Abstract:
BACKGROUND:The role of pulsatile hemodynamics in the management of patients with acute heart failure syndrome (AHFS) remains to be elucidated. We investigated the changes of the pulsatile hemodynamics along the hospital course of AHFS in relation to short-term outcomes. METHODS:A total of 80 AHFS patients (73.2 ± 14.1 years, 82.5% men) were enrolled and followed up for up to 6 months after discharge. Measures of the pulsatile hemodynamics including brachial and central systolic blood pressure (SBP) and pulse (PP) pressure, carotid-femoral pulse wave velocity (cf-PWV), carotid augmentation index (cAI and cAI(75)) and carotid augmented pressure (cAP) were obtained within 24 h of admission, before discharge, and 2 weeks after discharge. RESULTS:During a follow-up of 174 ± 32 days (16-183 days), 29 patients experienced events including rehospitalization for heart failure, nonfatal myocardial infarction, nonfatal stroke, and mortality. Predischarge brachial and central PP, and cAP, and postdischarge brachial and central SBP and PP, cAP, and cf-PWV were significantly lower in patients without events than those with events. Predischarge central PP (hazard ratio per 1-s.d. and 95% confidence interval: 1.62 (1.12-2.34)) and cAP (1.47 (1.05-2.05)) predicted events independent of age and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels. Similarly, postdischarge brachial and central SBP and PP, cAP, and cf-PWV were also significant independent predictors. CONCLUSION:Suboptimal recovery of the perturbations of the pulsatile hemodynamics in patients hospitalized due to AHFS may relate to adverse short-term outcomes and warrant aggressive treatment.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Sung SH,Yu WC,Cheng HM,Chuang SY,Wang KL,Huang CM,Chen CHdoi
10.1038/ajh.2011.26subject
Has Abstractpub_date
2011-07-01 00:00:00pages
775-82issue
7eissn
0895-7061issn
1941-7225pii
ajh201126journal_volume
24pub_type
杂志文章abstract:BACKGROUND:Blood pressure is known to be higher in heavy drinkers than in nondrinkers. The aim of this study was to determine whether the alcohol-blood pressure relationship is modified by therapy for hypertension in the elderly. METHODS:Men aged > or = 65 years (n = 1,396) with or without current history of antihyper...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2010.52
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:The adipose tissue renin-angiotensin system (RAS) has been implicated in the pathophysiology of obesity and dysfunction of adipose tissue. However, neither regulation of angiotensinogen (AGT) expression in adipose tissue nor secretion of adipose tissue-derived AGT has been fully elucidated in humans. METHOD...
journal_title:American journal of hypertension
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doi:10.1038/ajh.2009.263
更新日期:2010-04-01 00:00:00
abstract::Echocardiography (ECHO) is useful to document changes in left ventricular mass (LVM) in groups of patients, but may be too variable for use in the individual patient. Magnetic resonance imaging (MRI) may be a more precise and reliable method to quantify the mass of the left ventricule. This study reports the accuracy,...
journal_title:American journal of hypertension
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更新日期:1995-03-01 00:00:00
abstract::In essential hypertension (EHT) the presence of a metabolic syndrome increases the risk of cardiovascular disease. A cell membrane abnormality is implicated but its role in cardiovascular disease is unclear. Neutrophil accumulation, which occurs by beta2-integrin (CD11b/CD18) expression, followed by release of proinfl...
journal_title:American journal of hypertension
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更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:There is growing evidence that residential environment is associated with hypertension. Recently, interest has also turned toward examining the possible influence of remoteness on hypertension. The aim of this study is to explore the effect of remoteness, the shortest path between the subject location and th...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2012.36
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:To determine the effects of orthostatic hypotension (OH) measurement timing on its associations with dizziness, falls, fractures, cardiovascular disease (CVD), and mortality. METHODS:We analyzed OH measurements from the Action to Control Cardiovascular Risk in Diabetes BP trial, which evaluated two blood pre...
journal_title:American journal of hypertension
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更新日期:2019-06-11 00:00:00
abstract:BACKGROUND:Nocturnal blood pressure (BP) is associated with risk for cardiovascular events. However, the relationship between nocturnal BP in young adults and cognitive function in midlife remains unclear. METHODS:We used data from the ambulatory BP monitoring substudy of the Coronary Artery Risk Development in Young ...
journal_title:American journal of hypertension
pub_type: 杂志文章,多中心研究
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更新日期:2015-10-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,meta分析
doi:10.1016/j.amjhyper.2005.01.011
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Subjects with hypertension are frequently obese or insulin resistant, both conditions in which hyperuricemia is common. Obese and insulin-resistant subjects are also known to have blood pressure that is more sensitive to changes in dietary sodium intake. Whether hyperuricemia is a resulting consequence, mode...
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pub_type: 杂志文章,随机对照试验
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journal_title:American journal of hypertension
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更新日期:1998-01-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2006.02.005
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Activation of phosphatidylinositol 3-kinase (PI3K)-Akt signaling by statins increases the activity of endothelial nitric oxide synthase (eNOS). We investigate whether statins (pitavastatin) improve cardiac function and remodeling via eNOS production associated with the PI3K-Akt signaling pathway, Rho-kinase ...
journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Uncontrolled treatment-resistant hypertension (TRH), i.e., blood pressure (BP, mm Hg) ≥140/≥90mm Hg in and out of office on ≥3 different BP medications at optimal doses, is common and has a poor prognosis. Aldosterone antagonist (AA) and renin-guided therapy (RGT) are effective strategies for improving BP co...
journal_title:American journal of hypertension
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doi:10.1093/ajh/hpw016
更新日期:2016-08-01 00:00:00
abstract::A wide pulse pressure (PP) may constitute an independent predictor of cardiovascular morbidity and mortality. We assessed the reference values of brachial clinic PP, according to age and gender in a nonselected population (61,724 subjects) who were undergoing a routine systematic health examination. According to mean ...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(01)01284-5
更新日期:2001-05-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpt095
更新日期:2013-10-01 00:00:00
abstract::Components of the kallikrein kinin system have been associated with the pathophysiology of hypertension in animal and human studies. In this study, we examined the distribution of four different polymorphisms of the kinin B1 and B2 receptor genes in a population of 120 normotensive and 77 hypertensive African-American...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(00)01215-2
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:The collateral circulation is important in maintenance of blood supply to the ischemic kidney distal to renal artery stenosis (RAS). Obesity metabolic syndrome (MetS) preserves renal blood flow (RBF) in the stenotic kidney, but whether this is related to an increase of collateral vessel growth is unknown. We...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpy127
更新日期:2018-11-13 00:00:00
abstract::To examine the effects of hypertension on renal graft function, we studied the clinical course of 144 kidney transplant recipients who had functioning grafts for three to 13 years. The patients were divided into three groups: normotensive (n = 32), controlled hypertensive (n = 49) and uncontrolled hypertensive group (...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/2.5.341
更新日期:1989-05-01 00:00:00
abstract:BACKGROUND:Structural atherosclerotic damage, arterial stiffness, pulse pressure (PP), and renal hemodynamics may interact and influence each other. Renal resistance index (RRI) appears as a good indicator of systemic vascular changes. The aim of our study was to assess the independent relationships of carotid intima-m...
journal_title:American journal of hypertension
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更新日期:2016-04-01 00:00:00
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journal_title:American journal of hypertension
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journal_title:American journal of hypertension
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journal_title:American journal of hypertension
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doi:10.1016/j.amjhyper.2004.10.020
更新日期:2005-03-01 00:00:00
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更新日期:1988-07-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Patients with chronic kidney disease (CKD) have a disproportionate risk of cardiovascular disease. This study was designed to assess the association between two noninvasive measures of cardiovascular risk, pulse wave analysis (PWA), and carotid intima-media thickness (IMT), in a cohort of CKD patients enroll...
journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00
abstract::High K diets prevent hypertensive endothelial injury and intimal thickening. Cholesterol esters often deposit during hypercholesterolemia. Would a high K diet influence cholesterol ester deposits? In a normal rat on a normal diet, no cholesterol esters are detected in the aorta. Stroke prone SHR rats were fed for 3 mo...
journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:1990-02-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
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更新日期:1997-05-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
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更新日期:1998-03-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:A high 24-hour ambulatory diastolic (DBP) but not systolic (SBP) blood pressure variability (BPV) is significantly predictive of long-term cardiovascular mortality in untreated hypertensive subjects, independent of office or 24-hour SBP. The present study was aimed to investigate hemodynamic factors that are...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpw144
更新日期:2017-03-01 00:00:00