Inhibition of nitric oxide synthesis increases erythrocyte membrane fluidity and unsaturated fatty acid content.

abstract：BACKGROUND:C-reactive protein (CRP) predicts cardiovascular outcome. Oxidative stress is considered to be involved in endothelial alteration. We hypothesized that in essential hypertension (EH), oxidative stress, as measured by 8-iso-prostaglandin-F(2alpha) (8-iso-PGF(2alpha)), should be associated with increased CRP a...

journal_title：American journal of hypertension

authors： Cottone S,Mulè G,Nardi E,Vadalà A,Guarneri M,Briolotta C,Arsena R,Palermo A,Riccobene R,Cerasola G

更新日期：2006-03-01 00:00:00

abstract：:Congenital protein C deficiency is now widely recognized as a genetic risk for venous thrombosis. However, it remains uncertain whether this condition also confers risk for arterial thrombosis. We evaluated the association of congenital protein C deficiency with hypertension and silent cerebrovascular disease using br...

journal_title：American journal of hypertension

authors： Kario K,Sakata T,Higashikawa M,Katayama Y,Hoshide S,Shimada K,Miyata T

更新日期：2001-08-01 00:00:00

abstract：:Components of the kallikrein kinin system have been associated with the pathophysiology of hypertension in animal and human studies. In this study, we examined the distribution of four different polymorphisms of the kinin B1 and B2 receptor genes in a population of 120 normotensive and 77 hypertensive African-American...

journal_title：American journal of hypertension

authors： Gainer JV,Brown NJ,Bachvarova M,Bastien L,Maltais I,Marceau F,Bachvarov DR

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Research on associations between blood pressure, brain structure, and cognitive function has produced somewhat inconsistent results. In part, this may be due to differences in age ranges studied and because of sex differences in physiology and/or exposure to risk factors, which may lead to different time cou...

journal_title：American journal of hypertension

authors： Cherbuin N,Mortby ME,Janke AL,Sachdev PS,Abhayaratna WP,Anstey KJ

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:We aimed to assess the predictive value of circulating levels of des-acyl ghrelin, an abundant form of ghrelin in humans, for the risk of cardiovascular disease (CVD) in older hypertensive patients. We simultaneously evaluated other biomarkers, such as high-molecular-weight (HMW) adiponectin, high-sensitivit...

journal_title：American journal of hypertension

authors： Yano Y,Nakazato M,Toshinai K,Inokuchi T,Matsuda S,Hidaka T,Hayakawa M,Kangawa K,Shimada K,Kario K

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Calcium channel blockers such as amlodipine are effective antihypertensive agents. In this study we investigated the effects of amlodipine on vascular oxidative stress, expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1), and endothelial function in angiotensin (Ang) II-infused ra...

journal_title：American journal of hypertension

authors： Zhou MS,Jaimes EA,Raij L

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:A resequencing study of renal epithelial sodium channel (ENaC) genes was conducted to identify rare variants associated with blood pressure (BP) salt-sensitivity. METHODS:The Genetic Epidemiology Network of Salt-Sensitivity (GenSalt) study was conducted among 1,906 participants who underwent a 7-day low-sod...

journal_title：American journal of hypertension

authors： Gu X,Gu D,He J,Rao DC,Hixson JE,Chen J,Li J,Huang J,Wu X,Rice TK,Shimmin LC,Kelly TN

更新日期：2018-01-12 00:00:00

abstract：BACKGROUND:A high 24-hour ambulatory diastolic (DBP) but not systolic (SBP) blood pressure variability (BPV) is significantly predictive of long-term cardiovascular mortality in untreated hypertensive subjects, independent of office or 24-hour SBP. The present study was aimed to investigate hemodynamic factors that are...

journal_title：American journal of hypertension

authors： Hsu PF,Cheng HM,Sung SH,Chuang SY,Lakatta EG,Yin FC,Chou P,Chen CH

更新日期：2017-03-01 00:00:00

abstract：:The efficacy and safety of doxazosin (DOX) for the treatment of hypertension was investigated. A multicenter, double-blind, placebo-controlled, parallel design was employed. A 4-week placebo runin period was followed by a 9-week double-blind period during which patients were randomly assigned to placebo or 2, 4, or 8 ...

journal_title：American journal of hypertension

authors： Cubeddu LX,Pool JL,Bloomfield R,Klotman PE,Pickering BI,Wombolt DG,Nelson EB,Halperin A

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:The direct renin inhibitor aliskiren is known to exhibit a strong antihypertensive effect. However, the organoprotective potential of aliskiren beyond its antihypertensive properties is less clear. This study investigates the antifibrotic nephroprotective effects of aliskiren in a nonhypertensive mouse model...

journal_title：American journal of hypertension

authors： Gross O,Girgert R,Rubel D,Temme J,Theissen S,Müller GA

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:The collateral circulation is important in maintenance of blood supply to the ischemic kidney distal to renal artery stenosis (RAS). Obesity metabolic syndrome (MetS) preserves renal blood flow (RBF) in the stenotic kidney, but whether this is related to an increase of collateral vessel growth is unknown. We...

journal_title：American journal of hypertension

authors： Zhang X,Kim SR,Ferguson CM,Ebrahimi B,Hedayat AF,Lerman A,Lerman LO

更新日期：2018-11-13 00:00:00

abstract：:Hormone replacement therapy (HRT, estrogen plus progestagen) in postmenopausal women has beneficial effects on the cardiovascular system. However, effects on blood pressure, determined with office measurements, remain controversial. We studied the effects of HRT in 29 healthy normotensive postmenopausal women (mean ag...

journal_title：American journal of hypertension

authors： van Ittersum FJ,van Baal WM,Kenemans P,Mijatovic V,Donker AJ,van der Mooren MJ,Stehouwer CD

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:The renin-angiotensin system (RAS) plays a major role in promoting left ventricular (LV) remodeling in essential hypertension. We designed a controlled, randomized pilot study aimed to test the hypothesis that the dual RAS blockade with angiotensin-converting enzyme (ACE) inhibitor (ACEi) + angiotensin II re...

journal_title：American journal of hypertension

authors： Grandi AM,Solbiati F,Laurita E,Maresca AM,Nicolini E,Marchesi C,Gianni M,Guasti L,Venco A

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Subclinical cardiac damage has recently emerged as a potential predictor of adverse renal outcome. We therefore retrospectively evaluated the effect of left-ventricular hypertrophy (LVH), diagnosed electrocardiographically, on the renal outcome of hypertensive patients managed in primary care. METHODS:From ...

journal_title：American journal of hypertension

authors： Ravera M,Noberasco G,Signori A,Re M,Filippi A,Cannavò R,Weiss U,Cricelli C,Deferrari G,Paoletti E

更新日期：2013-05-01 00:00:00

abstract：:The aim of this study was to compare the efficacy (lowering diastolic blood pressure to 90 mm Hg or less) of urapidil, a postsynaptic alpha-blocker with central action with that of captopril in a randomized, double-blind, multicenter study. Two hundred ninety-five essential hypertensives (WHO I/II) (140 male, 155 fema...

journal_title：American journal of hypertension

authors： Rosenthal J,Schäfer N,Haerlin R,Wurst W,Solleder P

更新日期：1988-07-01 00:00:00

abstract：:The present study evaluates the growth promoting effect of insulin on the proliferative activity of cells from rat mesenteric arteries in culture in order to test the hypothesis that insulin may play a pathogenetic role in the hypertrophy of resistance vessels. The proliferative effect of insulin was studied in cultur...

journal_title：American journal of hypertension

authors： Cruzado M,Risler N,Castro C,Ortiz A,Rüttler ME

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Obesity has been described as a predictor of cardiovascular mortality, and some studies have reported an association with obesity and increased aortic stiffness. Other studies have not identified obesity to be an independent risk factor. Therefore, the purpose of our study was to determine the association be...

journal_title：American journal of hypertension

authors： Rodrigues SL,Baldo MP,Lani L,Nogueira L,Mill JG,Sa Cunha Rd

更新日期：2012-10-01 00:00:00

abstract：:In this study, 395 healthy children had blood pressure and heart rate measured both at rest and during a stressful video game. Identical measurement procedures were used for three annual examinations. Consistently, black children demonstrated significantly greater pressor responses than white children. In view of the ...

journal_title：American journal of hypertension

authors： Murphy JK,Alpert BS,Walker SS

更新日期：1991-07-01 00:00:00

abstract：:To clarify characteristics of the patients in whom exercise training lowers blood pressure and to elucidate the mechanisms by which exercise training lowers blood pressure, we evaluated 24-h blood pressure, glomerular filtration rate (GFR), renal blood flow (RBF), filtration fraction (FF), plasma renin activity (PRA),...

journal_title：American journal of hypertension

authors： Kohno K,Matsuoka H,Takenaka K,Miyake Y,Nomura G,Imaizumi T

更新日期：1997-08-01 00:00:00

abstract：:Increased dietary sodium intake has been associated with an increase in blood pressure as well as a decrease in insulin-mediated glucose disposal in young healthy adults. The purpose of this study was to determine whether dietary sodium intake is associated with changes in oral glucose tolerance, insulin sensitivity, ...

journal_title：American journal of hypertension

authors： Dengel DR,Mayuga RS,Kairis GM,Goldberg AP,Weir MR

更新日期：1997-09-01 00:00:00

abstract：:In order to examine the relationship existing between dietary calcium and the development of hypertension, we developed a long-term study in the Lyon hypertensive rat strain (LH) and two control strains, the Lyon normotensive (LN) and low blood pressure rats (LL) given enriched (HCa, 2.5%), deprived (LCa, 0.03%) and n...

journal_title：American journal of hypertension

authors： Pernot F,Schleiffer R,Bergmann C,Vincent M,Sassard J,Gairard A

更新日期：1990-11-01 00:00:00

abstract：:Pneumonia is a major direct cause of death in the elderly. Although aspiration based on a reduced cough reflex is one of the causes of pneumonia in the elderly, there are few studies of angiotensin-I converting enzyme inhibitors (ACE inhibitors), which are antihypertensive drugs that induce cough, as a factor influenc...

journal_title：American journal of hypertension

authors： Okaishi K,Morimoto S,Fukuo K,Niinobu T,Hata S,Onishi T,Ogihara T

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Hypertension presents high prevalence rates following kidney transplantation (Tx). The aims of the present study were to investigate the prevalence and possible risk factors for hypertension and blood pressure (BP) control over time after pediatric kidney Tx, as well as to assess possible effects of hyperten...

journal_title：American journal of hypertension

authors： Stabouli S,Printza N,Dotis J,Gkogka C,Kollios K,Kotsis V,Papachristou F

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus (DM) and hypertension (HT) frequently coexist. Increased central aortic pressures indexes are associated with HT; however, possible associations of these indexes with future development of DM have never been studied in HT. METHODS:We recruited 178 patients with uncomplicated nondiabetic HT...

journal_title：American journal of hypertension

authors： Chen JY,Chou CH,Lee YL,Tsai WC,Lin CC,Huang YY,Chen JH

更新日期：2010-10-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitors (ACEIs), introduced in clinical practice in 1980, are a relatively new class of drugs. They have been useful in the treatment of hypertension, where they are effective monotherapy in 40% to 50% of the patients and in combination therapy in up to 90%. They are also useful in the...

journal_title：American journal of hypertension

authors： Kostis JB

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:The expression of Na(+)-K(+)-2Cl(-) cotransporter 1 (NKCC1) is upregulated in spontaneously hypertensive rat (SHR). We investigated whether expression of NKCC1 is epigenetically regulated during postnatal development of hypertension. METHODS:The mesenteric arteries from 5-, 10-, and 18-week-old Wistar-Kyoto...

journal_title：American journal of hypertension

authors： Cho HM,Lee HA,Kim HY,Han HS,Kim IK

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Hypertension and proteinuria are risk factors for adverse renal outcomes in patients with chronic kidney disease. This study investigated the associations of blood pressure and proteinuria on renal function in a community-based population. METHODS:We analyzed data from a nationwide database of 141,514 subje...

journal_title：American journal of hypertension

authors： Hirayama A,Konta T,Kamei K,Suzuki K,Ichikawa K,Fujimoto S,Iseki K,Moriyama T,Yamagata K,Tsuruya K,Kimura K,Narita I,Kondo M,Asahi K,Kurahashi I,Ohashi Y,Watanabe T

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Few previous studies have reported the association of aortic stiffness with marine n-3 fatty acids (Fas) in the general population. The aim of this study was to determine the combined and independent associations of 2 major marine n-3 FAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with aort...

journal_title：American journal of hypertension

authors： Sekikawa A,Shin C,Masaki KH,Barinas-Mitchell EJ,Hirooka N,Willcox BJ,Choo J,White J,Evans RW,Fujiyoshi A,Okamura T,Miura K,Muldoon MF,Ueshima H,Kuller LH,Sutton-Tyrrell K,ERA JUMP Study Group.

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Exaggerated sympathetic cardiovascular (CV) reactivity to stress associates with elevated risk for clinical and preclinical end points of CV disease. It would be useful to identify these individuals, preferably from feasible measurements commonly used in health care. Our study examined the association betwee...

journal_title：American journal of hypertension

authors： Hintsala HE,Kiviniemi AM,Antikainen R,Mäntysaari M,Jokelainen J,Hassi J,Tulppo MP,Herzig KH,Keinänen-Kiukaanniemi S,Rintamäki H,Jaakkola JJK,Ikäheimo TM

更新日期：2019-05-09 00:00:00

abstract：:We sought to determine whether reductions in blood pressure in hypertensives after acute exercise persist for more than the 2 to 3 h found in controlled laboratory settings. Subjects (n = 11) were obese (32 +/- 4% body fat), sedentary (VO2max 27 +/- 4 mL/kg/min) 60 +/- 6-year-old men with stage 1 or 2 essential hypert...

journal_title：American journal of hypertension

authors： Taylor-Tolbert NS,Dengel DR,Brown MD,McCole SD,Pratley RE,Ferrell RE,Hagberg JM

更新日期：2000-01-01 00:00:00