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Noninvasive detection of vascular dysfunction in alcoholic patients.

Abstract：

:Vasodilation is impaired in various conditions, such as hypercholesterolemia and tobacco use. We evaluated brachial artery flow-mediated vasodilation (FMD) after blood pressure (BP) cuff occlusion using high-resolution B-mode ultrasound in 20 alcoholics, without any coexisting conditions such as smoking, hypertension, or cholesterolemia, after a 3-month period of abstinence. They were compared with a control group of 20 alcohol-free healthy subjects. We measured the diameter of the brachial artery under baseline conditions, during reactive hyperemia (with increased flow causing endothelium-dependent dilatation), and after administration of sublingual glyceryl trinitrate (GTN), an endothelium-independent dilator. We performed an echocardiographic study (Esaote Au3) according to guidelines of the American Society of Echocardiography to assess left ventricular mass (LVM), wall thickness, systolic stress, and diastolic function changes. FMD (% diameter change) was significantly less in the alcoholic patients than in the controls (6.03+/-3.67 v 13.7+/-4.65; P < .05), whereas no difference was noted after GTN administration (13.7+/-7.97 v 16.0+/-5.12, P = NS). Echocardiographic study showed no differences between the study group for LVM, wall thickness, and systolic stress; diastolic function expressed as E/A ratio inversion was significantly impaired. These data demonstrate an impairment of endothelial-dependent vasodilatation in chronic alcohol abusers, which may contribute to the excess prevalence of cardiovascular diseases in these individuals.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Maiorano G,Bartolomucci F,Contursi V,Minenna FS,Di Mise R,Palasciano A,Allegrini B,Amoruso M,Kozàkovà M

doi

10.1016/s0895-7061(98)00173-3

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

137-44

issue

2 Pt 1

eissn

0895-7061

issn

1941-7225

pii

S0895-7061(98)00173-3

journal_volume

12

pub_type

杂志文章

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