Actions of peroxisome proliferator-activated receptors-gamma agonists explaining a possible blood pressure-lowering effect.


:The metabolic syndrome is a cluster of disturbances such as type 2 diabetes mellitus, hypertension, central obesity, dyslipidemia, and others for which insulin resistance and compensatory hyperinsulinemia have been proposed to be the underlying disorders. Several possible mechanisms linking insulin resistance and compensatory hyperinsulinemia with hypertension have been described, such as renal sodium reabsorption enhancement, sympathetic nervous system activation, and blunted insulin-mediated vasodilation caused by endothelial dysfunction. Peroxisome proliferator-activated receptors-gamma agonists or thiazolidinediones (TZD) are a class of agents for the treatment of type 2 diabetes mellitus that act through improvement of insulin sensitivity. In parallel to their antihyperglycemic action, these drugs were found to exert beneficial effects on other components of the metabolic syndrome. For example all TZD have been shown to reduce blood pressure (BP) levels in both animal and human studies. In addition a considerable number of in vitro and in vivo studies report actions of TZD on the cardiovascular system that could explain this blood pressure-lowering effect of TZD, such as restoration of blunted endothelium-mediated vasodilation, attenuation of sympathetic overactivity, inhibition of intracellular Ca(2+) increase, and proliferation of vascular smooth muscle cells and others. This review summarizes the current evidence about these actions of TZD that could positively influence BP, representing possible mechanisms of BP amelioration.


Am J Hypertens


Sarafidis PA,Lasaridis AN




Has Abstract


2006-06-01 00:00:00














  • Insulin resistance, glucose intolerance and hyperinsulinemia in patients with hypertension.

    abstract::Plasma glucose and insulin responses to an oral glucose challenge and insulin-stimulated glucose uptake were measured in 47 age-, weight-, and sex-matched lean white men (16 with normal blood pressure, 14 with untreated hypertension, nine treated with a thiazide diuretic only, and eight treated with combined diuretic ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Swislocki AL,Hoffman BB,Reaven GM

    更新日期:1989-06-01 00:00:00

  • Brachial Pressure Control Fails to Account for Most Distending Pressure-Independent, Age-Related Aortic Hemodynamic Changes in Adults.

    abstract:BACKGROUND:Although several characteristics of aortic function, which are largely determined by age, predict outcomes beyond brachial blood pressure (BP), the extent to which brachial BP control accounts for age-related variations in aortic function is uncertain. We aimed to determine the extent to which brachial BP co...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Hodson B,Norton GR,Booysen HL,Sibiya MJ,Raymond A,Maseko MJ,Majane OH,Libhaber E,Sareli P,Woodiwiss AJ

    更新日期:2016-05-01 00:00:00

  • Hypertension, pulse, and other cardiovascular risk factors and vitamin D status in Finnish men.

    abstract:BACKGROUND:Debate exists about the relationship between hypovitaminosis D and cardiovascular (CVD) risk. METHODS:This study investigated baseline (n=2,271) 25-hydroxyvitamin D (25(OH)D) and baseline and 4 year (n=1,957) CVD risk in a cohort of Finnish middle-aged male smokers. RESULTS:The prevalences of measured hype...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Ke L,Graubard BI,Albanes D,Fraser DR,Weinstein SJ,Virtamo J,Brock KE

    更新日期:2013-08-01 00:00:00

  • Disturbances of transmembranous sodium transport systems induced by ethanol in human erythrocytes. An approach to the pressor effect of alcohol.

    abstract::Several epidemiological and clinical studies have established a clear association between alcohol consumption and hypertension. The mechanism of the pressor effect of ethanol is not well understood. We studied the in vitro effects of increasing amounts of ethanol on different Na+ transport systems from human erythrocy...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Coca A,Garay RP,Aguilera MT,De la Sierra A,Urbano-Márquez A

    更新日期:1989-10-01 00:00:00

  • Research opportunities and directions on the blood pressure problem. Combining predictors.

    abstract::While only a small percentage of the population has high blood pressure, a much larger segment of the US population has a high-normal (above optimal) blood pressure, and is at increased risk for hypertension and its cardiovascular sequelae. Hypertension is thus a population-wide problem and must be approached in much ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Stamler J

    更新日期:1991-11-01 00:00:00

  • Blood Pressure, Chronic Kidney Disease Progression, and Kidney Allograft Failure in Kidney Transplant Recipients: A Secondary Analysis of the FAVORIT Trial.

    abstract:BACKGROUND:In chronic kidney disease, intensive systolic blood pressure (SBP) control reduces mortality at a cost of greater acute kidney injury risk. Kidney transplantation involves implantation of denervated kidneys and immunosuppressive medications that increase acute kidney injury risk. The optimal blood pressure (...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: Malhotra R,Katz R,Weiner DE,Levey AS,Cheung AK,Bostom AG,Ix JH

    更新日期:2019-08-14 00:00:00

  • Adjusting adiposity and body weight measurements for height alters the relationship with blood pressure in children.

    abstract:BACKGROUND:Adiposity measures are associated with increased pediatric blood pressure (BP). However, this correlation can be confounded by the relationship of both variables to height. We evaluated whether adiposity and anthropometric measures were associated with pediatric BP before and after adjusting each value for h...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Willig AL,Casazza K,Dulin-Keita A,Franklin FA,Amaya M,Fernandez JR

    更新日期:2010-08-01 00:00:00

  • Pretreatment blood pressure as a predictor of 21-year mortality.

    abstract::Our objective was to evaluate pretreatment predictors of longevity, particularly blood pressure, in a large cohort of hypertensive men. During 1974 to 1976, 10,367 male hypertensive veterans (47% black) were identified at screening and subsequently characterized in 32 special Veterans Administration (VA) hypertension ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Perry HM Jr,Miller JP,Baty JD,Carmody SE,Sambhi MP

    更新日期:2000-06-01 00:00:00

  • The Metabolic Syndrome Does Not Affect Development of Collateral Circulation in the Poststenotic Swine Kidney.

    abstract:BACKGROUND:The collateral circulation is important in maintenance of blood supply to the ischemic kidney distal to renal artery stenosis (RAS). Obesity metabolic syndrome (MetS) preserves renal blood flow (RBF) in the stenotic kidney, but whether this is related to an increase of collateral vessel growth is unknown. We...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Zhang X,Kim SR,Ferguson CM,Ebrahimi B,Hedayat AF,Lerman A,Lerman LO

    更新日期:2018-11-13 00:00:00

  • Prevention and Treatment of Hypertension Study (PATHS). Rationale and design.

    abstract::Alcohol consumption has been recognized as an important correlate of blood pressure in many epidemiologic studies, but few interventional studies have been conducted to examine the effect of a reduction in alcohol intake on blood pressure. Because these studies have usually included few subjects and been of short dura...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cushman WC,Cutler JA,Bingham SF,Harford T,Hanna E,Dubbert P,Collins JF,Dufour M,Follman D,Allender PS

    更新日期:1994-09-01 00:00:00

  • Vitamin D and subsequent systolic hypertension among women.

    abstract:BACKGROUND:We examined data from a cohort of Caucasian women for evidence of an association between serum vitamin D (25-hydroxyvitamin D (25(OH)D)) insufficiency and greater risk of systolic hypertension in the population-based longitudinal Michigan Bone Health and Metabolism Study (MBHMS). METHODS:The cohort includes...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Griffin FC,Gadegbeku CA,Sowers MR

    更新日期:2011-03-01 00:00:00

  • Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: the Hypertension Genetic Epidemiology Network (HyperGEN) Study.

    abstract:BACKGROUND:Postural change in systolic blood pressure (SBP) is prospectively associated with several disease outcomes including hypertension, stroke, and coronary heart disease. The objective of this study was to characterize further a possible quantitative trait locus on chromosome 18q21 influencing SBP response to a ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Pankow JS,Dunn DM,Hunt SC,Leppert MF,Miller MB,Rao DC,Heiss G,Oberman A,Lalouel JM,Weiss RB

    更新日期:2005-05-01 00:00:00

  • Role of nitric oxide in cocaine-induced acute hypertension.

    abstract::Cocaine causes acute hypertension by blocking catecholamine reuptake. There is evidence that it also impairs the peripheral endothelial nitric oxide system, which is normally vasodilatory. We further explored the role of nitric oxide in cocaine-induced vasoconstriction in anesthetized rats, and in vitro by using isola...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Mo W,Singh AK,Arruda JA,Dunea G

    更新日期:1998-06-01 00:00:00

  • Hypertension and arterial stiffness: the Atherosclerosis Risk in Communities Study. ARIC Investigators.

    abstract::Our objective was to describe the relationship of arterial stiffness and hypertension in a large, population-based sample of men and women. Hypertension-related increases in arterial stiffness may reflect the distending pressure and/or structural alterations in the artery. Included were 10,712 participants, ages 45 to...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Arnett DK,Boland LL,Evans GW,Riley W,Barnes R,Tyroler HA,Heiss G

    更新日期:2000-04-01 00:00:00

  • Salt-sensitive hypertension in conscious rats induced by chronic nitric oxide blockade.

    abstract::This study examined the effects of alterations in salt-intake on blood pressure (BP) in rats chronically treated intravenously with or without the nitric oxide synthase (NOS) inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) (8.6 mg/kg/day). The changes in mean arterial pressure (MAP), the renal cortical and medul...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Nakanishi K,Hara N,Nagai Y

    更新日期:2002-02-01 00:00:00

  • Inflammatory mechanisms of atheroma formation. Influence of fluid mechanics and lipid-derived inflammatory mediators.

    abstract::It has been suggested that atheroma formation is a chronic inflammatory response to lipid-derived inflammatory mediators accumulating at selected arterial sites. At large artery flow dividers and curvatures, secondary flow phenomena create zones of stagnation and recirculation that deprive endothelial cells of shear s...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Henry PD,Chen CH

    更新日期:1993-11-01 00:00:00

  • Low-density lipoprotein particle size and coronary atherosclerosis in subjects belonging to hypertensive sibships.

    abstract:BACKGROUND:Dyslipidemia in hypertensive sibships may be characterized by atherogenic small low-density lipoprotein (LDL) particles. Whether LDL particle size is associated with the extent of coronary atherosclerosis in hypertensive sibships is unknown. METHODS:Subjects (n = 792, mean age 62 years, 60% women) were asce...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kullo IJ,Bailey KR,McConnell JP,Peyser PA,Bielak LF,Kardia SL,Sheedy PF 2nd,Boerwinkle E,Turner ST

    更新日期:2004-09-01 00:00:00

  • Prevention of high salt diet-induced cardiac hypertrophy and fibrosis by spironolactone.

    abstract:BACKGROUND:High salt diet causes cardiac hypertrophy and fibrosis and increases cardiac aldosterone, while decreasing plasma aldosterone. The present study assessed, in Wistar rats, the effect of high salt diet on left and right ventricle (LV and RV, respectively) weight and fibrosis both with and without the aldostero...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Lal A,Veinot JP,Leenen FH

    更新日期:2003-04-01 00:00:00

  • Blood pressure variability and urinary electrolyte excretion in normotensive adults.

    abstract::The principal aim of the present study was to determine the relationship of ambulatory blood pressure (BP) to urinary electrolyte excretion in normotensives. Twenty-five young adults underwent ambulatory BP and heart rate monitoring while collecting urine over 24 h. The correlations of 24 h urine sodium excretion and ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Ruddy MC,Arora A,Malka ES,Bialy GB

    更新日期:1993-06-01 00:00:00

  • Clinical studies of drug reversal of hypertensive left ventricular hypertrophy.

    abstract::Because left ventricular hypertrophy (LVH) is a strong risk factor for cardiac morbidity and mortality considerable interest has been generated concerning the possible effects of modifying LVH in hypertensive patients. In animal models disproportionate regression of left ventricular (LV) mass in relation to blood pres...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,评审


    authors: Liebson PR

    更新日期:1990-06-01 00:00:00

  • Blood pressure, low-density lipoprotein cholesterol, and incidences of coronary artery disease and ischemic stroke in Japanese: the Suita study.

    abstract:BACKGROUND:Blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) are risk factors for coronary artery disease (CAD) and ischemic stroke. However, the hazards of their coexistence are not fully understood in Asian populations. We investigated whether the relationship between BP and cardiovascular disease (...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Tsukinoki R,Okamura T,Watanabe M,Kokubo Y,Higashiyama A,Nishimura K,Takegami M,Murakami Y,Okayama A,Miyamoto Y

    更新日期:2014-11-01 00:00:00

  • Hypertension in HIV-infected patients: prevalence and related factors.

    abstract:BACKGROUND:Little is known about hypertension in the HIV-infected population. This study aimed to assess the prevalence of hypertension and related factors in HIV-infected patients. METHODS:In this prospective cross-sectional study, 710 HIV-infected patients (626 on combination antiretroviral therapy and 84 naive) man...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Jericó C,Knobel H,Montero M,Sorli ML,Guelar A,Gimeno JL,Saballs P,López-Colomés JL,Pedro-Botet J

    更新日期:2005-11-01 00:00:00

  • Relationship between nutrition and blood pressure: a cross-sectional analysis from the NutriNet-Santé Study, a French web-based cohort study.

    abstract:BACKGROUND:Hypertension is the most prevalent chronic disease worldwide. Lifestyle behaviors for its prevention and control are recommended within worldwide guidelines. Nevertheless, their combined relationship with blood pressure (BP) level, particularly in the general population, would need more investigations. Our a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Lelong H,Galan P,Kesse-Guyot E,Fezeu L,Hercberg S,Blacher J

    更新日期:2015-03-01 00:00:00

  • Retinal arteriolar narrowing and left ventricular hypertrophy in African Americans. the Atherosclerosis Risk in Communities (ARIC) study.

    abstract:BACKGROUND:Whether microvascular disease contributes to the development of left ventricular hypertrophy (LVH) is unclear. We examined the relationship of retinal microvascular signs with LVH in an African-American population. METHODS:A population-based, cross-sectional study of 1,439 middle-aged African-American parti...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Tikellis G,Arnett DK,Skelton TN,Taylor HW,Klein R,Couper DJ,Richey Sharrett A,Yin Wong T

    更新日期:2008-03-01 00:00:00

  • Blood pressure in people in Greenland assessed by measuring renovasculopathies of hypertension at autopsy.

    abstract::Surveys taken of blood pressure in Greenland indicated prevailing levels similar to those in the USA. Morphometrically measured renovasculopathies in 88 autopsies confirmed blood pressure levels comparable to the survey findings. At clinic visits, the recorded blood pressures in 48 of the autopsies verified the morpho...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Tracy RE,Mulvad G,Pederson HS,Jul E,Bjerregaard P,Newman WP 3rd

    更新日期:1996-06-01 00:00:00

  • Renovascular hypertension induces myocardial mitochondrial damage, contributing to cardiac injury and dysfunction in pigs with metabolic syndrome.

    abstract:BACKGROUND:Subjects with renovascular hypertension (RVH) often manifest with metabolic syndrome (MetS) as well. Coexisting MetS and hypertension increases cardiovascular morbidity and mortality, but the mechanisms underlying cardiac injury remain unknown. We hypothesized that superimposition of MetS induces myocardial ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Aghajani Nargesi A,Farah MC,Zhu XY,Zhang L,Tang H,Jordan KL,Saadiq IM,Lerman A,Lerman LO,Eirin A

    更新日期:2020-12-05 00:00:00

  • Effects of hyperinsulinemia on the regulation of regional blood flow and blood pressure in anesthetized dogs: hemodynamic role of nitric oxide.

    abstract::The purpose of this study was to investigate whether acute hyperinsulinemia induces selective hemodynamic effects in the mesenteric, renal, and iliac vascular beds, and to determine whether nitric oxide (NO) plays a role in the regulation of blood flow and mean arterial pressure (MAP) during acute hyperinsulinism. In ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Villa E,García-Robles R,Romero JC

    更新日期:1998-10-01 00:00:00

  • Association of Post-Saline Load Plasma Aldosterone Levels With Left Ventricular Hypertrophy in Primary Hypertension.

    abstract:BACKGROUND:Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular morbidity in hypertension. Current evidence suggests a contribution to LVH of plasma aldosterone levels that are inappropriately elevated for the salt status. The aim of this study was to investigate whether inappropriate mod...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Catena C,Verheyen ND,Url-Michitsch M,Kraigher-Krainer E,Colussi G,Pilz S,Tomaschitz A,Pieske B,Sechi LA

    更新日期:2016-03-01 00:00:00

  • Oil and water? Economic advantage and biomedical progress do not mix well in a government guidelines committee.

    abstract::This article examines the results of the Joint National Committee's Fifth Report on the treatment of hypertension (JNC-V), especially regarding the economic arguments put forth therein. Economics are a poor basis for treatment decisions, as the cheapest therapies may not be the best for any given patient. Broad treatm...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Ménard J

    更新日期:1994-10-01 00:00:00

  • Oxidative stress in hypertensive,diabetic, and diabetic hypertensive rats.

    abstract:BACKGROUND:Reactive oxygen species play a key role in the formation of endothelial dysfunction accompanying diabetes mellitus, hypertension, and other cardiovascular diseases. METHOD:This study compares oxidative stress (OS) in Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR), non-insulin-dependent Cohen...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Friedman J,Peleg E,Kagan T,Shnizer S,Rosenthal T

    更新日期:2003-12-01 00:00:00