Actions of peroxisome proliferator-activated receptors-gamma agonists explaining a possible blood pressure-lowering effect.


:The metabolic syndrome is a cluster of disturbances such as type 2 diabetes mellitus, hypertension, central obesity, dyslipidemia, and others for which insulin resistance and compensatory hyperinsulinemia have been proposed to be the underlying disorders. Several possible mechanisms linking insulin resistance and compensatory hyperinsulinemia with hypertension have been described, such as renal sodium reabsorption enhancement, sympathetic nervous system activation, and blunted insulin-mediated vasodilation caused by endothelial dysfunction. Peroxisome proliferator-activated receptors-gamma agonists or thiazolidinediones (TZD) are a class of agents for the treatment of type 2 diabetes mellitus that act through improvement of insulin sensitivity. In parallel to their antihyperglycemic action, these drugs were found to exert beneficial effects on other components of the metabolic syndrome. For example all TZD have been shown to reduce blood pressure (BP) levels in both animal and human studies. In addition a considerable number of in vitro and in vivo studies report actions of TZD on the cardiovascular system that could explain this blood pressure-lowering effect of TZD, such as restoration of blunted endothelium-mediated vasodilation, attenuation of sympathetic overactivity, inhibition of intracellular Ca(2+) increase, and proliferation of vascular smooth muscle cells and others. This review summarizes the current evidence about these actions of TZD that could positively influence BP, representing possible mechanisms of BP amelioration.


Am J Hypertens


Sarafidis PA,Lasaridis AN




Has Abstract


2006-06-01 00:00:00














  • Development of structural vascular changes with subpressor angiotensin II administration in rats.

    abstract::We investigated whether the slow pressor action of small doses of angiotensin II (ANG II) administered to rats was accompanied by the development of structural vascular changes. Male Sprague-Dawley rats (350 to 400 g) were given ANG II intraperitoneally, 200 ng/kg/min, for 7 to 10 days or 6 weeks, or 100 ng/kg/min for...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Simon G,Cserep G,Limas C

    更新日期:1995-01-01 00:00:00

  • Endothelial dysfunction in resistance arteries is related to high blood pressure and circulating low density lipoproteins in previously treated hypertension.

    abstract:BACKGROUND:Peripheral endothelial dysfunction has been demonstrated in hypertension. However, its relationship to blood pressure (BP) load, vascular structure, and metabolic disturbances in patients with long-standing, previously treated hypertension is unclear. METHODS:A total of 41 patients with stage I to III essen...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Olsen MH,Wachtell K,Aalkjaer C,Devereux RB,Dige-Petersen H,Ibsen H

    更新日期:2001-09-01 00:00:00

  • Diuretics for Hypertension: A Review and Update.

    abstract::This review and update focuses on the clinical features of hydrochlorothiazide (HCTZ), the thiazide-like agents chlorthalidone (CTDN) and indapamide (INDAP), potassium-sparing ENaC inhibitors and aldosterone receptor antagonists, and loop diuretics. Diuretics are the second most commonly prescribed class of antihypert...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Roush GC,Sica DA

    更新日期:2016-10-01 00:00:00

  • Intracerebroventricular metformin attenuates salt-induced hypertension in spontaneously hypertensive rats.

    abstract::The aim of this study was to examine the effects of long-term continuous intracerebroventricular (icv) infusion of metformin on blood pressure (BP) in spontaneously hypertensive rats (SHR). To accelerate the development of hypertension, SHR were fed a 8% NaCl diet during the 3-week study period. Metformin was given in...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Petersen JS,Andersen D,Muntzel MS,Diemer NH,Holstein-Rathlou NH

    更新日期:2001-11-01 00:00:00

  • Hemodynamic and endocrine responsiveness to mental arithmetic task and mirror drawing test in patients with essential hypertension.

    abstract::To evaluate the reactivity to psychological stress in patients with essential hypertension we investigated hemodynamic and endocrinologic changes during a mental arithmetic task (MAT) and a mirror drawing test (MDT) in 10 hypertensive subjects. Hemodynamic changes were assessed continuously using an ambulatory radionu...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Yoshiuchi K,Nomura S,Ando K,Ohtake T,Shimosawa T,Kumano H,Kuboki T,Suematsu H,Fujita T

    更新日期:1997-03-01 00:00:00

  • How should we treat hypertensive women with cardiac and renal impairment?

    abstract::Arterial hypertension is the most common chronic medical condition requiring office visits to physicians and is a major contributing factor to the development of myocardial infarction and stroke. Its importance as a cardiovascular risk factor is at least as significant in women as in men; however, the ever-growing lit...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Ruilope LM,Suarez C

    更新日期:1997-10-01 00:00:00

  • Blood flow pattern in the middle cerebral artery in relation to indices of arterial stiffness in the systemic circulation.

    abstract:BACKGROUND:The brain is perfused at high-volume flow throughout systole and diastole. We explored the association of blood flow in the middle cerebral artery (MCA) with the pulsatile components of blood pressure in the systemic circulation and indices of arterial stiffness. METHODS:We enrolled 334 untreated subjects (...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Xu TY,Staessen JA,Wei FF,Xu J,Li FH,Fan WX,Gao PJ,Wang JG,Li Y

    更新日期:2012-03-01 00:00:00

  • Dietary Sodium Modifies Serum Uric Acid Concentrations in Humans.

    abstract:BACKGROUND:Subjects with hypertension are frequently obese or insulin resistant, both conditions in which hyperuricemia is common. Obese and insulin-resistant subjects are also known to have blood pressure that is more sensitive to changes in dietary sodium intake. Whether hyperuricemia is a resulting consequence, mode...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,随机对照试验


    authors: Todd AS,Walker RJ,MacGinley RJ,Kelly J,Merriman TR,Major TJ,Johnson RJ

    更新日期:2017-11-06 00:00:00

  • Patterns of insulin secretion and responsiveness in Wistar-Kyoto and spontaneously hypertensive rats.

    abstract::An intravenous glucose tolerance test (IVGTT) was performed on 16 spontaneously hypertensive rats (SHR) and 15 Wistar-Kyoto rats (WKY) by challenging them with an intravenous glucose load of 0.125 g/100 g body weight. Serum glucose and insulin were measured at 0, 15, 30, 60, 120, and 240 min. In a second experiment, o...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Gaboury CL,Karanja N,Holcomb SR,Torok J,McCarron DA

    更新日期:1991-08-01 00:00:00

  • Hemodynamics of seasonal adaptation.

    abstract::To investigate the possibility that seasonal adaptation requires significant hemodynamic changes, 5 normotensive and 21 mildly hypertensive subjects were followed through 4 seasons for changes in systemic hemodynamics and sympathetic nervous activity. In the upright position wintertime blood pressures increased by 3% ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Izzo JL Jr,Larrabee PS,Sander E,Lillis LM

    更新日期:1990-05-01 00:00:00

  • Impact of Percutaneous Revascularization on Left Ventricular Mass and Its Relationship to Outcome in Hypertensive Patients With Renal Artery Stenosis.

    abstract:BACKGROUND:We investigated the effects of percutaneous transluminal renal angioplasty on left ventricular (LV) mass, and the impact of LV mass reduction on outcomes. METHODS:A total of 144 hypertensive patients with renal artery stenosis (RAS) (mean age 69 years; 22.2% fibromuscular dysplasia (FMD)) who underwent angi...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Iwashima Y,Fukuda T,Horio T,Kusunoki H,Hayashi SI,Kamide K,Kawano Y,Ishimitsu T,Yoshihara F

    更新日期:2020-05-21 00:00:00

  • Positive association between circulating free insulin-like growth factor-1 levels and coronary flow reserve in arterial systemic hypertension.

    abstract:BACKGROUND:The reduction of coronary flow reserve (CFR) found in arterial hypertension may be due to changes in afterload, left ventricular (LV) structure, and metabolic factors. Also, insulin-like growth factor-1 (IGF-1) may be associated with the magnitude of CFR in relation to its modulating action on cardiac and en...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Galderisi M,Caso P,Cicala S,De Simone L,Barbieri M,Vitale G,de Divitiis O,Paolisso G

    更新日期:2002-09-01 00:00:00

  • Protein phosphorylation and intracellular free calcium in platelets of patients with essential hypertension.

    abstract::Platelet intracellular free calcium concentration [Ca2+]i from patients with essential hypertension has been found to be elevated, but the intracellular effects of this increase are still unclear. As protein phosphorylation is an important regulatory step in cell activation and increased protein phosphorylation has be...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Haller H,Lindschau C,Quass P,Distler A

    更新日期:1992-03-01 00:00:00

  • G-6A polymorphism of angiotensinogen gene modulates the effect of blood pressure on carotid intima-media thickness. The Bogalusa Heart Study.

    abstract:BACKGROUND:The adverse association between blood pressure and carotid artery intima-media thickness (IMT), a surrogate measure of subclinical atherosclerosis, is well-known. However, whether the G-6A polymorphism of the angiotensinogen (AGT) gene, a candidate gene of hypertension and vascular remodeling, modulates this...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Bhuiyan AR,Chen W,Srinivasan SR,Rice J,Mock N,Tang R,Bond MG,Boerwinkle E,Berenson GS

    更新日期:2007-10-01 00:00:00

  • Intrafamilial aggregation and heritability of left ventricular geometric remodeling is independent of cardiac mass in families of African ancestry.

    abstract:BACKGROUND:Whether left ventricular (LV) geometric remodeling, as indexed by relative wall thickness (RWT), aggregates in families and is inherited independent of LV mass (LVM) and additional confounders is uncertain. METHODS:We determined whether RWT as assessed from 2D targeted M-mode echocardiography shows intrafam...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Peterson VR,Norton GR,Redelinghuys M,Libhaber CD,Maseko MJ,Majane OH,Brooksbank R,Woodiwiss AJ

    更新日期:2015-05-01 00:00:00

  • Associations of Reservoir-Excess Pressure Parameters Derived From Central and Peripheral Arteries With Kidney Function.

    abstract:BACKGROUND:Central artery reservoir-excess pressure parameters are clinically important but impractical to record directly. However, diastolic waveform morphology is consistent across central and peripheral arteries. Therefore, peripheral artery reservoir-excess pressure parameters related to diastolic waveform morphol...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Armstrong MK,Schultz MG,Picone DS,Black JA,Dwyer N,Roberts-Thomson P,Sharman JE

    更新日期:2020-04-01 00:00:00

  • Correlation between blood pressure responses to dietary sodium and potassium intervention in a Chinese population.

    abstract:BACKGROUND:Blood pressure (BP) responses to dietary sodium and potassium intake vary among individuals. We examined the correlation between BP responses to dietary low-sodium, high-sodium, and potassium supplementation interventions in a feeding study. METHODS:A total of 1,906 Chinese aged > or = 16 years participated...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Zhao Q,Gu D,Chen J,Bazzano LA,Rao DC,Hixson JE,Jaquish CE,Cao J,Chen J,Li J,Rice T,He J

    更新日期:2009-12-01 00:00:00

  • Determinants of long-term mortality in patients with type B acute aortic dissection.

    abstract:BACKGROUND:Type B acute aortic dissection (AAD) carries a high short- and midterm mortality rate; however, knowledge related to long-term outcome is largely incomplete. The objective of this study was to identify long-term predictors including antihypertensive medications in type B AAD. METHODS:We conducted a clinical...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Sakakura K,Kubo N,Ako J,Fujiwara N,Funayama H,Ikeda N,Nakamura T,Sugawara Y,Yasu T,Kawakami M,Momomura S

    更新日期:2009-04-01 00:00:00

  • LASSBio-294, A compound with inotropic and lusitropic activity, decreases cardiac remodeling and improves Ca²(+) influx into sarcoplasmic reticulum after myocardial infarction.

    abstract:BACKGROUND:Myocardial infarction (MI) is commonly associated with cardiac hypertrophy, reduced Ca²(+) uptake into the sarcoplasmic reticulum (SR) and impaired myocardial relaxation. Treatment to prevent MI-associated complications is currently lacking. The purpose of the present study was to investigate the remodeling ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Costa DG,da Silva JS,Kümmerle AE,Sudo RT,Landgraf SS,Caruso-Neves C,Fraga CA,de Lacerda Barreiro EJ,Zapata-Sudo G

    更新日期:2010-11-01 00:00:00

  • Inactive Matrix Gla Protein, Arterial Stiffness, and Endothelial Function in African American Hemodialysis Patients.

    abstract:BACKGROUND:Matrix Gla protein (MGP) is a vascular calcification inhibitor dependent upon vitamin K for activation. Evidence suggests that elevated plasma inactive MGP levels (desphospho-uncarboxylated MGP, dp-ucMGP; indicating poorer vascular vitamin K status) are associated with greater cardiovascular disease (CVD) ri...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Fain ME,Kapuku GK,Paulson WD,Williams CF,Raed A,Dong Y,Knapen MHJ,Vermeer C,Pollock NK

    更新日期:2018-05-07 00:00:00

  • Importance of left ventricular mass as a predictor of cardiovascular morbidity in hypertension.

    abstract::Arterial hypertension is a powerful risk factor for cardiovascular disease, but the ability to use blood pressure measurements to predict complications in individual patients or small groups is limited. One possible approach to identifying hypertensive patients at high risk is based on the observation that the presenc...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Devereux RB

    更新日期:1989-08-01 00:00:00

  • Angiotensin receptors: history and mysteries.

    abstract::Angiotensin receptors became relatively easy to study when radioactive derivatives of the peptide were synthesized for radioimmunoassays. Binding assays in vitro led to the discovery of receptors in many tissues different from those involved in the classic actions of angiotensin. The physiologic significance of recept...

    journal_title:American journal of hypertension

    pub_type: 历史文章,杂志文章


    authors: Goodfriend TL

    更新日期:2000-04-01 00:00:00

  • Two high affinity (Ca2+ + Mg2+)-ATPases of vascular smooth muscle plasma membrane preparation. Their relation to the Ca2(+)-pumping ATPase.

    abstract::High affinity Ca2(+)-activated, Mg2(+)-dependent ATP-ase [Ca2+ + Mg2+)-ATPase) activities were characterized in the membrane fractions of the porcine aorta. The (Ca2+ + Mg2+)-ATPase activity, similar to those found in the plasma membranes of the erythrocyte and the heart, ie, Ca2(+)-pumping ATPase activity, was not fo...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Yoshida Y,Sun HT,Imai S

    更新日期:1990-08-01 00:00:00

  • An additive effect of endothelial nitric oxide synthase gene polymorphisms contributes to the severity of atherosclerosis in patients on dialysis.

    abstract:BACKGROUND:Reduced synthesis of nitric oxide (NO) is considered a major proatherogenic mechanism in patients with end-stage renal disease (ESRD), but genetic factors impinging on this mechanism have been little studied in this population. METHODS:We tested the relationship between carotid intima-media thickness (IMT) ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Spoto B,Benedetto FA,Testa A,Tripepi G,Mallamaci F,Maas R,Boeger RH,Zoccali C

    更新日期:2007-07-01 00:00:00

  • Blood pressure and the risk of stroke, cardiovascular disease, and all-cause mortality among Japanese: the JPHC Study.

    abstract:BACKGROUND:Little is known about the influence of blood pressure (BP) on cardiovascular disease (CVD) outcomes among Asian populations. METHODS:We examined population attributable fractions (PAFs) and hazard ratios (HRs) associated with BP in relation to stroke and coronary heart disease (CHD) incident and mortality w...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Ikeda A,Iso H,Yamagishi K,Inoue M,Tsugane S

    更新日期:2009-03-01 00:00:00

  • An in-depth examination of the excretion of albumin and other sensitive markers of renal damage in mild hypertension.

    abstract::In an in-depth examination to better define the renal effects of mild hypertension, we used urinary proteins to indicate damage to the glomerulus (albumin), tubular reabsorption capability (retinol-binding protein), and turnover of tubular tissue (alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase) in a group ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Mueller PW,Hall WD,Caudill SP,MacNeil ML,Arepally A

    更新日期:1995-11-01 00:00:00

  • Association of home and ambulatory blood pressure changes with changes in cardiovascular biomarkers during antihypertensive treatment.

    abstract:BACKGROUND:Our aim was to assess whether home blood pressure (HBP) and ambulatory BP monitoring measurement (ABPM), in addition to office BP (OBP) predict changes of cardiovascular biomarkers during antihypertensive treatment. METHODS:Two hundred and fifty-two hypertensive patients (mean age, 68 years; men: 41%) under...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: Yano Y,Hoshide S,Shimizu M,Eguchi K,Ishikawa J,Ishikawa S,Shimada K,Kario K

    更新日期:2012-03-01 00:00:00

  • The effect of sleep intervals on analysis of 24-h ambulatory blood pressure data.

    abstract::Twenty-four hour blood pressure exposure and circadian blood pressure variability may be important predictors of hypertensive end-organ damage. Since sleep is a major determinant of circadian blood pressure decline, day/night blood pressure changes may be affected by sleep intervals. The current study compares 24-h bl...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Rosansky SJ,Menachery SJ,Wagner CM,Jackson K

    更新日期:1995-07-01 00:00:00

  • Echocardiographic comparison of left ventricular structure and function in hypertensive patients with primary aldosteronism and essential hypertension.

    abstract:BACKGROUND:In experimental renovascular hypertension, aldosterone has been implicated in myocardial remodeling and fibrosis, but it is uncertain whether excess aldosterone effects left ventricular structure and function in hypertensive patients. METHODS:Hypertensive patients from the Cardiovascular Center of the New Y...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: Goldkorn R,Yurenev A,Blumenfeld J,Fishman D,Devereux RB

    更新日期:2002-04-01 00:00:00

  • Insulin resistance in secondary hypertension.

    abstract::The insulin sensitivity of five essential hypertensive patients was compared to five patients with renovascular hypertension, five patients with primary hyperaldosteronism, and five normotensive subjects, using the euglycemic hyperinsulinemic clamp technique. Essential hypertensive patients had significantly lower ins...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Shamiss A,Carroll J,Rosenthal T

    更新日期:1992-01-01 00:00:00