当前位置： SCI文献检索 > AMERICAN JOURNAL OF HYPERTENSION期刊下所有文献 > Circulating des-acyl ghrelin improves cardiovascular risk prediction in older hypertensive patients.

Circulating des-acyl ghrelin improves cardiovascular risk prediction in older hypertensive patients.

Abstract：

BACKGROUND:We aimed to assess the predictive value of circulating levels of des-acyl ghrelin, an abundant form of ghrelin in humans, for the risk of cardiovascular disease (CVD) in older hypertensive patients. We simultaneously evaluated other biomarkers, such as high-molecular-weight (HMW) adiponectin, high-sensitivity C-reactive protein (hs-CRP), and plasminogen activator inhibitor 1 (PAI-1), for their usefulness in risk prediction. METHODS:We enrolled 590 older hypertensive patients (mean age = 72.9 years; 41.0% men). The incidences of CVD, including coronary artery disease, stroke, congestive heart failure, and sudden death, were prospectively ascertained. RESULTS:During an average duration of 2.8 (SD = 0.7) years (1,653 person-years), there were 42 CVD events. Patients with CVD events had lower levels of des-acyl ghrelin at baseline than those without CVD events (median = 78.2 vs. 114.7 fmol/ml; P < 0.001). No difference was found among other biomarkers between the patients with CVD events and those without such events. The Cox proportional hazards model adjusted by covariables revealed that the hazard ratio for CVD events in patients with a 1-SD decrease of log des-acyl ghrelin was 1.8 (95% confidence interval = 1.3-2.4). Incorporation of des-acyl ghrelin in the risk model (including age, current smoking, 24-hour systolic blood pressure, preexisting CVD, and carotid intima-media thickness) improved the C statistics (from 0.683 to 0.721; P = 0.22) and resulted in a net reclassification improvement of 20.5% (P = 0.02). In contrast, HMW adiponectin, hs-CRP, and PAI-1 provided no improvement in risk prediction. CONCLUSIONS:Des-acyl ghrelin improved the prediction of CVD events in older hypertensive patients.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Yano Y,Nakazato M,Toshinai K,Inokuchi T,Matsuda S,Hidaka T,Hayakawa M,Kangawa K,Shimada K,Kario K

doi

10.1093/ajh/hpt232

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

727-33

issue

5

eissn

0895-7061

issn

1941-7225

pii

hpt232

journal_volume

27

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF HYPERTENSION文献大全
  • High plasma immunoreactive leptin level in essential hypertension.

    abstract：:Insulin resistance, the most important factor in metabolic syndrome X, has been considered to raise blood pressure. Recently it was reported that insulin resistance was related to an elevated plasma level of leptin, which is an adipocyte-specific ob gene product and which plays a role in food intake suppression, therm...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(97)00310-5

    authors： Agata J,Masuda A,Takada M,Higashiura K,Murakami H,Miyazaki Y,Shimamoto K

    更新日期：1997-10-01 00:00:00

  • Prevention of high salt diet-induced cardiac hypertrophy and fibrosis by spironolactone.

    abstract：BACKGROUND:High salt diet causes cardiac hypertrophy and fibrosis and increases cardiac aldosterone, while decreasing plasma aldosterone. The present study assessed, in Wistar rats, the effect of high salt diet on left and right ventricle (LV and RV, respectively) weight and fibrosis both with and without the aldostero...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(02)03268-5

    authors： Lal A,Veinot JP,Leenen FH

    更新日期：2003-04-01 00:00:00

  • Captopril renography. Early observations and diagnostic criteria.

    abstract：:This article describes the methods and the interpretation of captopril renography. The essentials of the methods are the discontinuation of diuretics, the refraining from solid foods before administration of 25 mg captopril, hydration to induce diuresis, the performing of 1-min sequential images, data acquisition with...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/4.12.678s

    authors： Oei HY

    更新日期：1991-12-01 00:00:00

  • National prevalence and associated risk factors of hypertension and prehypertension among Vietnamese adults.

    abstract：BACKGROUND:Hypertension has recently been identified as the leading risk factor for global mortality. This study aims to present the national prevalence of hypertension and prehypertension and, their determinants in Vietnamese adults. METHODS:Nationally representative data were obtained from the National Adult Overwei...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpu092

    authors： Do HT,Geleijnse JM,Le MB,Kok FJ,Feskens EJ

    更新日期：2015-01-01 00:00:00

  • Specific genetic influences on nighttime blood pressure.

    abstract：OBJECTIVES:Nighttime blood pressure (BP) has been shown to be superior to daytime BP in predicting hypertension related target organ damage and cardiac mortality. In our Georgia Cardiovascular Twin Study, we showed that apart from the genes that also influence daytime BP, specific genetic determinants explained 44% and...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,meta分析

    doi：10.1093/ajh/hpu162

    authors： Xu X,Su S,Treiber FA,Vlietinck R,Fagard R,Derom C,Gielen M,Loos RJ,Snieder H,Wang X

    更新日期：2015-04-01 00:00:00

  • Effect of amlodipine on mesangial cell proliferation and protein synthesis.

    abstract：:Mesangial cells in the glomerulus have several important physiological functions, as has been demonstrated by past research. Platelet derived growth factor, thrombin, endothelin, and angiotensin II have all been shown to affect mesangial cell growth and protein synthesis. First generation Ca channel blockers also have...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：

    authors： Shultz PJ,Raij L

    更新日期：1992-12-01 00:00:00

  • Effect of Betanin, a Beetroot Component, on Vascular Tone in Isolated Porcine Arteries.

    abstract：BACKGROUND:Beetroot has attracted much attention because of its blood pressure-lowering properties. Although beetroot contains various nutritional compounds, including inorganic nitrate, some of their physiological properties are not fully understood. In this study, we examined whether betanin, a beetroot component, ha...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpaa006

    authors： Tawa M,Masuoka T,Yamashita Y,Nakano K,Ishibashi T

    更新日期：2020-04-01 00:00:00

  • Association between adducin-1 G460W variant and blood pressure in Swedes is dependent on interaction with body mass index and gender.

    abstract：BACKGROUND:The W allele of the G460W polymorphism in the adducin-1 gene has been occasionally associated with increased blood pressure (BP). The aim of this study was to test whether the G460W variant is associated with BP levels and BP progression rate and whether G460W associations with BP are affected by sex, body m...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2007.04.007

    authors： Fava C,Montagnana M,Almgren P,Rosberg L,Guidi GC,Berglund G,Melander O

    更新日期：2007-09-01 00:00:00

  • Improvement in metabolic risk factors for coronary heart disease associated with cilazapril treatment.

    abstract：:Patients with hypertension tend to be glucose intolerant, hyperinsulinemic, and dyslipedemic. Since all of these changes increase risk of coronary heart disease (CHD), it is important to know what effect antihypertensive treatment has on these variables. The current open-labelled, uncontrolled study was initiated in o...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章

    doi：10.1093/ajh/5.8.506

    authors： Shieh SM,Sheu WH,Shen DD,Fuh MM,Jeng CY,Jeng JR,Chen YD,Reaven GM

    更新日期：1992-08-01 00:00:00

  • Relationships among hyperuricemia, metabolic syndrome, and endothelial function.

    abstract：BACKGROUND:We evaluated the relationship of the severity of hyperuricemia and the flow-mediated vasodilatation of the brachial artery (FMD) in patients with and without the metabolic syndrome (MetS). METHODS:In a cross-sectional study, FMD was obtained in 2,732 Japanese healthy men (49 ± 8 years) who had no cardiovasc...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2011.55

    authors： Tomiyama H,Higashi Y,Takase B,Node K,Sata M,Inoue T,Ishibashi Y,Ueda S,Shimada K,Yamashina A

    更新日期：2011-07-01 00:00:00

  • Erythrocyte cation metabolism in salt-sensitive hypertensive blacks as affected by dietary sodium and calcium.

    abstract：:The role of dietary salt and calcium on changes in cellular cation metabolism has been evaluated in 11 salt-sensitive hypertensive black adults maintained on the following four metabolic diets for 56 days, 14 days on each diet in a repeated measures format: 356 mg Ca-1000 mg sodium (NA); 356 mg Ca-4000 mg Na; 934 Ca-1...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/1.4.386

    authors： Zemel MB,Kraniak J,Standley PR,Sowers JR

    更新日期：1988-10-01 00:00:00

  • Blood pressure in people in Greenland assessed by measuring renovasculopathies of hypertension at autopsy.

    abstract：:Surveys taken of blood pressure in Greenland indicated prevailing levels similar to those in the USA. Morphometrically measured renovasculopathies in 88 autopsies confirmed blood pressure levels comparable to the survey findings. At clinic visits, the recorded blood pressures in 48 of the autopsies verified the morpho...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(95)00440-8

    authors： Tracy RE,Mulvad G,Pederson HS,Jul E,Bjerregaard P,Newman WP 3rd

    更新日期：1996-06-01 00:00:00

  • Increased human urotensin II levels are correlated with carotid atherosclerosis in essential hypertension.

    abstract：BACKGROUND:Circulating blood levels of human urotensin II (U-II), the most potent vasoconstrictor peptide identified to date, are increased in patients with essential hypertension. Our previous studies showed that U-II accelerates human macrophage foam cell formation and vascular smooth muscle cell proliferation, sugge...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2006.08.001

    authors： Suguro T,Watanabe T,Ban Y,Kodate S,Misaki A,Hirano T,Miyazaki A,Adachi M

    更新日期：2007-02-01 00:00:00

  • Clinical experience with intravenous fenoldopam.

    abstract：:Fenoldopam (Corlopam), a new dopaminergic agent in clinical development by SmithKline Beecham Pharmaceuticals, is a dopamine-1 (DA1) agonist at post-synaptic dopamine receptors. Preclinical and clinical studies have demonstrated that it is a potent renal vasodilator as well as a peripheral vasodilator. In both normal ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/3.6.120s

    authors： Holcslaw TL,Beck TR

    更新日期：1990-06-01 00:00:00

  • Young Scholars Award Lecture: Intratubular angiotensinogen in hypertension and kidney diseases.

    abstract：:Recent findings related to the renin-angiotensin system have provided a more elaborated understanding of the pathophysiology of hypertension and kidney diseases. These findings have led to unique concepts and issues regarding the intrarenal renin-angiotensin system. Angiotensinogen is the only known substrate for reni...

    journal_title：American journal of hypertension

    pub_type：

    doi：10.1016/j.amjhyper.2005.11.014

    authors： Kobori H,Ozawa Y,Suzaki Y,Prieto-Carrasquero MC,Nishiyama A,Shoji T,Cohen EP,Navar LG

    更新日期：2006-05-01 00:00:00

  • Childhood predictors of high blood pressure.

    abstract：:Longitudinal studies in children have tracked blood pressure through childhood and from childhood into adult life. However, many children do not maintain their rank during these periods of observation. Several of the factors contributing to maintenance of rank order are reviewed, such as initial level of blood pressur...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/4.11s.608s

    authors： Mahoney LT,Clarke WR,Burns TL,Lauer RM

    更新日期：1991-11-01 00:00:00

  • Feasibility of home blood pressure measurement in elderly individuals: cross-sectional analysis of a population-based sample.

    abstract：BACKGROUND:Home blood pressure measurement (HBPM) is recommended by hypertension guidelines, particularly in the elderly. However, feasibility of HBPM in this age group has not been fully established. Our objective was therefore to assess HBPM feasibility in elderly individuals of the general population. METHODS:After...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,多中心研究

    doi：10.1038/ajh.2012.121

    authors： Cacciolati C,Tzourio C,Dufouil C,Alpérovitch A,Hanon O

    更新日期：2012-12-01 00:00:00

  • Pretreatment blood pressure as a predictor of 21-year mortality.

    abstract：:Our objective was to evaluate pretreatment predictors of longevity, particularly blood pressure, in a large cohort of hypertensive men. During 1974 to 1976, 10,367 male hypertensive veterans (47% black) were identified at screening and subsequently characterized in 32 special Veterans Administration (VA) hypertension ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(99)00214-9

    authors： Perry HM Jr,Miller JP,Baty JD,Carmody SE,Sambhi MP

    更新日期：2000-06-01 00:00:00

  • Albumin excretion rate and metabolic modifications in patients with essential hypertension. Effects of two angiotensin converting enzyme inhibitors.

    abstract：:A prospective randomized, double-blind, double-dummy study investigated the effects of two angiotensin converting enzyme (ACE) inhibitors on urinary albumin excretion in nondiabetic patients with mild to moderate essential hypertension. At the end of a 4-week placebo run-in period, 36 patients were randomly allocated ...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1093/ajh/7.1.46

    authors： Puig JG,Mateos FA,Ramos TH,Lavilla MP,Capitán MC,Gil A

    更新日期：1994-01-01 00:00:00

  • High-fructose feeding elicits insulin resistance without hypertension in normal mongrel dogs.

    abstract：:This study was undertaken to characterize blood pressure (by continuous blood pressure recording), renal hemodynamics, and excretory function in high-fructose-fed insulin-resistant dogs. We fed 10 mongrel dogs for 28 days with a normal sodium diet containing 60% of the calories either as fructose (n = 6) or dextrose (...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(95)00118-9

    authors： Pamies-Andreu E,Fiksen-Olsen M,Rizza RA,Romero JC

    更新日期：1995-07-01 00:00:00

  • Glucocorticoid sensitivity of circulating monocytes in essential hypertension.

    abstract：BACKGROUND:Essential hypertension ranks among the strongest cardiovascular risk factors. Cytokine production by monocytes plays a key role in atherosclerosis development and acute coronary syndromes. We investigated whether stimulated monocyte cytokine release and its inhibition by glucocorticoids would differ between ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2004.01.010

    authors： Wirtz PH,von Känel R,Frey K,Ehlert U,Fischer JE

    更新日期：2004-06-01 00:00:00

  • Actions of peroxisome proliferator-activated receptors-gamma agonists explaining a possible blood pressure-lowering effect.

    abstract：:The metabolic syndrome is a cluster of disturbances such as type 2 diabetes mellitus, hypertension, central obesity, dyslipidemia, and others for which insulin resistance and compensatory hyperinsulinemia have been proposed to be the underlying disorders. Several possible mechanisms linking insulin resistance and comp...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/j.amjhyper.2005.12.017

    authors： Sarafidis PA,Lasaridis AN

    更新日期：2006-06-01 00:00:00

  • New approaches to screening for vascular and cardiac risk.

    abstract：:Cardiovascular morbid events occur as a consequence of vascular and cardiac disease, which can be identified long before symptoms of organ involvement become apparent. Early detection of abnormalities in the small arteries, especially deficiency of endothelial nitric oxide bioactivity, and of structural changes of rem...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/s0895-7061(01)02092-1

    authors： Cohn JN

    更新日期：2001-06-01 00:00:00

  • Association of renal resistive index with target organ damage in essential hypertension.

    abstract：BACKGROUND:The renal resistive index (RI) measured using Doppler ultrasonography has been used as a diagnostic tool in the daily work-up of kidney diseases. A better understanding of its relationship with preclinical organ damage may help in determining overall cardiovascular risk in hypertensive patients. METHODS:We ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2012.113

    authors： Doi Y,Iwashima Y,Yoshihara F,Kamide K,Takata H,Fujii T,Kubota Y,Nakamura S,Horio T,Kawano Y

    更新日期：2012-12-01 00:00:00

  • Temporary treatment with AT1 receptor blocker, valsartan, from early stage of hypertension prevented vascular remodeling.

    abstract：BACKGROUND:The present study examined the inhibitory action of temporary treatment with an angiotensin type 1 (AT(1)) receptor blocker (ARB) on vascular remodeling using hypertensive mice with overexpression of the human renin (hRN) and angiotensinogen (hANG) genes. METHODS:hRN/hANG transgenic mice (hRN/hANG-Tg) were ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2011.6

    authors： Inaba S,Iwai M,Furuno M,Kanno H,Senba I,Okayama H,Mogi M,Higaki J,Horiuchi M

    更新日期：2011-05-01 00:00:00

  • Chronic hypertension leads to hyperinsulinemia in Sprague-Dawley rats treated with nitric oxide synthase inhibitor.

    abstract：:Insulin resistance and hypertension, as well as dyslipidemia, frequently cooccur. Evidence that nitric oxide (NO) plays a crucial role in the long-term regulation of systolic blood pressure led us to examine whether enhanced vasoconstriction and hypertension induced by NO synthase inhibitor could lead to insulin and l...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(98)00089-2

    authors： Erlich Y,Rosenthal T

    更新日期：1998-09-01 00:00:00

  • Does evidence-based medicine suggest that physicians should not be measuring blood pressure in the hypertensive patient?

    abstract：:The most common reason for an outpatient physician visit is for the diagnosis and treatment of hypertension. The Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC) VII, which is increasingly evidence-based, advises the clinician to use studies of the mean response...

    journal_title：American journal of hypertension

    pub_type： 社论,评审

    doi：10.1016/j.amjhyper.2003.12.007

    authors： Graves JW,Sheps SG

    更新日期：2004-04-01 00:00:00

  • Training students in education of the hypertensive patient: enhanced performance after a simulated patient instructor (SPI)-based exercise.

    abstract：:The process whereby a physician explains to the ill patient what has gone wrong and what can be done about it can be taught and evaluated by simulated patients (SPIs). This study was designed to determine whether a training experience in educating a diabetic SPI improves subsequent performance with a hypertensive SPI....

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(98)00034-x

    authors： Zweifler AJ,Sisson JC,Wolf FM,Trabin NL,Dicken LL,Gruppen LD,Grum CM,Baum KD

    更新日期：1998-05-01 00:00:00

  • Plasma levels of prorenin and renin in blacks and whites: their relative abundance and associations with plasma aldosterone concentration.

    abstract：BACKGROUND:All renin arises from prorenin. The proportion of renin relative to prorenin could influence overall renin-angiotensin-aldosterone activity. We sought to determine whether prorenin levels were related to extracellular volume, as reflected by the levels of plasma renin activity (PRA), and to aldosterone. MET...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2012.83

    authors： Tu W,Eckert GJ,Pratt JH,Jan Danser AH

    更新日期：2012-09-01 00:00:00

  • Impact of spironolactone on vascular, myocardial, and functional parameters in untreated patients with a hypertensive response to exercise.

    abstract：BACKGROUND:Although a hypertensive response to exercise (HRE) is associated with cardiac risk and masked hypertension (MHT), its mechanisms and appropriate treatment remain unclear. We investigated spironolactone as a treatment for abnormal vascular and myocardial stiffness in HRE. METHODS:In this randomized, double-b...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,随机对照试验

    doi：10.1093/ajh/hpt008

    authors： Hare JL,Sharman JE,Leano R,Jenkins C,Wright L,Marwick TH

    更新日期：2013-05-01 00:00:00