Abstract:
BACKGROUND:Blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) are risk factors for coronary artery disease (CAD) and ischemic stroke. However, the hazards of their coexistence are not fully understood in Asian populations. We investigated whether the relationship between BP and cardiovascular disease (CVD) outcomes are modified by LDL-C level in a Japanese population. METHODS:Individuals aged 30-79 years (n = 5,151) were classified into 6 groups according to LDL-C levels (<140 and ≥140mg/dL or lipid medication) and BP levels (optimal BP, prehypertension, and hypertension; reference: low LDL-C and optimal BP). Hazard ratios (HRs) were calculated after adjusting for age, high-density lipoprotein cholesterol, diabetes, smoking status, and alcohol consumption. The effect modification of LDL-C on BP-CVD association was assessed using likelihood ratio tests. RESULTS:There were 264 CAD and 215 ischemic stroke events during 13 years of follow-up. With low LDL-C, the HRs of prehypertension and hypertension for CAD were 2.01 and 4.71, respectively. Similar trends of HRs were observed with high LDL-C (optimal BP = 2.09, prehypertension = 3.45, hypertension = 5.94). However, the HRs for ischemic stroke did not differ between normal and high LDL-C levels at the same BP level. The apparent effect modification of LDL-C was not observed in the BP-CVD association in either CAD (P = 0.48) or ischemic stroke (P = 0.39). CONCLUSIONS:The HRs for CAD in prehypertensive and hypertensive groups were higher than those in the optimal BP group at the same LDL-C levels in a Japanese population; however, there was no statistical effect modification of LDL-C on the BP-CAD association.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Tsukinoki R,Okamura T,Watanabe M,Kokubo Y,Higashiyama A,Nishimura K,Takegami M,Murakami Y,Okayama A,Miyamoto Ydoi
10.1093/ajh/hpu059subject
Has Abstractpub_date
2014-11-01 00:00:00pages
1362-9issue
11eissn
0895-7061issn
1941-7225pii
hpu059journal_volume
27pub_type
杂志文章abstract::Subtle abnormalities of carbohydrate metabolism and overt diabetes mellitus are both associated with a substantial increase in the prevalence of hypertension and the accelerated development of atherosclerosis. Hypertension is also a presumed independent risk factor for atherosclerosis, although some of the atherogenic...
journal_title:American journal of hypertension
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doi:10.1093/ajh/6.7.260s
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND:Renal tubulointerstitial infiltration of activated T cells and macrophages is invariably present and plays a role in elevation of arterial pressure in nearly all animal models of hypertension (HTN). The role, if any, of elevated renal arterial pressure in the pathogenesis of this inflammatory process is unce...
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abstract:BACKGROUND:Hypertension has recently been identified as the leading risk factor for global mortality. This study aims to present the national prevalence of hypertension and prehypertension and, their determinants in Vietnamese adults. METHODS:Nationally representative data were obtained from the National Adult Overwei...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpu092
更新日期:2015-01-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2004.03.676
更新日期:2004-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/ajh/4.12.939
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1016/s0895-7061(00)01249-8
更新日期:2000-10-01 00:00:00
abstract:BACKGROUND:We examined the associations of epithelial sodium channel (ENaC) genes with blood pressure (BP) changes and hypertension incidence in a longitudinal family study. METHODS:A total of 2,755 Han Chinese participants of the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) baseline examination were eli...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpu060
更新日期:2014-11-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/0895-7061(95)00440-8
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,多中心研究,评审
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更新日期:1989-12-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(98)00047-8
更新日期:1998-07-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1016/s0895-7061(97)00496-2
更新日期:1998-03-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpv115
更新日期:2016-03-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2009.101
更新日期:2009-09-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(97)00321-x
更新日期:1998-02-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpaa030
更新日期:2020-09-10 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2007.03.015
更新日期:2007-08-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/3.1.62
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journal_title:American journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.amjhyper.2005.10.005
更新日期:2006-07-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章
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journal_title:American journal of hypertension
pub_type: 杂志文章,meta分析,评审
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1999-12-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2010.226
更新日期:2011-03-01 00:00:00
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doi:10.1093/ajh/hpw165
更新日期:2017-04-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ajh/4.2.161s
更新日期:1991-02-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/7.3.276
更新日期:1994-03-01 00:00:00
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更新日期:2017-07-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1038/ajh.2011.171
更新日期:2011-11-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2009.211
更新日期:2010-01-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1093/ajh/2.11.828
更新日期:1989-11-01 00:00:00