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Ambulatory--not office--blood pressures decline during hormone replacement therapy in healthy postmenopausal women.

Abstract：

:Hormone replacement therapy (HRT, estrogen plus progestagen) in postmenopausal women has beneficial effects on the cardiovascular system. However, effects on blood pressure, determined with office measurements, remain controversial. We studied the effects of HRT in 29 healthy normotensive postmenopausal women (mean age 52.3 [3.8] years, median duration of amenorrhea 34.5 months), using ambulatory blood pressure monitoring at baseline and at 3 and 12 months of follow-up. Women were randomized to two groups: an HRT group (N = 14), treated with 1 mg 17beta-estradiol once daily and 5 or 10 mg dydrogesterone once daily during the third and fourth week of every 4 weeks; and a control group (C-group, N = 15), which did not receive therapy. Blood pressures did not differ between the groups at baseline (HRT group 117.1 (9.2)/74.4 (6.6) mm Hg, C-group 113.8 (11.2)/71.3 (7.4) mm Hg). During the follow-up period, changes from baseline of office blood pressures did not differ significantly between the groups. However, changes (95% CI) of mean 24-h blood pressures differed significantly between the two groups after 1 year of follow-up: a decrease of blood pressures was observed in the HRT group (delta systolic/delta diastolic = -5.54 [-8.86 to -2.21]/-4.23 [-6.66 to -1.80] mm Hg), whereas an increase was found in the C-group (+3.33 [-0.69 to +7.35]/+1.67 [-1.75 to +5.09] mm Hg; P [HRT v control group] = .001/.005). We conclude that HRT may have blood pressure lowering properties in healthy, normotensive postmenopausal women.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

van Ittersum FJ,van Baal WM,Kenemans P,Mijatovic V,Donker AJ,van der Mooren MJ,Stehouwer CD

doi

10.1016/s0895-7061(98)00165-4

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

1147-52

issue

10

eissn

0895-7061

issn

1941-7225

pii

S0895-7061(98)00165-4

journal_volume

11

pub_type

临床试验,杂志文章,随机对照试验

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