当前位置： SCI文献检索 > AMERICAN JOURNAL OF HYPERTENSION期刊下所有文献 > Glomerular Density in Biopsy-Proven Hypertensive Nephrosclerosis.

Glomerular Density in Biopsy-Proven Hypertensive Nephrosclerosis.

Abstract：

BACKGROUND:Previous autopsy studies suggested that a reduced nephron number is associated with increased risk of hypertension and chronic kidney disease. However, the significance of the nephron number estimated from a renal biopsy in patients with hypertensive nephrosclerosis (HNS) has not yet been elucidated. METHODS:In this cross-sectional study, we examined the clinicopathological findings of biopsy-proven HNS patients with preserved renal function (estimated glomerular filtration rate ≥ 60 ml/min/1.73 m(2)). The glomerular density (GD; the number of glomeruli per total renal cortical area) in biopsy specimens was evaluated as a surrogate of the nephron number. Renal biopsies from kidney transplant donors were used as healthy controls. RESULTS:A total of 58 HNS patients were enrolled. The GD value in the HNS patients was low compared with those in the kidney transplant donors (2.0 vs. 3.2 /mm(2)). These differences remained significant when globally sclerotic glomeruli were included in the calculation of the GD. Of note, the GD in HNS patients with overt proteinuria (≥1 g/day) was significantly lower than that of HNS patients with mild proteinuria (<1g/day; 1.8 vs. 2.2/mm(2), P = 0.014). In contrast, other histopathological parameters, including the severity of global glomerulosclerosis, interstitial fibrosis/tubular atrophy and arterial and arteriole lesions were comparable between the 2 HNS subgroups. In addition, the GD was identified as a factor that was associated with the amount of urinary protein excretion at biopsy, independent of other clinicopathological factors. CONCLUSIONS:These results suggest that a low GD is a renal histological characteristic of HNS patients, especially those with overt proteinuria.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Haruhara K,Tsuboi N,Kanzaki G,Koike K,Suyama M,Shimizu A,Miyazaki Y,Kawamura T,Ogura M,Yokoo T

doi

10.1093/ajh/hpu267

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

1164-71

issue

9

eissn

0895-7061

issn

1941-7225

pii

hpu267

journal_volume

28

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF HYPERTENSION文献大全
  • Effects of omapatrilat on blood pressure and renal injury in L-NAME and L-NAME plus DOCA-treated rats.

    abstract：BACKGROUND:This study investigates the effects of chronic administration of omapatrilat (OMA) on blood pressure (BP), renal injury, and other variables in N(omega)-nitro-L-arginine methyl ester (L-NAME) hypertension and in the low-renin model produced by the simultaneous administration of L-NAME and deoxycorticosterone...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(02)03144-8

    authors： Rodriguez-Gomez I,Wangensteen R,Atucha NM,O'Valle F,Del Moral RG,Garcia-Estañ J,Vargas F,Osuna A

    更新日期：2003-01-01 00:00:00

  • Ethnic differences in the identification of left ventricular hypertrophy in the hypertensive patient.

    abstract：:Left ventricular hypertrophy (LVH) is more prevalent in black than white hypertensives, but this difference is greater when identified by electrocardiography (ECG) than by echocardiography. We evaluated the proposal that current ECG criteria for LVH are less specific, and therefore, less useful, in blacks than whites....

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(99)00027-8

    authors： Chapman JN,Mayet J,Chang CL,Foale RA,Thom SA,Poulter NR

    更新日期：1999-05-01 00:00:00

  • Body mass index is not independently associated with increased aortic stiffness in a Brazilian population.

    abstract：BACKGROUND:Obesity has been described as a predictor of cardiovascular mortality, and some studies have reported an association with obesity and increased aortic stiffness. Other studies have not identified obesity to be an independent risk factor. Therefore, the purpose of our study was to determine the association be...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2012.91

    authors： Rodrigues SL,Baldo MP,Lani L,Nogueira L,Mill JG,Sa Cunha Rd

    更新日期：2012-10-01 00:00:00

  • Impact of spironolactone on vascular, myocardial, and functional parameters in untreated patients with a hypertensive response to exercise.

    abstract：BACKGROUND:Although a hypertensive response to exercise (HRE) is associated with cardiac risk and masked hypertension (MHT), its mechanisms and appropriate treatment remain unclear. We investigated spironolactone as a treatment for abnormal vascular and myocardial stiffness in HRE. METHODS:In this randomized, double-b...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,随机对照试验

    doi：10.1093/ajh/hpt008

    authors： Hare JL,Sharman JE,Leano R,Jenkins C,Wright L,Marwick TH

    更新日期：2013-05-01 00:00:00

  • Calcium channel blockers for hypertension: dissecting the evidence for adverse effects.

    abstract：:Safety in the drug treatment of hypertension can only be seen in relation to efficacy, which has now come to mean not just blood pressure (BP) reduction but improvements in hard end points including mortality. Information on safety can come from a variety of sources, in an ascending hierarchy, which is as follows: cas...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/s0895-7061(96)00508-0

    authors： Opie LH

    更新日期：1997-05-01 00:00:00

  • Analysis of molecular heterogeneity of Dahl/Iwai salt-sensitive rats and salt-resistant rats.

    abstract：:Molecular evidence, using DNA fingerprint analyses, of extensive genetic heterogeneity between spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) and even within some of the WKY colonies has been reported. Thus we investigated the genetic relations between Dahl S and R rats newly inbred by Dr. Iwai. Gen...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：

    authors： Umemura S,Yamaguchi S,Hayashi S,Nyui N,Yokoyama N,Sumita YI,Hibi K,Yabana M,Kihara M,Tamura K,Ishigami T,Ishii M

    更新日期：1997-05-01 00:00:00

  • Hyperinsulinemia and insulin resistance are associated with preeclampsia in African-Americans.

    abstract：:There is evidence that hyperinsulinemia and insulin resistance play a role in the development of hypertension. Accordingly, in our ongoing longitudinal study of pregnancy-induced hypertension, we have measured fasting levels of insulin and glucose at 18 to 25 weeks gestation in 140 nulliparous African-American women f...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(94)00166-9

    authors： Sowers JR,Saleh AA,Sokol RJ

    更新日期：1995-01-01 00:00:00

  • Plasma marinobufagenin-like and ouabain-like immunoreactivity in adrenocorticotropin-treated rats.

    abstract：:Recently, an endogenous digitalis-like factor (EDLF) was shown to be stimulated in corticotropin (ACTH) hypertension in the rat. We have shown that mammalian plasma contains a vasoconstrictor Na,K-ATPase inhibitor, which cross-reacts with an antibody to amphibian EDLF, marinobufagenin. In the present experiment, the e...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(98)00042-9

    authors： Fedorova OV,Anderson DE,Bagrov AY

    更新日期：1998-07-01 00:00:00

  • Maternal endothelial progenitor colony-forming units with macrophage characteristics are reduced in preeclampsia.

    abstract：BACKGROUND:Endothelial progenitor cells (EPCs) provide paracrine support to the vascular endothelium and may also replace damaged or senescent endothelial cells. Low numbers of endothelial progenitor colony-forming units (CFU-ECs) in culture are a predictive biomarker of vascular disease. We hypothesized that the numbe...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2009.101

    authors： Lin C,Rajakumar A,Plymire DA,Verma V,Markovic N,Hubel CA

    更新日期：2009-09-01 00:00:00

  • Relation of left ventricular hypertrophy, afterload, and contractility to left ventricular performance in Goldblatt hypertension.

    abstract：:To analyze the determinants of left ventricular (LV) performance (myocardial afterload, chamber size, mass, and contractility) in Goldblatt hypertension, 19 anesthetized one-kidney, one-clip (1K1C) and 28 two-kidney, one-clip (2K1C) male Wistar rats were studied 58 to 62 days after clipping, together with 19 sham-oper...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/5.5.292

    authors： de Simone G,Devereux RB,Volpe M,Camargo MJ,Wallerson DC,Laragh JH

    更新日期：1992-05-01 00:00:00

  • Increased human urotensin II levels are correlated with carotid atherosclerosis in essential hypertension.

    abstract：BACKGROUND:Circulating blood levels of human urotensin II (U-II), the most potent vasoconstrictor peptide identified to date, are increased in patients with essential hypertension. Our previous studies showed that U-II accelerates human macrophage foam cell formation and vascular smooth muscle cell proliferation, sugge...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2006.08.001

    authors： Suguro T,Watanabe T,Ban Y,Kodate S,Misaki A,Hirano T,Miyazaki A,Adachi M

    更新日期：2007-02-01 00:00:00

  • Short-term antihypertensive medication does not exacerbate sleep-disordered breathing in newly diagnosed hypertensive patients.

    abstract：:It has been speculated for some time that various antihypertensive medications may have a deleterious effect on respiration during sleep and thereby enhance the apparent association between hypertension and sleep apnea/hypopnea (SAH). However, there are few data to support this contention. The present study used a dou...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0895-7061(96)00507-9

    authors： Bartel PR,Loock M,Becker P,Robinson E,van der Meyden C,Rossouw S

    更新日期：1997-06-01 00:00:00

  • Factors Associated With Physician Recommendation of Home Blood Pressure Monitoring and Blood Pressure in the US Population.

    abstract：BACKGROUND:Hypertension guidelines recommend home blood pressure monitoring (HBPM) to help achieve blood pressure (BP) control. We hypothesized that HBPM use with a physician recommendation would be associated with lower BP and greater medication adherence. METHODS:We used data from 6,320 adults with hypertension in t...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpaa093

    authors： Tang O,Foti K,Miller ER,Appel LJ,Juraschek SP

    更新日期：2020-09-10 00:00:00

  • Augmentation index relates to progression of aortic disease in adults with Marfan syndrome.

    abstract：BACKGROUND:Noninvasive applanation tonometry (APT) is useful to assess aortic stiffness and pulse wave reflection. Moreover, APT can predict outcome in many conditions such as arterial hypertension. In this study, we test whether APT measurements relate to progression of aortic disease in Marfan syndrome (MFS). METHOD...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2009.115

    authors： Mortensen K,Aydin MA,Rybczynski M,Baulmann J,Schahidi NA,Kean G,Kühne K,Bernhardt AM,Franzen O,Mir T,Habermann C,Koschyk D,Ventura R,Willems S,Robinson PN,Berger J,Reichenspurner H,Meinertz T,von Kodolitsch Y

    更新日期：2009-09-01 00:00:00

  • Effects of isradipine on peripheral hemodynamic reflex responses in mild-to-moderate essential hypertension.

    abstract：:In a randomized double-blind, placebo-controlled, crossover study of isradipine (5 mg twice daily), effects on peripheral hemodynamic reflex responses were studied in nine patients (mean age 48 years) at baseline and after six weeks of active treatment. Assessments included vital signs, resting blood flow in the calf ...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/ajh/4.2.194s

    authors： Duprez D,De Backer T,De Pue N,Hermans L,De Buyzere M,Clement DL

    更新日期：1991-02-01 00:00:00

  • Reference values for clinic pulse pressure in a nonselected population.

    abstract：:A wide pulse pressure (PP) may constitute an independent predictor of cardiovascular morbidity and mortality. We assessed the reference values of brachial clinic PP, according to age and gender in a nonselected population (61,724 subjects) who were undergoing a routine systematic health examination. According to mean ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(01)01284-5

    authors： Asmar R,Vol S,Brisac AM,Tichet J,Topouchian J

    更新日期：2001-05-01 00:00:00

  • Plasma viscosity in isolated systolic hypertension: the role of pulse pressure.

    abstract：:Atherosclerosis is increasingly recognized as an inflammatory vascular disease, and high blood pressure (BP) has been suggested to exert a proinflammatory action. Whether plasma viscosity (PV), a major determinant of blood flow in microcirculation and a marker of systemic inflammation and cardiovascular risk, is incre...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2005.01.014

    authors： Ciuffetti G,Schillaci G,Lombardini R,Pirro M,Vaudo G,Mannarino E

    更新日期：2005-07-01 00:00:00

  • Efficacy and safety of angiotensin receptor blockers in older patients: a meta-analysis of randomized trials.

    abstract：BACKGROUND:The efficacy and safety of angiotensin receptor blockers (ARBs) in the older population is unclear. OBJECTIVES:To determine the efficacy and safety of ARBs in older patients. METHODS:Randomized trials that compared ARBs to control and reported clinical outcomes in patients with a mean age of 65 years or ol...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,meta分析,评审

    doi：10.1093/ajh/hpu209

    authors： Elgendy IY,Huo T,Chik V,Pepine CJ,Bavry AA

    更新日期：2015-05-01 00:00:00

  • The effect of sodium supplementation on glucose tolerance and insulin concentrations in patients with hypertension and diabetes mellitus.

    abstract：:Severe short-term sodium restriction or extreme sodium loading may alter glucose tolerance and insulin resistance in patients with hypertension, but it is unclear whether variations in sodium intake within the clinically observed range affect glucose tolerance. To examine this issue, 21 patients with primary hypertens...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0895-7061(01)01310-3

    authors： Ames RP

    更新日期：2001-07-01 00:00:00

  • Blood pressure, brain structure, and cognition: opposite associations in men and women.

    abstract：BACKGROUND:Research on associations between blood pressure, brain structure, and cognitive function has produced somewhat inconsistent results. In part, this may be due to differences in age ranges studied and because of sex differences in physiology and/or exposure to risk factors, which may lead to different time cou...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpu120

    authors： Cherbuin N,Mortby ME,Janke AL,Sachdev PS,Abhayaratna WP,Anstey KJ

    更新日期：2015-02-01 00:00:00

  • Intranasal angiotensin II directly influences central nervous regulation of blood pressure.

    abstract：:Intranasal administration of some peptides has been shown to directly influence central nervous functions, thus pointing to a nose-brain pathway for these substances in humans. The present study investigated whether intranasal administration of angiotensin II (ANG II) affects central nervous functions of cardiovascula...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0895-7061(98)00095-8

    authors： Derad I,Willeke K,Pietrowsky R,Born J,Fehm HL

    更新日期：1998-08-01 00:00:00

  • The association of nephrolithiasis with hypertension and obesity: a review.

    abstract：:Kidney stones affect hypertensive patients disproportionately compared to normotensive individuals. On the other hand, some prospective data suggest that a history of nephrolithiasis was associated with a greater tendency to develop hypertension. Newer epidemiologic data also link obesity and diabetes, features of the...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1038/ajh.2007.62

    authors： Obligado SH,Goldfarb DS

    更新日期：2008-03-01 00:00:00

  • Impaired fibrinolysis and insulin resistance in patients with hypertension.

    abstract：:Plasma plasminogen activator inhibitor type 1 (PAI-1) and tissue plasminogen activator (tPA) antigens and activities were measured in 28 patients with hypertension and 12 normal controls. Steady state plasma glucose (SSPG) concentrations were also determined after an infusion of somatostatin, insulin and glucose. Pati...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章

    doi：10.1016/0895-7061(95)00442-4

    authors： Jeng JR,Sheu WH,Jeng CY,Huang SH,Shieh SM

    更新日期：1996-05-01 00:00:00

  • Blood pressure and cognitive functioning among independent elderly.

    abstract：BACKGROUND:The morbidity and mortality benefits of blood pressure (BP) control for the elderly is well documented. The cognitive consequences of hypertension control in this population, however, are still under debate. We aim to study the association between BP and cognitive performance in the elderly. Specifically, we...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(03)01005-7

    authors： Paran E,Anson O,Reuveni H

    更新日期：2003-10-01 00:00:00

  • Altering therapy of type II diabetes mellitus from insulin to tolazamide increases blood pressure in spite of weight loss.

    abstract：:In a retrospective study we investigated the effects of altering treatment of type II diabetes mellitus from insulin to tolazamide on weight and blood pressure. In 17 patients, weight decreased from 136 +/- 6 to 131 +/- 6% of ideal body weight (P = .01). Even though weight loss occurred, mean systolic blood pressure i...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(95)00046-R

    authors： Schmitt JK,Johns SB

    更新日期：1995-05-01 00:00:00

  • Independent association of plasma leptin levels and left ventricular isovolumic relaxation in uncomplicated hypertension.

    abstract：BACKGROUND:On the basis of evidence of plasma leptin (LE) effects on cardiovascular system, we assessed possible association of LE and Doppler-derived left ventricular (LV) diastolic function in arterial hypertension. METHODS:Doppler echocardiography, blood sample for fasting plasma LE levels, and euglycemic hyperinsu...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(01)02137-9

    authors： Galderisi M,Tagliamonte MR,D'Errico A,Carella C,Varricchio G,Mondillo S,de Divitiis O,Paolisso G

    更新日期：2001-10-01 00:00:00

  • Antihypertensive drug treatment and fibrinolytic function.

    abstract：:Thromboembolic complications such as ischemic stroke and myocardial infarction are significantly more frequent in patients with arterial hypertension. From the available intervention studies, it appears that pharmacologic treatment of hypertension-at least with diuretics and beta-blockers-may more effectively protect ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/s0895-7061(97)00496-2

    authors： Lottermoser K,Weisser B,Hertfelder HJ,Wöstmann B,Vetter H,Düsing R

    更新日期：1998-03-01 00:00:00

  • Blood pressure variability and urinary electrolyte excretion in normotensive adults.

    abstract：:The principal aim of the present study was to determine the relationship of ambulatory blood pressure (BP) to urinary electrolyte excretion in normotensives. Twenty-five young adults underwent ambulatory BP and heart rate monitoring while collecting urine over 24 h. The correlations of 24 h urine sodium excretion and ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/6.6.480

    authors： Ruddy MC,Arora A,Malka ES,Bialy GB

    更新日期：1993-06-01 00:00:00

  • Effects of dual blockade of Renin-Angiotensin system on concentric left ventricular hypertrophy in essential hypertension: a randomized, controlled pilot study.

    abstract：BACKGROUND:The renin-angiotensin system (RAS) plays a major role in promoting left ventricular (LV) remodeling in essential hypertension. We designed a controlled, randomized pilot study aimed to test the hypothesis that the dual RAS blockade with angiotensin-converting enzyme (ACE) inhibitor (ACEi) + angiotensin II re...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/ajh.2007.47

    authors： Grandi AM,Solbiati F,Laurita E,Maresca AM,Nicolini E,Marchesi C,Gianni M,Guasti L,Venco A

    更新日期：2008-02-01 00:00:00

  • Renal depressor mechanisms of physical training in patients with essential hypertension.

    abstract：:To clarify characteristics of the patients in whom exercise training lowers blood pressure and to elucidate the mechanisms by which exercise training lowers blood pressure, we evaluated 24-h blood pressure, glomerular filtration rate (GFR), renal blood flow (RBF), filtration fraction (FF), plasma renin activity (PRA),...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0895-7061(97)00109-x

    authors： Kohno K,Matsuoka H,Takenaka K,Miyake Y,Nomura G,Imaizumi T

    更新日期：1997-08-01 00:00:00