Abstract:
BACKGROUND:The presence of asymptomatic left ventricular diastolic dysfunction (LVDD) in hypertensive patients can be associated with the development of cardiac events. The increase in sympathetic activity may be 1 of the mechanisms that predisposes to this outcome. In this study, we analyzed 2 hypotheses: (i) whether sympathetic activity is higher in the presence of LVDD, independent of blood pressure control and (ii) whether different classes of LVDD have a different effect on sympathetic activity. METHODS:After analyzing left ventricular function using echo Doppler cardiography, 45 hypertensive patients receiving treatment were allocated into 3 groups: normal function (LV-NF, n = 15), impaired relaxation (LV-IR, n = 15), and pseudonormal or restrictive (LV-P/R, n = 15). An age-, sex-, and body mass index-matched control group of normotensive volunteers (N, n = 14) was included. Muscle sympathetic nerve activity (MSNA), heart rate, and systolic blood pressure variabilities and baroreflex sensitivity were evaluated while the patient was in a supine position. RESULTS:Blood pressure and antihypertensive drug use were similar among the hypertensive groups. The LV-IR and LV-P/R groups had similar MSNA (33±1 and 32±1 bursts/min, respectively), which was significantly higher than that of the LV-NF and N groups (26±3 and 15±2 bursts/min, respectively). The LV-IR and LV-P/R groups had significantly higher LF-systolic blood pressure variability and significantly lower baroreflex sensitivity compared with the N group. CONCLUSIONS:The presence of asymptomatic LVDD is associated with increased MSNA, independent of blood pressure control. The sympathetic hyperactivity associated with LVDD is similar in the different patterns of LVDD studied.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
de Souza SB,Rocha JA,Cuoco MA,Guerra GM,Ferreira-Filho JC,Borile S,Krieger EM,Bortolotto LA,Consolim-Colombo FMdoi
10.1093/ajh/hpt032subject
Has Abstractpub_date
2013-07-01 00:00:00pages
912-7issue
7eissn
0895-7061issn
1941-7225pii
hpt032journal_volume
26pub_type
杂志文章,随机对照试验abstract:BACKGROUND:We examined the associations of epithelial sodium channel (ENaC) genes with blood pressure (BP) changes and hypertension incidence in a longitudinal family study. METHODS:A total of 2,755 Han Chinese participants of the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) baseline examination were eli...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpu060
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To estimate the prevalence and determinants of hypertension in India based on a new definition by the 2017 American College of Cardiology/American Heart Association (2017 ACC/AHA) Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults, and compare prevalence estima...
journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2020-03-13 00:00:00
abstract::The effects of increased dietary calcium intake on blood pressure and arterial function were investigated in one-kidney deoxycorticosterone-salt hypertensive Wistar rats. The calcium content of the control diet was 1.1%, and that of the high calcium diet, 2.5%. During the 10-week study calcium supplementation markedly...
journal_title:American journal of hypertension
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journal_title:American journal of hypertension
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更新日期:2007-07-01 00:00:00
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journal_title:American journal of hypertension
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doi:10.1093/ajh/2.9.675
更新日期:1989-09-01 00:00:00
abstract::Reversible posterior leukoencephalopathy syndrome (RPLS) is an uncommon entity related to multiple and different pathologies, the most common being hypertensive crisis. It is believed to be secondary to the breakdown on the blood-brain barrier. At the beginning, it is undistinguishable from other leukoencephalopathies...
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journal_title:American journal of hypertension
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更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:The present study examined the inhibitory action of temporary treatment with an angiotensin type 1 (AT(1)) receptor blocker (ARB) on vascular remodeling using hypertensive mice with overexpression of the human renin (hRN) and angiotensinogen (hANG) genes. METHODS:hRN/hANG transgenic mice (hRN/hANG-Tg) were ...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2011.6
更新日期:2011-05-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1093/ajh/2.8.650
更新日期:1989-08-01 00:00:00
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journal_title:American journal of hypertension
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2005-03-01 00:00:00
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journal_title:American journal of hypertension
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更新日期:1993-11-01 00:00:00
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journal_title:American journal of hypertension
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更新日期:2003-01-01 00:00:00
abstract::Angiotension converting enzyme (ACE) inhibitors and beta-blockers have been reported to possess disparate effects on insulin sensitivity. The aim of this study was to study the effects of the selective beta-1 blocker bisoprolol and of the ACE inhibitor captopril on cellular insulin action in hypertensive individuals. ...
journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-12-01 00:00:00
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journal_title:American journal of hypertension
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更新日期:1991-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1988-07-01 00:00:00
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journal_title:American journal of hypertension
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更新日期:2010-08-01 00:00:00
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更新日期:2014-11-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1997-08-01 00:00:00
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更新日期:2010-08-01 00:00:00
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journal_title:American journal of hypertension
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更新日期:2014-08-01 00:00:00
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journal_title:American journal of hypertension
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更新日期:1997-10-01 00:00:00
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journal_title:American journal of hypertension
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更新日期:2006-03-01 00:00:00
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journal_title:American journal of hypertension
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更新日期:1993-04-01 00:00:00
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journal_title:American journal of hypertension
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更新日期:2019-10-16 00:00:00
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更新日期:2005-10-01 00:00:00