidney stones, cert...
journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1016/j.amjhyper.2003.08.008
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Obesity is a risk factor for the development of cardiovascular diseases that are associated with impaired angiogenesis. Nifedipine, a calcium-channel blocker, has a number of blood pressure (BP)-independent effects as well, such as improving endothelial function and decreasing oxidative stress. Here, we inve...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2011.239
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:We investigated the effects of percutaneous transluminal renal angioplasty on left ventricular (LV) mass, and the impact of LV mass reduction on outcomes. METHODS:A total of 144 hypertensive patients with renal artery stenosis (RAS) (mean age 69 years; 22.2% fibromuscular dysplasia (FMD)) who underwent angi...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpaa036
更新日期:2020-05-21 00:00:00
abstract::The "totality" of hypertension clinical trial endpoint data has shown that the absolute benefit of pharmacological blood pressure (BP) lowering is directly related to the BP level and baseline cardiovascular risk, albeit with attenuation of the relative risk reduction per unit of BP lowering in patients with diabetes ...
journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1093/ajh/hpw087
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Activation of RhoA/Rho kinase (ROK) pathway by angiotensin II (Ang II) is involved in the pathophysiology of hypertension and remodeling. In Bartter's and Gitelman's syndrome (BS/GS), the short-term and long-term signaling of Ang II are blunted. The BS/GS have also reduced expression and response on Ang II c...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2005.03.747
更新日期:2005-09-01 00:00:00