Blood pressure, low-density lipoprotein cholesterol, and incidences of coronary artery disease and ischemic stroke in Japanese: the Suita study.


BACKGROUND:Blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) are risk factors for coronary artery disease (CAD) and ischemic stroke. However, the hazards of their coexistence are not fully understood in Asian populations. We investigated whether the relationship between BP and cardiovascular disease (CVD) outcomes are modified by LDL-C level in a Japanese population. METHODS:Individuals aged 30-79 years (n = 5,151) were classified into 6 groups according to LDL-C levels (<140 and ≥140mg/dL or lipid medication) and BP levels (optimal BP, prehypertension, and hypertension; reference: low LDL-C and optimal BP). Hazard ratios (HRs) were calculated after adjusting for age, high-density lipoprotein cholesterol, diabetes, smoking status, and alcohol consumption. The effect modification of LDL-C on BP-CVD association was assessed using likelihood ratio tests. RESULTS:There were 264 CAD and 215 ischemic stroke events during 13 years of follow-up. With low LDL-C, the HRs of prehypertension and hypertension for CAD were 2.01 and 4.71, respectively. Similar trends of HRs were observed with high LDL-C (optimal BP = 2.09, prehypertension = 3.45, hypertension = 5.94). However, the HRs for ischemic stroke did not differ between normal and high LDL-C levels at the same BP level. The apparent effect modification of LDL-C was not observed in the BP-CVD association in either CAD (P = 0.48) or ischemic stroke (P = 0.39). CONCLUSIONS:The HRs for CAD in prehypertensive and hypertensive groups were higher than those in the optimal BP group at the same LDL-C levels in a Japanese population; however, there was no statistical effect modification of LDL-C on the BP-CAD association.


Am J Hypertens


Tsukinoki R,Okamura T,Watanabe M,Kokubo Y,Higashiyama A,Nishimura K,Takegami M,Murakami Y,Okayama A,Miyamoto Y




Has Abstract


2014-11-01 00:00:00














  • Ethnicity and differences between clinic and ambulatory blood pressure measurements.

    abstract:BACKGROUND:This study investigated the relationship of ethnicity to the differences between blood pressure (BP) measured in a clinic setting and by ambulatory blood pressure monitoring (ABPM) in individuals with a previous diagnosis of hypertension (HT) and without a previous diagnosis of hypertension (NHT). METHODS:A...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Martin U,Haque MS,Wood S,Greenfield SM,Gill PS,Mant J,Mohammed MA,Heer G,Johal A,Kaur R,Schwartz C,McManus RJ

    更新日期:2015-06-01 00:00:00

  • A single mechanism to explain the effect of calcium on renal function.

    abstract::It is known that calcium induces the formation of potent vasodilators in endothelial cells and vasoconstriction in smooth muscle cells, whereas in the renal parenchyma, it modulates sodium excretion through vascular and tubular mechanisms. Consequently, an increased concentration of calcium in renal circulation may in...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Lahera V,Ruilope LM,Romero JC

    更新日期:1991-07-01 00:00:00

  • Augmentation index relates to progression of aortic disease in adults with Marfan syndrome.

    abstract:BACKGROUND:Noninvasive applanation tonometry (APT) is useful to assess aortic stiffness and pulse wave reflection. Moreover, APT can predict outcome in many conditions such as arterial hypertension. In this study, we test whether APT measurements relate to progression of aortic disease in Marfan syndrome (MFS). METHOD...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Mortensen K,Aydin MA,Rybczynski M,Baulmann J,Schahidi NA,Kean G,Kühne K,Bernhardt AM,Franzen O,Mir T,Habermann C,Koschyk D,Ventura R,Willems S,Robinson PN,Berger J,Reichenspurner H,Meinertz T,von Kodolitsch Y

    更新日期:2009-09-01 00:00:00

  • Different normalizations for body size and population attributable risk of left ventricular hypertrophy: the MAVI study.

    abstract:BACKGROUND:Different methods of normalizing left ventricular (LV) mass for body size identify generally similar relative risks of adverse cardiovascular outcome but with variable prevalences of LV hypertrophy (H). Preliminary results from a population with high prevalence of obesity suggest that the population attribut...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: de Simone G,Devereux RB,Maggioni AP,Gorini M,de Divitiis O,Verdecchia P,MAVI (MAssa Ventricolare sinistra nell'Ipertensione) Study Group.

    更新日期:2005-10-01 00:00:00

  • Silent cerebral infarcts in basal ganglia are advanced in congenital protein C-deficient heterozygotes with hypertension.

    abstract::Congenital protein C deficiency is now widely recognized as a genetic risk for venous thrombosis. However, it remains uncertain whether this condition also confers risk for arterial thrombosis. We evaluated the association of congenital protein C deficiency with hypertension and silent cerebrovascular disease using br...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kario K,Sakata T,Higashikawa M,Katayama Y,Hoshide S,Shimada K,Miyata T

    更新日期:2001-08-01 00:00:00

  • Recommendations for special populations: diabetes mellitus and the metabolic syndrome.

    abstract::Cardiovascular diseases (CVD) are the major causes of mortality in persons with diabetes, and many factors, including hypertension, contribute to this high prevalence of CVD. The incidence of hypertension in patients with diabetes is approximately twofold higher than in age-matched subjects without the disease, and co...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Sowers JR

    更新日期:2003-11-01 00:00:00

  • Evaluation of the IITC tail cuff blood pressure recorder in the rat against intraarterial pressure according to criteria for human devices.

    abstract::National standards govern the manufacture and marketing of medical devices in the United States, including those for indirect blood pressure measurement in man. There are no comparable standards for devices for recording in laboratory animals. Noninvasive tail cuff blood pressure (BP) recording in the rat is widely ac...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Jamieson MJ,Gonzales GM,Jackson TI,Koerth SM,Romano WF,Tan DX,Castillon F 3rd,Skinner MH,Grossmann M,Shepherd AM

    更新日期:1997-02-01 00:00:00

  • Control of hypertension in treated children and its association with target organ damage.

    abstract:BACKGROUND:The aim of our study was to investigate the control of hypertension (HT) in treated children using ambulatory blood pressure (BP) monitoring (ABPM). METHODS:We retrospectively reviewed all ABPM studies in our center. Controlled HT was defined as systolic and diastolic BP index (patients' BP divided by the 9...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Seeman T,Dostálek L,Gilík J

    更新日期:2012-03-01 00:00:00

  • Endothelin: key mediator of hypertension in preeclampsia.

    abstract::Preeclampsia is a pregnancy-induced hypertensive disorder characterized by proteinuria and widespread maternal endothelial dysfunction. It remains one of the most common disorders in pregnancy and remains one of the leading causes of maternal and fetal morbidity. Recent research has revealed that placental insufficien...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: George EM,Granger JP

    更新日期:2011-09-01 00:00:00

  • Report of the Working Party Group on Determining the Radionuclide of Choice.

    abstract::There are a variety of radiopharmaceuticals that can be used to perform captopril renography effectively. We examined a number of technetium and iodine compounds and the circumstances under which each radiopharmaceutical compound is the compound of choice. Considerations of cost, ease of use, reliability, dosage, and ...

    journal_title:American journal of hypertension

    pub_type: 共识发展会议,杂志文章,评审


    authors: Blaufox MD,Dubovsky EV,Hilson AJ,Taylor A Jr,de Zeeuw R

    更新日期:1991-12-01 00:00:00

  • Developmental studies demonstrate age-dependent elevation of renin activity in TGR(mRen2)27 rats.

    abstract::The objective of the present study was to determine the relationship between plasma renin levels, and the development of hypertension and cardiac hypertrophy in TGR (mREN2)27 hypertensive rats. Systolic blood pressure and left ventricular mass index (LVMI) were measured in transgenic heterozygote and normotensive Spra...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Véniant M,Whitworth CE,Ménard J,Sharp MG,Gonzales MF,Bruneval P,Mullins JJ

    更新日期:1995-12-01 00:00:00

  • Relationship between nutrition and blood pressure: a cross-sectional analysis from the NutriNet-Santé Study, a French web-based cohort study.

    abstract:BACKGROUND:Hypertension is the most prevalent chronic disease worldwide. Lifestyle behaviors for its prevention and control are recommended within worldwide guidelines. Nevertheless, their combined relationship with blood pressure (BP) level, particularly in the general population, would need more investigations. Our a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Lelong H,Galan P,Kesse-Guyot E,Fezeu L,Hercberg S,Blacher J

    更新日期:2015-03-01 00:00:00

  • Do beta-blockers really increase peripheral vascular resistance? Review of the literature and new observations under basal conditions.

    abstract::Most antihypertensive drugs act by counteracting vasoconstrictor mechanisms and lower blood pressure by lowering vascular resistance. The beta-blockers, which have the unique feature of counteracting cardiac sympathetic drive, seem to be a major exception to this generalization. Moreover, their degree of cardiodepress...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Man in't Veld AJ,Van den Meiracker AH,Schalekamp MA

    更新日期:1988-01-01 00:00:00

  • Erythropoietin and obstructive sleep apnea.

    abstract:OBJECTIVE:We tested the hypothesis that repetitive severe hypoxemia resulting from obstructive sleep apnea would increase serum erythropoietin, and that this increase would be attenuated by effective treatment of obstructive sleep apnea. METHODS:We studied healthy untreated patients with obstructive sleep apnea (18 se...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Winnicki M,Shamsuzzaman A,Lanfranchi P,Accurso V,Olson E,Davison D,Somers VK

    更新日期:2004-09-01 00:00:00

  • Left ventricular hypertrophy and clinical outcomes in hypertensive patients.

    abstract::The prevalence of left ventricular hypertrophy (LVH) rises with severity of hypertension (HT), age, and obesity. Its prevalence ranges from 20% in mildly hypertensive patients to almost 100% in those with severe or complicated HT. However, the diagnosis of LVH is not straightforward, and the definitions and criteria u...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Ruilope LM,Schmieder RE

    更新日期:2008-05-01 00:00:00

  • Gender-specific correlates of leptin with hypertension-related phenotypes in African Americans.

    abstract::Leptin may be a link in the relationship of obesity with hypertension. We evaluated associations of leptin with blood pressure (BP) in 54 normotensive and 114 hypertensive African American individuals. Plasma leptin was higher (P <.03) in hypertensive women than in normotensive women, although body mass index did not ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: El-Gharbawy AH,Kotchen JM,Grim CE,Kaldunski M,Hoffmann RG,Pausova Z,Hamet P,Kotchen TA

    更新日期:2002-11-01 00:00:00

  • Erythrocyte Na-K-Cl cotransport activity in low renin essential hypertensive patients. A 23Na nuclear magnetic resonance study.

    abstract::The Na-K-Cl cotransport activity in red blood cells from essential hypertensive men with low (n = 8, mean age 42 +/- 4 years) or normal renin activity (n = 4, mean age 43 +/- 3 years), and in normotensive men with normal renin activity (n = 7, mean age 38 +/- 4 years) has been evaluated by means of a recently develope...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Cacciafesta M,Ferri C,Carlomagno A,De Angelis C,Scuteri A,Guidoni L,Luciani AM,Rosi A,Viti V,Santucci A

    更新日期:1994-02-01 00:00:00

  • Identification of a functional Na+/Mg2+ exchanger in human trophoblast cells.

    abstract:BACKGROUND:Ionized magnesium levels are elevated in fetal blood compared with maternal blood, suggesting that the placenta may possess an active transport mechanism for magnesium. In the present study, we sought to determine the existence of an active transport mechanism for magnesium in the placenta using cultured tro...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Standley PR,Standley CA

    更新日期:2002-06-01 00:00:00

  • The relation between peripheral vascular structure, left ventricular hypertrophy, and ambulatory blood pressure in essential hypertension.

    abstract::The relations between left ventricular mass (LVM), peripheral resistance artery structure, and ambulatory BP were studied in 83 patients with previously untreated or poorly regulated essential hypertension and 20 healthy controls of similar age and sex. LVM was assessed by echocardiography. Signs of left ventricular h...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Sihm I,Schroeder AP,Aalkjaer C,Holm M,Mørn B,Mulvany M,Thygesen K,Lederballe O

    更新日期:1995-10-01 00:00:00

  • Brachial Pressure Control Fails to Account for Most Distending Pressure-Independent, Age-Related Aortic Hemodynamic Changes in Adults.

    abstract:BACKGROUND:Although several characteristics of aortic function, which are largely determined by age, predict outcomes beyond brachial blood pressure (BP), the extent to which brachial BP control accounts for age-related variations in aortic function is uncertain. We aimed to determine the extent to which brachial BP co...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Hodson B,Norton GR,Booysen HL,Sibiya MJ,Raymond A,Maseko MJ,Majane OH,Libhaber E,Sareli P,Woodiwiss AJ

    更新日期:2016-05-01 00:00:00

  • Maternal body mass index, height, and risks of preeclampsia.

    abstract:BACKGROUND:There is an association between maternal body mass index (BMI) and preeclampsia, but if BMI has an effect on preeclampsia of all severities is debated. If there is an association between maternal height and preeclampsia of all severities is unknown. METHODS:In this population-based cohort study including 50...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Sohlberg S,Stephansson O,Cnattingius S,Wikström AK

    更新日期:2012-01-01 00:00:00

  • Clofibrate acutely reverses saline-induced endothelial dysfunction: role of calcium-activated potassium channels.

    abstract:BACKGROUND:Endothelium-dependent vascular relaxation is impaired in various disease states including hypertension. METHODS:We investigated whether a single bolus dose of clofibrate could rapidly reverse saline-induced endothelial dysfunction, in vivo, in salt-loaded Sprague-Dawley (S-D) rats. S-D rats, 5 weeks of age,...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Sankaralingam S,Desai KM,Wilson TW

    更新日期:2006-11-01 00:00:00

  • Comparisons of the effects of different long-acting delivery systems on the pharmacokinetics and pharmacodynamics of diltiazem.

    abstract::The benzothiazepine calcium channel antagonist diltiazem is a short-acting drug. To achieve effective 24-h blood pressure control with once-daily dosing, it relies on various extended drug-delivery systems that have grown in importance as a result of the recent reports relating the use of short-acting calcium channel ...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Smith DH,Neutel JM,Weber MA

    更新日期:1999-10-01 00:00:00

  • What time is the "biologic zero hour" of circadian variability?

    abstract::Most ambulatory blood pressure monitoring (ABPM) studies have used a mechanical clock as the reference time, but there is no biologic background for assuming that midnight by the mechanical clock is zero hour by the biologic clock. The aim of this study was to determine the biologic zero hour as the zero reference tim...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Okutani M,Komori S,Iwasaki H,Mochizuki Y,Kohno I,Mochizuki S,Ishii H,Ijiri H,Tamura K

    更新日期:1997-07-01 00:00:00

  • Antihypertensive drug treatment and fibrinolytic function.

    abstract::Thromboembolic complications such as ischemic stroke and myocardial infarction are significantly more frequent in patients with arterial hypertension. From the available intervention studies, it appears that pharmacologic treatment of hypertension-at least with diuretics and beta-blockers-may more effectively protect ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Lottermoser K,Weisser B,Hertfelder HJ,Wöstmann B,Vetter H,Düsing R

    更新日期:1998-03-01 00:00:00

  • Characterization of imidazoline-guanidinium receptive sites in renal medulla from human kidney.

    abstract::Previous studies showed that alpha 2-adrenergic receptors and imidazoline-guanidinium receptive sites (IGRS) are colocalized in rabbit and human renal proximal tubule. In the present study we investigated the localization of these two binding sites in the renal medulla from human kidney. Binding studies performed with...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Lachaud V,Limon I,Tesson F,Coupry I,Parini A

    更新日期:1992-04-01 00:00:00

  • MIDAS, the Multicenter Isradipine/Diuretic Atherosclerosis Study. Design features and baseline data.

    abstract::The Multicenter Isradipine/Diuretic Atherosclerosis Study (MIDAS) is a randomized, double-blind, active-control trial to compare the effectiveness of two treatment regimens for the control of hypertension in reducing the rate of progression of early extracranial carotid artery atherosclerosis in hypertensive patients....

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Applegate WB,Byington RP

    更新日期:1991-02-01 00:00:00

  • Inflammatory activation and left ventricular mass in essential hypertension.

    abstract:BACKGROUND:Inflammation is an independent risk factor for high blood pressure, and as a consequence inflammatory cytokines could be related with left ventricular hypertrophy (LVH). We sought to assess the association and predictive role of different cytokine levels with LVH in a group of patients with essential hyperte...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Roselló-Lletí E,Rivera M,Martínez-Dolz L,González Juanatey JR,Cortés R,Jordán A,Morillas P,Lauwers C,Calabuig JR,Antorrena I,de Rivas B,Portolés M,Bertomeu V

    更新日期:2009-04-01 00:00:00

  • Association of Orthostatic Hypotension Timing With Clinical Events in Adults With Diabetes and Hypertension: Results From the ACCORD Trial.

    abstract:OBJECTIVE:To determine the effects of orthostatic hypotension (OH) measurement timing on its associations with dizziness, falls, fractures, cardiovascular disease (CVD), and mortality. METHODS:We analyzed OH measurements from the Action to Control Cardiovascular Risk in Diabetes BP trial, which evaluated two blood pre...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Juraschek SP,Lipsitz LA,Beach JL,Mukamal KJ

    更新日期:2019-06-11 00:00:00

  • Lack of agreement between office and ambulatory blood pressure responses to hydrochlorothiazide.

    abstract:BACKGROUND:Differences between the antihypertensive responses to drug therapy measured by office blood pressure (OBP) and ambulatory blood pressure monitoring (ABPM) techniques have been noted but rarely analyzed. We studied whether the OBP and 24-h ABPM responses to hydrochlorothiazide differ and, if so, the relevance...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Finkielman JD,Schwartz GL,Chapman AB,Boerwinkle E,Turner ST

    更新日期:2005-03-01 00:00:00