当前位置： SCI文献检索 > AMERICAN JOURNAL OF HYPERTENSION期刊下所有文献 > Fibrinolytic/hemostatic variables in arterial hypertension: response to treatment with irbesartan or atenolol.

Fibrinolytic/hemostatic variables in arterial hypertension: response to treatment with irbesartan or atenolol.

Abstract：

:Essential hypertension is often accompanied by abnormalities of the coagulation/fibrinolytic system, predisposing to a procoagulant state. The aim of the present study was to compare the effects of atenolol (beta1-blocker agent) and irbesartan (angiotensin II type 1 receptor antagonist) on plasma levels of hemostatic/fibrinolytic and endothelial function markers in a cohort of previously untreated hypertensives. Fifty-four patients were randomly assigned to atenolol 25 to 150 mg (26 patients) or irbesartan 75 to 300 mg (28 patients). The plasma levels of plasminogen activator inhibitor-1 antigen, thrombomodulin, tissue factor pathway inhibitor antigen, fibrinogen, and factor XII were determined before and after 6 months of therapy. Age, gender distribution, body mass index, lipid profile, and baseline values of the measured markers were similar in both groups. Baseline values for systolic and diastolic blood pressure, as well as the reduction after treatment, were not significantly different between the two groups. Treatment with irbesartan was associated with a significant decrease in the levels of all the parameters. Similar findings were observed in the atenolol group, except for factor XII and tissue factor pathway inhibitor levels, which were not significantly decreased in this group. The reduction, however, of fibrinogen, plasminogen activator inhibitor-1, and thrombomodulin was significantly greater in the irbesartan than in the atenolol group. In conclusion, the results indicated that, despite an equally controlled blood pressure, 6-month therapy with irbesartan was associated with a more favorable modification of hemostatic/fibrinolytic status than atenolol.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Makris TK,Stavroulakis GA,Krespi PG,Hatzizacharias AN,Triposkiadis FK,Tsoukala CG,Votteas VV,Kyriakidis MK

doi

10.1016/s0895-7061(00)00262-4

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

783-8

issue

7

eissn

0895-7061

issn

1941-7225

pii

S0895-7061(00)00262-4

journal_volume

13

pub_type

临床试验,杂志文章

相关文献

AMERICAN JOURNAL OF HYPERTENSION文献大全
  • Aging and hypertension are independent risk factors for reduced number of circulating endothelial progenitor cells.

    abstract：BACKGROUND:Recent studies have revealed the existence of bone marrow-derived endothelial progenitor cells (EPCs). The number of circulating EPCs might reflect the pathogenesis of atherosclerosis and progression of cardiovascular diseases (CVDs). The purpose of this study was to evaluate the relationship between the num...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2008.278

    authors： Umemura T,Soga J,Hidaka T,Takemoto H,Nakamura S,Jitsuiki D,Nishioka K,Goto C,Teragawa H,Yoshizumi M,Chayama K,Higashi Y

    更新日期：2008-11-01 00:00:00

  • Predictive value for mortality of the double product at rest obtained by home blood pressure measurement: the Ohasama study.

    abstract：BACKGROUND:To clarify whether the double product (DP) (product of systolic blood pressure (SBP) and pulse rate (PR)) at rest based on home blood pressure (HBP) measurement has prognostic value for mortality. METHODS:HBP data of 2,583 participants from a Japanese general population (40% men) ≥35 years of age (mean, 59 ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2012.3

    authors： Inoue R,Ohkubo T,Kikuya M,Metoki H,Asayama K,Kanno A,Obara T,Hirose T,Hara A,Hoshi H,Totsune K,Satoh H,Kondo Y,Imai Y

    更新日期：2012-05-01 00:00:00

  • Ambulatory--not office--blood pressures decline during hormone replacement therapy in healthy postmenopausal women.

    abstract：:Hormone replacement therapy (HRT, estrogen plus progestagen) in postmenopausal women has beneficial effects on the cardiovascular system. However, effects on blood pressure, determined with office measurements, remain controversial. We studied the effects of HRT in 29 healthy normotensive postmenopausal women (mean ag...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0895-7061(98)00165-4

    authors： van Ittersum FJ,van Baal WM,Kenemans P,Mijatovic V,Donker AJ,van der Mooren MJ,Stehouwer CD

    更新日期：1998-10-01 00:00:00

  • Association of Orthostatic Hypotension Timing With Clinical Events in Adults With Diabetes and Hypertension: Results From the ACCORD Trial.

    abstract：OBJECTIVE:To determine the effects of orthostatic hypotension (OH) measurement timing on its associations with dizziness, falls, fractures, cardiovascular disease (CVD), and mortality. METHODS:We analyzed OH measurements from the Action to Control Cardiovascular Risk in Diabetes BP trial, which evaluated two blood pre...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpz015

    authors： Juraschek SP,Lipsitz LA,Beach JL,Mukamal KJ

    更新日期：2019-06-11 00:00:00

  • Validity of plasma aldosterone-to-renin activity ratio in African American and white subjects with resistant hypertension.

    abstract：BACKGROUND:Recent reports suggesting that primary aldosteronism (PA) is more common than historically thought have often relied on use of the plasma aldosterone concentration (PAC) to plasma renin activity (PRA) ratio (ARR) to identify patients with PA. Prior determinations of the validity of the ARR had been generally...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2005.01.002

    authors： Nishizaka MK,Pratt-Ubunama M,Zaman MA,Cofield S,Calhoun DA

    更新日期：2005-06-01 00:00:00

  • Paraoxonase 1 (PON1) C/T-108 association with longitudinal mean arterial blood pressure.

    abstract：BACKGROUND:Blood pressure is a complex quantitative trait with a strong genetic component. In this study, we leveraged the Veterans Affairs electronic medical record system to explore the relationship between Paraoxonase 1 (PON1)-108 C/T (rs705379) and mean arterial blood pressure (MAP). METHODS:Outpatient blood press...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2012.106

    authors： Bhatnagar V,Liu L,Nievergelt CM,Richard E,Brophy VH,Pandey B,Lipkowitz MS,O'Connor DT

    更新日期：2012-11-01 00:00:00

  • Increased Circulating Visfatin Is Associated With Progression of Kidney Disease in Non-Diabetic Hypertensive Patients.

    abstract：BACKGROUD:Declining renal function is an independent risk factor for all-cause mortality in cardiovascular disease. Visfatin has been described as a marker of inflammation and endothelial dysfunction, but whether circulating visfatin levels are predictive to a subsequent decline in renal function remains unclear. METH...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpv132

    authors： Hsu CY,Huang PH,Chen TH,Chiang CH,Leu HB,Huang CC,Chen JW,Lin SJ

    更新日期：2016-04-01 00:00:00

  • Blood pressure and metabolic responses to moderate sodium restriction in isradipine-treated hypertensive patients.

    abstract：:This multicenter, randomized, controlled clinical trial assessed the influence of sodium chloride intake on the antihypertensive effect of the calcium channel blocker isradipine. Participants with uncomplicated hypertension controlled by isradipine entered a 4-week sodium-restricted (60 to 80 mmol/24 h) period. Partic...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0895-7061(96)00295-6

    authors： McCarron DA,Weder AB,Egan BM,Krishna GG,Morris CD,Cohen M,Oparil S

    更新日期：1997-01-01 00:00:00

  • Impaired vasodilator capacity and exaggerated pressor response to isometric exercise in subjects with family history of hypertension.

    abstract：:The nature of the cardiovascular response to isometric exercise is still debated. An adequate blood supply to exercising muscles at the onset of contraction seems to be an important factor controlling the extent of pressor response to isometric contraction. In comparison to normotensive subjects without familiar hyper...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/1.3.106s

    authors： Borghi C,Costa FV,Boschi S,Ambrosioni E

    更新日期：1988-07-01 00:00:00

  • Home blood pressure level, blood pressure variability, smoking, and stroke risk in Japanese men: the Ohasama study.

    abstract：BACKGROUND:Hypertension and smoking independently contribute to the risk of stroke. Our objective was to investigate home blood pressure (HBP) levels, day-by-day BP variability, and smoking in the prediction of stroke in Japanese men. METHODS:In this study, 902 men (mean age, 58.6 years) without a past history of stro...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2012.62

    authors： Hashimoto T,Kikuya M,Ohkubo T,Satoh M,Metoki H,Inoue R,Asayama K,Kanno A,Obara T,Hirose T,Hara A,Hoshi H,Totsune K,Satoh H,Sato H,Imai Y

    更新日期：2012-08-01 00:00:00

  • Myocardial collagen and mechanics after preventing hypertrophy in hypertensive rats.

    abstract：:To determine if a remodeling of the collagen matrix would occur in the absence of hypertrophy and cell necrosis and if such a remodeling could alter active and passive stiffness of the intact myocardium, five rats with genetic hypertension (SHR) were treated (SHRT) with hydralazine for 32 weeks, beginning at four week...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/2.9.675

    authors： Narayan S,Janicki JS,Shroff SG,Pick R,Weber KT

    更新日期：1989-09-01 00:00:00

  • Differentiation and growth of vascular smooth muscle cells in experimental hypertension.

    abstract：:In this review we have analyzed the present knowledge about the differentiation and growth processes in vascular smooth muscle cells (SMC) in hypertension. The study of smooth muscle (SM) and nonmuscle (NM) myosin isoform expression has permitted us to identify a three-stage specific maturational pathway, namely, feta...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/7.7.661

    authors： Pauletto P,Sarzani R,Rappelli A,Chiavegato A,Pessina AC,Sartore S

    更新日期：1994-07-01 00:00:00

  • Relationships among hyperuricemia, metabolic syndrome, and endothelial function.

    abstract：BACKGROUND:We evaluated the relationship of the severity of hyperuricemia and the flow-mediated vasodilatation of the brachial artery (FMD) in patients with and without the metabolic syndrome (MetS). METHODS:In a cross-sectional study, FMD was obtained in 2,732 Japanese healthy men (49 ± 8 years) who had no cardiovasc...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2011.55

    authors： Tomiyama H,Higashi Y,Takase B,Node K,Sata M,Inoue T,Ishibashi Y,Ueda S,Shimada K,Yamashina A

    更新日期：2011-07-01 00:00:00

  • The sympathetic nervous system and long-term blood pressure regulation.

    abstract：:There is considerable evidence that activation of the sympathetic nervous system plays an important role in the pathogenesis of several cardiovascular diseases, including hypertension. However, the mechanisms that account for sympathetic activation and the precise mechanisms that mediate neurally induced hypertension ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/s0895-7061(01)02082-9

    authors： Lohmeier TE

    更新日期：2001-06-01 00:00:00

  • Barriers to hypertension care and control in young urban black men.

    abstract：:Barriers to high blood pressure (HBP) care and control have been reported in the literature for > 30 years. Few reports on barriers, however, have focused on the young black man with HBP, the age/sex/race group with the highest rates of early severe and complicated HBP and the lowest rates of awareness, treatment, and...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0895-7061(99)00121-1

    authors： Hill MN,Bone LR,Kim MT,Miller DJ,Dennison CR,Levine DM

    更新日期：1999-10-01 00:00:00

  • Specific genetic influences on nighttime blood pressure.

    abstract：OBJECTIVES:Nighttime blood pressure (BP) has been shown to be superior to daytime BP in predicting hypertension related target organ damage and cardiac mortality. In our Georgia Cardiovascular Twin Study, we showed that apart from the genes that also influence daytime BP, specific genetic determinants explained 44% and...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,meta分析

    doi：10.1093/ajh/hpu162

    authors： Xu X,Su S,Treiber FA,Vlietinck R,Fagard R,Derom C,Gielen M,Loos RJ,Snieder H,Wang X

    更新日期：2015-04-01 00:00:00

  • Endocrine and renal effects of nifedipine gastrointestinal therapeutic system in patients with essential hypertension. Results of a multicenter trial. The Modern Approach to the Treatment of Hypertension Study Group.

    abstract：:Use of thiazide diuretics and beta-blockers in the treatment of hypertension may result in metabolic derangements and/or disturbances in the parameters of renal function, which offset the benefits of blood pressure reduction by adversely affecting other cardiovascular risk factors, particularly in special patient grou...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,多中心研究

    doi：

    authors： Tuck ML,Bravo EL,Krakoff LR,Friedman CP

    更新日期：1990-12-01 00:00:00

  • Association between adducin-1 G460W variant and blood pressure in Swedes is dependent on interaction with body mass index and gender.

    abstract：BACKGROUND:The W allele of the G460W polymorphism in the adducin-1 gene has been occasionally associated with increased blood pressure (BP). The aim of this study was to test whether the G460W variant is associated with BP levels and BP progression rate and whether G460W associations with BP are affected by sex, body m...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2007.04.007

    authors： Fava C,Montagnana M,Almgren P,Rosberg L,Guidi GC,Berglund G,Melander O

    更新日期：2007-09-01 00:00:00

  • Maternal endothelial progenitor colony-forming units with macrophage characteristics are reduced in preeclampsia.

    abstract：BACKGROUND:Endothelial progenitor cells (EPCs) provide paracrine support to the vascular endothelium and may also replace damaged or senescent endothelial cells. Low numbers of endothelial progenitor colony-forming units (CFU-ECs) in culture are a predictive biomarker of vascular disease. We hypothesized that the numbe...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2009.101

    authors： Lin C,Rajakumar A,Plymire DA,Verma V,Markovic N,Hubel CA

    更新日期：2009-09-01 00:00:00

  • Calcineurin inhibitors cause renal afferent activation in rats: a novel mechanism of cyclosporine-induced hypertension.

    abstract：:Inhibition of calcineurin-mediated signaling in T lymphocytes is a major mechanism of cyclosporine A (CsA)-induced immunosuppression, and previous rat studies have suggested that inhibition of calcineurin-mediated signaling in central neuronal pools involved in blood pressure regulation plays an important role in caus...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(00)00288-0

    authors： Zhang W,Victor RG

    更新日期：2000-09-01 00:00:00

  • Comparison of target organ damage in renovascular and essential hypertension.

    abstract：:In many reports, the prevalence of target organ damage in renovascular hypertension (RVH) appears to be higher than in essential hypertension (EH). Since in most studies the renal artery stenosis is part of a diffuse atherosclerotic disease, it is not known whether these complications are due to RVH itself or to the v...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(96)00199-9

    authors： Losito A,Fagugli RM,Zampi I,Parente B,de Rango P,Giordano G,Cao P

    更新日期：1996-11-01 00:00:00

  • Interaction of 1,25-dihydroxyvitamin D and plasma renin activity in high renin essential hypertension.

    abstract：:Renin secretion by the kidney is inhibited by an increase in free intracellular calcium concentration. This increase in free intracellular calcium content may be augmented by serum 1,25-dihydroxyvitamin D. In 10 subjects with high renin hypertension, an increase in dietary sodium intake resulted in an increase in urin...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/ajh/3.12.903

    authors： Burgess ED,Hawkins RG,Watanabe M

    更新日期：1990-12-01 00:00:00

  • Ambulatory blood pressure after acute exercise in older men with essential hypertension.

    abstract：:We sought to determine whether reductions in blood pressure in hypertensives after acute exercise persist for more than the 2 to 3 h found in controlled laboratory settings. Subjects (n = 11) were obese (32 +/- 4% body fat), sedentary (VO2max 27 +/- 4 mL/kg/min) 60 +/- 6-year-old men with stage 1 or 2 essential hypert...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0895-7061(99)00141-7

    authors： Taylor-Tolbert NS,Dengel DR,Brown MD,McCole SD,Pratley RE,Ferrell RE,Hagberg JM

    更新日期：2000-01-01 00:00:00

  • Likelihood ratios in the diagnosis of renal artery stenosis by magnetic resonance angiography compared with renal angiography.

    abstract：BACKGROUND:Renal angiography (RA) is considered to be the gold standard for the diagnosis of renal artery stenosis (RAS). However, it is invasive and potentially harmful; hence there is a need for an optimal noninvasive test. Magnetic resonance angiography (MRA) is currently accepted as the optimal noninvasive test by ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2003.07.016

    authors： Attallah N,Yee J,Gutierrez A,Musial J,Parasuraman R

    更新日期：2003-12-01 00:00:00

  • Genetic susceptibility of the donor kidney contributes to the development of renal damage after syngeneic transplantation.

    abstract：:Solitary kidneys, especially in rats, appear vulnerable to develop functional and structural damage. However, differences in susceptibility exist between strains. It is not clear whether this is intrinsic to the kidney or due to environmental factors. Therefore, the aim of the present study was to investigate possible...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(99)00024-2

    authors： Kouwenhoven EA,van Dokkum RP,Marquet RL,Heemann UW,de Bruin RW,IJzermans JN,Provoost AP

    更新日期：1999-06-01 00:00:00

  • Effect of age on blood pressure parameters and risk of cardiovascular death in men.

    abstract：BACKGROUND:Elevated blood pressure (BP) is a risk factor for cardiovascular disease (CVD), but it remains unclear which component-alone or in combination-is the best predictor. We sought to determine which BP parameters are important predictors of CVD death across a wide age range. METHODS:We used a prospective cohort...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2005.06.024

    authors： Bowman TS,Sesso HD,Gaziano JM

    更新日期：2006-01-01 00:00:00

  • Should Blood Pressure Targets After Lacunar Stroke Vary by Body Size? The SPS3 Trial.

    abstract：BACKGROUND:It is unknown whether the physiological impact of a given blood pressure (BP) varies by body size. We explored interactions between higher vs. lower systolic BP (SBP) targets and anthropometric measures (body mass index (BMI), body surface area (BSA), height, weight) and recurrent stroke and death in the Sec...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1093/ajh/hpu228

    authors： Field TS,McClure LA,White CL,Pergola PE,Hart RG,Benavente OR,Hill MD,SPS3 Investigators.

    更新日期：2015-06-01 00:00:00

  • Lack of difference in oxalate-dependent Ca2+ uptake by membrane homogenate of African-American and white subjects.

    abstract：:In order to further characterize previously described racial differences in intracellular Ca2+ homeostasis, the activity of sarcoplasmic-endoplasmic reticulum Ca2+-ATPase was measured in cultured skin fibroblasts from normotensive African-Americans and whites. Cells originated from apparently healthy, normotensive Afr...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(96)00415-3

    authors： Yang XY,Aviv A,Hopp L

    更新日期：1997-04-01 00:00:00

  • Improved cardiovascular risk stratification by a simple ECG index in hypertension.

    abstract：BACKGROUND:We determined the prognostic value of the Cornell/strain [C/S] index, a simple electrocardiographic (ECG) index for left ventricular hypertrophy (LVH) defined by the presence of either a classic strain pattern or a Cornell voltage (sum of R in aVL + S in V(3)) >2.0 mV in women or 2.4 mV in men, or both. MET...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0895-7061(03)00912-9

    authors： Verdecchia P,Angeli F,Reboldi G,Carluccio E,Benemio G,Gattobigio R,Borgioni C,Bentivoglio M,Porcellati C,Ambrosio G

    更新日期：2003-08-01 00:00:00

  • Associations of Apelin, Visfatin, and Urinary 8-Isoprostane With Severe Hypertension in African Americans: The MH-GRID Study.

    abstract：BACKGROUND:Apelin is an adipokine directly associated with adiposity, insulin resistance, and decreased blood pressure. Urinary 8-isoprostane is a marker of chronic oxidative endothelial stress. Visfatin, an adipokine that acts by binding and activating the insulin receptor, has been associated with hypertension. As se...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpw007

    authors： Horbal SR,Seffens W,Davis AR,Silvestrov N,Gibbons GH,Quarells RC,Bidulescu A

    更新日期：2016-07-01 00:00:00